Article
Pediatrics
Fabienne Carre, Nicolas Leboulanger, Briac Thierry, Francois Simon, Vincent Couloigner, Francoise Denoyelle, Romain Luscan
Summary: A retrospective study evaluated the impact of COVID-19 lockdown on pediatric otolaryngology emergency activity, revealing a significant decrease in consultations and surgeries, as well as a reduction in surgery rates for infections of any type.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Letter
Medicine, General & Internal
Jonathan P. Shepherd, Simon C. Moore, Abigail Long, Laura M. Mercer Kollar, Steven A. Sumner
Summary: This study compared emergency department visits for violence-related injuries occurring at home and outside the home in Cardiff, Wales, before and after the implementation of COVID-19 lockdown measures in March 2020.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Editorial Material
Emergency Medicine
Michael M. Dinh, Saartje Berendsen Russell
Summary: The ongoing public health crisis caused by COVID-19 emphasizes the importance of coordinated health resource management and reducing the risk of ED overcrowding. Current time-based performance targets have hindered efforts to address core issues in patient flow in EDs, emphasizing the need for a stronger focus on optimizing hospital occupancy, clinician engagement, and data for more appropriate and sustainable solutions. Appropriate policy drivers are necessary to facilitate whole-of-hospital models of care, with a focus on avoidable admissions, complications, and reduced hospital length of stay.
EMERGENCY MEDICINE AUSTRALASIA
(2021)
Article
Health Care Sciences & Services
Bisheng Shen, Baoxin Chen, Kuangyi Li, Weiyin Cheng, Mohammad Mofatteh, Robert W. Regenhardt, Jack Wellington, Zhangrong Liang, Qi Tang, Jingli Chen, Yimin Chen
Summary: This study aimed to assess the impact of the COVID-19 pandemic lockdown on non-COVID-19 emergency department (ED) visits in a tertiary hospital. The results showed a significant reduction in ED visits during the lockdown period in 2020 compared to 2019, with a subsequent increase in 2021. Additionally, the proportion of critically ill patients with respiratory system involvement, severe trauma, and poisoning decreased in 2020, while the rates of emergency ambulance calls, hospitalizations, and deaths increased.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2023)
Article
Health Care Sciences & Services
Jalmari Tuominen, Teemu Koivistoinen, Juho Kanniainen, Niku Oksala, Ari Palomaki, Antti Roine
Summary: Emergency department crowding is a recognized threat to patient safety and is associated with increased mortality. This article presents the results of a prospective crowding early warning software that accurately predicts future service demand and potentially improves treatment outcomes. The software achieved high AUC scores for predicting next hour and 24-hour crowding using simple statistical models, and also successfully predicted afternoon crowding at 1 p.m.
JOURNAL OF MEDICAL SYSTEMS
(2023)
Article
Public, Environmental & Occupational Health
Jens Wretborn, Daniel B. Wilhelms, Ulf Ekelund
Summary: A study in Sweden found that ED crowding measured by mSEAL or occupancy rate was not significantly associated with short-term mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Emergency Medicine
Suhrith Bhattaram, Varsha S. Shinde, Ishan Lamba, Rebecca S. Gladwin, Kadainti Venkata Subbaraya Sharma
Summary: During the COVID-19 lockdown period, there was an increase in cases of self-harm and violence, with changes in sociodemographic characteristics and incidence rates. Upgradation of healthcare and law enforcement infrastructure may be necessary to deal with similar situations more efficiently.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Dalia Morales-Arraez, Anjara Hernandez, Alberto Hernandez-Bustabad, Carla Amaral, Cristina Reygosa, David Nicolas-Perez, Antonio Zebenzui Gimeno-Garcia, Manuel Hernandez-Guerra
Summary: This study demonstrates that prioritized endoscopic activities following ESGE criteria during the COVID-19 pandemic are not associated with increased contagion risk, and can increase the rate of relevant endoscopic findings and cancer detection rate.
