Exposure of Human Skin Organoids to Low Genotoxic Stress Can Promote Epithelial-to-Mesenchymal Transition in Regenerating Keratinocyte Precursor Cells

Modeling medulloblastoma in vivo and with human cerebellar organoids

(2020) Claudio Ballabio et al.   Nature Communications

Early Events in Actin Cytoskeleton Dynamics and E-Cadherin-Mediated Cell-Cell Adhesion during Epithelial-Mesenchymal Transition

(2020) Irina Y. Zhitnyak et al.   Cells

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

(2020) Dylan J. Richards et al.   Nature Biomedical Engineering

Individual Calculation of Effective Dose and Risk of Malignancy Based on Monte Carlo Simulations after Whole Body Computed Tomography

(2020) Markus Kopp et al.   Scientific Reports

Epithelial-To-Mesenchymal Transition Markers and CD44 Isoforms Are Differently Expressed in 2D and 3D Cell Cultures of Prostate Cancer Cells

(2019) Fabrizio Fontana et al.   Cells

Human 3D cellular model of hypoxic brain injury of prematurity

(2019) Anca M. Pașca et al.   NATURE MEDICINE

Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis

(2019) Kimberly Box et al.   eLife

Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch

(2019) Caterina Miro et al.   Nature Communications

KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes

(2019) Nicolas O. Fortunel et al.   Nature Biomedical Engineering

Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis

(2018) Chiharu Kimura-Yoshida et al.   Nature Communications

Cohort Profile: the EPI-CT study: A European pooled epidemiological study to quantify the risk of radiation-induced cancer from paediatric CT

(2018) Marie-Odile Bernier et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

When skin’s defence against pollution fails

(2018) Elizabeth Svoboda   NATURE

Regeneration of the entire human epidermis using transgenic stem cells

(2017) Tobias Hirsch et al.   NATURE

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Double strand break induction and kinetics indicate preserved hypersensitivity in keratinocytes to subtherapeutic doses for 7weeks of radiotherapy

(2017) Fredrik Qvarnström et al.   RADIOTHERAPY AND ONCOLOGY

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

(2017) Jarno Drost et al.   SCIENCE

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Human epidermal stem cells: Role in adverse skin reactions and carcinogenesis from radiation

(2016) Michèle T. Martin et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Bioengineering a Human Plasma-Based Epidermal Substitute With Efficient Grafting Capacity and High Content in Clonogenic Cells

(2015) Maia M. Alexaline et al.   Stem Cells Translational Medicine

Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a

(2014) Mina Sasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Knockdown of Filaggrin in a Three-Dimensional Reconstructed Human Epidermis Impairs Keratinocyte Differentiation

(2014) Valérie Pendaries et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin Cancer Incidence among Atomic Bomb Survivors from 1958 to 1996

(2014) Hiromi Sugiyama et al.   RADIATION RESEARCH

Vangl2 Regulates E-Cadherin in Epithelial Cells

(2014) Tadahiro Nagaoka et al.   Scientific Reports

VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration

(2012) B. B. Williams et al.   JOURNAL OF CELL SCIENCE

Global Gene Expression Responses to Low- or High-Dose Radiation in a Human Three-Dimensional Tissue Model

(2011) Alexandre Mezentsev et al.   RADIATION RESEARCH

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway

(2010) Jacinta Caddy et al.   DEVELOPMENTAL CELL

Exploration of the functional hierarchy of the basal layer of human epidermis at the single-cell level using parallel clonal microcultures of keratinocytes

(2010) Nicolas O. Fortunel et al.   EXPERIMENTAL DERMATOLOGY

A low-dose hypersensitive keratinocyte loss in response to fractionated radiotherapy is associated with growth arrest and apoptosis

(2009) Ingela Turesson et al.   RADIOTHERAPY AND ONCOLOGY