☆ 4.5 Article

Pharmacokinetic Considerations of Inhaled Pharmaceuticals for Systemic Delivery

CURRENT PHARMACEUTICAL DESIGN (2016)

Journal

CURRENT PHARMACEUTICAL DESIGN

Volume 22, Issue 17, Pages 2532-2548

Publisher

BENTHAM SCIENCE PUBL LTD

DOI: 10.2174/1381612822666160128150005

Keywords

Pharmacokinetic; inhaled; systemic delivery; inhaled carriers; drug's intrinsic property; bioavailability

Categories

Pharmacology & Pharmacy

Funding

National Natural Science Foundation of China [81172997]
PUMC Youth Fund from the Fundamental Research Funds for the Central Universities grants of the People's Republic of China [33320140077]
Beijing Health and Technical Personal of High-level Plan [2014-2-014]

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Abstract

Background: Systemic pulmonary delivery is considered to have advantages over oral or intravenous administration for certain drugs. Methods: In this article, we review the effects of intrinsic drug properties and drug loading carriers on the pharmacokinetic parameters of inhaled drugs in the context of use in systemic pulmonary delivery. Results: The delivery of drugs via inhalation can be advisable to achieve a fast onset of action; enhance the systemic bioavailability of drugs with poor oral absorption, including peptides and proteins; avoid invasive administration and improve patient compliance. To optimize the functioning of this delivery system, there is high demand for a systematic understanding of the pharmacokinetic characteristics, which are closely related to the pharmacodynamic and toxicological effects. Conclusion: The pharmacokinetic parameters of inhaled drug products are affected by many factors, including physiological and pathological variables and the intrinsic drug and formulation properties.

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