Article
Genetics & Heredity
Qi Wang, Yonghe Wu, Tim Vorberg, Roland Eils, Carl Herrmann
Summary: Regulation of gene expression through multiple epigenetic components is a complex process that can have downstream effects on tumor suppressor or oncogenes. The IRENE software tool quantitatively analyzes differential epigenetic modifications and successfully identifies known cancer genes through network-based approaches.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Richard Sean Lee, Kirti Sad, Dorelle V. Fawwal, Jennifer Marie Spangle
Summary: Breast cancer is a frequent and deadly disease in women, with histone-modifying enzymes playing a role in treatment response and patient outcomes. Epigenetic changes to chromatin affect the tumor environment and can be targeted for breast cancer treatment. Understanding these mechanisms may improve therapeutic interventions and patient outcomes.
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Plant Sciences
Justin Su, Zhujun Yao, Yixuan Wu, Joohyun Lee, Jeeyon Jeong
Summary: This article mainly introduces the latest understanding of chromatin-based regulation of iron homeostasis in plants, highlighting recent studies in Arabidopsis and rice. Understanding iron homeostasis in plants is crucial as it is relevant to fundamental biological questions, agriculture, biofortification, and human health.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Genetics & Heredity
Sonam Tulsyan, Mehreen Aftab, Sandeep Sisodiya, Asiya Khan, Atul Chikara, Pranay Tanwar, Showket Hussain
Summary: The global cancer cases and mortality rates are increasing, and efficient biomarkers are needed for accurate screening and diagnosis. Alterations in epigenetic marks may serve as potential biomarkers for early cancer detection. This review discusses the key epigenetic mechanisms and their deregulation in cancer etiology, exploring the future prospects of cancer precision medicine.
FRONTIERS IN GENETICS
(2022)
Review
Pharmacology & Pharmacy
Roya Ramezankhani, Roya Solhi, Hamidreza Aboulkheyr Es, Massoud Vosough, Moustapha Hassan
Summary: Gastric adenocarcinoma (GAC) is the third leading cause of cancer-related death worldwide, with a high mortality rate and resistance to treatment protocols due to heterogeneous molecular pathogenesis, making it crucial to discover key etiologic molecular alterations. Epigenetic modifications play a significant role in repressing or activating cancer-related genes and forming new epigenetic signatures, which can impact cancer initiation and progression. Targeting key epigenetic drivers such as MLLs, ARID1A, and EZH2 may potentially attenuate cancer progression in GAC by manipulating the 3D chromatin structure and regulating the expression of tumor suppressor genes and oncogenes.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Plant Sciences
Charlie Keyzor, Benoit Mermaz, Efstathios Trigazis, SoYoung Jo, Jie Song
Summary: The study demonstrates that the chromatin modification H3K27me3 is crucial in Arabidopsis flower development and self-fertility control. The demethylases ELF6 and JMJ13 regulate carpel and stamen growth antagonistically by targeting genes involved in cell elongation and hormone regulation, ultimately balancing between self-pollination and out-crossing in A. thaliana.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Plant Sciences
Huijia Kang, Tianyi Fan, Jiabing Wu, Yan Zhu, Wen-Hui Shen
Summary: Plants, as sessile organisms, are constantly exposed to diverse stresses, including pathogen invasion. Recent studies have found that pathogen infections can induce epigenetic changes in plants, leading to the reprogramming of plant defense genes. These mechanisms could be used in the design of stress-resistant plant varieties.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Angeliki Ntorla, Joseph Robert Burgoyne
Summary: Histone crotonylation is a newly identified epigenetic modification that regulates gene expression and is functionally distinct from histone acetylation, potentially regulating cellular metabolic status through competition for modification sites. It plays diverse functional roles within the cell, including signal-dependent gene activation, spermatogenesis, and tissue injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roberta Noberini, Giulia Robusti, Tiziana Bonaldi
Summary: In the past 15 years, research has shown the potential of investigating histone post-translational modifications and variants in clinical samples for discovering biomarkers and therapeutic targets in cancer biology. Mass spectrometry has emerged as a powerful tool for unbiased, comprehensive, and quantitative investigation of histones in clinical samples, with recent advancements in technology expanding its application possibilities. The 'bottom-up' strategy of analyzing short proteolytic peptides has shown success in clinical sample analysis, offering a promising approach for histone PTM profiling.
Article
Microbiology
Shilin Zhang, Xiao Xue, Sennan Qiao, Lin Jia, Xue Wen, Yichen Wang, Cong Wang, Hongrui Li, Jiuwei Cui
Summary: This study reveals the epigenetic mechanism by which umifenovir controls CVB4 infections. Umifenovir enhances the methylation of the IL-10 gene and reduces its acetylation, leading to a decrease in IL-10 expression and subsequent CVB4 replication.
MICROBIOLOGY SPECTRUM
(2023)
Review
Endocrinology & Metabolism
Lindsay Moritz, Saher Sue Hammoud
Summary: This article explores the molecular mechanisms underlying male fertility and the process of chromatin remodeling. It points out the current gaps in understanding of the chromatin remodeling process and suggests future research directions to enhance our knowledge of the histone-to-protamine exchange and the etiology of idiopathic male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Chloe D. Goldsmith, Thomasina Donovan, Nicole Vlahovich, David B. Pyne
Summary: This perspective article discusses how exercise can delay T cell ageing by analyzing the relationship between metabolism and epigenetics, proposing a potential impact of exercise on CD4+ T cell plasticity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Vivienne Woo, Theresa Alenghat
Summary: The complex relationship between the gastrointestinal tract and microbiota is regulated by epigenetic modifications, including modifications to DNA or histones and regulation of non-coding RNAs. Further research is needed to fully understand the mechanisms of epigenetic regulation.
Review
Cell Biology
Shihang Zhou, Hongliang Zeng, Jinhua Huang, Li Lei, Xiaoliang Tong, Si Li, Ying Zhou, Haoran Guo, Manal Khan, Liping Luo, Rong Xiao, Jing Chen, Qinghai Zeng
Summary: Melanogenesis is a complex process involving multiple genes and signaling pathways, with epigenetics playing a key role in regulating the expression of key genes. Epigenetic-based therapy provides novel opportunities for treating dermatoses caused by pigmentation disturbances.
AGEING RESEARCH REVIEWS
(2021)