Review
Sport Sciences
Benjamin Singh, Kellie Toohey
Summary: This study evaluated the effectiveness of exercise in improving bone-related outcomes among cancer survivors through a systematic review and meta-analysis. The results showed that various modes of supervised and unsupervised exercise were associated with improvements in bone density, providing evidence for clinicians and other healthcare professionals to recommend exercise for preventing bone loss in cancer survivors.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Review
Oncology
Kellie Toohey, Michael Chapman, Anne-Marie Rushby, Kat Urban, Gemma Ingham, Benjamin Singh
Summary: This systematic review with meta-analysis aimed to evaluate the safety, feasibility, and effectiveness of exercise in the palliative care phase for people with advanced cancer. The results showed that exercise can improve quality of life, fitness, and strength, while reducing fatigue in cancer patients.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Sport Sciences
Sandra Christine Hayes, Ben Singh, Hildegard Reul-Hirche, Kira Bloomquist, Karin Johansson, Charlotta Jonsson, Melanie Louise Plinsinga
Summary: Exercise has positive effects on the prevention and treatment of cancer-related lymphedema (CRL), improving symptoms and health outcomes. A combination of aerobic and resistance exercise is recommended, and exercise should be guided by symptom response.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Oncology
Samuel T. Orange, Alastair R. Jordan, Adam Odell, Owen Kavanagh, Kirsty M. Hicks, Tristan Eaglen, Stephen Todryk, John M. Saxton
Summary: This study found that acute aerobic exercise can inhibit colon cancer cell proliferation by regulating DNA damage and repair through IL-6-induced mechanisms.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Sport Sciences
Koro Quevedo-Jerez, Erreka Gil-Rey, Sara Maldonado-Martin, Fernando Herrero-Roman
Summary: The study investigated the exercise intensity distribution and cardiovascular response in aerobic and resistance training among cancer survivors, highlighting the need for more supervision for less fit survivors and emphasizing the importance of individualized aerobic and resistance training to improve adherence.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Review
Oncology
Pedro Machado, Sara Pimenta, Barbara Oliveiros, Jose Pedro Ferreira, Raul A. Martins, Joana Cruz
Summary: Surgical treatment affects health-related quality of life (HRQoL) and increases fatigue symptoms in patients with lung cancer (LC) and colorectal cancer (CRC). Exercise training improves physical function and reduces fatigue after lung cancer surgery, but shows no significant effects after colorectal cancer surgery. Further research is needed to clarify the impact of exercise on HRQoL and fatigue in colorectal cancer patients post-surgery.
Article
Multidisciplinary Sciences
Christina M. Dieli-Conwright, Nathalie Sami, Mary K. Norris, Junxiang Wan, Hiroshi Kumagai, Su-Jeong Kim, Pinchas Cohen
Summary: MOTS-c, a mitochondrial derived peptide, has exercise mimetic activity with beneficial effects on metabolism and exercise capacity. The effects of MOTS-c in breast cancer survivors are influenced by race and a 16-week exercise intervention can increase MOTS-c levels among non-Hispanic White BCS.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Hong Yang, Yiwen Liu, Jinyu Kong
Summary: Patients with lung adenocarcinoma and EGFR-activating mutations exhibit good response to tyrosine kinase inhibitors but often develop resistance. Cancer stem cells (CSCs) play a crucial role in tumor initiation, invasion, and treatment response. Aerobic exercise can reduce oxidative stress, inhibit HIF-1 and ALDH1, and decrease CSCs, potentially enhancing the sensitivity of drug-resistant cells to gefitinib in lung adenocarcinoma treatment.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Geriatrics & Gerontology
Mary E. Medysky, Kelcey A. Bland, Sarah E. Neil-Sztramko, Kristin L. Campbell, Donald R. Sullivan, Kerri M. Winters-Stone
Summary: The authors systematically reviewed exercise trials in persons with lung cancer and found that the principles of exercise training and reporting of FITT components were not fully incorporated in these trials. Therefore, future studies should focus on applying exercise training principles and reporting FITT components more thoroughly.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2021)
Review
Cell Biology
Sina Taghvimi, Omid Vakili, Elahe Soltani Fard, Seyyed Hossein Khatami, Neda Karami, Mortaza Taheri-Anganeh, Mahsa Salehi, Babak Negahdari, Hassan Ghasemi, Ahmad Movahedpour
Summary: Lung cancer therapeutic resistance, especially chemoresistance, remains a major challenge in treating this disease. Recent studies have shown that transfer of exosomes, specifically noncoding RNAs, plays a crucial role in lung cancer chemoresistance by modulating various proteins and genes. Understanding these molecular mechanisms can help improve lung cancer therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Environmental Sciences
Fei Qin, Shuqiang Cui, Yanan Dong, Minxiao Xu, Zhongwei Wang, Chaoyi Qu, Jiexiu Zhao
Summary: This study found that aerobic pre-exercise can alleviate lung injury caused by urban PM2.5 in aging rats by modulating inflammatory pathways.
