Article
Ophthalmology
Mustapha El Hamdaoui, Alexander M. Levy, Mokshad Gaonkar, Timothy J. Gawne, Christopher A. Girkin, Brian C. Samuels, Rafael Grytz
Summary: The study evaluated the effect of scleral crosslinking on experimental myopia in tree shrew eyes using genipin injections. Results showed that scleral crosslinking with genipin can slow axial elongation and myopia progression, with treatment effect increasing with higher genipin doses. Unexpected effects on ocular structures were also observed, indicating a need for further optimization of genipin delivery before clinical consideration.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Mustapha El Hamdaoui, Alexander M. Levy, Aaron B. Stuber, Christopher A. Girkin, Timothy W. Kraft, Brian C. Samuels, Rafael Grytz
Summary: Scleral crosslinking using genipin is a promising treatment option for myopia control, but its safety is still unclear. This study investigated the effects of retrobulbar injections of genipin on retinal structure and function in tree shrews. The results showed that genipin injections caused retinal thinning and reduced retinal function, with higher doses leading to noticeable tissue degeneration.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Lei Guo, Rui Hua, Xinxin Zhang, Ting Yu Yan, Yang Tong, Xin Zhao, Shi Chao Chen, Moying Wang, Neil M. Bressler, Jun Kong
Summary: The study finds that scleral cross-linking may cause glaucomatous changes in guinea pig eyes and raises safety concerns for controlling myopia.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Xiaona Sun, Xiaoming Yan, Duo Chen, Xiaoyu Liu, Yuan Wu
Summary: The study investigated the efficacy and safety of microbial transglutaminases (mTGases) during scleral collagen cross-linking (CXL) in vivo. The results showed that mTGase treatment significantly increased the elastic modulus of the sclera, indicating effective stiffening of the tissue. Morphological observations also revealed an increase in the density of collagen bundles and diameter of collagen fibrils in the mTGase-treated group. No apoptosis or histological damage was detected, suggesting the safety of mTGase-mediated scleral CXL.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yanbing Wang, Zhenquan Wu, Bingqian Liu, Jiang Lu, Silvia Tanumiharjo, Jianbing Huang, Xiujuan Zhao, Lin Lu
Summary: Myopia is increasing globally, yet there is no effective treatment available. Using 4S-PEG can effectively control myopia progression with low cytotoxicity, showing promise for application in treatment.
Article
Ophthalmology
Ling Ying Ge, Tian Hong Wu, Yue Qi Liu, Chun Jiang, Xue Yin
Summary: This study demonstrates that UVA-CXL can significantly improve the success rate of trabeculectomy by inhibiting filtering bleb vascularization and increasing sclera stiffness. CXL also activates the TRPV4 pathway, leading to suppression of vascular endothelial cell growth.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Jinlei Ma, Fangyuan Wu, Zhiyong Liu, Yijiong Fang, Xu Chu, Linyan Zheng, Anquan Xue, Kaihui Nan, Jia Qu, Lingyun Cheng
Summary: This study characterized the biomechanical properties of genipin-crosslinked human dura mater as a reinforcing material for posterior scleral reinforcement (PSR) and compared it with crosslinked human sclera. The results demonstrated differences between crosslinked dura mater and crosslinked sclera in terms of resistance to enzyme degradation, density, and elastic modulus. Clinical outcomes showed that the use of crosslinked dura mater as a reinforcing patch in PSR can effectively manage the progression of high myopia without any material-specific complications.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Brandon G. Gerberich, Bailey G. Hannon, Dillon M. Brown, A. Thomas Read, Matthew D. Ritch, Elisa Schrader Echeverri, Lauren Nichols, Cahil Potnis, Sreesh Sridhar, Maya G. Toothman, Stephen A. Schwaner, Erin J. Winger, Hannah Huang, Gabby S. Gershon, Andrew J. Feola, Machelle T. Pardue, Mark R. Prausnitz, C. Ross Ethier
Summary: This study assessed the neuroprotective effects of scleral stiffening treatments in an experimental model of glaucoma. The results showed that neither global nor local scleral stiffening provided demonstrable neuroprotection in hypertensive eyes.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Zhe Chen, Xiaotong Lv, Lingbo Lai, Yushan Xu, Fengju Zhang
