4.6 Article

First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-CanonicalFLT3Mutations

Journal

FRONTIERS IN ONCOLOGY
Volume 10, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.01538

Keywords

sorafenib; FLT3mutation; FLT3-V592; FLT3-N676; AML; TKI

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Funding

  1. MD Anderson Cancer Centre Leukemia Support Grant (CCSG) [CA016672]

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The prognostics implications of patients with acute myeloid leukemia harboring non-canonicalFLT3is unknown. The use of tyrosine kinase inhibitors in this patient population has not been previously reported. We report successful targeted therapy against non-ITD, non-D835 driverFLT3alterations in two patient case studies with acute myeloid leukemia.

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