Article
Pediatrics
Roshit K. Bothara, Aditya Raina, Brennan Carne, Tony Walls, Andrew McCombie, Michael W. Ardagh, Laura R. Joyce
Summary: This study identified a significant reduction in paediatric presentations to a tertiary emergency department in New Zealand during the national Level 4 Lockdown for COVID-19. The proportional increase in <1-year-old group may suggest a greater need for community-based child health services during the pandemic, and mental health support services may also need to adapt and expand to provide adequate psychological support for children. Recognizing the needs of vulnerable groups, such as children, will be critical for informing response plans for similar events in the future.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2021)
Article
Pediatrics
Melissa Shack, Adrienne Davis, Evangeline W. J. Zhang, Daniel Rosenfield
Summary: The study found a significant increase in children presenting to the emergency department with bicycle-related injuries during the COVID-19 pandemic, with fractures being the most common type of injury. Further research is needed to explore strategies for reducing bicycle-related injuries.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Review
Health Care Sciences & Services
Ioannis Pantazopoulos, Stamatoula Tsikrika, Stavroula Kolokytha, Emmanouil Manos, Konstantinos Porpodis
Summary: COVID-19 is an emerging global public health concern that has led to the restructuring of emergency care delivery in hospitals. The overwhelming volume of published papers each week has made it challenging for emergency physicians to keep up with the ever-changing information. This review aims to provide emergency physicians with a summary of the current literature on managing COVID-19 patients in the emergency department.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Emergency Medicine
Arjun K. Venkatesh, Alexander T. Janke, Li Shu-Xia, Craig Rothenberg, Pawan Goyal, Aisha Terry, Michelle Lin
Summary: This study used a national emergency medicine clinical quality registry to describe recent trends in ED visitation during the pandemic, revealing a significant initial decline followed by some recovery, but still below pre-pandemic levels. The proportion of visits for select emergency conditions increased early in the pandemic, yet visits for acute myocardial infarction and cerebrovascular disease remained lower in 2020 compared to 2019. Despite variation in the trajectory of the COVID-19 outbreak, the overall pattern of ED visits was similar across regions and time.
ANNALS OF EMERGENCY MEDICINE
(2021)
Review
Health Care Sciences & Services
Marina Sartini, Alessio Carbone, Alice Demartini, Luana Giribone, Martino Oliva, Anna Maria Spagnolo, Paolo Cremonesi, Francesco Canale, Maria Luisa Cristina
Summary: Overcrowding in emergency departments is a widespread phenomenon globally, causing significant negative impacts on hospitals. It results in reduced resources, decreased quality of care, and a lack of timely critical services for patients with medical emergencies.
Article
Multidisciplinary Sciences
Nicholas M. Mohr, Anusha Krishnadasan, Karisa K. Harland, Patrick Ten Eyck, William R. Mower, Walter A. Schrading, Juan Carlos C. Montoy, L. Clifford McDonald, Preeta K. Kutty, Elisabeth Hesse, Scott Santibanez, David N. Weissman, Patricia Slev, David A. Talan
Summary: The risk of SARS-CoV-2 infection was similar for unvaccinated U.S. emergency department healthcare personnel compared to nonclinical staff and healthcare personnel engaged in direct patient care. Many identified risk factors were related to community exposures.
