Journal
SCIENCE ADVANCES
Volume 6, Issue 35, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aaz0127
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Funding
- Novo Nordisk
- NIH [EB-000244]
- Bill and Melinda Gates Foundation [OPP1139937]
- NSF GRFP fellowship
- Division of Gastroenterology, Brigham and Woman's Hospital
- MIT Undergraduate Research Opportunities Program (UROP)
- Viking Olof Bjork scholarship trust
- Bill and Melinda Gates Foundation [OPP1139937] Funding Source: Bill and Melinda Gates Foundation
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Ingestible electronic devices enable noninvasive evaluation and diagnosis of pathologies in the gastrointestinal (GI) tract but generally cannot therapeutically interact with the tissue wall. Here, we report the development of an orally administered electrical stimulation device characterized in ex vivo human tissue and in in vivo swine models, which transiently anchored itself to the stomach by autonomously inserting electrically conductive, hooked probes. The probes provided stimulation to the tissue via timed electrical pulses that could be used as a treatment for gastric motility disorders. To demonstrate interaction with stomach muscle tissue, we used the electrical stimulation to induce acute muscular contractions. Pulses conductively signaled the probes' successful anchoring and detachment events to a parenterally placed device. The ability to anchor into and electrically interact with targeted GI tissues controlled by the enteric nervous system introduces opportunities to treat a multitude of associated pathologies.
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