Selective Review of Neuroimaging Findings in Youth at Clinical High Risk for Psychosis: On the Path to Biomarkers for Conversion

Progressive reconfiguration of resting-state brain networks as psychosis develops: Preliminary results from the North American Prodrome Longitudinal Study (NAPLS) consortium

(2019) Hengyi Cao et al.   SCHIZOPHRENIA RESEARCH

GABA levels and TSPO expression in people at clinical high risk for psychosis and healthy volunteers: a PET-MRS study

(2019) Tania Da Silva et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies—PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice

(2019) Stefania Tognin et al.   SCHIZOPHRENIA BULLETIN

Cingulum bundle abnormalities and risk for schizophrenia

(2019) Jennifer Fitzsimmons et al.   SCHIZOPHRENIA RESEARCH

Hyperactivity and Reduced Activation of Anterior Hippocampus in Early Psychosis

(2019) Maureen McHugo et al.   AMERICAN JOURNAL OF PSYCHIATRY

Hippocampal Pathology in Clinical High-Risk Patients and the Onset of Schizophrenia

(2019) Frank A. Provenzano et al.   BIOLOGICAL PSYCHIATRY

Integrating machining learning and multimodal neuroimaging to detect schizophrenia at the level of the individual

(2019) Du Lei et al.   HUMAN BRAIN MAPPING

Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study

(2019) Oliver D. Howes et al.   NEUROPSYCHOPHARMACOLOGY

Global and Specific Cortical Volume Asymmetries in Individuals With Psychosis Risk Syndrome and Schizophrenia: A Mixed Cross-sectional and Longitudinal Perspective

(2019) Katherine S F Damme et al.   SCHIZOPHRENIA BULLETIN

Discovery and Validation of Prediction Algorithms for Psychosis in Youths at Clinical High Risk

(2019) Michelle A. Worthington et al.   Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data

(2018) Pontus Plavén-Sigray et al.   BIOLOGICAL PSYCHIATRY

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

(2018) Theo G.M. van Erp et al.   BIOLOGICAL PSYCHIATRY

TSPO expression and brain structure in the psychosis spectrum

(2018) Sina Hafizi et al.   BRAIN BEHAVIOR AND IMMUNITY

Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis

(2018) Gemma Modinos et al.   NEUROPSYCHOPHARMACOLOGY

Interaction between TSPO—a neuroimmune marker—and redox status in clinical high risk for psychosis: a PET–MRS study

(2018) Sina Hafizi et al.   NEUROPSYCHOPHARMACOLOGY

Use of Machine Learning to Determine Deviance in Neuroanatomical Maturity Associated With Future Psychosis in Youths at Clinically High Risk

(2018) Yoonho Chung et al.   JAMA Psychiatry

TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward

(2018) Tomás R. Guilarte   PHARMACOLOGY & THERAPEUTICS

Prediction of psychosis in prodrome: development and validation of a simple, personalized risk calculator

(2018) TianHong Zhang et al.   PSYCHOLOGICAL MEDICINE

Cerebello-thalamo-cortical hyperconnectivity as a state-independent functional neural signature for psychosis prediction and characterization

(2018) Hengyi Cao et al.   Nature Communications

Prediction Models of Functional Outcomes for Individuals in the Clinical High-Risk State for Psychosis or With Recent-Onset Depression

(2018) Nikolaos Koutsouleris et al.   JAMA Psychiatry

Association of baseline inflammatory markers and the development of negative symptoms in individuals at clinical high risk for psychosis

(2018) David R. Goldsmith et al.   BRAIN BEHAVIOR AND IMMUNITY

Preliminary data indicating a connection between stress-induced prefrontal dopamine release and hippocampal TSPO expression in the psychosis spectrum

(2018) Christin Schifani et al.   SCHIZOPHRENIA RESEARCH

Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis

(2018) Matthijs G. Bossong et al.   JAMA Psychiatry

Neurocognitive and neuroanatomical maturation in the clinical high-risk states for psychosis: A pattern recognition study

(2018) Lana Kambeitz-Ilankovic et al.   NeuroImage-Clinical

Imaging Microglial Activation in Individuals at Clinical High Risk for Psychosis: an In Vivo PET Study with [18F]FEPPA

(2017) Sina Hafizi et al.   NEUROPSYCHOPHARMACOLOGY

Evaluation of machine learning algorithms and structural features for optimal MRI-based diagnostic prediction in psychosis