Summary: Myopia is becoming more severe and alters the cellular mechanics of scleral fibroblasts. Scleral UVA-Riboflavin Collagen Crosslinking (sCXL) shows promise for myopia treatment. This study investigates the effect of sCXL on the mechanical properties of scleral fibroblasts and finds that it effectively moderates the deformation difficulty of these cells after myopia.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Liugui Chen, Wei Jin, Xinlei Hao, Xuejie Li, Yiqiao Xing
Summary: This study found that the scleral spur length significantly increased in different accommodation stimuli states and was significantly correlated with the length of the ciliary muscle, Schlemm's canal, and trabecular meshwork. The contractile ability and compliance of the scleral spur play an important role in maintaining the morphology of the Schlemm's canal.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Jiawei Lin, Zhiming Wang, Hecheng Meng, Xiaoming Guo
Summary: This study improved the emulsification properties of gum arabic by crosslinking it with genipin, resulting in enhanced emulsifying stability and decreased dosage of emulsifier. The genipin-crosslinked gum arabic showed larger molecular weight and more compact conformation, leading to more stable emulsions even after sterilization or prolonged storage at elevated temperatures.
CARBOHYDRATE POLYMERS
(2021)
Article
Multidisciplinary Sciences
Hongwei Gu, Ya Liang, Yao Shen, Jie Shuai, Qiuli Yu, Huaijin Guan, Zhilan Yuan
Summary: This study investigated the inhibitory effect of a hyaluronic acid hydrogel loaded with hydroxycamptothecin (HCPT) on scar formation after filtration surgery in rabbits. The results showed that HCPT significantly inhibited the proliferation of rabbit scleral fibroblasts and accelerated the degradation of extracellular matrix deposition, effectively preventing scar formation after filtration surgery.
Article
Chemistry, Multidisciplinary
Shintaro Nakagawa, Daisuke Aoki, Yuki Asano, Naoko Yoshie
Summary: A highly stretchable elastomer with unprecedented strain-stiffening capability has been developed based on a highly homogeneous network structure enabled by a module assembly strategy. This elastomer, synthesized by efficient end-linking of a star-shaped aliphatic polyester precursor, exhibits high strength, remarkable stretchability, good fatigue resistance, and notch insensitivity. It also shows extraordinary strain-stiffening capability that exceeds the performance of any existing soft material, due to strain-induced ordering of the polymer chains in a uniformly stretched network.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Hongjie Ji, Zuhua Qiu, Yuzhuo Wang, Li Dong, Jie Cao, Bo Lian, Min Wang
Summary: In this study, genipin-crosslinked collagen scaffolds were prepared using porcine small intestinal submucosa (SIS) under different conditions. The crosslinking degree, macroscopic morphology, microstructure, swelling ratio, shrinkage temperature, degradation degree, maximum stress, and cytotoxicity of the scaffolds were evaluated. The results showed that SIS can be efficiently crosslinked with genipin, resulting in high crosslinking degree and shrinkage temperature, as well as low swelling ratio and degradation degree. Crosslinking time and genipin concentration were found to have an impact on the properties of the scaffolds. Fixation with genipin did not introduce cytotoxicity in SIS. The crosslinking degree and maximum stress of SIS can be increased by fixation at alkaline conditions.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Ophthalmology
Wenjing Song, Yu Cheng, Xiaoming Yan, Songlin Yang
Summary: The study found that local genipin immersion crosslinking without corneal epithelium can activate keratocytes in the corneal stroma and is relatively safe for thin corneas. Genipin not only crosslinks collagen fibers but also activates keratocytes, and may even promote the secretion of collagen fibers.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Review
Cell Biology
Amber Douglass, Michael Dattilo, Andrew J. Feola
Summary: This article discusses whether menopause is a sex-specific risk factor for glaucoma and explores the potential role of menopause in the development of the disease.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Ophthalmology
Brandon G. Gerberich, Bailey G. Hannon, Dillon M. Brown, A. Thomas Read, Matthew D. Ritch, Elisa Schrader Echeverri, Lauren Nichols, Cahil Potnis, Sreesh Sridhar, Maya G. Toothman, Stephen A. Schwaner, Erin J. Winger, Hannah Huang, Gabby S. Gershon, Andrew J. Feola, Machelle T. Pardue, Mark R. Prausnitz, C. Ross Ethier
