Article
Medicine, Research & Experimental
Feng Bai, Li-Han Zhang, Xiong Liu, Chuying Wang, Chenglong Zheng, Jianping Sun, Min Li, Wei-Guo Zhu, Xin-Hai Pei
Summary: The study reveals a positive correlation between BRCA1 and GATA3 expression in human breast cancers. Depletion of BRCA1 stimulates methylation of GATA3 promoter, repressing GATA3 transcription. Additionally, GATA3 deficiency induces poorly-differentiated mammary tumors with activated EMT and increased metastatic potential.
Review
Oncology
Jiaqi Liu, Feiyang Luo, Liyan Wen, Zhanyi Zhao, Haitao Sun
Summary: Microbiomes are associated with cancer progression, treatment, and prognosis, particularly in regards to metastasis. This review summarizes recent advances in understanding the relationship between microbiomes and cancer metastasis and discusses potential applications in prevention, early detection, and treatment.
Review
Biochemistry & Molecular Biology
Misung Park, Dohee Kim, Sunghyub Ko, Ayoung Kim, Kyumin Mo, Hyunho Yoon
Summary: Breast cancer is the most common malignancy in women worldwide, and metastasis is the leading cause of high mortality. Currently, breast cancer is often discovered or diagnosed after metastasis has occurred, resulting in poor prognosis. Understanding the mechanisms and nature of breast cancer metastasis can facilitate the development of targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Szandra Schwarcz, Patrik Kovacs, Tunde Kovacs, Gyula Ujlaki, Petra Nyerges, Karen Uray, Peter Bai, Edit Miko
Summary: Commensal bacteria secrete metabolites that can reach cancer cells and affect cancer behavior. Deoxycholic acid (DCA), a secondary bile acid produced by intestinal microbes, may have both pro- and antineoplastic effects in cancers.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Sergey E. Parfenyev, Sergey V. Shabelnikov, Elena N. Tolkunova, Nickolai A. Barlev, Alexey G. Mittenberg
Summary: P53 plays a critical role in protecting the genome and preventing tumor formation, including metastases. The interaction between p53 and the transcription factor Zeb1 is important in carcinogenesis, particularly in the process of epithelial to mesenchymal transition (EMT). Additionally, the composition of Zeb1 interactome is affected by the presence of cancer stem cells and the level of Oct4/Sox2 expression, indicating that stemness influences the specificity of Zeb1 interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Ghader Babaei, Shiva Gholizadeh-Ghaleh Aziz, Nasrin Zare Zavieyh Jaghi
Summary: Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major factors contributing to cancer cell metastasis. Autophagy has recently gained attention, playing a dual role in cancer cell development depending on cancer type, tissue, and stage. Studies show different signaling pathways are involved in cancer stem cells, autophagy, and EMT. Investigating effective signaling pathways in all three processes could help determine appropriate therapeutic goals.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Celia Lopez-Menendez, Alberto Vazquez-Naharro, Vanesa Santos, Pierre Dubus, Patricia G. Santamaria, Angel Martinez-Ramirez, Francisco Portillo, Gema Moreno-Bueno, Marisa M. Faraldo, Amparo Cano
Summary: This study identifies the crucial role of E2A factors in breast cancer cell sternness, metastasis, and drug resistance, suggesting the potential therapeutic vulnerability of targeting E2A proteins in breast cancer.
Review
Medicine, Research & Experimental
Ghader Babaei, Mehdi Asghari Vostakolaei, Masoumeh Rajabi Bazl, Shiva Gholizadeh-Ghaleh Aziz, Elham Gholipour, Kazem Nejati-Koshki
Summary: Exosomes play fundamental roles in cell-cell communications and are associated with cancer metastasis by modulating EMT and CSCs.
Article
Environmental Sciences
Carola Murano, Simona Nonnis, Francesca Grassi Scalvini, Elisa Maffioli, Ilaria Corsi, Gabriella Tedeschi, Anna Palumbo
Summary: It is crucial to thoroughly study the mechanisms underlying the toxicity of microplastics (MPs) in key Mediterranean organisms, as the Mediterranean Sea is currently one of the major hotspots for MPs pollution. In this study, sea urchins were exposed to different concentrations of polystyrene-microbeads (micro-PS) to investigate the immune cells profile and proteome changes. The results showed that MPs exposure led to the internalization of micro-PS in sea urchin tissues and altered the protein profile of coelomocytes, indicating severe disruption of cellular metabolic pathways.
