Decades-old model of slow adaptation in sensory hair cells is not supported in mammals

TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells

(2020) Christopher L. Cunningham et al.   NEURON

Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex

(2020) Sihan Li et al.   Nature Communications

Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea

(2019) Mélanie Tobin et al.   eLife

Hair Bundle Stimulation Mode Modifies Manifestations of Mechanotransduction Adaptation

(2019) Giusy A. Caprara et al.   JOURNAL OF NEUROSCIENCE

Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

(2019) Son C. Le et al.   Nature Communications

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

(2018) Bifeng Pan et al.   NEURON

Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

(2018) Angela Ballesteros et al.   eLife

Human myosin VIIa is a very slow processive motor protein on various cellular actin structures

(2017) Osamu Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation

(2017) Thomas Effertz et al.   JOURNAL OF NEUROSCIENCE

Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells

(2017) A Catalina Vélez-Ortega et al.   eLife

Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer

(2016) A. W. Peng et al.   JOURNAL OF NEUROSCIENCE

Ca2+ induces PI(4,5)P2 clusters on lipid bilayers at physiological PI(4,5)P2 and Ca2+ concentrations

(2013) Maria J. Sarmento et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adaptation of Mammalian Auditory Hair Cell Mechanotransduction Is Independent of Calcium Entry

(2013) Anthony W. Peng et al.   NEURON

Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction

(2011) Anthony W. Peng et al.   Nature Communications

Calcium Balance and Mechanotransduction in Rat Cochlear Hair Cells

(2010) Maryline Beurg et al.   JOURNAL OF NEUROPHYSIOLOGY

Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging

(2009) Maryline Beurg et al.   NATURE NEUROSCIENCE