Article
Cardiac & Cardiovascular Systems
Michael Persson, Natalie Glaser, Anders Franco-Cereceda, Johan Nilsson, Martin J. Holzmann, Ulrik Sartipy
Summary: The study found that patients who received porcine bioprosthetic valves had a higher rate of reoperation compared to those who received bovine bioprosthetic valves, but porcine valves were associated with improved long-term survival. The risk of heart failure hospitalization did not differ between the two types of valves.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Li-Tan Yang, Zi Ye, Muhammad Wajih Ullah, Joseph J. Maleszewski, Christopher G. Scott, Ratnasari Padang, Sorin Pislaru, Vuyisile T. Nkomo, Sunil Mankad, Patricia A. Pellikka, Jae K. Oh, Veronique L. Roger, Maurice Enriquez-Sarano, Hector Michelena
Summary: This study aimed to assess lifetime morbidity and long-term survival in patients with bicuspid aortic valve (BAV) in the community. The results showed that BAV patients have a high lifetime morbidity burden, with a high incidence of complications such as aortic stenosis or regurgitation, aortic surgery, aortic aneurysm, infective endocarditis, and aortic dissection. Compared to patients with typical valvulo-aortopathy, patients with complex valvulo-aortopathy have lower survival rates.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Aschauer, Robert Zilberszac, Andreas Gleiss, Christian Colizzi, Thomas Binder, Piergiorgio Bruno, Guenther Laufer, Massimo Massetti, Harald Gabriel, Raphael Rosenhek
Summary: Bicuspid aortic valve (BAV) disease is associated with a high rate of cardiac events, but modern care leads to good survival with low rates of infective endocarditis, aortic dissection, and sudden death. Gradual degrees of aortic stenosis and regurgitation, the presence of aortic dilatation, and age are predictive factors for cardiac events.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Vaughn A. Starnes, Ramsey S. Elsayed, Robbin G. Cohen, Anna P. Olds, Markian M. Bojko, Wendy J. Mack, Raffaello M. Cutri, Hans C. Baertsch, Craig J. Baker, S. Ram Kumar, Michael E. Bowdish
Summary: This study compared outcomes of wrapped versus unwrapped techniques in adults with bicuspid aortic valves undergoing the Ross procedure. It found that in adults with bicuspid aortic valves, including pulmonary autografts in the Ross procedure stabilizes the aortic root and reduces the need for reoperation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Deborah J. Henderson, Lorraine Eley, Jasmin E. Turner, Bill Chaudhry
Summary: The development of arterial valves is poorly understood in both humans and mice. This review summarizes what is known about the development of human arterial valve leaflets and compares it to mice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Oliver Deutsch, Keti Vitanova, Hendrik Ruge, Magdalena Erlebach, Markus Krane, Ruediger Lange
Summary: This study compared the outcomes of new-generation self-expandable (SEV) and balloon-expandable (BEV) transcatheter heart valve replacement in patients with bicuspid aortic valve stenosis. The results showed similar performance between the two procedures, with SEV having more favorable hemodynamics but also a higher incidence of paravalvular leak and post-dilations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sameer A. Hirji, Zachary Wegermann, Sreekanth Vemulapalli, Paige Newell, Maria Grau-Sepulveda, Sean O'Brien, Vinod H. Thourani, Vinay Badhwar, Tsuyoshi Kaneko
Summary: This study analyzes the 5-year outcomes of isolated surgical aortic valve replacement (SAVR) in patients with bicuspid and tricuspid aortic valve stenosis. The results show that bicuspid patients have significantly lower 5-year mortality rates compared to tricuspid patients, especially in low-risk patients.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Sri Harsha Patlolla, Hartzell Schaff, John M. Stulak, Hector Michelena, Nishant Saran, Katherine S. King, Joseph A. Dearani