ENVIRONMENTAL POLLUTION
(2023)
Article
Oncology
Yanling He, Xiaoqin Dai, Shengnan Li, Xinyuan Zhang, Kunxiang Gong, Kai Song, Jian Shi
Summary: This study demonstrates that DCLK2 is highly expressed in breast cancer and is associated with poor prognosis. Silencing DCLK2 inhibits cell migration and invasion, while overexpression of DCLK2 enhances the migratory and invasive abilities of normal breast epithelial cells. Furthermore, downregulation of DCLK2 blocks the epithelial-mesenchymal transition process.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Pathology
Rui Zhang, Ziqi Meng, Xuwei Wu, Meihua Zhang, Songnan Zhang, Tiefeng Jin
Summary: The research demonstrated that Mortalin promotes proliferation, metastasis, and malignant progression of breast cancer, potentially through the Wnt/beta-Catenin signaling pathway. This suggests that Mortalin could serve as a biomarker and prognostic factor in breast cancer.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Cell Biology
Chunlei Guo, Shuang Li, Ang Liang, Mengchao Cui, Yunwei Lou, Hui Wang
Summary: PPA1 is highly expressed in breast cancer and correlated with poor survival in patients. Silencing PPA1 can inhibit breast cancer proliferation and metastasis. PPA1 serves as an activator of the PI3K/AKT/GSK3 beta/Slug-mediated breast cancer progression and is a potential therapeutic target for inhibiting tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junfeng Ke, Wenzhao Han, Fanwei Meng, Feng Guo, Yuhong Wang, Liping Wang
Summary: Studies have shown that CTI-2 inhibits the activation of the MAPK signaling pathway, reduces the expression of E-cadherin, N-cadherin, and vimentin, thus preventing the metastasis of breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Mohsin Ahmad Ghauri, Qi Su, Asmat Ullah, Jingjing Wang, Ammar Sarwar, Qing Wu, Dongdong Zhang, Yanmin Zhang
Summary: SAN has been found to inhibit cell proliferation, migration, and colonization characteristics in breast cancer, as well as showing significant inhibitory effects on EMT regulating protein expression. In animal model, SAN exhibits prominent anti-metastatic and anti-proliferative effects.
Article
Cell Biology
Massimo Saini, Laura Schmidleitner, Helena Dominguez Moreno, Elisa Donato, Mattia Falcone, Johanna M. Bartsch, Corinna Klein, Vanessa Vogel, Roberto Wuerth, Nicole Pfarr, Elisa Espinet, Mareike Lehmann, Melanie Koenigshoff, Manuel Reitberger, Simon Haas, Elisabeth Graf, Thomas Schwarzmayr, Tim-Matthia Strom, Saskia Spaich, Marc Suetterlin, Andreas Schneeweiss, Wilko Weichet, Gunnar Schotta, Maximilia Reichert, Nicola Aceto, Martin R. Sprick, Andreas Trumpp, Christina H. Scheel
Summary: The acquisition of mesenchymal traits is a key factor in breast cancer progression. However, the relevance of epithelial-to-mesenchymal transition (EMT) is controversial and depends on the specific context. In this study, researchers isolated epithelial and mesenchymal populations from metastatic breast cancer biopsies and assessed their functional potential in vivo. The results show that decreasing levels of the epithelial cell adhesion molecule (EPCAM) are associated with a decline in disease propagation. Mechanistically, persistent EPCAM expression identifies epithelial clones that resist EMT induction and propagate competitively, while loss of EPCAM defines clones arrested in a mesenchymal state with suppressed tumorigenicity and metastatic potential. These findings highlight the importance of EMT in breast cancer metastasis and suggest potential targets for therapeutic intervention.