(2017) Raymond Salvador et al.   PLoS One

Patterns of white matter microstructure in individuals at ultra-high-risk for psychosis: associations to level of functioning and clinical symptoms

(2017) K. Krakauer et al.   PSYCHOLOGICAL MEDICINE

Comorbid diagnoses for youth at clinical high risk of psychosis

(2017) Jean Addington et al.   SCHIZOPHRENIA RESEARCH

Ventricular enlargement and progressive reduction of cortical gray matter are linked in prodromal youth who develop psychosis

(2017) Yoonho Chung et al.   SCHIZOPHRENIA RESEARCH

Using clinical information to make individualized prognostic predictions in people at ultra high risk for psychosis

(2017) Andrea Mechelli et al.   SCHIZOPHRENIA RESEARCH

Development and Validation of a Clinically Based Risk Calculator for the Transdiagnostic Prediction of Psychosis

(2017) Paolo Fusar-Poli et al.   JAMA Psychiatry

PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia

(2017) M A Di Biase et al.   Translational Psychiatry

Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [ 11 C]PBR28 study

(2017) Sudhakar Selvaraj et al.   SCHIZOPHRENIA RESEARCH

Stronger default mode network connectivity is associated with poorer clinical insight in youth at ultra high-risk for psychotic disorders

(2017) Sarah V. Clark et al.   SCHIZOPHRENIA RESEARCH

Structural anomalies of the peripheral olfactory system in psychosis high-risk subjects

(2017) Bruce I. Turetsky et al.   SCHIZOPHRENIA RESEARCH

Depression and clinical high-risk states: Baseline presentation of depressed vs. non-depressed participants in the NAPLS-2 cohort

(2017) Emily R. Kline et al.   SCHIZOPHRENIA RESEARCH

Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study

(2016) Peter S. Bloomfield et al.   AMERICAN JOURNAL OF PSYCHIATRY

Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers

(2016) Brett A. Clementz et al.   AMERICAN JOURNAL OF PSYCHIATRY

Resting Hyperperfusion of the Hippocampus, Midbrain, and Basal Ganglia in People at High Risk for Psychosis

(2016) Paul Allen et al.   AMERICAN JOURNAL OF PSYCHIATRY

An Individualized Risk Calculator for Research in Prodromal Psychosis

(2016) Tyrone D. Cannon et al.   AMERICAN JOURNAL OF PSYCHIATRY

Individual prediction of long-term outcome in adolescents at ultra-high risk for psychosis: Applying machine learning techniques to brain imaging data

(2016) Sanne de Wit et al.   HUMAN BRAIN MAPPING

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms and Future Directions

(2016) Brian J Miller et al.   NEUROPSYCHOPHARMACOLOGY

Prediction of outcome in the psychosis prodrome using neuroanatomical pattern classification

(2016) Lana Kambeitz-Ilankovic et al.   SCHIZOPHRENIA RESEARCH

Ultrastructural alterations of oligodendrocytes in prefrontal white matter in schizophrenia: A post-mortem morphometric study

(2016) O.V. Vikhreva et al.   SCHIZOPHRENIA RESEARCH

A Review of the Functional and Anatomical Default Mode Network in Schizophrenia

(2016) Mao-Lin Hu et al.   Neuroscience Bulletin

Patients with first-episode, drug-naive schizophrenia and subjects at ultra-high risk of psychosis shared increased cerebellar-default mode network connectivity at rest

(2016) Houliang Wang et al.   Scientific Reports

Identifying Individuals at High Risk of Psychosis: Predictive Utility of Support Vector Machine using Structural and Functional MRI Data

(2016) Isabel Valli et al.   Frontiers in Psychiatry

Abnormal regional homogeneity as potential imaging biomarker for psychosis risk syndrome: a resting-state fMRI study and support vector machine analysis

(2016) Shuai Wang et al.   Scientific Reports

Outcomes of Nontransitioned Cases in a Sample at Ultra-High Risk for Psychosis

(2015) Ashleigh Lin et al.   AMERICAN JOURNAL OF PSYCHIATRY

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

(2015) Tyrone D. Cannon et al.   BIOLOGICAL PSYCHIATRY

North American Prodrome Longitudinal Study (NAPLS 2)

(2015) Jean Addington et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

Association of Thalamic Dysconnectivity and Conversion to Psychosis in Youth and Young Adults at Elevated Clinical Risk

(2015) Alan Anticevic et al.   JAMA Psychiatry

Classifying individuals at high-risk for psychosis based on functional brain activity during working memory processing

