Review
Biochemistry & Molecular Biology
Farzane Sivandzade, Luca Cucullo
Summary: Neurodegenerative diseases lead to paralysis, cognitive decline, and sensory loss. Stem cell therapy shows promise in treating these disorders by repairing damaged neural tissue and protecting healthy cells. Progress in stem cell technologies may lead to realistic and efficacious treatments for neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Jing Yang, Wei Zhang, Shugeng Zhang, Ashok Iyaswamy, Jichao Sun, Jigang Wang, Chuanbin Yang
Summary: A key feature of neurodegenerative diseases (NDs) like Alzheimer's disease (AD) and Parkinson's disease (PD) is the accumulation of misfolded protein aggregates, which have limited effective therapeutic agents. TFEB, a regulator of lysosomal biogenesis and autophagy, plays a crucial role in protein aggregate degradation and is regarded as a promising therapeutic target for these NDs.
Review
Biochemistry & Molecular Biology
Cadiele Oliana Reichert, Debora Levy, Sergio P. Bydlowski
Summary: The human body has biological redox systems that can prevent or reduce damage caused by increased oxidative stress throughout life. The PON enzymes, particularly PON1, are associated with neurodegenerative diseases and play a crucial role in their development.
Review
Biochemistry & Molecular Biology
JunHyuk Woo, Hyesun Cho, YunHee Seol, Soon Ho Kim, Chanhyeok Park, Ali Yousefian-Jazi, Seung Jae Hyeon, Junghee Lee, Hoon Ryu
Summary: The brain requires a significant amount of energy, with mitochondria serving as the energy generator within cells and playing a crucial role in the pathogenesis of neurodegenerative disorders.
Review
Pharmacology & Pharmacy
Jessica Silva dos Santos, Joao Pedro Goncalves Cirino, Patricia de Oliveira Carvalho, Manoela Marques Ortega
Summary: Kaempferol, a flavonoid antioxidant found in fruits and vegetables, has shown neuroprotective effects in the central nervous system through modulation of proinflammatory signaling pathways. The differences in biological benefits and pharmacokinetic behaviors between KPF aglycone and its glycosides are notable. Future studies are needed to clarify the mechanisms of Kaempferol's action in CNS diseases and the impact of glycosylation on its bioactivity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ya-jing Liu, Yu Ding, Yan-qing Yin, Hui Xiao, Gang Hu, Jia-wei Zhou
Summary: Cspg4high microglia, characterized by unique transcriptomic signature, are one of the origins of microgliosis during neurodegeneration. They can proliferate in response to pathological alpha-synuclein stimulation, and show higher survival rates in transplantation therapy. Additionally, these cells are detected in the brain of AD patients, suggesting their involvement in AD pathogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Delsuz Rezaee, Fatemeh Saadatpour, Nayyereh Akbari, Anahita Zoghi, Sajad Najafi, Parisa Beyranvand, Fahimeh Zamani-Rarani, Mohammad Amin Rashidi, Saeid Bagheri-Mohammadi, Mohammad Bakhtiari
Summary: MicroRNAs (miRNAs) have been found to play significant roles in regulating the development and functions of the central nervous system (CNS). Dysregulation of miRNAs has been associated with various neurodegenerative diseases and CNS tumors. They affect the expression of key genes and proteins involved in the pathogenesis of these diseases.
AGEING RESEARCH REVIEWS
(2023)
Review
Immunology
Lilian Gomes de Oliveira, Yan de Souza Angelo, Antonio H. Iglesias, Jean Pierre Schatzmann Peron
Summary: Neuroinflammatory and neurodegenerative diseases are major public health issues worldwide, with mitochondrial dysfunction playing a significant role. Regulation of mitochondrial dynamics is essential for CNS health maintenance, impacting the development and progression of neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anne-Laure Hemonnot-Girard, Audrey J. Valverde, Jennifer Hua, Charlene Delaygue, Nathalie Linck, Tangui Maurice, Francois Rassendren, Helene Hirbec
Summary: This study investigated the impact of CX3CR1 haplodeficiency on Alzheimer's disease pathology progression in a mouse model. The results showed that CX3CR1 deficiency had little effect on the pathology progression, but the APP(swe)/PSEN1(dE9):CX3CR1(+/eGFP) mouse line is a useful model for studying the role of microglia in Alzheimer's disease. Additionally, despite higher A beta plaque density in females, their glial reaction, inflammation status and memory deficits were not different from age-matched males.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Pharmacology & Pharmacy
Jonathan A. Holbrook, Heledd H. Jarosz-Griffiths, Emily Caseley, Samuel Lara-Reyna, James A. Poulter, Caroline H. Williams-Gray, Daniel Peckham, Michael F. McDermott
Summary: The prevalence of neurodegenerative diseases is increasing, characterized by progressive neuronal loss, protein aggregation, metabolic abnormalities, and immune dysregulation. Research has shown that low-grade systemic inflammation may impact the development and progression of these diseases, and inflammation may also be a causative factor.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Youngpyo Nam, Gyeong Joon Moon, Sang Ryong Kim
Summary: Neurotrophic factors play a crucial role in neurodegenerative diseases, and Rheb, as a regulator of NTFs expression, is an important therapeutic target for treating these diseases. AAV transduction can effectively promote neuroprotection by upregulating NTFs in conditions like AD and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Jonathan Voeglein, Irena Kostova, Thomas Arzberger, Soheyl Noachtar, Marianne Dieterich, Jochen Herms, Peer Schmitz, Viktoria Ruf, Otto Windl, Sigrun Roeber, Mikael Simons, Gunter U. Hoeglinger, Adrian Danek, Armin Giese, Johannes Levin
Summary: In neurodegenerative diseases, seizure prevalence varies among different diseases, with cognitive symptoms increasing the risk of seizures and motor symptoms decreasing the risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Surabhi Thapliyal, Tanveer Singh, Shailendra Handu, Manisha Bisht, Puja Kumari, Priyanka Arya, Pallavi Srivastava, Ravi Gandham
Summary: Ferulic acid is a naturally occurring compound found in various foods, and is being studied for its potential therapeutic effects on neurological disorders, due to its antioxidative and anti-inflammatory properties. Experimental studies suggest that ferulic acid may have promising therapeutic potential for a range of neurological diseases, but further research is needed to validate its efficacy.
NEUROCHEMICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Tapan Behl, Gagandeep Kaur, Aayush Sehgal, Shaveta Bhardwaj, Sukhbir Singh, Camelia Buhas, Claudia Judea-Pusta, Diana Uivarosan, Mihai Alexandru Munteanu, Simona Bungau
Summary: Neurodegeneration is a pathological condition where the nervous system or neuron loses structure and function, with no known treatment yet, and matrix metalloproteinases (MMPs) play a crucial role in the progression of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Sueun Lee, Seung Mok Ryu, Do-Hyun Kim, Ye Eun Lee, Sung-Jun Lee, Sohi Kang, Joong Sun Kim, Soong-In Lee
Summary: The study aimed to evaluate the therapeutic efficacy of GDT for TMT-induced hippocampal neurodegeneration and seizures at the molecular level.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Malgorzata Ziemka-Nalecz, Justyna Janowska, Lukasz Strojek, Joanna Jaworska, Teresa Zalewska, Malgorzata Frontczak-Baniewicz, Joanna Sypecka
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Justyna Janowska, Malgorzata Ziemka-Nalecz, Joanna Sypecka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Neurosciences
Justyna Janowska, Justyna Gargas, Malgorzata Ziemka-Nalecz, Teresa Zalewska, Leonora Buzanska, Joanna Sypecka
EXPERIMENTAL NEUROLOGY
(2019)
Article
Neurosciences
Joanna Jaworska, Teresa Zalewska, Joanna Sypecka, Malgorzata Ziemka-Nalecz
MOLECULAR NEUROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Teresa Zalewska, Joanna Jaworska, Joanna Sypecka, Malgorzata Ziemka-Nalecz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Justyna Janowska, Justyna Gargas, Malgorzata Ziemka-Nalecz, Teresa Zalewska, Joanna Sypecka
MOLECULAR NEUROBIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Karolina Ziabska, Malgorzata Ziemka-Nalecz, Paulina Pawelec, Joanna Sypecka, Teresa Zalewska
Summary: The complement system plays a crucial role in maintaining healthy brain function and responding to brain disorders, but dysregulation can lead to neuronal damage and dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Justyna Gargas, Justyna Janowska, Karolina Ziabska, Malgorzata Ziemka-Nalecz, Joanna Sypecka
Summary: This study aimed at developing a protocol for efficient culture of rat neonatal glial cells in oxygen concentrations relevant to the nervous tissue. The protocol allows for obtaining three major cell populations and can be used to model selected neuropathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Paulina Pawelec, Joanna Sypecka, Teresa Zalewska, Malgorzata Ziemka-Nalecz
Summary: Givinostat/ITF2357 did not attenuate the inflammatory response after neonatal hypoxia-ischemia, with no significant changes in chemokines and cytokines, but potentially causing a decrease in MIP-1 alpha levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Karolina Ziabska, Justyna Gargas, Joanna Sypecka, Malgorzata Ziemka-Nalecz
Summary: This study examined the effects of sodium butyrate on the proliferation and M1/M2 polarization of primary microglial cells after oxygen and glucose deprivation (OGD) in vitro. The results showed that sodium butyrate can inhibit the proliferation of microglial cells and convert them from the unfavorable M1 phenotype to the beneficial M2 phenotype.
PHARMACOLOGICAL REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Teresa Zalewska, Paulina Pawelec, Karolina Ziabska, Malgorzata Ziemka-Nalecz
Summary: Epidemiological studies and clinical observations suggest that there are sex-related differences in brain responses to neurological conditions. These differences, influenced by sex hormones, genetics, and epigenetics, can have significant impacts on disease susceptibility and progression. Understanding the disparities between men and women could aid in developing personalized approaches to treat challenging disorders.
