Article
Immunology
Jingjing Li, Yajuan Xu, Yanjun Cai, Miao Zhang, Zongzong Sun, Yanjie Ban, Shanshan Zhai, Yingqi Hao, Qian Ouyang, Bo Wu, Mengqi Wang, Wentao Wang
Summary: The study investigates the association between differential metabolites, small intestinal microflora, and maternal outcomes in subclinical hypothyroidism (SCH) during pregnancy. The results suggest that differential metabolites in the SCH group are associated with small intestinal bacterial overgrowth (SIBO) and may affect pregnancy outcomes. Bile acids and cholesterol are identified as potential biomarkers.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Jiaxi Luo, Jialing Yuan
Summary: LT4 therapy can reduce the risk of premature delivery and amniotic fluid abnormalities in pregnant women with SCH and TPOAb+.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ping Zhu, Ruifeng Chu, Shilei Pan, Xiaolan Lai, Jianmin Ran, Xiuhong Li
Summary: This study found that women with subclinical hypothyroidism diagnosed by the 2017 American Thyroid Association guidelines during early pregnancy have higher risks of adverse pregnancy outcomes, such as premature delivery, gestational diabetes mellitus, and gestational anemia.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Zheng Ding, Yindi Liu, Spyridoula Maraka, Nadia Abdelouahab, He-Feng Huang, William D. Fraser, Jianxia Fan
Summary: This study aimed to evaluate the effects of levothyroxine (LT4) treatment on pregnancy and neonatal outcomes among pregnant women with subclinical hypothyroidism (SCH) based on the 2017 American Thyroid Association diagnostic criteria. The results indicated that pregnant women with SCH treated with LT4 had a lower risk of pregnancy loss, preterm birth, and gestational hypertension compared to those in the control group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sima Nazarpour, Fahimeh Ramezani Tehrani, Mina Amiri, Maryam Rahmati, Fereidoun Azizi
Summary: Maternal subclinical hyperthyroidism (SH) appears to be a risk factor for preterm delivery, especially in women with higher urinary iodine concentration (UIC).
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Xue-Feng Jiao, Miao Zhang, Jingjing Chen, Qiang Wei, Linan Zeng, Dan Liu, Chuan Zhang, Hailong Li, Kun Zou, Li Zhang, Lingli Zhang
Summary: This study conducted a systematic review and meta-analysis on pregnant women with subclinical hypothyroidism (SCH) and found no evidence of benefit from LT4 therapy on pregnancy, neonatal, and childhood outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Charles Megier, Gregoire Dumery, Dominique Luton
Summary: Thyroid hormones and iodine are crucial for regulating various physiological functions, such as metabolic rate, protein synthesis, and fetal development. Imbalances in thyroid and iodine metabolism can have negative effects, especially during pregnancy. The placenta, as the interface between the mother and fetus, plays a vital role in regulating thyroid and iodine metabolism. This review provides an update on the current understanding of thyroid and iodine metabolism in both normal and pathological pregnancies, highlighting their importance for maternal and fetal health.
Article
Medicine, General & Internal
Roxanne Hastie, Stephen Tong, Richard Hiscock, Anthea Lindquist, Linda Lindstroem, Anna-Karin Wikstroem, Inger Sundstroem-Poromaa
Summary: This study found that lithium use during pregnancy is associated with an increased risk of spontaneous preterm birth, birth of a large for gestational age infant, and cardiac malformations. These potential risks should be considered when making treatment decisions during pregnancy.
Review
Food Science & Technology
Yunfeng Cui, Minqi Liao, Aihua Xu, Gengdong Chen, Jun Liu, Xiaoxuan Yu, Shuna Li, Xingyao Ke, Sixian Tan, Zeyan Luo, Qian Wang, Yanhua Liu, Donghong Wang, Fangfang Zeng
Summary: This study aimed to investigate the effects of pre-conception dietary intake on pregnancy outcomes. The results showed that pre-pregnancy intake of fried food, fast food, red and processed meat, heme iron, and a low-carbohydrate diet were positively associated with the risk of gestational diabetes mellitus (GDM), while high dietary fiber intake and folic acid supplementation were negatively associated with GDM risk. Maternal caffeine intake before pregnancy increased the risk of spontaneous abortion, while folic acid supplementation had protective effects on total adverse neonatal outcomes, preterm birth, and small-for-gestational age (SGA).