Article
Emergency Medicine
Burak Bekgoz, Ebru Erek Kazan, Ahmet Fatih Kahraman, Ishak San
Summary: This study evaluates the change in the number of EMS cases during the lockdown period, non-lockdown period, and pre-pandemic period. The results show that the number of EMS cases decreased during the pandemic, especially during the lockdown. However, the number of calls increased significantly during the lockdown period, resulting in longer response times and talk times.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Giovanni Di Nardo, Cesare Cremon, Annamaria Staiano, Vincenzo Stanghellini, Osvaldo Borrelli, Caterina Strisciuglio, Claudio Romano, Saverio Mallardo, Elena Scarpato, Giovanni Marasco, Silvia Salvatore, Letizia Zenzeri, Enrico Felici, Licia Pensabene, Simona Sestito, Ruggiero Francavilla, Paolo Quitadamo, Mariella Baldassarre, Valentina Giorgio, Renato Tambucci, Chiara Ziparo, Pasquale Parisi, Maria Raffaella Barbaro, Giovanni Barbara
Summary: Functional gastrointestinal disorders, such as IBS, affect many children worldwide due to disturbed neuroimmune function. Low-grade inflammation and mucosal immune activation play a significant role in symptom generation among pediatric patients with IBS, potentially influencing new therapeutic strategies.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Elise Payen, Antoine Neuraz, Letizia Zenzeri, Cecile Talbotec, Elie Abi Nader, Lucienne Chatenoud, Stephanie Chhun, Olivier Goulet, Frank M. Ruemmele, Benedicte Pigneur
Summary: The study found that early use of Adalimumab (ADA) in pediatric Crohn's disease patients can effectively maintain remission, especially when used as monotherapy.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Giovanni Barbara, Cesare Cremon, Massimo Bellini, Maura Corsetti, Giovanni Di Nardo, Francesca Falangone, Lorenzo Fuccio, Francesca Galeazzi, Paola Iovino, Giovanni Sarnelli, Edoardo Vincenzo Savarino, Vincenzo Stanghellini, Annamaria Staiano, Cristina Stasi, Cesare Tosetti, Rossella Turco, Enzo Ubaldi, Rocco Maurizio Zagari, Letizia Zenzeri, Giovanni Marasco
Summary: This study provides consensus on the diagnosis and treatment of irritable bowel syndrome (IBS), suggesting a symptom-based diagnostic strategy and evaluating and recommending different treatment methods.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Giovanni Di Nardo, Enrico Felici, Letizia Zenzeri, Maurizio Mennini, Melania Evangelisti, Pasquale Parisi, Anna Claudia Massolo, Cesare Hassan, Marisa Piccirillo, Livia Lucchini, Silvia Furio, Giovanna Quatrale, Caterina Strisciuglio
Summary: This study aimed to assess the superiority of split-dose regimen of SPMC compared with SPMC day-before regimen for bowel cleansing before colonoscopy in children. The results showed that the rate of successful cleansing level was significantly higher in the split-dose group. The BBPS scores were significantly higher in the split-dose group for the whole colon, right colon, and transverse colon. Patient acceptability was better in the split-dose group and the percentage of children needing nasogastric tube placement was lower.
DIGESTIVE ENDOSCOPY
(2023)
Article
Pediatrics
Rossella Turco, Angela Mauro, Paolo Quitadamo, Giovanni Gaglione, Francesco Esposito, Giovanni Di Nardo, Vincenzo Tipo
Summary: We present 4 clinical cases of infants with acute appendicitis, highlighting the challenges faced by clinicians in diagnosing and managing this condition in infants. Even without conclusive diagnostic work-up, intraoperative diagnosis and appendectomy were performed. Maintaining a high index of suspicion for acute appendicitis in infants with intra-abdominal sepsis of unclear etiology is crucial to avoid complications and prolonged hospitalization.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2023)
Review
Gastroenterology & Hepatology
Giovanni Di Nardo, Letizia Zenzeri, Matteo Guarino, Alessio Molfino, Pasquale Parisi, Giovanni Barbara, Vincenzo Stanghellini, Roberto De Giorgio
