Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 22, Issue 18, Pages 2650-2656Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612822666160217142949
Keywords
Antioxidants; Mitochondria; Muscle; Oxidative stress; Type 2 diabetes
Categories
Funding
- European Regional Development Fund (ERDF A way to build Europe)
- Ministry of Health of the Valencian Regional Government
- Carlos III Health Institute [CES10/030, CP10/0360, CD14/00043]
- [PI13/1025]
- [PI12/1984]
- [PI13/0073]
- [PI15/01424]
- [CIBERehd CB06/04/0071]
- [PROMETEOII2014/035]
- [UGP-14-93]
- [UGP-14-95]
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Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.
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