Summary: This study assessed the neuroprotective effects of scleral stiffening treatments in an experimental model of glaucoma. The results showed that neither global nor local scleral stiffening provided demonstrable neuroprotection in hypertensive eyes.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
Lavanya Vasudevan, Sandra S. S. Stinnett, Lauren Hart, Pedro Gomez Altamirano, Angel Gonzalez, Kristin Weaver, Beverly Gray, John Bartlett
Summary: This study aimed to assess the intention of pregnant individuals to accept routine and COVID-19 vaccines for their baby after birth and to identify demographic and nondemographic characteristics associated with vaccination intention. The results showed that only 67% of pregnant individuals planned to vaccinate their baby with routine vaccines, and 35% would vaccinate their baby with a COVID-19 vaccine as soon as possible. Younger pregnant individuals and those identifying as Black or African American had lower vaccination intention. Routine vaccination intention was associated with familiarity with vaccination schedule, trimester of pregnancy, ethnicity, history of prior birth, and computer access.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Editorial Material
Ophthalmology
Tika Zbornik Thompson, Joshua L. Jones, Rick Pittman, Sandra S. Stinnett, Noelle E. Younge, Michael Cotten, Sharon F. Freedman, S. Grace Prakalapakorn
Summary: This retrospective study investigated the possible differences between male and female mixed-sex multiple gestation infants in terms of the stage of retinopathy of prematurity (ROP) developed and the need for ROP treatment. The study found that there was no statistically significant difference between sexes in the most severe stage of ROP developed or the need for ROP treatment among mixed-sex twin infants. However, males received treatment at an earlier post-menstrual age (PMA) than females, despite females having a lower mean birthweight and slower mean growth velocity compared to males.
Article
Ophthalmology
Ailin Song, Jay B. Lusk, Anthony N. Kuo, Kelly W. Muir, Sandra S. Stinnett, Durga S. Borkar
Summary: This systematic analysis assessed the levels of evidence (LOE) behind American Academy of Ophthalmology (AAO) Preferred Practice Pattern (PPP) guidelines and found an increasing emphasis on evidence from randomized controlled trials from 2012 to 2021. However, the number of recommendations with reported LOE has decreased, indicating a need for improvement in future guidelines.
Article
Ophthalmology
Vidisha Goyal, A. Thomas Read, Dillon M. Brown, Luke Brawer, Kaitlyn Bateh, Bailey G. Hannon, Andrew J. Feola, C. Ross Ethier
Summary: We constructed an atlas of retinal ganglion cell axons for normotensive eyes in Brown Norway rats and developed/evaluated metrics of axonal damage in hypertensive eyes. These tools are important for evaluating regional changes in retinal ganglion cells and overall levels of damage in glaucoma studies using Brown Norway rats.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Ophthalmology
Vidisha Goyal, A. Thomas Read, Matthew D. Ritch, Bailey G. Hannon, Gabriela Sanchez Rodriguez, Dillon M. Brown, Andrew J. Feola, Adam Hedberg-Buenz, Grant A. Cull, Juan Reynaud, Mona K. Garvin, Michael G. Anderson, Claude F. Burgoyne, C. Ross Ethier
Summary: AxoNet 2.0, an automated deep learning tool, was developed to accurately quantify retinal ganglion cell (RGC) axonal loss and morphologic change. The tool showed excellent performance and promising generalization on different animal models. This study is of great importance for investigating glaucomatous optic neuropathy in animal models.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Ophthalmology
Praruj Pant, Anita Kundu, Jay K. Rathinavelu, Xin Wei, Rupesh Agrawal, Sandra S. Stinnett, Jane S. Kim, Akshay S. Thomas, Sharon Fekrat
Summary: This study aimed to characterize choroidal vascular changes in BRVO eyes with CME by comparing the CVI, SFCT, and CST. The results showed differences in CVI between BRVO eyes and fellow eyes at presentation, but these differences resolved over time. The study provides important insights for predicting visual outcomes and treatment patterns for patients with BRVO-related CME.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Grace E. Nipp, Ahmad A. Aref, Sandra S. Stinnett, Kelly W. Muir
Summary: The number of microinvasive glaucoma surgeries (MIGS) has increased significantly in recent years, with no substantial decline in trabeculectomies or aqueous shunt surgeries. This has resulted in an increase in the total number of procedures performed per fellow each year.