ENVIRONMENTAL POLLUTION
(2021)
Article
Sport Sciences
Kevin Boldt, Venus Joumaa, Jeannine Turnbull, Paul W. M. Fedak, Walter Herzog
Summary: Aerobic and resistance exercise training have distinct effects on cardiac structure; combining aerobic and resistance training may lead to greater benefits for cardiac health and performance.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Oncology
Farha Inam, Rebecca J. Bergin, David Mizrahi, David W. Dunstan, Melissa Moore, Natalie Maxwell-Davis, Linda Denehy, Brigid M. Lynch, Christopher T. V. Swain
Summary: The study explored the key components of physical activity programs for breast cancer patients, emphasizing the importance of person-centered and flexible programs, as well as the integration of physical activity within the broader health system.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Geriatrics & Gerontology
Erik D. Hanson, Lauren C. Bates, Elizabeth P. Harrell, David B. Bartlett, Jordan T. Lee, Chad W. Wagoner, Mohamdod S. Alzer, Dean J. Amatuli, Brian C. Jensen, Allison M. Deal, Hyman B. Muss, Kirsten A. Nyrop, Claudio L. Battaglini
Summary: Exercise may attenuate immunosenescence and improve immune cell response in older breast cancer survivors, although deficits in certain cell types like MAIT and CD3(+) are observed at baseline. Acute exercise leads to mobilization of immune cells, with trends towards improvement in BCS post-exercise, suggesting potential benefits of exercise training in rescuing immune dysfunction associated with aging and cancer.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Oncology
Gitte Holmen Olofsson, Marta Kramer Mikkelsen, Anne-Mette Ragle, Anne Birgitte Christiansen, Anne Pries Olsen, Lise Heide-Ottosen, Cecilia Bech Horsted, Cia Moon Scharbau Pedersen, Lotte Engell-Noerregaard, Torben Lorentzen, Gitte Fredberg Persson, Anders Vinther, Dorte Lisbet Nielsen, Per Thor Straten
Summary: Exercise training has been found to play an important role in cancer care by reducing treatment side effects and improving quality of life. Studies on mouse tumor models have shown that exercise can increase the infiltration of immune cells into the tumor, leading to altered tumor microenvironment and reduced tumor growth. Additionally, the infiltration of T and NK cells into the tumor microenvironment has been correlated with the response to immune checkpoint inhibitors in patients. To investigate this further, a clinical trial called HI AIM has been initiated to study the effects of high intensity exercise on immune cell infiltration in the tumor microenvironment of lung cancer patients.
Review
Oncology
Kellie Toohey, Michael Chapman, Anne-Marie Rushby, Kat Urban, Gemma Ingham, Benjamin Singh
Summary: This systematic review with meta-analysis aimed to evaluate the safety, feasibility, and effectiveness of exercise in the palliative care phase for people with advanced cancer. The results showed that exercise can improve quality of life, fitness, and strength, while reducing fatigue in cancer patients.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Review
Oncology
Kellie Toohey, Maddison Hunter, Karen McKinnon, Tamara Casey, Murray Turner, Suzanne Taylor, Catherine Paterson
Summary: This systematic review aimed to determine the efficacy of prehabilitation in participants diagnosed with breast cancer. Results showed that prehabilitation improved outcomes including physical function, quality of life, and psychosocial variables. Future investigations should consider intervention timeframes, follow-up, and population groups.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Jessica T. Watzek, Louisa G. Gordon, Carolina X. Sandler, Rosalind R. Spence, Dimitrios Vagenas, Christopher Pyke, Sandra C. Hayes
Summary: The purpose of this analysis was to compare the cost-consequences of a 12 week exercise intervention under high versus low supervision conditions in women with breast cancer. Results showed that a higher level of supervision was associated with a greater proportion of women experiencing health improvements, but further research is needed to determine the long-term health impacts of these group differences.
Review
Oncology
Catherine Paterson, Kellie Toohey, Rachel Bacon, Phillip S. Kavanagh, Cara Roberts
Summary: This umbrella systematic review finds that people affected by cancer have unmet supportive care needs in various domains, such as psychological/emotional, health system/information, interpersonal/intimacy, social, physical, family, practical, daily living, spiritual, patient-clinician communication, and cognitive needs. These findings highlight the need for targeted improvements and contributions to clinical trials, clinical guidelines, and policies.