(2015) Kerstin Bendfeldt et al.   NeuroImage-Clinical

Motivational and neurocognitive deficits are central to the prediction of longitudinal functional outcome in schizophrenia

(2014) G. Fervaha et al.   ACTA PSYCHIATRICA SCANDINAVICA

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Imaging Neuroinflammation in Gray and White Matter in Schizophrenia: An In-Vivo PET Study With [18F]-FEPPA

(2014) M. Kenk et al.   SCHIZOPHRENIA BULLETIN

Towards a Psychosis Risk Blood Diagnostic for Persons Experiencing High-Risk Symptoms: Preliminary Results From the NAPLS Project

(2014) Diana O. Perkins et al.   SCHIZOPHRENIA BULLETIN

Detecting the Psychosis Prodrome Across High-Risk Populations Using Neuroanatomical Biomarkers

(2014) Nikolaos Koutsouleris et al.   SCHIZOPHRENIA BULLETIN

Excess Early Mortality in Schizophrenia

(2013) Thomas Munk Laursen et al.   Annual Review of Clinical Psychology

Presynaptic Striatal Dopamine Dysfunction in People at Ultra-high Risk for Psychosis: Findings in a Second Cohort

(2013) Alice Egerton et al.   BIOLOGICAL PSYCHIATRY

Cortisol Levels and Risk for Psychosis: Initial Findings from the North American Prodrome Longitudinal Study

(2013) Elaine F. Walker et al.   BIOLOGICAL PSYCHIATRY

Neuroimaging Biomarkers for Early Drug Development in Schizophrenia

(2013) Jason R. Tregellas   BIOLOGICAL PSYCHIATRY

Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies

(2013) P. Fusar-Poli et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Functional development in clinical high risk youth: Prediction of schizophrenia versus other psychotic disorders

(2013) Sarah I. Tarbox et al.   PSYCHIATRY RESEARCH

Altered relationships between age and functional brain activation in adolescents at clinical high risk for psychosis

(2013) Katherine H. Karlsgodt et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

White Matter Microstructure in Individuals at Clinical High Risk of Psychosis: A Whole-Brain Diffusion Tensor Imaging Study

(2013) Christian Clemm von Hohenberg et al.   SCHIZOPHRENIA BULLETIN

Assessment of everyday functioning in schizophrenia: Implications for treatments aimed at negative symptoms

(2013) Philip D. Harvey   SCHIZOPHRENIA RESEARCH

Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis

(2013) Susanna L. Fryer et al.   Frontiers in Psychiatry

The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment

(2012) Oliver D. Howes et al.   ARCHIVES OF GENERAL PSYCHIATRY

Brain Structural Abnormalities at the Onset of Schizophrenia and Bipolar Disorder: A Meta-analysis of Controlled Magnetic Resonance Imaging Studies

(2012) Luca De Peri et al.   CURRENT PHARMACEUTICAL DESIGN

Using Support Vector Machine to identify imaging biomarkers of neurological and psychiatric disease: A critical review

(2012) Graziella Orrù et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Negative symptoms in individuals at clinical high risk of psychosis

(2012) Danijela Piskulic et al.   PSYCHIATRY RESEARCH

Neural and Behavioral Correlates of Aberrant Salience in Individuals at Risk for Psychosis

(2012) Jonathan P. Roiser et al.   SCHIZOPHRENIA BULLETIN

Transition to Psychosis Associated With Prefrontal and Subcortical Dysfunction in Ultra High-Risk Individuals

(2012) P. Allen et al.   SCHIZOPHRENIA BULLETIN

Alterations in White Matter Evident Before the Onset of Psychosis

(2012) Francesco Carletti et al.   SCHIZOPHRENIA BULLETIN

Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia

(2012) Norichika Iwashiro et al.   SCHIZOPHRENIA RESEARCH

Dopamine Synthesis Capacity Before Onset of Psychosis: A Prospective [18F]-DOPA PET Imaging Study

(2011) Oliver D. Howes et al.   AMERICAN JOURNAL OF PSYCHIATRY

Neuroanatomical Abnormalities That Predate the Onset of Psychosis

(2011) Andrea Mechelli et al.   ARCHIVES OF GENERAL PSYCHIATRY

Are There Progressive Brain Changes in Schizophrenia? A Meta-Analysis of Structural Magnetic Resonance Imaging Studies