OPHTHALMOLOGY GLAUCOMA
(2023)
Article
Ophthalmology
Dennis Y. Akrobetu, Cason B. Robbins, Justin P. Ma, Snnath Soundararajan, Michael S. Quist, Sandra S. Stinnett, Kathryn P. L. Moore, Kim G. Johnson, Andy J. Liu, Dilraj S. Grewal, Sharon Fekrat
Summary: The purpose of this study was to assess the intrasession repeatability of macular OCTA parameters in AD, MCI, PD, and NC patients. The results showed that the repeatability of macular OCTA metrics was similar and moderate to good in both NC and neurodegenerative disease groups.
OPHTHALMOLOGY SCIENCE
(2023)
Editorial Material
Biophysics
C. Ross Ethier, Thao (Vicky) Nguyen
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Multidisciplinary Sciences
Babak N. Safa, Mohammad Reza Bahrani Fard, C. Ross Ethier
Summary: This study used a biometric dataset to investigate the effects of iris biomechanics on PACG. The findings showed significant radial strains in the iris during the pupillary light reflex. Finite-element modeling revealed a significant impact of sphincter muscle traction on iris deformations.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Ophthalmology
Andrew J. Feola, Christopher A. Girkin, C. Ross Ethier, Brian C. Samuels
Summary: The study found that choroidal expansion significantly impacts tissue deformation within the optic nerve head, and choroidal geometry also plays a role in these deformations. Elevated intraocular pressure and intracranial pressure lead to distortions in the retrolaminar neural tissue and lamina cribrosa, respectively.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Colleen M. McDowell, Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph Van Batenburg-Sherwood, J. Cameron Millar, Markus H. Kuehn, Gulab Zode, Ted S. Acott, Michael G. Anderson, Sanjoy K. Bhattacharya, Jacques A. Bertrand, Terete Borras, Diane E. Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A. Faralli, Rudolf Fuchshofer, Preethi S. Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W. M. John, Paul L. Kaufman, Kate E. Keller, Mary J. Kelley, Ruth A. Kelly, David Krizaj, Ajay Kumar, Brian C. Leonard, Raquel L. Lieberman, Paloma Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J. McLellan, Philip Mzyk, Andrews Nartey, Louis R. Pasquale, Gaurang C. Patel, Padmanabhan P. Pattabiraman, Donna M. Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R. Samples, E. Griffen Samples, Najam Sharif, Joel S. Schuman, Val C. Sheffield, Cooper H. Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B. Toris, Karen Y. Torrejon, Amir Vahabikashi, Janice A. Vranka, Ting Wang, Colin E. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, Michael P. Fautsch, Ernst R. Tamm, Abbot F. Clark, C. Ross Ethier, W. Daniel Stamer
Summary: This article highlights the importance of using mice as a valuable model system for studying conventional outflow resistance and intraocular pressure. It also outlines the minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. These standards are expected to enhance scientific rigor and replicability of research findings.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)