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Balsam Bohlega, Afshan Zahedi, George Tomlinson, Denice S. Feig
Summary: The study found that using a weight-based dosing method of starting thyroxine for women newly diagnosed with subclinical hypothyroidism during pregnancy increased the odds of reaching the target TSH range within 4-8 weeks. This approach should be considered by clinicians when initiating treatment during pregnancy.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Svetlana Popova, Danijela Dozet, Graham O'Hanlon, Valerie Temple, Juergen Rehm
Summary: The study estimated the prevalence of alcohol use during pregnancy as a risk factor in live births in British Columbia, Canada. It found that prenatal alcohol exposure was associated with younger maternal age, fewer antenatal visits, being primiparous, a history of mental illness, substance use, and smoking. Babies exposed to alcohol during pregnancy had higher odds of adverse neonatal outcomes like low birth weight, respiratory distress, breastfeeding difficulties, and feeding problems. More consistent screening and prevention efforts targeting alcohol use during pregnancy are urgently needed in Canada.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Pediatrics
Amna Umer, Emma Watson, Christa Lilly, Sara Woods, Candice Lefeber, Janine Breyel, Collin John
Summary: This study used population-level data from a state-wide surveillance tool to examine the independent and combined effects of in utero exposure to opioids, stimulants, and cannabis on birth outcomes in a rural population. The results showed that maternal exposure to these substances increased the risk of preterm birth, low birth weight, and small for gestational age. This study has important policy implications for improving maternal and child health in socioeconomically disadvantaged and underserved rural populations.
JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Patricia Lemieux, Jennifer M. Yamamoto, Kara A. Nerenberg, Amy Metcalfe, Alex Chin, Rshmi Khurana, Lois Elizabeth Donovan
Summary: The study found that most women on thyroid replacement before conception had TSH measured during pregnancy, but a portion did not. Overtreatment with levothyroxine in pregnancy was associated with preterm delivery, highlighting the need for clinicians to avoid overtreatment during pregnancy.
Article
Endocrinology & Metabolism
Jiajia Chen, Jing Zhu, Xianping Huang, Shenzhi Zhao, Huiqiu Xiang, Panpan Zhou, Tong Zhou, Zhangye Xu
Summary: This study aimed to evaluate the intellectual development of offspring born to mothers with SCH-TPOAb(-). The results showed that TSH levels were correlated with the intellectual development of offspring, and early treatment in SCH-TPOAb(-) pregnant women with TSH levels between 4.0 and 10.0 mIU/L significantly improved the intellectual development levels of the approximately two-year-old offspring.
Article
Public, Environmental & Occupational Health
Zana Percy, Ann M. Vuong, Yingying Xu, Changchun Xie, Maria Ospina, Antonia M. Calafat, Andy Hoofnagle, Bruce P. Lanphear, Joseph M. Braun, Kim M. Cecil, Kim N. Dietrich, Kimberly Yolton, Aimin Chen
Summary: The study found that gestational exposure to certain OPEs may influence maternal and neonatal thyroid function, with bis(1,3-dichloro-2-propyl)-phosphate being strongly associated with alterations in thyroid hormone levels. Other OPEs showed weaker evidence of association with thyroid hormone alterations. Replication in other cohorts is needed to confirm these findings.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Ecology
Cunguo Wang, Ivano Brunner, Shengwei Zong, Mai-He Li
Summary: Accurate assessment of seasonality and factors affecting fine root biomass and necromass variation is crucial for predicting forest carbon cycling. This study analyzed 67 research studies and found that temperate forests have higher fine root biomass but lower necromass compared to tropical and boreal forests. Gymnosperm forests have smaller fine root biomass and necromass but similar biomass/necromass ratio compared to angiosperm forests. Climate and soil environment are major factors influencing fine root dynamics.
Article
Engineering, Biomedical
Meirong Li, Zheng-Ian Lin, Jingyu Yang, Haoqiang Huang, Guan-Lin Liu, Qiqi Liu, Xinmeng Zhang, Ying Zhang, Zhourui Xu, Haoming Lin, Yujuan Chai, Xin Chen, Bao-Tsan Ko, Jia Liu, Chih-Kuang Chen, Chengbin Yang
Summary: Osteosarcoma is a highly invasive and deadly cancer that often occurs in children and adolescents. The overexpression of PLK1 gene in tumors promotes cancer cell proliferation and transformation, making it a therapeutic target for osteosarcoma. However, current RNA interference-based therapies lack a safe and efficient nonviral gene vector. In this study, biodegradable and CO2-derivative cationic poly(vinylcyclohexene carbonates) (CPCHCs) were used as gene vectors for siPLK1 therapeutic strategy in osteosarcoma treatment. Among them, CPCHC60 showed excellent performance in gene transfection efficiency, endo-lysosome escaping, biodegradability, and biosafety. The treatment with CPCHCs/siRNA nanoparticles significantly down-regulated the expression level of PLK1 gene in osteosarcoma cells, leading to cell arrest and apoptosis, resulting in significant tumor regression both in vitro and in vivo. This study provides new insights into the development of superior nonviral gene vectors for cancer treatment and holds high potential for translational nanomedicine applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Operations Research & Management Science
Jin-Cheng Lu, Mei-Juan Li
Summary: This study introduces the phenomenon of strategically setting distance measure weights in TOPSIS, which may affect the fairness of the results. To prevent this, the idea of DEA is introduced to determine the objective weights of distance measures, and an improved TOPSIS is proposed. The proposed method not only determines weights objectively, achieves full ranking of alternatives, but also provides improvement directions. Additionally, the advantages of the method are analyzed, and the meaning and properties of the new relative closeness are discussed and proved. Finally, an example is used to illustrate the effectiveness and usefulness of the proposed method for evaluating innovation development in high-tech industries in central and western regions of China.