(2011) Bayanne Olabi et al.   BIOLOGICAL PSYCHIATRY

Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study

(2011) O Howes et al.   MOLECULAR PSYCHIATRY

Phase-Specific Brain Change of Spatial Working Memory Processing in Genetic and Ultra-High Risk Groups of Schizophrenia

(2011) Jung-Seok Choi et al.   SCHIZOPHRENIA BULLETIN

Abnormal Relationship Between Medial Temporal Lobe and Subcortical Dopamine Function in People With an Ultra High Risk for Psychosis

(2011) P. Allen et al.   SCHIZOPHRENIA BULLETIN

Disease Prediction in the At-Risk Mental State for Psychosis Using Neuroanatomical Biomarkers: Results From the FePsy Study

(2011) Nikolaos Koutsouleris et al.   SCHIZOPHRENIA BULLETIN

Neuroanatomical Maps of Psychosis Onset: Voxel-wise Meta-Analysis of Antipsychotic-Naive VBM Studies

(2011) P. Fusar-Poli et al.   SCHIZOPHRENIA BULLETIN

Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study

(2011) Dylan G. Gee et al.   SCHIZOPHRENIA RESEARCH

Abnormal Frontostriatal Interactions in People With Prodromal Signs of Psychosis

(2010) Paolo Fusar-Poli et al.   ARCHIVES OF GENERAL PSYCHIATRY

Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia

(2010) Lawrence S. Kegeles et al.   ARCHIVES OF GENERAL PSYCHIATRY

Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [11C]DAA1106

(2010) Akihiro Takano et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Voxel-based analysis of postnatal white matter microstructure in mice exposed to immune challenge in early or late pregnancy

(2010) Qi Li et al.   NEUROIMAGE

Neuroanatomy of vulnerability to psychosis: A voxel-based meta-analysis

(2010) P. Fusar-Poli et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Progressive Structural Brain Changes During Development of Psychosis

(2010) Tim B. Ziermans et al.   SCHIZOPHRENIA BULLETIN

Progressive lateral ventricular enlargement in schizophrenia: A meta-analysis of longitudinal MRI studies

(2010) Matthew J. Kempton et al.   SCHIZOPHRENIA RESEARCH

Predictive validity of clinical variables in the “at risk” for psychosis population: International comparison with results from the North American Prodrome Longitudinal Study

(2010) Andrew Thompson et al.   SCHIZOPHRENIA RESEARCH

Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia

(2009) Oliver D. Howes et al.   ARCHIVES OF GENERAL PSYCHIATRY

White Matter Integrity and Prediction of Social and Role Functioning in Subjects at Ultra-High Risk for Psychosis

(2009) Katherine H. Karlsgodt et al.   BIOLOGICAL PSYCHIATRY

Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis

(2009) Nicolas A. Crossley et al.   HUMAN BRAIN MAPPING

Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study

(2009) J. Doorduin et al.   JOURNAL OF NUCLEAR MEDICINE

White matter connectivity and psychosis in ultra-high-risk subjects: A diffusion tensor fiber tracking study

(2009) Bart D. Peters et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

White-matter markers for psychosis in a prospective ultra-high-risk cohort

(2009) O. J. N. Bloemen et al.   PSYCHOLOGICAL MEDICINE

No evidence for structural brain changes in young adolescents at ultra high risk for psychosis

(2009) Tim B. Ziermans et al.   SCHIZOPHRENIA RESEARCH

Progressive brain structural changes mapped as psychosis develops in ‘at risk’ individuals

(2009) Daqiang Sun et al.   SCHIZOPHRENIA RESEARCH

Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis

(2009) Tsutomu Takahashi et al.   SCHIZOPHRENIA RESEARCH

Prediction of Psychosis in Youth at High Clinical Risk

(2008) Tyrone D. Cannon et al.   ARCHIVES OF GENERAL PSYCHIATRY

Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R)-[11C]PK11195 Positron Emission Tomography Study

(2008) Bart N. van Berckel et al.   BIOLOGICAL PSYCHIATRY

Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair

(2008) Ming-Kai Chen et al.   PHARMACOLOGY & THERAPEUTICS

Corpus callosum shape alterations in individuals prior to the onset of psychosis

(2008) Mark Walterfang et al.   SCHIZOPHRENIA RESEARCH

Neural bases of different cognitive strategies for facial affect processing in schizophrenia

(2008) Eric Fakra et al.   SCHIZOPHRENIA RESEARCH

White matter abnormalities in subjects at ultra high-risk for schizophrenia and first-episode schizophrenic patients

(2008) H WITTHAUS et al.   SCHIZOPHRENIA RESEARCH