Article
Immunology
Qianhui Xu, Shaohuai Chen, Yuanbo Hu, Wen Huang
Summary: This study comprehensively investigated the role of immune cell infiltration patterns in tumor progression and clinical outcomes in breast cancer. Different immune infiltration patterns were identified, with high ICI scores suggesting immune-exhausted phenotype and low ICI scores corresponding to immune-activated phenotype with potential immunotherapeutic advantage. The findings contribute to a better understanding of the complexity of the tumor immune microenvironment and could potentially optimize precision immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyue Ren, Chao Chang, Teng Qi, Pengyu Yang, Yuanbo Wang, Xiaorui Zhou, Feng Guan, Xiang Li
Summary: Dysregulation of clusterin (CLU) has been found in various cancers, including gliomas. High CLU expression is associated with worse prognosis and higher risk in low-grade glioma patients. CLU is involved in immune status and has correlations with immune cells and immune-related pathways in gliomas. These findings suggest that CLU may serve as a potential biomarker or target in glioma immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Hao Zhang, Nan Zhang, Wantao Wu, Ran Zhou, Shuyu Li, Zeyu Wang, Ziyu Dai, Liyang Zhang, Zaoqu Liu, Jian Zhang, Peng Luo, Zhixiong Liu, Quan Cheng
Summary: A computational framework was used to identify immune cell-specific long noncoding RNAs (lncRNAs) in glioblastoma (GBM) and develop a signature that could predict survival outcomes and response to immunotherapy. This signature showed superior performance compared to previous signatures and was correlated with immune cell infiltration and immunotherapy response.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Immunology
Long Wang, Beibei Gao, Mingyue Wu, Wei Yuan, Ping Liang, Jinyu Huang
Summary: Using the ImmuCellAI tool, the study estimated the abundance of 24 immune cell types in atherosclerotic tissues, revealing a diverse landscape dominated by T cells and myeloid cells. Macrophages and dendritic cells showed varied abundance in normal and diseased tissues. The findings suggest a distinct profile of atherosclerosis-infiltrating immune cell subpopulations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Shupeng Li, Ziwei Li, Xinyu Wang, Junzhe Zhong, Daohan Yu, Hao Chen, Wenbin Ma, Lingling Liu, Minghuang Ye, Ruofei Shen, Chuanlu Jiang, Xiangqi Meng, Jinquan Cai
Summary: The study revealed that HK3 significantly promotes immune cell infiltration in glioma, and its expression level is closely related to tumor grade and prognosis.
CANCER CELL INTERNATIONAL
(2023)
Article
Immunology
Shuying Liu, Jiaying Ge, Yiting Chu, Shuangyu Cai, Jun Wu, Aixiu Gong, Jinghan Zhang
Summary: By analyzing gene datasets of human periodontitis, a gene signature related to the disease was identified, which may be associated with the cell death pathway called cuproptosis. Further research showed that these genes were linked to immune cells and exhibited differential expression between clusters of cuproptosis in periodontitis. The diagnostic capacity of the identified biomarkers was confirmed using an external dataset and clinical samples.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wuping Yang, Lei Li, Kenan Zhang, Kaifang Ma, Haibiao Xie, Yanqing Gong, Jingcheng Zhou, Kan Gong
Summary: The study found that ACE2 expression was reduced in ccRCC and decreased ACE2 was associated with worse pathological features and poor prognosis in ccRCC. Low ACE2 expression in ccRCC may partially affect the prognosis due to altered immune cells infiltration levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Fuxing Chen, Lingzhi Shen, Ying Wang, Yaping Chen, Xuejiao Pan, Hui Liang, Hu Yu
Summary: Cervical cancer tumor microenvironment is complex and diverse, with immune cell infiltration playing a role in immune escape and immunotherapy response. Using PCA and TIDE, we calculated individual ICI scores and probabilities of immune escape, respectively. Analysis of different patient responses to immunotherapy and prediction of therapeutic benefits were performed. High ICI scores were associated with immune escape through the JAK-STAT signaling pathway and low CD8+ T cell counts. Patients with high scores may benefit more from anti-PD-L1 immunotherapy, while those with low scores may be better suited for anti-CTLA-4 treatment. Combination therapies with targeted inhibitors may improve efficacy and reduce recurrence risk. The ICI model enhances understanding of immune escape and guides immunotherapy in cervical cancer patients.
Article
Immunology
Cuncan Deng, Guofei Deng, Hongwu Chu, Songyao Chen, Xiancong Chen, Xing Li, Yulong He, Chunhui Sun, Changhua Zhang
Summary: This study explored the influence of hypoxia in gastric cancer (GC) and established a hypoxia-related prognostic panel. High hypoxia scores were associated with poor prognosis and abnormal immune infiltration in GC patients. In addition, the high hypoxia score group was more sensitive to chemotherapy and immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Nan Zhang, Hao Zhang, Wantao Wu, Ran Zhou, Shuyu Li, Zeyu Wang, Ziyu Dai, Liyang Zhang, Fangkun Liu, Zaoqu Liu, Jian Zhang, Peng Luo, Zhixiong Liu, Quan Cheng
Summary: The study identifies tumor-infiltrating immune cell-associated lncRNAs (TIIClncRNAs) in low-grade glioma (LGG) and shows that these lncRNAs can predict immunotherapy outcomes.
