Article
Endocrinology & Metabolism
Beatriz Maria Veloso Pereira, Mariana Charleaux de Ponte, Ana Paula Malavolta Luz, Karina Thieme
Summary: This study aimed to show the expression profile of key DNA (de)methylation enzymes and their differences between sexes under obesity and diabetic condition. Female mice have a different profile of DNMTs expression, and metabolic condition negatively modulated the glomerular expression of TET1 and TET3 only in females. This study provides valuable knowledge on the epigenetic profile of DKD in males and females.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Amirhossein Davoodvandi, Banafsheh Nikfar, Russel J. Reiter, Zatollah Asemi
Summary: Melatonin plays important roles in mammals, regulating circadian rhythms, enhancing immunity, and inhibiting cancer. Epigenetic drugs have gained attention for their potential in cancer treatment. This report summarizes the effects of melatonin on DNA methylation in cancer cells and discusses the impact of artificial light on melatonin secretion and cancer cell DNA methylation.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Physiology
Mahavir Singh, Shanna J. Hardin, Akash K. George, Wintana Eyob, Dragana Stanisic, Sathnur Pushpakumar, Suresh C. Tyagi
Summary: A high-fat diet induces gut dysbiosis and cardiac muscle remodeling, particularly increasing white adipose tissue. Treatment with lactobacillus can reverse dysbiosis-induced cardiac injury by increasing lipolysis and decreasing lipogenesis, creating a healthier gut microbiota balance and reducing cardiac damage.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Pengcheng Liu, Fan Yang, Lizhi Zhang, Ying Hu, Bangjie Chen, Jianpeng Wang, Lei Su, Mingyue Wu, Wenjian Chen
Summary: DNA methylation is a crucial epigenetic mechanism for gene expression regulation, and DNMTs play a vital role in this process. The abnormal function of DNMTs is closely associated with cancer development, making them an important target for cancer treatment research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jing Liao, Biyan Peng, Guangyi Huang, Chunli Diao, Yuanjun Qin, Yiyi Hong, Jiali Lin, Yunru Lin, Li Jiang, Ningning Tang, Fen Tang, Jiamin Liang, Jun Zhang, Yumei Yan, Qi Chen, Zhou Zhou, Chaolan Shen, Wei Huang, Kongqian Huang, Qianqian Lan, Ling Cui, Haibin Zhong, Fan Xu, Min Li, Yantao Wei, Peng Lu, Mingyuan Zhang
Summary: The study investigates the role of NOX4 inhibitor GLX351322 in acute ocular hypertension-induced retinal injury. The inhibitor reduced ROS overproduction, inhibited inflammatory factor release, and suppressed glial cell activation and hyperplasia. It also improved retinal degeneration and function by inhibiting the redox-sensitive factor pathway mediated by ROS overproduction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Ecology
Marco Gerdol, Claudia La Vecchia, Maria Strazzullo, Pasquale De Luca, Stefania Gorbi, Francesco Regoli, Alberto Pallavicini, Enrico D'Aniello
Summary: DNA methylation is a crucial epigenetic mechanism that regulates gene expression in all organisms. In metazoans, the pattern of DNA methylation changes during embryogenesis and adulthood, leading to the development of a stable and unique methylation pattern in differentiated cells. The study sheds light on DNA methylation regulators in Mytilus galloprovincialis, providing insights into the role of this mechanism in bivalve genome regulation.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Seong Ji Woo, Youngmi Kim, Harry Jung, Jae Jun Lee, Ji Young Hong
Summary: In this study, we found that miR-148a may protect against tuberculous pleural fibrosis by inhibiting the expression of NOX4 and POLDIP2, and reducing fibrogenesis and epithelial mesenchymal transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Flavia Rezende, Pedro Felipe Malacarne, Niklas Mueller, Birgit Rathkolb, Martin Hrabe de Angelis, Katrin Schroeder, Ralf P. Brandes
Summary: The study found that Nox4 knockout mice exhibited similar weight loss and sodium sparing function under a low sodium diet, but showed reduced systolic blood pressure, heart-rate ratio, and heart to body weight ratio compared to wild-type mice, indicating that Nox4 plays a role in blood pressure regulation induced by low sodium diets.