ASIA-PACIFIC JOURNAL OF OPERATIONAL RESEARCH
(2023)
Article
Dermatology
Xin Zhou, Wentao Liu, Sulian Yang, Angela Wu, Peiran Chen, Songchao Yin, Sybren de Hoog, Meirong Li, Peiying Feng
Summary: This study aimed to explore the correlation between tinea capitis and allergic diseases in children and analyze their risk factors. Epidemiological changes in childhood tinea capitis and risk factors for allergic disease were monitored in a single center over three consecutive five-year intervals. The results showed that M. canis and T. mentagrophytes were the most prevalent pathogens of tinea capitis in the last 15 years, and atopic dermatitis/eczema and allergic rhinitis were the most frequently associated allergic diseases.
Article
Ecology
Jiangping Cai, Jacob Weiner, Wentao Luo, Xue Feng, Guojiao Yang, Jiayu Lu, Xiao-Tao Lu, Mai-He Li, Yong Jiang, Xingguo Han
Summary: Atmospheric nitrogen (N) deposition is changing grassland productivity and community structure worldwide. Different forms of deposited N have different consequences for productivity due to their different fertilization and acidification effects. Changes in plant functional traits may mediate these effects. In this study, the responses of aboveground primary productivity and community functional composition to the addition of three nitrogen compounds were investigated. The results suggest that N forms with different fertilizing and acidifying effects influence productivity through different functional trait pathways.
Article
Environmental Sciences
Peng He, Simone Fontana, Chengcang Ma, Heyong Liu, Li Xu, Ruzhen Wang, Yong Jiang, Mai -He Li
Summary: This study measured leaf traits, community composition, and aboveground biomass at seven different sites along a transect in forest-steppe ecotones in northeast China. The results showed that dominant species in the ecotone communities had high nitrogen content, large leaf area, and low leaf mass per unit area. The ecotone communities also had the highest functional trait diversity. Therefore, vegetation management should focus on maintaining functional trait diversity and promoting plant species with rapid resource acquisition strategies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Horticulture
Xiaoya Ru, Yuan Jiang, Qi Luo, Runhong Wang, Xinxin Feng, Jinghong Wang, Zhao Wang, Meirong Li, Zhenjiang Qu, Baofeng Su, Hao Feng, Dong Zhang, Deli Liu, Qiang Yu, Jianqiang He
Summary: This study investigates the impact of changes in phenology on frost risk for apple trees. The results show that apple budburst and fruit-setting are expected to advance, but at a decreasing rate. The combination of high emission scenarios and distant time periods have a greater impact. While frost frequency is expected to decrease, frost intensity tends to increase. There are regional differences in the changes in frost risk.
SCIENTIA HORTICULTURAE
(2023)
Article
Psychology, Multidisciplinary
Siyi Liu, Aitao Lu, Xiaodan Chen, Meifang Zhang, Chuqi Liu, Meirong Li
Summary: An increasing number of studies have been conducted to explore the psychological factors influencing career decisions of individuals with disabilities. This study examined the role of task-oriented psychological capital as a mediator between private/public self-consciousness and career decision-making self-efficacy, with disability status as a moderator. With a sample of 257 individuals with disabilities and 258 individuals without disabilities, it was found that task-oriented psychological capital mediated the relationship between private/public self-consciousness and career decision-making self-efficacy. However, this mediation was weaker for individuals with disabilities compared to those without disabilities, indicating a moderating effect of disability status. The results highlight the potential synergy between private/public self-consciousness and task-oriented psychological capital in the development of career decision-making self-efficacy for individuals with and without disabilities.
