Article
Genetics & Heredity
Chong Zhang, Zhehao He, Ling Cheng, Jinlin Cao
Summary: The study focused on exploring potential prognostic markers of LUAD and successfully built a five-gene prognostic model, which effectively divided samples into high- and low-risk groups with favorable survival outcomes in the training set. Further analysis using GSEA, TMB, and immune infiltration revealed differences in gene expression, mutation frequency, and immune activity between the two risk groups.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Yun-Qiang Zhang, Kai Li, Qiang Guo, Dan Li
Summary: This study explores the roles and mechanisms of quercetin target genes in the progression of lung adenocarcinoma (LUAD). The differentially expressed quercetin target genes were found to be involved in biological processes and prognosis of LUAD. The risk model based on these quercetin target genes can be used to assess the prognosis of LUAD patients.
FRONTIERS IN GENETICS
(2022)
Article
Orthopedics
Xingyin Chen, Zhengyun Ye, Pan Lou, Wei Liu, Ying Liu
Summary: This study identified metabolism-related lncRNAs as prognostic factors for osteosarcoma through analysis of transcriptomic data from the TCGA database and constructed a prognostic signature. Specific alterations in lncRNA expression were strongly correlated with poor prognosis, indicating potential new therapeutic targets and metabolic regulatory mechanisms for osteosarcoma.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Genetics & Heredity
Bo Peng, Han Lou, Chen Chen, Lei Wang, Huawei Li, Tong Lu, Ruisi Na, Ran Xu, Tong Xin, Lingqi Yao, Henghui Xu, Kaiyu Wang, Xin Liu, Linyou Zhang
Summary: In this study, mitochondrial homeostasis-related lncRNAs (MHRlncRNAs) were identified through coexpression analysis, and a prognostic signature composed of three MHRlncRNAs was constructed to predict the prognosis and guide individualized treatment in lung adenocarcinoma (LUAD) patients. The study also investigated the underlying tumor microenvironment, tumor mutation burden, and immune landscape behind different risk groups based on the LUAD subtypes regrouped by this risk model.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Hongxiang Feng, Chaoyang Liang, Yuhui Shi, Deruo Liu, Jin Zhang, Zhenrong Zhang
Summary: In this study, a six-gene signature was established to predict the prognosis of lung adenocarcinoma (LUAD) patients and was found to be significantly associated with immune cell infiltration. This finding may provide a theoretical basis for targeted immunotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Jixin Wang, Xiangjun Yin, Yin-Qiang Zhang, Xuming Ji
Summary: This study developed a four-lncRNA prognostic signature for lung adenocarcinoma patients, which was found to be effective in predicting overall survival. The correlation analysis revealed a relationship between immune cell infiltration subtypes and these lncRNAs.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Fada Xia, Yuanliang Yan, Cong Shen
Summary: This study established a prognostic signature for COAD based on 15 pyroptosis-related lncRNAs, which was found to be associated with the immune landscape of COAD patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Xin Hu, Liuxing Wu, Ben Liu, Kexin Chen
Summary: This study investigated the immune infiltration status and prognostic value of immune-related lncRNAs in AEG. They identified two immune infiltration subtypes, selected six prognosis-related lncRNAs, and constructed an immune risk signature. The results showed that the immune-related risk signature could be an independent prognostic factor in AEG patients and predict the response to immunotherapy and chemotherapy effectively.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Qianhui Zhou, Jiali Xiong, Yan Gao, Rong Yi, Yuzhu Xu, Quefei Chen, Lin Wang, Ying Chen
Summary: Lung cancer is a common and deadly disease, and lung adenocarcinoma is a highly prevalent subtype. This study aimed to identify potential biomarkers for predicting the prognosis of lung adenocarcinoma. By analyzing clinical and RNA sequencing data, a risk prediction model containing 13 mitochondria-associated lncRNAs was developed, which could accurately predict the prognosis of patients.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Immunology
Wentao Zhang, Haizeng Qu, Xiaoqing Ma, Liang Li, Yanjun Wei, Ye Wang, Renya Zeng, Yuanliu Nie, Chenggui Zhang, Ke Yin, Fengge Zhou, Zhe Yang
Summary: This study aimed to create a survival prediction model for lung adenocarcinoma patients based on cuproptosis and immune-related genes, which can enhance personalized treatment. Through RNA sequencing analysis, key genes related to cuproptosis and immune response were identified, and a risk prognostic model was developed. The results showed significantly reduced survival rates in the high-risk group, along with lower levels of immune cell infiltration and immune checkpoint expression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Kai Zhao, Xiangyu Li, Yuanxin Shi, Yun Lu, Peng Qiu, Zhengdong Deng, Wei Yao, Jianming Wang
Summary: This study comprehensively analyzed the potential values of pyroptosis-related lncRNAs in pancreatic adenocarcinoma (PAAD). A risk signature based on pyroptosis-related lncRNAs was established and validated, showing clinical significance and connection with the tumor immune microenvironment (TIME). The results suggest that this risk signature could be used for prognosis prediction and guide immunotherapeutic strategies in PAAD patients.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Zhengyan Yang, Jianling Zhu, Tiantian Yang, Wenjun Tang, Xiaowei Zheng, Shaoping Ji, Zhiguang Ren, Feng Lu
Summary: In this study, a prognostic 9-gene signature composed of lrRIGs was established for lung adenocarcinoma (LUAD) patients. The high-risk group identified by this gene signature showed worse overall survival. Furthermore, a nomogram combining the gene signature and other prognostic factors was developed and demonstrated excellent performance in predicting overall survival rate.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Guoliang Cui, Jinhui Liu, Can Wang, Renjun Gu, Manli Wang, Zhiguang Sun, Fei Wei
Summary: This study investigates the role of long noncoding RNAs in colon adenocarcinoma and establishes a prognostic signature consisting of six long noncoding RNAs. The study finds differences in prognosis, immune cell infiltration, and tumor mutation burden between different risk groups of COAD patients. Certain drugs are also identified to be more sensitive in the high-risk group.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Xiaona Xie, Qianzi Liu, Xuehua Zhou, Rongtao Liang, Shengbo Yang, Min Xu, Haiyang Zhao, Chengye Li, Yanfan Chen, Xueding Cai
Summary: This study classified the raw data of lung adenocarcinoma patients and explored the connection between copper-dependent cell death and tumor development, prognosis, and immune response. A reliable CRG score was established to predict overall survival and a credible nomogram was created to enhance the clinical application of the CRG score and estimate the survival probability of patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Genetics & Heredity
Yi Zhou, Qi Shu, Zailin Fu, Chen Wang, Jianrong Gu, Jianbo Li, Yifang Chen, Minghua Xie
Summary: This study identified Cuproptosis-related lncRNAs associated with cutaneous melanoma (CM) and constructed a new risk model that accurately predicts the prognosis of CM and evaluates the immune microenvironment. This provides a new perspective for future clinical treatment of CM.
FRONTIERS IN GENETICS
(2022)