Article
Veterinary Sciences
Joana Alpoim-Moreira, Carina Fernandes, Jorge Pimenta, Miguel Bliebernicht, Maria Rosa Rebordao, Pedro Castelo-Branco, Anna Szostek-Mioduchowska, Dariusz J. Skarzynski, Graca Ferreira-Dias
Summary: This study reveals that equine endometriosis is epigenetically modulated through the transcriptional regulation of anti-fibrotic genes (MMP2 and MMP9). These findings are important for understanding and treating endometriosis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biology
Olaia Martinez-Iglesias, Ivan Carrera, Vinogran Naidoo, Ramon Cacabelos
Summary: This study investigates the effects of AntiGan, a novel antitumoral bioproduct, on liver and colorectal cancer cells. AntiGan showed antitumor effects, increased Bax expression, and decreased cell viability in both cell lines. It also exhibited epigenetic properties, affecting the expression of COX-2, IL-17, DNMTs, and SIRT1.
Article
Biochemistry & Molecular Biology
Ignacio Silva-Llanes, Chang Hoon Shin, Jose Jimenez-Villegas, Myriam Gorospe, Isabel Lastres-Becker
Summary: The transcription factor NRF2 regulates the expression of genes encoding epigenetic regulatory factors by binding to their promoter regions containing ARE sequences. This study confirms NRF2's role in regulating histone deacetylases, DNA methyltransferases, and proteins involved in microRNA biogenesis. Additionally, NRF2 is found to be involved in the degradation of miR-155-5p through its interaction with Nfe2l2 mRNA. These findings demonstrate the epigenetic regulatory function of NRF2 and its potential implications for therapeutic strategies.
Article
Endocrinology & Metabolism
Mousa Vatanmakanian, Joshua J. Steffan, Sweaty Koul, Augusto C. Ochoa, Lakshmi S. Chaturvedi, Hari K. Koul
Summary: Prostate cancer progression is characterized by decreased SPDEF expression due to hypermethylation, which can be partially reversed through inhibition of DNMTs. This study highlights the important role of epigenetic regulation in prostate cancer development and suggests DNMTs as a potential therapeutic target for limiting tumor progression and therapy resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Psychiatry
Robert C. Smith, Henry Sershen, David S. Janowsky, Abel Lajtha, Matthew Grieco, Jon A. Gangoiti, Ilya Gertsman, Wynnona S. Johnson, Thomas D. Marcotte, John M. Davis
Summary: The study analyzed the effects of smoked cannabis on human peripheral blood cells and found that in the high concentration THC group, CB2 mRNA levels increased while immunological markers did not show significant changes. The changes in DNMT and TET mRNA suggest potential epigenetic effects of THC in human lymphocytes.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
M. Herranz-Iturbide, J. Lopez-Luque, E. Gonzalez-Sanchez, D. Caballero-Diaz, E. Crosas-Molist, B. Martin-Mur, M. Gut, A. Esteve-Codina, V Jaquet, J. X. Jiang, N. J. Torok, I Fabregat
Summary: NOX4 plays a role in promoting hepatocyte proliferation and repair during liver regeneration, with its deletion leading to accelerated liver recovery. NOX4-deleted mice show faster cell proliferation and better liver weight restoration, suggesting the potential of NOX4 as a therapeutic target for improving liver regeneration.
