Induction of ER Stress by an AAV5 BDD FVIII Construct Is Dependent on the Strength of the Hepatic-Specific Promoter

Published 2020 View Full Article

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Title
Induction of ER Stress by an AAV5 BDD FVIII Construct Is Dependent on the Strength of the Hepatic-Specific Promoter
Authors
Keywords
AAV5, endoplasmic reticulum, hemophilia A, gene therapy, valoctocogene roxaparvovec, molecular chaperone, hybrid liver-specific promoter, 100ATGB, ER stress, AAV5-hFVIII-SQ
Journal
Molecular Therapy-Methods & Clinical Development
Volume 18, Issue -, Pages 620-630
Publisher
Elsevier BV
Online
2020-07-09
DOI
10.1016/j.omtm.2020.07.005

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