Article
Biochemistry & Molecular Biology
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Summary: The study suggests that microRNA-34a can effectively reduce the activation status of glioblastoma cells and enhance survival rates against multiple glioblastoma cell types. Combination therapy of temozolomide with microRNA-34a loaded nanocells targeted to epidermal growth factor receptor (EGFR) significantly enhances sensitivity of glioblastoma cells to treatment.
MOLECULAR MEDICINE
(2021)
Review
Pathology
Mahshid Mowla, Atieh Hashemi
Summary: Recent studies have highlighted the significant role of exosomal miRNAs in cancer drug resistance, especially in predicting cancer drug resistance, showing promising potential in future applications.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Oncology
Narjes Jafari, Saeid Abediankenari, Hadi Hossein-Nataj
Summary: The study revealed that the effect of miR mimic in target gene repression may depend on its concentration and cell type, while pre-miRNAs may have a regulatory function in target repression. These findings will help to develop effective therapeutic strategies in cancer treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Ming Li, Wei Ma
Summary: MiR-26a expression is negatively correlated with multidrug resistance (MDR) in human osteosarcoma, and its enforced expression can reverse MDR by directly targeting MCL1. This suggests a potential tactic of manipulating miR-26a for overcoming MDR in osteosarcoma chemotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
X. J. Deng, H. L. Zheng, X. Q. Ke, M. Deng, Z. Z. Ma, Y. Zhu, Y. Y. Cui
Summary: This study identified that hsa-miR-34a-5p was decreased in multidrug resistant gastric cancer cells and could reverse MDR by promoting apoptosis and inhibiting migration and invasiveness after chemotherapy. The mechanism of hsa-miR-34a-5p may involve the regulation of SIRT1, P-gp, and MRP1, thereby enhancing chemotherapy sensitivity in MDR gastric cancer cells.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Jiancheng Lv, Zijian Zhou, Jingzi Wang, Xiao Yang, Hao Yu, Jie Han, Dexiang Feng, Baorui Yuan, Qikai Wu, Pengchao Li, Qiang Lu, Haiwei Yang
Summary: The study found that circFAM114A2 is downregulated in urothelial carcinoma, with higher expression associated with better survival in patients and histological grade. This circRNA inhibits cell proliferation and enhances cisplatin sensitivity by sponging miR-222-3p/miR-146a-5p to regulate P27/P21 expression. CircFAM114A2 shows potential as a prognostic biomarker and therapeutic target for urothelial carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Marianna Abate, Angela Lombardi, Amalia Luce, Manuela Porru, Carlo Leonetti, Marco Bocchetti, Virginia Campani, Giuseppe De Rosa, Sossio Fabio Graziano, Valeria Nele, Francesco Cardile, Federica Zito Marino, Renato Franco, Andrea Ronchi, Marianna Scrima, Rossella Sperlongano, Roberto Alfano, Gabriella Misso, Evzen Amler, Michele Caraglia, Silvia Zappavigna
Summary: This study demonstrates that nanodiamonds can effectively deliver miRNA to inhibit tumor development and progression. The nanodiamonds have excellent biocompatibility, and the miR-34a conjugated with nanodiamonds can effectively inhibit cancer cell proliferation and migration. Furthermore, the miR-34a-conjugated nanodiamonds exhibit remarkable anti-tumor effects in mouse models.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Environmental Sciences
Zhiyao Ren, Yunfeng Xu, Xin Wang, Min Ren
Summary: This study identified a KCNQ1OT1/miR-34a/Notch3 axis that promotes breast cancer progression through effects on cell proliferation and metastasis, which is associated with poor patient prognosis. These findings propose a novel treatment approach for breast cancer by targeting this axis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Megan N. Dang, Carolina Gomez Casas, Emily S. Day
Summary: The introduction of miR-34a into TNBC cells through miR-34a/NS holds promise for precise gene regulation, with the potential to improve patient prognosis in an aggressive disease. This nanotechnology-based approach demonstrates efficient regulation of downstream miR-34a targets to reduce TNBC cell viability, proliferation, and migration. Further research shows that pulsed near-infrared light can effectively release miRNA from the nanoshells, with the released miR-34a being as potent as transfected miR-34a.
Article
Engineering, Environmental
Xiaqing Wu, Jiao Yan, Xiaoqing Han, Runxiao Zheng, Panpan Song, Yanjing Wang, Haiyuan Zhang
Summary: This study successfully reprogrammed tumor-associated macrophages (TAMs) from immunosuppressive to immunostimulatory state using Au-DP@FeCaC NPs, and achieved efficient chemotherapy of multidrug-resistant (MDR) cancer by releasing doxorubicin (Dox) under acidic conditions.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Vivek Kumar, Archana Pandey, Arisha Arora, Priyanka Gautam, Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan
Summary: This study aimed to evaluate the therapeutic and diagnostic potential of microRNA (miRNA) in the management of epithelial ovarian cancer (EOC). Expression analysis and functional enrichment revealed the association of miRNA with the disease and involvement of target genes in cancer progression pathways. miRNA-205 and miRNA-34a were found to be significantly downregulated and upregulated, respectively, in EOC, and showed significant negative correlation with their target genes. The combined miRNA-target gene panel exhibited higher diagnostic value in predicting the risk of EOC.
DNA AND CELL BIOLOGY
(2023)
Article
Oncology
Chuanzhuo Wang, He Xin, Guangxin Yan, Zhaoyu Liu
Summary: The aim of this study was to investigate the regulatory mechanism of lncRNA NONHSAG028908.3 on CRC. The results showed that silencing of NONHSAG028908.3 inhibited proliferation, migration, and invasion of CRC cells. Furthermore, NONHSAG028908.3 regulated ALDOA expression by sponging miR-34a-5p, promoting malignant activities in CRC.