Article
Agronomy
Yanyan Ni, Wenfa Xiao, Jianfeng Liu, Zunji Jian, Maihe Li, Jin Xu, Lei Lei, Jianhua Zhu, Qi Li, Lixiong Zeng, Paolo Cherubini
Summary: Through a study on the relationship between the radial growth of Pinus massoniana and climate variability in natural forests and planted forests in subtropical China, it was found that the growth-climate relationships are largely similar in both types of forests. The effects of climate variables on tree growth vary among different sites and latitudinal gradients. These findings not only enrich our understanding of the impacts of climate on forest growth, but also provide implications for future forest sustainable management in subtropical regions of central China.
AGRICULTURAL AND FOREST METEOROLOGY
(2023)
Article
Environmental Sciences
Peng Zhang, Xiao-Tao Lu, Guangze Jin, Zhili Liu, Mai-He Li
Summary: The study found that the C:N:P stoichiometry of plant organs and the plant community varied significantly along the succession chronosequence, mainly driven by changes in tree size and plant diversity. However, the C:N:P stoichiometry in litter and soil did not change with succession. Additionally, the C-N-P scaling relationships among plant organs and ecosystem components were consistent, indicating a conservative allocation strategy of elements in this ecosystem.
Article
Biochemistry & Molecular Biology
Shuxiang Yan, Jianjie He, Mi Tang, Bangfa Ming, Huaixin Li, Shipeng Fan, Yiyi Xiong, Hongbo Chao, Libin Zhang, Aihua Wang, Maoteng Li
Summary: The study investigated the recombination landscape in a DH population of Brassica napus and found that crossover events were unevenly distributed across the genome, with a higher frequency at the distal ends of each chromosome. Genes associated with plant defense and regulation were found in the regions with high crossover frequencies. The construction of a bin map identified specific recombination bins related to seed oil content on chromosomes A08, A09, C03, and C06.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kang Chen, Yongtai Yin, Yiran Ding, Hongbo Chao, Maoteng Li
Summary: By analyzing the morphology and gene expression of oil bodies (OBs) and starch granules (SGs) in Brassica napus embryos, it was found that embryos with high oil content had larger OBs in the late developmental stages, while embryos with low oil content had larger OBs in the early developmental stages. There was no significant difference in SG size between embryos with high and low oil content. These results provide new insights into the dynamics of OBs and SGs in B. napus embryos.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Meirong Li, Jingyu Yang, Xinhuang Yao, Xiang Li, Zhourui Xu, Shiqi Tang, Bangxu Sun, Suxia Lin, Chengbin Yang, Jia Liu
Summary: Colorectal cancer (CRC) is a common and deadly cancer, and there is an urgent need for safe and effective therapies. siRNA-based RNA interference targeting PD-L1 shows potential in CRC treatment but lacks efficient delivery vectors. In this study, a novel co-delivery vector named ASCP was successfully developed for delivering CpG ODNs and siPD-L1. ASCP promoted dendritic cells maturation and exhibited good biosafety. Mild photothermal therapy mediated by ASCP killed tumor cells and released tumor-associated antigens, enhancing the anti-tumor immune response. The combination of MPTT and mild photothermal heating-enhanced gene/immunotherapy effectively inhibited CRC. This study provides new insights into the design of synergistic therapies for tumor treatment and may contribute to nanomedicine in CRC treatment.
Article
Mathematics, Interdisciplinary Applications
Meijuan Li, Jiarong Zhang, Zijie Shen
Summary: In this study, a dynamic TOPSIS method based on modified Jaccard similarity and angle similarity for three-parameter interval grey numbers (TPIGNs) is proposed for multi-attribute decision-making. By incorporating time-series data into conventional two-dimensional static data, a dynamic TOPSIS model is constructed. The results of comparative and sensitivity analyses demonstrate the effectiveness and flexibility of the proposed method in providing a more holistic and dynamic perspective for decision-making.
GREY SYSTEMS-THEORY AND APPLICATION
(2023)
Article
Microbiology
Xiaohong Weng, Mingyu Wang, Xin Sui, Beat Frey, Yingnan Liu, Rongtao Zhang, Hongwei Ni, Maihe Li
Summary: The soil microbiome in wetland ecosystems, which plays a vital role in nutrient cycling and climate regulation, is influenced by nitrogen (N) addition. However, the impact of high ammonium nitrogen additions on the diversity and composition of soil bacterial communities in temperate wetland ecosystems is not well understood. This study used high-throughput sequencing to investigate the changes in soil bacterial diversity and community structure with increasing ammonium concentrations in a wetland in China. The results showed that nitrogen addition significantly altered various soil physicochemical parameters, but did not significantly affect the bacterial community structure. Acidobacteriota, Proteobacteria, Chloroflexi, Verrucomicrobiota, and Actinobacteriota were found to be the most dominant bacterial phyla in the soils. Overall, this study provides insights into the response of the soil microbiome in wetland ecosystems to nitrogen deposition.