Summary: The study evaluated the outcomes of repair of bicuspid aortic valves for aortic regurgitation and found that disease progression with calcification or fibrosis is the most common cause of valve failure. The clinical outcomes of bicuspid aortic valve repair for severe AR appear superior to aortic valve replacement with bioprosthesis.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Sri Harsha Patlolla, Hartzell V. Schaff, Gabor Bagameri, Joseph A. Dearani, Kevin L. Greason, Richard C. Daly, Juan A. Crestanello, John M. Stulak, Katherine S. King, Alberto Pochettino, Nishant Saran
Summary: Enlargement of the sinus of Valsalva is common in patients with bicuspid aortic valves. The management of the sinus during aortic valve replacement and ascending aorta repair is controversial. This study found that ascending aorta replacement may have a remodeling/stabilizing effect on the spared bicuspid aortic root, especially in patients with smaller sinus dimensions. The study also showed that the retained aortic sinuses enlarge slowly over time and that the sinus diameter is not a risk factor for survival or reoperation within the limited follow-up period.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Anders Holmgren, Tone Bull Enger, Ulf Naslund, Vibeke Videm, Solveig Valle, Karen Julie Dybvad Evjemo, Orjan Friberg, Alexander Wahba
Summary: A study on 5086 patients from 3 Swedish hospitals showed that patients with bicuspid valve morphology had better long-term survival rates compared to the general Swedish population. Factors such as age, renal dysfunction, diabetes, chronic obstructive pulmonary disease, and other comorbidities were associated with higher long-term mortality after aortic valve replacement surgery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Natalie Glaser, Veronica Jackson, Per Eriksson, Ulrik Sartipy, Anders Franco-Cereceda
Summary: The study aimed to analyze long-term survival in patients with Bicuspid Aortic Valve (BAV) who underwent aortic valve surgery. Results showed that the survival of BAV patients following surgery was excellent and similar to the general population, with slightly lower survival rates for women compared to men. These findings suggest that the timing of surgery according to current guidelines is appropriate and provide valuable information about the natural history of BAV in patients post-aortic valve surgery.
Article
Engineering, Biomedical
Alexander D. Kaiser, Rohan Shad, Nicole Schiavone, William Hiesinger, Alison L. Marsden
Summary: This study investigated the fluid-structure interaction simulations of bicuspid aortic valve disease in patients, revealing that chronic exposure to high local flow contributes to dilation and aneurysm formation.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Shufen Li, Weihua Zhuang, Jingruo Chen, Lilan Li, Gaocan Li, Junli Li, Yanbiao Liao, Mao Chen, Yunbing Wang
Summary: A fluorescent probe MeTT1 was prepared for visualization of LDs in cells and tissues, showing aggregation-induced emission property. MeTT1 exhibited significant fluorescence emission enhancement in oleic acid compared to water, providing a simple tool for studying the pathogenesis of cardiovascular diseases with lipid deposition.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Multidisciplinary Sciences
Jooae Choe, Hyun Jung Koo, Joon-Won Kang, Joon Bum Kim, Hee Jun Kang, Dong Hyun Yang
Summary: This study confirmed a significant correlation between bicuspid aortic valve annulus diameter measured on CT and surgical aortic valve size. The difference between CT-derived diameter and surgical AVR size is influenced by operator factors and types of prostheses rather than the bicuspid valve itself.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Lisa O. F. Bearpark, Ulrik Sartipy, Anders Franco-Cereceda, Natalie Glaser
Summary: This study investigated clinical outcomes in patients with bicuspid aortic valves (BAV) after surgical treatment for endocarditis. The results showed that BAV patients had improved survival after surgical treatment, especially in those with native valve endocarditis. However, the original valve morphology did not affect survival in patients with prosthetic valve endocarditis.
