Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis

Development of the brain vasculature and the blood-brain barrier in zebrafish

(2019) Claudia Quiñonez-Silvero et al.   DEVELOPMENTAL BIOLOGY

ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor

(2019) Dong Li et al.   NATURE MEDICINE

Zebrafish earn their drug discovery stripes

(2019) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Combination treatment of celecoxib and ciprofloxacin attenuates live S. aureus induced oxidative damage and inflammation in murine microglia via regulation of cytokine balance

(2018) Rajen Dey et al.   JOURNAL OF NEUROIMMUNOLOGY

Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs

(2018) Manoj Kumar Jaiswal   MEDICINAL RESEARCH REVIEWS

The identity and function of microglia in neurodegeneration

(2018) Wilbur M. Song et al.   NATURE IMMUNOLOGY

MicroRNA expression analysis identifies a subset of downregulated miRNAs in ALS motor neuron progenitors

(2018) Mafalda Rizzuti et al.   Scientific Reports

Inflammation in ALS/FTD pathogenesis

(2018) Madelyn E. McCauley et al.   ACTA NEUROPATHOLOGICA

Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS

(2018) Éric Martineau et al.   eLife

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Cellular Organization of Zebrafish Visuomotor Circuits

(2016) Michael B. Orger   CURRENT BIOLOGY

Comparative morphometric analysis of microglia in the spinal cord of SOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis

(2016) Tomohiro Ohgomori et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms

(2016) Claudia Figueroa-Romero et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ZNStress: a high-throughput drug screening protocol for identification of compounds modulating neuronal stress in the transgenic mutant sod1G93R zebrafish model of amyotrophic lateral sclerosis

(2016) Alexander McGown et al.   Molecular Neurodegeneration

INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model

(2016) Lorena Benedetti et al.   Scientific Reports

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

(2015) A. Emde et al.   EMBO JOURNAL

Immune cell dynamics in the CNS: Learning from the zebrafish

(2014) Nynke Oosterhof et al.   GLIA

Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD

(2014) Serena Lattante et al.   HUMAN MOLECULAR GENETICS

Loss of function of C9orf72 causes motor deficits in a zebrafish model of Amyotrophic Lateral Sclerosis

(2013) Sorana Ciura et al.   ANNALS OF NEUROLOGY

A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening

(2013) M. M. J. Da Costa et al.   Disease Models & Mechanisms

Loss and gain of FUS function impair neuromuscular synaptic transmission in a genetic model of ALS

(2013) Gary A.B. Armstrong et al.   HUMAN MOLECULAR GENETICS

Calcium Channel Agonists Protect against Neuromuscular Dysfunction in a Genetic Model of TDP-43 Mutation in ALS

(2013) G. A. B. Armstrong et al.   JOURNAL OF NEUROSCIENCE

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis

(2013) Philippe Corcia et al.   PLoS One

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth

(2013) B. Schmid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation

(2013) C Parisi et al.   Cell Death & Disease

Neuromuscular effects of G93A-SOD1 expression in zebrafish

(2012) Stacey A Sakowski et al.   Molecular Neurodegeneration

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

(2012) Annelies Van Hoecke et al.   NATURE MEDICINE

Selective increase of two ABC drug efflux transporters at the blood–spinal cord barrier suggests induced pharmacoresistance in ALS

(2012) Michael R. Jablonski et al.   NEUROBIOLOGY OF DISEASE

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

(2012) Johannes Brettschneider et al.   PLoS One

Developmental exposures to ethanol or dimethylsulfoxide at low concentrations alter locomotor activity in larval zebrafish: Implications for behavioral toxicity bioassays

(2011) Te-Hao Chen et al.   AQUATIC TOXICOLOGY

Inhibition of Bacterial Multidrug Resistance by Celecoxib, a Cyclooxygenase-2 Inhibitor

(2010) Arunasree M. Kalle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

(2010) T. Ramesh et al.   Disease Models & Mechanisms

miRNA malfunction causes spinal motor neuron disease

(2010) S. Haramati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo

(2009) Edor Kabashi et al.   HUMAN MOLECULAR GENETICS

Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

(2008) Francesca Peri et al.   CELL

A small molecule enhances RNA interference and promotes microRNA processing

(2008) Ge Shan et al.   NATURE BIOTECHNOLOGY