Review
Biochemistry & Molecular Biology
Antonios Lazaridis, Eleni Gavriilaki, Stella Douma, Eugenia Gkaliagkousi
Summary: Essential hypertension is a highly heterogeneous disease with a complex etiology, where subclinical inflammation and abnormal activation of TLR signaling play crucial roles in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Melissa Tomasi, Alessandro Cherubini, Serena Pelusi, Sara Margarita, Cristiana Bianco, Francesco Malvestiti, Lorenzo Miano, Stefano Romeo, Daniele Prati, Luca Valenti
Summary: This study investigates the relationship between circulating IL32 concentration and blood pressure control in individuals at high risk of metabolic dysfunction associated fatty liver disease (MAFLD). The results show that higher IL32 levels are independently associated with impaired blood pressure control, indicating a close association between IL32 concentration and cardiovascular disease risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Meena S. Madhur, Fernando Elijovich, Matthew R. Alexander, Ashley Pitzer, Jeanne Ishimwe, Justin P. Van Beusecum, David M. Patrick, Charles D. Smart, Thomas R. Kleyman, Justin Kingery, Robert N. Peck, Cheryl L. Laffer, Annet Kirabo
Summary: Even after blood pressure normalization, patients with hypertension still face elevated cardiovascular risk such as stroke, heart failure, and heart attack, possibly due to underlying immune cell activation. Triggers like viral infections, autoimmunity, and lifestyle factors can initiate immune activation leading to chronic inflammation and hypertension. T cells play a central role in the immune responses contributing to hypertension.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zaida Zakaria, Zaidatul Akmal Othman, Joseph Bagi Suleiman, Nur Asyilla Che Jalil, Wan Syaheedah Wan Ghazali, Victor Udo Nna, Mahaneem Mohamed
Summary: In MAFLD rats, bee bread demonstrated antioxidant, anti-inflammatory, anti-steatotic, and anti-fibrotic effects.
Article
Food Science & Technology
Hrvoje Urlic, Marko Kumric, Goran Dujic, Josip Vrdoljak, Daniela Supe-Domic, Zeljko Dujic, Josko Bozic
Summary: This study investigated the anti-inflammatory effects of CBD in hypertensive patients and found that oral CBD administration significantly reduced serum concentrations of IL-8, IL-10, and IL-18. Higher baseline levels of IL-8 and IL-10 predicted greater reduction in diastolic blood pressure, and the extent of reduction in IL-8 and IL-10 serum levels correlated with the extent of reduction in diastolic blood pressure.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Dentistry, Oral Surgery & Medicine
F. Cavalla, A. Letra, R. M. Silva, G. P. Garlet
Summary: Periodontal and periapical lesions are infectious inflammatory osteolytic conditions mediated by a complex inflammatory immune response. The RANKL/OPG ratio plays a key role in determining osteolytic activity, which can be modulated by proinflammatory cytokines and effector cells. Understanding the molecular mechanisms associated with host response and immunological tolerance is crucial for the management of lesion activity.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Ewa Olechno, Anna Puscion-Jakubik, Malgorzata Elzbieta Zujko
Summary: Chokeberry has positive effects on various metabolic parameters such as dyslipidemia and hypertension, increasing antioxidant defense mechanisms and potentially reducing the risk of metabolic disorders.
Article
Microbiology
Vivekanandhan Aravindhan, Anup Bobhate, Kuppan Sathishkumar, Aruna Patil, Satyavani Kumpatla, Vijay Viswanathan
Summary: This study investigated the prevalence of latent tuberculosis infection (LTBI) among diabetes patients and the relationship with immunoendocrine biomarkers.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lengyun Wei, Xianlong Ye, Siyuan Cui, Dashuai Li, Shenglong Zhu
Summary: This study investigates the role of free fatty acid receptor 4 (FFAR4) and fibroblast growth factor 21 (FGF21) in metabolic disorders. The findings reveal that FFAR4 deficiency leads to increased levels of FGF21, and the double knockout of FGF21 and FFAR4 results in severe metabolic abnormalities likely caused by decreased energy expenditure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Meiyu Jin, Lianwen Zheng, Yunfei Wei, Jiaqi Cheng, Di Zhang, Siru Yan, Haiyan Qin, Qi Wang, Xinxin Ci, Haihua Feng
Summary: This study found that E. cloacae can promote the development of nonalcoholic fatty liver disease (NAFLD) and atherosclerosis by inducing inflammation and lipid accumulation. These findings are important for studying the pathogenesis and drug screening of these diseases.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Chen-Hua Liu
Summary: This article is linked to the paper by Poynard et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Bethany L. Goodlett, Chang Sun Kang, Eunsoo Yoo, Shobana Navaneethabalakrishnan, Dakshnapriya Balasubbramanian, Sydney E. Love, Braden M. Sims, Daniela L. Avilez, Winter Tate, Delilah R. Chavez, Gaurav Baranwal, Mary B. Nabity, Joseph M. Rutkowski, Dongin Kim, Brett M. Mitchell
Summary: Renal lymphangiogenesis can lower blood pressure and is associated with favorable alterations in renal immune cells and increased sodium excretion.
