Article
Biotechnology & Applied Microbiology
Yidong Cheng, Hao Yu, Kai Li, Jiancheng Lv, Juntao Zhuang, Kexin Bai, Qikai Wu, Xiao Yang, Haiwei Yang, Qiang Lu
Summary: Accumulating evidence has shown that hsa_circ_0003098 plays a vital role in bladder cancer (BCa). The overexpression of hsa_circ_0003098 is associated with poor prognosis and promotes BCa cell proliferation, migration, invasion, and tumor growth. Mechanistically, hsa_circ_0003098 acts as a sponge for miR-377-5p, promoting the upregulation of ACAT2 expression and inducing cholesteryl ester accumulation. Therefore, hsa_circ_0003098 could serve as a potential biomarker and therapeutic target for BCa.
Article
Oncology
Yachong Liu, Jia Song, Hongwei Zhang, Zhibin Liao, Furong Liu, Chen Su, Weijian Wang, Mengzhen Han, Lu Zhang, He Zhu, Zhanguo Zhang, Huifang Liang, Lei Zhang, Bixiang Zhang, Xiaoping Chen
Summary: In this study, it was found that EIF4A3-induced circTOLLIP promotes the progression of HCC through the circTOLLIP/miR-516a-5p/PBX3/EMT axis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Huyan Ting, Lina Gao, Na Gao, Chaochao Wang, Wuli Guo, Xiaojie Zhou, Qi Li
Summary: Bladder cancer impairs NK cell function and immune surveillance through exosomes. Specific miRNAs in exosomes may interfere with gene stability in NK cells and can be potential targets for BC therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yuan Chen, Shiben Ji, Jianxin Ying, Yongchang Sun, Jun Liu, Guohong Yin
Summary: This study identifies a novel biomarker, KRT6A, for early diagnosis of bladder tumors and reveals its role in promoting bladder tumor progression. Additionally, it uncovers the regulatory axis of KRT6A/miR-31-5p in bladder tumor growth.
Article
Oncology
Junlong Zhuang, Lan Shen, Meiqian Li, Jingya Sun, Jiange Hao, Jiaxuan Li, Zhen Zhu, Shuning Ge, Dianzheng Zhang, Hongqian Guo, Ruimin Huang, Jun Yan
Summary: Cancer-associated fibroblasts (CAF) promote cancer stemness and chemoresistance in urothelial bladder cancer (UBC) by overexpressing miR-146a-5p. MiR-146a-5p also enhances UBC stemness and chemoresistance by targeting ARID1A and PRKAA2 mRNA in UBC cells. Elevated levels of exosomal miR-146a-5p in UBC patients' serum are associated with tumor stage and relapse risk.
Article
Cell Biology
Ping-Ping Chen, Zhen-Sheng Zhang, Jin-Cai Wu, Jin-Fang Zheng, Fan Lin
Summary: In this study, it was found that in HCC, SNHG12 promotes EMT by targeting and inhibiting miR-516a-5p, thus upregulating HEG1 expression. Silencing SNHG12 can inhibit proliferation, migration, invasion, and promote apoptosis of HCC cells, while overexpression of SNHG12 produces opposite effects.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Wenbiao Ren, Jiao Hu, Huihuang Li, Jinbo Chen, Jian Ding, Xiongbing Zu, Benyi Fan
Summary: miR-616-5p is upregulated in bladder cancer and promotes invasion and migration; NR2C2 is a downstream target of miR-616-5p; High expression of NR2C2 correlates with better prognosis in bladder cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Jinhui Yang, Fuming Qi, Bo Tan, Guangcheng Dai, Rongxin Chen, Wenjie Wan, Bo Cheng, Boxin Xue
Summary: In this study, circSPECC1 was found to be significantly up-regulated in bladder cancer tissues and cell lines. Increased expression of circSPECC1 was associated with poor prognosis in bladder cancer. Knockdown of circSPECC1 was shown to impair the proliferation and migration of bladder cancer cells. Mechanistically, circSPECC1 was found to sponge miR-136-5p and promote the expression of GNAS, which reversed the effects of circSPECC1 suppression on cell proliferation and migration. This study suggested that circSPECC1 contributes to the growth and metastasis of bladder cancer and has potential as a non-invasive biomarker for diagnosis and therapeutic target for treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biotechnology & Applied Microbiology
Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Liu
Summary: The study demonstrates that high expression of KCNQ1OT1 in bladder cancer promotes tumor progression by regulating the miR-218-5p/HS3ST3B1 signaling pathway.
CANCER GENE THERAPY
(2021)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Biochemistry & Molecular Biology
Yue-Wei Yin, Kai-Long Liu, Bao-Sai Lu, Wei Li, Ya-Lin Niu, Chen-Ming Zhao, Zhan Yang, Ping-Ying Guo, Jin-Chun Qi
Summary: RBM24 regulates bladder cancer progression by positively regulating Runx1t1 expression, forming a positive feedback loop that drives cancer cell proliferation. Interrupting this feedback loop may be a potential therapeutic strategy for treating bladder cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Jinhui Yang, Xiaoyun Liu, Guangcheng Dai, Lanying Qu, Bo Tan, Bo Zhu, Fuming Qi, Xinyu Gai, Bo Cheng
Summary: The study found that circNT5E expression is increased in bladder cancer tissues, positively correlated with larger tumor size and lower survival rate. Inhibition of circNT5E can suppress the growth and metastasis of bladder cancer cells, and circNT5E enhances HOXC8 expression by capturing miR-502-5p.
Article
Oncology
Z. Wen, G. Huang, Y. Lai, L. Xiao, X. Peng, K. Liu, C. Zhang, X. Chen, R. Li, X. Li, Y. Lai, L. Ni
Summary: This study successfully identified a diagnostic panel of serum miRNAs for early detection of bladder cancer, showing high sensitivity and specificity. The panel of three miRNAs represents a potential non-invasive method for early detection of BC.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yangyang Xia, Shouzhen Chen, Jianfeng Cui, Yong Wang, Xiaochen Liu, Yangli Shen, Li Gong, Xuewen Jiang, Wenfu Wang, Yaofeng Zhu, Shuna Sun, Jiangxia Li, Yongxin Zou, Benkang Shi
Summary: Hyperactivation of STAT3 is closely related to cancer progression, and BBR has been shown to have anti-tumor effects on BCa cells by inhibiting JAK1-STAT3 signaling through upregulation of miR-17-5p, which may serve as a potential therapeutic option for BCa treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Xuanyu Chen, Song Chen
Summary: The study aimed to explore the effects of LINC00649 on the proliferation, migration, and invasion of bladder cancer and identified a potential mechanism involving the regulation of the miR-15a-5p/HMGA1 axis. High expression of LINC00649 was associated with poor overall survival in bladder cancer patients, while upregulation of LINC00649 enhanced the malignant progression of bladder cancer cells in vitro. This suggests that LINC00649 may serve as a biomarker and therapeutic target for bladder cancer.