Summary: Chronic intestinal pseudoobstruction (CIPO) is a rare and severe form of gastrointestinal dysmotility, and the current treatment options are limited. There is a need for further research on new drugs and nutritional support strategies for these patients.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Pediatrics
Angela Mauro, Francesca Casini, Antonella Talenti, Clelia Di Mari, Anna Rita Benincaso, Giovanni Di Nardo, Luca Bernardo
Summary: Celiac disease is an immune-mediated enteropathy caused by gluten sensitivity in genetically susceptible individuals. In rare cases, it can lead to a severe and potentially life-threatening manifestation known as celiac crisis. Early identification of celiac crisis symptoms is crucial for prompt diagnosis and management. We report a case of a 22-month-old child with celiac crisis presenting with weight loss, vomiting, and diarrhea accompanied by malnutrition.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Francesco La Torre, Jurgen Sota, Antonella Insalaco, Giovanni Conti, Emanuela Del Giudice, Riccardo Lubrano, Luciana Breda, Maria Cristina Maggio, Adele Civino, Violetta Mastrorilli, Roberta Loconte, Marco Francesco Natale, Camilla Celani, Mery Romeo, Serena Patroniti, Cristina Gentile, Antonio Vitale, Valeria Caggiano, Carla Gaggiano, Federico Diomeda, Marco Cattalini, Giuseppe Lopalco, Giacomo Emmi, Paola Parronchi, Stefano Gentileschi, Fabio Cardinale, Emma Aragona, Farhad Shahram, Achille Marino, Patrizia Barone, Carla Moscheo, Burcugul Ozkiziltas, Francesco Carubbi, Ohoud Alahmed, Ludovica Iezzi, Benson Ogunjimi, Angela Mauro, Maria Tarsia, Ayman Abdel-Monem Ahmed Mahmoud, Henrique Ayres Mayrink Giardini, Petros P. Sfikakis, Katerina Laskari, Ewa Wiesik-Szewczyk, Jose Hernandez-Rodriguez, Bruno Frediani, Veronica Gomez-Caverzaschi, Abdurrahman Tufan, Ibrahim A. Almaghlouth, Alberto Balistreri, Gaafar Ragab, Claudia Fabiani, Luca Cantarini, Donato Rigante
Summary: The potential role of Streptococcus salivarius K12 (SSK12) in controlling febrile flares in patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome was evaluated. The results showed that SSK12 significantly reduced the number and duration of febrile flares, lowered body temperature, provided a steroid-sparing effect, and reduced accompanying symptoms related to the syndrome.
FRONTIERS IN MEDICINE
(2023)
Review
Pediatrics
Claudia Mandato, Angelo Colucci, Roberta Lanzillo, Annamaria Staiano, Elena Scarpato, Luigi Schiavo, Francesca Felicia Operto, Maria Rosaria Serra, Cristina Di Monaco, Julia Sara Napoli, Grazia Massa, Pietro Vajro
Summary: Purpose of this study was to explore the role of lifestyle and diet in the development and progression of multiple sclerosis (MS) and investigate the potential benefits of diets and dietary supplementations in improving patient outcomes. Findings revealed that there is no universally best diet for MS, but healthy and balanced diets rich in fruits, vegetables, whole grains, and lean proteins while limiting processed foods, sugar, and saturated fat appear to have antioxidant and anti-inflammatory properties and promote a gut microbiota that supports gut and brain barriers. Vitamin D and polyunsaturated fatty acids are the most studied supplements for reducing MS-associated inflammation. In addition, counseling on appropriate diet and maintaining physical activity is recommended for MS prevention and management in both adults and children until more research is available on newer approaches.
Article
Rheumatology
Samuel Channon-Wells, Ortensia Vito, Andrew J. McArdle, Eleanor G. Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G. Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J. Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A. Herberg, Myrsini Kaforou, Aubrey J. Cunnington, Oleg Blyuss, Michael Levin
Summary: This study evaluated immunomodulatory treatments for multisystem inflammatory syndrome in children (MIS-C) and found that glucocorticoids or glucocorticoids plus intravenous immunoglobulin were not significantly different from intravenous immunoglobulin alone in terms of clinical efficacy. Initial treatment with glucocorticoids may be a safe alternative to immunoglobulin or combined therapy.