Review
Oncology
Wen Jess Li, Xiaozhuo Liu, Emily M. Dougherty, Dean G. Tang
Summary: The article reviews the tumor suppressive role of miRNA-34a in prostate cancer and discusses therapeutic development strategies for advanced prostate cancer patients.
Article
Chemistry, Multidisciplinary
Esra Dirimtekin, Maria Mortoglou, Ceren Alavanda, Asmaa Benomar Yemlahi, Esra Arslan Ates, Ilter Guney, Pinar Uysal-Onganer
Summary: miR-34a is downregulated and associated with inhibition of tumor growth and invasion in ovarian cancer, while FOXP1 is reported as either an oncogene or tumor suppressor. It is found that miR-34a and FOXP1 are reversely correlated, and inhibition of miR-34a leads to upregulation of FOXP1 expression and increased cellular invasion. miR-34a could be a potential biomarker for improving the diagnostic efficiency of ovarian cancer, and its overexpression may reduce pathogenesis by targeting FOXP1.
Article
Urology & Nephrology
C. G. H. Ronnau, S. Fussek, F. P. Smit, T. W. Aalders, O. van Hooij, P. M. C. Pinto, M. Burchardt, J. A. Schalken, G. W. Verhaegh
Summary: This study identified several novel deregulated miRNAs in CRPC tissue, including two microRNAs potentially involved in tumor invasion. The data support the hypothesized involvement of miRNAs in PCa tumorigenesis and progression to CRPC. The applicability of these miRNAs as novel biomarkers for CRPC needs further investigation.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Chemistry, Medicinal
Shadi Shayanfar, Ali Shayanfar, Morteza Ghandadi
ARCHIV DER PHARMAZIE
(2016)
Article
Chemistry, Medicinal
Milad Iranshahy, Zahra Tayarani-Najaran, Jamal Kasaian, Morteza Ghandadi, Seyed Ahmad Emami, Javad Asili, Jima N. Chandran, Bernd Schneider, Mehrdad Iranshahi
PHYTOTHERAPY RESEARCH
(2016)
Article
Oncology
Morteza Ghandadi, Javad Behravan, Khalil Abnous, Fatemeh Mosaffa
ONCOLOGY RESEARCH AND TREATMENT
(2016)
Review
Pharmacology & Pharmacy
Morteza Ghandadi, Reza Valadan, Hamidreza Mohammadi, Javad Akhtari, Shabanali Khodashenas, Sorour Ashari
CURRENT PHARMACEUTICAL DESIGN
(2019)
Article
Toxicology
Sorour Ashari, Mohammad Karami, Mohammad Shokrzadeh, Morteza Ghandadi, Nasrin Ghassemi-Barghi, Ayat Dashti, Mohammad Ranaee, Hamidreza Mohammadi
TOXICOLOGY MECHANISMS AND METHODS
(2020)
Article
Chemistry, Multidisciplinary
Morteza Ghandadi
Summary: In this study, an in-silico approach was used to identify potential RIOK2 inhibitors, and two compounds with potential anticancer activity were discovered. The stable protein-ligand interactions between these compounds and RIOK2 were validated through prediction and simulation. Overall, this study identifies two potential RIOK2 inhibitors.
Article
Biochemistry & Molecular Biology
Morteza Ghandadi
Summary: Tuberculosis is a life-threatening disease and lack of an effective vaccine poses a global health issue. A multi-epitope vaccine against TB has been designed using immunoinformatic tools. The vaccine includes immunodominant epitopes from antigenic proteins and adjuvants. Bioinformatics tools were used to evaluate the vaccine's 3D structure and potential interactions with toll-like receptors. The constructed vaccine shows promising immunological and physicochemical properties and experimental investigations are recommended.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2022)
Article
Toxicology
Sorour Ashari, Mohammad Karami, Mohammad Shokrzadeh, Abouzar Bagheri, Morteza Ghandadi, Mohammad Ranaee, Ayat Dashti, Hamidreza Mohammadi
Summary: This study evaluated the protective effects of quercetin in kidney tissue and HEK-293 cells against DEHP-induced nephrotoxicity. The results showed that quercetin reduced cytotoxicity and oxidative damage in HEK-293 cells and significantly suppressed DEHP-induced kidney damage in rats. Mechanistic analysis revealed that the NF-kappa B signaling pathway may be involved in the protective effects of quercetin against DEHP-induced nephrotoxicity.
TOXICOLOGY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Saeed Norouzi, Rezvan Yazdian Robati, Morteza Ghandadi, Khalil Abnous, Javad Behravan, Fatemeh Mosaffa
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2020)
Article
Medicine, Research & Experimental
Ehsan Karimikia, Javad Behravan, Afshin Zarghi, Morteza Ghandadi, Sina Omid Malayeri, Razieh Ghodsi
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Morteza Ghandadi, Javad Behravan, Samira Biabani, Sara Abbaspor, Fatemeh Mosaffa
PHARMACEUTICAL SCIENCES
(2019)
Review
Pharmacology & Pharmacy
Morteza Ghandadi, Amirhossein Sahebkar
CURRENT PHARMACEUTICAL DESIGN
(2017)
Article
Biochemistry & Molecular Biology
Morteza Ghandadi, Javad Behravan, Khalil Abnous, Melika Ehtesham Gharaee, Fatemeh Mosaffa
Article
Chemistry, Medicinal
Khalil Abnous, Hesam Manavi, Soghra Mehri, Mona Alibolandi, Hossein Kamali, Morteza Ghandadi, Farzin Hadizadeh
RESEARCH IN PHARMACEUTICAL SCIENCES
(2017)