Article
Cardiac & Cardiovascular Systems
David A. A. Jaques, Peter Vollenweider, Murielle Bochud, Belen Ponte
Summary: This study describes the impact of age on the rate of kidney function decline and its interaction with risk factors for chronic kidney disease, particularly hypertension, in the general population. The results show that age contributes non-linearly to the decline of kidney function, with older individuals experiencing the fastest decline. Hypertension is found to be a major contributing factor, as the decline in kidney function worsened with age only in hypertensive participants.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Sweta Ghosh, Subir Kumar Juin, Partha Nandi, Suchandra Bhattacharyya Majumdar, Anamika Bose, Rathindranath Baral, Parames C. Sil, Subrata Majumdar
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Cell Biology
Suravi Majumder, Matthew Amin, Sathnur Pushpakumar, Utpal Sen
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Article
Parasitology
Nivedita Roy, Sweta Ghosh, Subir Kumar Juin, Rishila Ghosh, Suchandra Bhattacharya Majumdar, Subrata Majumdar
EXPERIMENTAL PARASITOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Sweta Ghosh, Subir Kumar Juin, Subrata Majumdar
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Infectious Diseases
Supriya Khanra, Subir Kumar Juin, Junaid Jibran Jawed, Sweta Ghosh, Shreyasi Dutta, Shaik Abdul Nabi, Jyotirmayee Dash, Dipak Dasgupta, Subrata Majumdar, Rahul Banerjee
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Physiology
Dragana Stanisic, Nevena Jeremic, Suravi Majumder, Sathnur Pushpakumar, Akash George, Mahavir Singh, Suresh C. Tyagi
Summary: The study found that a high fat diet can lead to dysbiosis, decreased gingival blood flow, and periodontal matrix remodeling, triggering inflammation and causing bone resorption and the development of periodontal disease.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sweta Ghosh, Subir Kumar Juin, Suchandra Bhattacharyya Majumdar, Subrata Majumdar
Summary: This study revealed a novel pathway of melanoma CSC maintenance and tumorigenicity, highlighting the crucial role of GCS in melanoma treatment and offering potential solutions for chemotherapy resistance challenges in a clinical setting.
MOLECULAR CARCINOGENESIS
(2021)
Article
Pharmacology & Pharmacy
Suravi Majumder, Sathnur Pushpakumar, Subir K. Juin, Venkatakrishna R. Jala, Utpal Sen
Summary: TLR4 mutation may alleviate hypertension-induced renal injury by activating autophagy and suppressing apoptosis.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Subir Kumar Juin, Sathnur Pushpakumar, Utpal Sen
Summary: The study found that in diabetic kidney, PPAR gamma expression was decreased, while RXR alpha, RXR beta, and RAR gamma 1 expression was increased, along with upregulations of PAI-1, MMP-9, and MMP-13. Additionally, collagen IV, fibronectin, and laminin expression were increased, while elastin expression was decreased in the diabetic kidney.
Article
Hematology
Abhijnan Chattopadhyay, Pujun Guan, Suravi Majumder, Kaveeta Kaw, Zhen Zhou, Chen Zhang, Siddharth K. Prakash, Anita Kaw, L. Maximillian Buja, Callie S. Kwartler, Dianna M. Milewicz
Summary: This study reveals that hypercholesterolemia drives complex phenotypic modulation of vascular smooth muscle cells (SMCs) and leads to atherosclerotic plaque formation. Deficiency of Perk in SMCs reduces plaque formation and prevents migration of SMCs from the medial layer of the aorta.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kaveeta Kaw, Abhijnan Chattopadhyay, Pujun Guan, Jiyuan Chen, Suravi Majumder, Xue-yan Duan, Shuangtao Ma, Chen Zhang, Callie S. Kwartler, Dianna M. Milewicz
Summary: This study investigates how the variant p.Arg149Cys in ACTA2 gene predisposes to atherosclerosis in individuals without cardiovascular risk factors. The variant increases intracellular cholesterol levels in smooth muscle cells, leading to atherosclerotic plaque formation. Treatment with the HMG-CoAR inhibitor pravastatin successfully reverses the increased plaque burden.
EUROPEAN HEART JOURNAL
(2023)
Article
Immunology
Subir Kumar Juin, Sweta Ghosh, Subrata Majumdar
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)