SEMINARS IN ONCOLOGY NURSING
(2023)
Article
Rehabilitation
Jacinta Brinsley, Ben Singh, Carol A. Maher
Summary: This study demonstrates the proof-of-concept for a chatbot-led digital lifestyle medicine program in aiding rehabilitation for return-to-work. In a community setting in Australia, 78 adult participants with active workers' compensation claims showed improvements in psychological health and return-to-work outcomes through this program, indicating that artificial intelligence can provide a practical, supportive, and cost-effective intervention.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Review
Oncology
Grace Laura Rose, Elizabeth Mary Stewart, Briana Kristine Clifford, Tom George Bailey, Alexandra Jane Rush, Claudia Rose Abbott, Sandra Christine Hayes, Andreas Obermair, Alexandra Leigh McCarthy
Summary: This study systematically reviewed the efficacy of exercise intervention for women during/following treatment for gynaecological cancer. The results showed that exercise intervention can improve aerobic capacity, muscular strength, and agility, but the effects on quality of life, body composition, balance, and flexibility were inconsistent.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Medicine, General & Internal
Sandra Hayes, Andreas Obermair, Linda Mileshkin, Alison Davis, Louisa G. Gordon, Elizabeth Eakin, Monika Janda, Vanessa L. Beesley, Elizabeth H. Barnes, Rosalind Renee Spence, Carolina Sandler, Tamara Jones, Dimitrios Vagenas, Penny Webb, John Andrews, Alison Brand, Yeh Chen Lee, Michael Friedlander, Kate Pumpa, Helene O'Neille, Merran Williams, Martin Stockler
Summary: This is a randomized controlled trial on the effect of exercise in ovarian cancer patients. The trial aims to determine the impact of exercise on progression-free survival and physical well-being. The study involves 500 women with newly diagnosed primary ovarian cancer who will be randomly assigned to an exercise intervention group or a control group. The findings will be disseminated through peer-reviewed publications and international conferences.
Review
Health Care Sciences & Services
Ben Singh, Timothy Olds, Jacinta Brinsley, Dot Dumuid, Rosa Virgara, Lisa Matricciani, Amanda Watson, Kimberley Szeto, Emily Eglitis, Aaron Miatke, Catherine E. M. Simpson, Corneel Vandelanotte, Carol Maher
Summary: Chatbot interventions have been found to be effective in increasing physical activity, fruit and vegetable consumption, sleep duration, and sleep quality.
NPJ DIGITAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Ben Singh, Susan Palmer, Carol Maher
Summary: This study aimed to examine the engagement, acceptability, and satisfaction with a supportive care networking app. The findings showed that the app was widely used, well received, and able to provide assistance for various supportive care tasks.
FRONTIERS IN DIGITAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Ben Singh, Timothy Olds, Rachel Curtis, Ty Ferguson, Lisa Matricciani, Wendy J. Brown, Dorothea Dumuid, Adrian Esterman, Carol Maher
Summary: This study aimed to examine the weight management strategies used by Australian adults, their socio-demographic characteristics, and their association with 12-month weight change. The results showed that most participants used at least one weight management strategy, with exercise/physical activity being the most common. Being physically active was associated with greater weight loss, while accepting current bodyweight was linked to a lower likelihood of using weight management strategies. The use of supplements and fasting were associated with poorer mental health and quality of life outcomes.
Article
Oncology
Tamara L. Jones, Lara Edbrooke, Jonathan C. Rawstorn, Sandra C. Hayes, Ralph Maddison, Linda Denehy, Camille E. Short
Summary: The purpose of this analysis was to explore the associations between exercise behavior and three behavioral constructs from different theories among breast cancer survivors. The results showed that identified motivation and habits were significantly associated with total activity, while identified motivation and coping self-efficacy were significantly associated with resistance training. The findings suggest that incorporating strategies that support identified motivation, habits, and coping self-efficacy could promote increased exercise behavior among breast cancer populations.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Medicine, General & Internal
Dorothea Dumuid, Ben Singh, Jacinta Brinsley, Rosa Virgara, Rachel G. Curtis, Sally Brinkman, Carol A. Maher
Summary: This study examines the well-being trends among South Australian students over 6 consecutive years and explores the influence of sociodemographic characteristics. The findings show a declining trend in students' well-being, especially since 2020. The largest disparities in well-being were observed for female students, those in later school grades, and those with lower parental education. Urgent and equitable support is needed for the well-being of all young people, particularly those facing disparities.
Review
Public, Environmental & Occupational Health
Gabrielle C. Gildea, Rosalind R. Spence, Tamara L. Jones, Jemma C. Turner, Eliza R. Macdonald, Sandra C. Hayes, Carolina X. Sandler
Summary: The aim of this systematic rapid review was to explore barriers, facilitators, perceptions, and preferences of physical activity for people diagnosed with cancer. A total of 118 studies involving 15 cancers were included in the review. Treatment-related side effects were the most commonly identified barrier, social support and guidance were the most commonly identified facilitators, and promoting health and recovery was the most commonly identified perception of benefit of physical activity.
PREVENTIVE MEDICINE REPORTS
(2023)