Article
Gastroenterology & Hepatology
Lenard M. Lichtenberger, Deepa Bhattarai, Tri M. Phan, Elizabeth J. Dial, Karen Uray
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2015)
Review
Biochemistry & Molecular Biology
Barbara C. Hansen, Sylvia Gografe, Stacy Pritt, Kai-lin Catherine Jen, Camille A. McWhirter, Susan M. Barman, Anthony Comuzzie, Molly Greene, Justin A. McNulty, Daniel Eugene Michele, Naz Moaddab, Randall J. Nelson, Karen Norris, Karen D. Uray, Ron Banks, Karin N. Westlund, Bill J. Yates, Jerald Silverman, Kenneth D. Hansen, Barbara Redman
Article
Gastroenterology & Hepatology
Kristin E. Killoran, Amber D. Miller, Karen S. Uray, Norman W. Weisbrodt, Robia G. Pautler, Sanna M. Goyert, Nico van Rooijen, Margaret E. Conner
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Ji Chu, Ngoc T. Pham, Nicole Olate, Karina Kislitsyna, Mary-Clare Day, Phillip A. LeTourneau, Alexander Kots, Randolph H. Stewart, Glen A. Laine, Charles S. Cox, Karen Uray
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biology
Jennifer Young, Beatrice Riviere, Charles S. Cox, Karen Uray
MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA
(2014)
Review
Oncology
Borbala Kiss, Edit Miko, Eva Sebo, Judit Toth, Gyula Ujlaki, Judit Szabo, Karen Uray, Peter Bai, Peter Arkosy
Review
Cell Biology
Karen Uray, Evelin Major, Beata Lontay
Article
Biochemistry & Molecular Biology
Azzam Aladdin, Yanhua Yao, Ciyu Yang, Gunther Kahlert, Marvi Ghani, Nikolett Kiraly, Anita Boratko, Karen Uray, Gunnar Dittmar, Krisztina Tar
Article
Cell Biology
Laura Janko, Tunde Kovacs, Miklos Laczik, Zsanett Sari, Gyula Ujlaki, Greta Kis, Ibolya Horvath, Miklos Antal, Laszlo Vigh, Balint L. Balint, Karen Uray, Peter Bai
Summary: The deletion of PARP2 induces mitochondrial biogenesis and activity, leading to mitochondrial fragmentation in myoblasts; strong reductants can reverse mitochondrial fragmentation, and the generation of reactive oxygen species of mitochondrial origin is a key factor.
Review
Biochemistry & Molecular Biology
Ivan P. Uray, Karen Uray
Summary: Mechanical signals are crucial for the survival, adaptation, and normal functioning of cells. Mechanotransduction, the process of converting mechanical information into intracellular biochemical signals, plays a key role in physiological and pathological processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tibor Docsa, Adam Sipos, Charles S. Cox, Karen Uray
Summary: Feeding intolerance and ileus are common complications in critically ill, surgical, and trauma patients, leading to longer hospital stays, increased infections, readmission rates, and medical costs. Current medical treatment for ileus is ineffective and has serious side effects. Inflammatory mediators play a critical role in the development of ileus, but their direct effects on gastrointestinal cells are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Job Baffin Kola, Tibor Docsa, Karen Uray
Summary: Normal gastrointestinal function relies on sensing and transducing mechanical signals into changes in intracellular signaling pathways. Both specialized and non-specialized cells in the gastrointestinal tract participate in physiological and pathological responses to mechanical signals. The role of mechanosensors in different cell types, examples of their role in normal physiology, and diseases involving mechanotransductive pathways are reviewed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Job Baffin Kola, Botagoz Turarova, Dora Csige, Adam Sipos, Luca Varga, Bence Gergely, Farah Al Refai, Ivan P. Uray, Tibor Docsa, Karen Uray
Summary: Although HCN2 channels are expressed in various cell types in the gut, their role in intestinal motility is not well understood. This study showed that inhibition of HCN2 significantly suppressed both spontaneous and agonist-induced contractile activity in the small intestine. The suppression of contractile activity by HCN2 inhibition was not affected by inflammatory mediators but was partially attenuated by increased stretch of the intestinal tissue.
Article
Biochemistry & Molecular Biology
Gyula Ujlaki, Tunde Kovacs, Andras Vida, Endre Kokai, Boglara Rauch, Szandra Schwarcz, Edit Miko, Eszter Janka, Adrienn Sipos, Csaba Hegedus, Karen Uray, Peter Nagy, Peter Bai
Summary: Breast cancer patients experience changes in their gut microbiome, leading to impaired production of antineoplastic bacterial metabolites. This study aimed to identify bacterial metabolites with antineoplastic properties. A library of 30 bacterial metabolites was screened for their effects on cell proliferation and epithelial-mesenchymal transition in breast cancer cells. Several metabolites exhibited cytostatic or hyperproliferative effects, and some inhibited epithelial-to-mesenchymal transition. Redox sets of metabolites were identified, with only one partner in the set possessing bioactivity, suggesting a potential role of local redox potential in the bacterial secretome. Among the bioactive metabolites, only 2,3-butanediol had both cytostatic and anti-EMT properties.