Article
Pharmacology & Pharmacy
Hongxue Li, Qian Xu, Chengye Xu, Yuxin Hu, Xingyang Yu, Kangqi Zhao, Mingqing Li, Meng Li, Junfang Xu, Hongyu Kuang
Summary: Hepatic gluconeogenesis is crucial in maintaining glucose metabolism homeostasis, particularly in cases of type 2 diabetes mellitus combined with non-alcoholic fatty liver disease (T2DM-NAFLD). Inhibiting liver inflammation has been shown to improve glucose metabolism disorders. Studies suggest that Bicyclol may be an effective drug for treating T2DM-NAFLD and other metabolic disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Z. Ugur Aydin, M. G. Ocak, S. Bayrak, D. Goller Bulut, K. Orhan
Summary: Fractal dimension (FD) of periapical lesions increased significantly 1 year post-treatment, with a greater increase in the control group compared to the DM group. Both groups showed a significant decrease in periapical index (PAI) scores over time. No gender differences were observed in FD changes.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Gabriele G. Schiattarella, Daniele Rodolico, Joseph A. Hill
Summary: HFpEF is a common chronic cardiovascular disease, where metabolic disturbance and inflammatory burden play important roles in its pathogenesis. The interplay between these two processes is complex, with metabolic inflammation having a central role in shaping the pathophysiology of HFpEF.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Erifili Venieri, Constantina Aggeli, Aris Anastasakis, Helen Sambatakou, Christodoulos Stefanadis, Dimitrios Tousoulis
Summary: This study assessed the mitral valve in HCM patients and found that patients with and without obstruction share some common anatomic features, but those with obstruction have unique characteristics that may contribute to LVOT obstruction.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Pharmacology & Pharmacy
Hassan Yousefi, Ladan Mashouri, Samuel C. Okpechi, Nikhilesh Alahari, Suresh K. Alahari
Summary: The outbreak of the novel coronavirus has caused a major global public health concern, with over 31 million cases confirmed and efforts being made to repurpose existing cancer drugs to treat COVID-19. These drugs target the viral replication cycle and immune response, offering a potential novel approach to combat the virus.
BIOCHEMICAL PHARMACOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Georgios Zakynthinos, Gerasimos Siasos, Evangelos Oikonomou, Maria Gazouli, Konstantinos Mourouzis, Marina Zaromitidou, Vasiliki Tsigkou, Evanthia Bletsa, Panagiota Stampouloglou, Stamatis Tsouroulas, Georgios Marinos, Konstantinos Vlasis, Manolis Vavuranakis, Christodoulos Stefanadis, Dimitris Tousoulis
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Eirini Pagkalidou, Athanasios Kordalis, Spyridon Deftereos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: Our network meta-analysis identified the most effective antiarrhythmics for pharmacologic cardioversion over different time settings, with intravenous vernakalant and flecainide showing the highest conversion rate within 4 hours. Flecainide, especially when compared to propafenone, demonstrated superiority for conversion rates within 12 hours, while amiodarone exhibited efficacy within 24 hours, particularly if ranolazine was added.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Letter
Medicine, General & Internal
Ioannis Doundoulakis, Dimitris Tsiachris, Konstantinos A. Gatzoulis, Christodoulos Stefanadis, Konstantinos Tsioufis
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Peripheral Vascular Disease
Shane A. Phillips, Kendra Osborn, Chueh-Lung Hwang, Ahmad Sabbahi, Mariann R. Piano
Summary: Oxidative stress is implicated in the development of many ethanol-induced pathologies, contributing to endothelial dysfunction and cardiovascular diseases such as hypertension. Ethanol consumption may alter vascular cell function and microvascular function, increasing the risk for hypertension. Data from human investigations have shown an association between alcohol consumption, changes in blood pressure, and hypertension risk.
CURRENT HYPERTENSION REVIEWS
(2021)