LANCET RHEUMATOLOGY
(2023)
Review
Pediatrics
Paolo Quitadamo, Sara Isoldi, Saverio Mallardo, Letizia Zenzeri, Silvia Ceccanti, Ilaria Battagliere, Margherita Del Bene, Giovanni Di Nardo
Summary: This review summarizes the clinical conditions associated with rectal bleeding in infants and provides an evidence-based diagnostic approach for the clinical management of patients with this symptom.
CURRENT PEDIATRIC REVIEWS
(2023)
Article
Microbiology
Veronica Folliero, Federica Dell'Annunziata, Biagio Santella, Emanuela Roscetto, Carla Zannella, Nicoletta Capuano, Alessandro Perrella, Anna De Filippis, Giovanni Boccia, Maria Rosaria Catania, Massimiliano Galdiero, Gianluigi Franci
Summary: The emergence of multidrug-resistant strains requires the urgent discovery of new antibacterial drugs. In this study, the anthelmintic avermectins were screened for antibacterial activity against gram-positive and gram-negative strains. Selamectin, a subset of avermectins, showed potent antibacterial activity against gram-positive strains, particularly Staphylococcus aureus. Further studies demonstrated its ability to inhibit bacterial growth, alter cell surface, and reduce biofilm biomass. Synergistic effects were also observed with other antibiotics. These findings suggest that selamectin may be a promising candidate for the treatment of S. aureus infections.
Article
Public, Environmental & Occupational Health
Bruno Charlier, Albino Coglianese, Federica De Rosa, Armando Cozzolino, Giovanni Boccia, Anna Borrelli, Mario Capunzo, Giovanni Genovese, Francesco De Caro, Amelia Filippelli, Fabrizio Dal Piaz, Viviana Izzo
Summary: The exposure of healthcare workers to antineoplastic drugs can lead to adverse health events due to chemical contamination of work surfaces. A UHPLC-MS/MS based protocol was developed and applied for the environmental monitoring of hospital working areas contaminated with various chemotherapeutics. The study uncovered critical aspects in the working protocols and workspace organization, leading to improved safety for healthcare workers.
JOURNAL OF PUBLIC HEALTH RESEARCH
(2023)
Article
Nutrition & Dietetics
Angela Pepe, Claudia Mandato, Tiziana Di Leo, Giovanni Boccia, Giulia Lucaroni, Gianluigi Franci, Carolina Mauro, Giuseppe Di Cara, Francesco Valitutti
Summary: This study aimed to estimate the prevalence of celiac disease (CD) among hospitalized children in a pediatric department of a Southern Italy University Hospital and explore the prevalence of clinical alerts related to malnutrition and systemic inflammation. The results showed that underweight/malnourished children accounted for 28.6% of CD patients. The study suggests that hospital-admission CD testing may be an effective approach to reduce the discrepancy of prevalence between case-finding and population-screening programs.
Article
Medicine, Research & Experimental
Danilo De Novellis, Veronica Folliero, Valentina Giudice, Luca Pezzullo, Giuseppina Sanna, Raffaele Fontana, Roberto Guariglia, Carla Zannella, Laura Mettivier, Idalucia Ferrara, Giovanni Boccia, Maria Teresa Buonanno, Maria Carmen Martorelli, Serena Luponio, Andrea Crudele, Pasquale Pagliano, Anna Maria Sessa, Francesca Velino, Maddalena Langella, Aldo Manzin, Massimiliano Galdiero, Carmine Selleri, Gianluigi Franci, Bianca Serio
Summary: This retrospective real-life study aimed to evaluate the seropositivity and neutralizing antibody rates against SARS-CoV-2 and its Omicron BA.1 variant in hematological patients. The study found that most hematological patients who received three or more vaccine doses exhibited adequate neutralizing antibody response against both the wild-type virus and the Omicron BA.1 variant. However, patients with B-cell lymphoproliferative disorders and/or those treated with anti-CD20 monoclonal antibodies showed a lower seropositivity rate.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