ANNALS OF CARDIOTHORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Lars Heubner, Ulrich Schneider, Christian Giebels, Irem Karliova, Alexander Raddatz, Hans-Joachim Schaefers
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2019)
Article
Cardiac & Cardiovascular Systems
Daniel W. Dudenhoeffer, Matthias W. Laschke, Christian Giebels, Irem Karliova, Ulrich Schneider, Michael D. Menger, Hans-Joachim Schaefers
THORACIC AND CARDIOVASCULAR SURGEON
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Ehrlich Tristan, Shunsuke Matsushima, Ulrich Schneider, Christian Giebels, Irem Karliova, Hans-Joachim Schaefers
ANNALS OF THORACIC SURGERY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Ulrich Schneider, Shunsuke Miyahara, Christian Giebels, Irem Karliova, Hans-Joachim Schaefers
ANNALS OF CARDIOTHORACIC SURGERY
(2019)
Article
Cardiac & Cardiovascular Systems
Shunsuke Matsushima, Alexander Hess, Julia Renata Laemmerzahl, Irem Karliova, Christian Giebels, Hans-Joachim Schaefers
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Ahmed Attia, Christian Giebels, Irem Karliova, Alexander Hess, Hans-Joachim Schaefers
Summary: Aortic valve-sparing operations aim to stabilize the root for stable aortic valve function. Graft dilatation, a known complication in other types of aortic replacement, can lead to failure in valve-preserving surgeries. Correcting graft dilatation using aortic valve repair concepts is crucial for successful outcomes.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Tristan Ehrlich, Irem Karliova, Lennart Froede, Christian Giebels, Takashi Kunihara, Hans-Joachim Schaefers
Summary: The study concluded that the long-term stability of aortic root remodeling for enlarged roots with AADA was comparable to tubular ascending aortic replacement (TAR) preserving a normal aortic root.
THORACIC AND CARDIOVASCULAR SURGEON
(2021)
Article
Cardiac & Cardiovascular Systems
Christian Giebels, Julia-Carolin Fister, Tristan Ehrlich, Jan Federspiel, Hans-Joachim Schaefers
Summary: This study analyzed reoperations after aortic root remodeling to determine the failure modes, operative risk, and long-term outcome. The main causes of failure were cusp repair failure, endocarditis, and cusp retraction. Reoperations can be performed with low morbidity and mortality, and isolated cusp repair may be an option for selected patients.
ANNALS OF THORACIC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Karen B. Abeln, Christian Giebels, Tristan Ehrlich, Jan M. Federspiel, Hans-Joachim Schaefers
Summary: The preservation or repair of the aortic valve has evolved dynamically over the past 20 years. Adequate valve durability is crucial for avoiding complications and improving survival. Factors such as the size of the aortic root and anatomy of the aortic valve play important roles in determining which valves can be repaired or preserved.
CURRENT CARDIOLOGY REPORTS
(2021)
Article
Surgery
Alexander Massmann, Christian Giebels, Arno Buecker, Hans-Joachim Schafers, Peter Fries
Summary: This case report presents percutaneous endovascular rescue techniques for unintended false-lumen thoracic endovascular aortic repair. The techniques successfully restored true-lumen perfusion and preserved visceral and peripheral perfusion.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Karen B. Abeln, Shunsuke Matsushima, Tristan Ehrlich, Christian Giebels, Hans-Joachim Schaefers
Summary: This study compared the midterm outcomes of repair and pulmonary autograft replacement for patients with a unicuspid aortic valve. The results showed no significant difference in survival between the Ross group and the repair group, but the Ross group had a lower reintervention rate. Repair of a unicuspid valve can be considered a bridge to pulmonary autograft replacement, especially for younger patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Tristan Ehrlich, Karen B. Abeln, Christian Burgard, Lennart Froede, Julia Schulze-Berge, Lucie Morgenthaler, Christian Giebels, Hans-Joachim Schaefers
Summary: This retrospective study assessed the long-term results of root remodelling with tricuspid aortic valves and the effects of concomitant cusp repair and annuloplasty. The results showed that cusp repair improves valve stability over time and annuloplasty improves early valve competency.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Infectious Diseases
Ornela Velollari, Christian Malte Reinhardt, Maike Knorr, Katharina Schnitzler, Dirk Graafen, Matthias Miederer, Ralph Stephan von Bardeleben, Thomas Muenzel, Kai-Helge Schmidt, Christian Giebels, Hans-Joachim Schaefers, Lukas Hobohm
Summary: This case study presents a patient with prosthesis endocarditis and paraaortic abscess caused by Cutibacterium acnes. The use of diagnostic imaging techniques confirmed the inflammatory process. The patient was treated with intravenous antibiotics and surgical intervention.
INFECTIOUS DISEASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Shunsuke Miyahara, Irem Karliova, Christian Giebels, Ulrich Schneider, Shunsuke Matsushima, Hans-Joachim Schaefers
INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)