Article
Multidisciplinary Sciences
Bradley D. Frank, Saveh Djalali, Agata W. Baryzewska, Paolo Giusto, Peter H. Seeberger, Lukas Zeininger
Summary: Researchers have achieved chemotactic motion of emulsion droplets, which can be controllably altered by modifying the droplets' geometry and composition. This finding has implications for the design of smart and adaptive microbots.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yangyang Hu, Yue Liu, Chenchao Ma, Kaixing Ai
Summary: MRPL12, a member of mitochondrial ribosomal proteins, is upregulated in lung adenocarcinoma (LUAD). High MRPL12 expression is associated with worse prognosis and correlated with immunomodulators, chemokines, and infiltration levels of multiple immune cells in LUAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hao Zhou, Shengjun Li, Yuansheng Lin
Summary: This study aimed to investigate the correlations of SH2D5 with prognosis and immune infiltration in lung adenocarcinoma (LUAD) by analyzing the SH2D5 expression profiles, clinical features, and immune infiltration in LUAD. The results showed that SH2D5 was significantly up-regulated in LUAD and correlated with unfavorable prognosis and immune infiltration. Furthermore, SH2D5 was associated with lung cancer and immunity. Lastly, the study investigated the relationship between the expression of SH2D5 and the use of antitumor drugs.
Article
Multidisciplinary Sciences
Ruoyu Dong, Jikuan Li, Guangwei Jiang, Ning Han, Yaochao Zhang, Xiaoming Shi
Summary: This study investigated the role of immune cell infiltration in the progression of atherosclerosis (AS) and identified 11 hub genes associated with AS through analysis of gene expression and protein-protein interaction networks. These hub genes showed good performance in distinguishing AS from control samples and were found to be correlated with angiogenesis and immune checkpoints.
Article
Oncology
Liyuan Yin, Wen Zhang, Dan Pu, Xiaoqian Zhai, Yiyun Lin, Qiang Wu, Tangel Chang, Jia Hu, Yan Li, Qinghua Zhou
Summary: This study investigated the tumor microenvironment of lung squamous carcinoma (LUSC) and found that the immune subtypes were associated with prognosis. A risk score model was constructed to predict overall survival rates. The findings provide important insights for the development of immunotherapy strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Physical
Li Yang, Yuan Chen, Zhenzhen Xu, Hong Xia, Toshiaki Natuski, Yusong Xi, Qingqing Ni
Summary: Carbon films were constructed on the surface of carbon fibers using magnetron sputtering to improve their surface defects and mechanical properties. The tensile properties of the fibers before and after modification were tested, and the effect of the modification method on the tensile properties and dispersion of the breaking strength of the fibers was analyzed. The magnetron sputtering process successfully repaired the surface and improved the dispersion of the breaking strength, while also enhancing the tensile fracture toughness through the crack effect mechanism.
Review
Environmental Sciences
Bismark Sarkodie, Jeremiah Amesimeku, Charles Frimpong, Ebenezer Kofi Howard, Quan Feng, Zhenzhen Xu
Summary: The textile industry is a major source of wastewater containing pollutants such as dyes and chemicals, which pose serious environmental risks when released into natural streams and bodies of water. To address these concerns, research has focused on low-cost technologies to produce absorbents for dye removal. Various techniques, including adsorption, enzymatic and photocatalytic degradation, have been used to remove dyes. Among them, photocatalysis using nanomaterials has emerged as a promising approach for wastewater treatment. Electrospinning methods have been used to create nanofibers with large surface areas, enabling efficient and reusable dye removal. This review discusses techniques for dye removal, electrospun nanofibers, their fabrication and application in photocatalysis, and identifies challenges and potential remedies for electrospun nanofibers in photocatalysis.
Article
Chemistry, Physical
Jin Zhang, Ze Mao, Zhiguo Sun, Di Wang, Anfang Wei, Zhenzhen Xu, Quan Feng, Qufu Wei
Summary: This article introduces an efficient method for preparing hierarchically porous substrate materials, using microemulsion electrospinning to fabricate structurally variable TiO2/SiO2/C nanofibers as the substrate materials of FSPCMs. The internal structure of the nanofibers can be tuned by varying the composition of the precursor solution. The manufactured FSPCMs were applied to temperature regulation textiles, effectively improving the temperature regulation performance.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Correction
Engineering, Chemical
Bin Wang, Heng Zhang, Zhenzhen Xu, Ying Xu, Xiaoling Hu, Hongyu Wang, Chunyan Wang, Ling Chen
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Optics
Dianzhuang Zheng, Shuiying Xiang, Xingxing Guo, Yahui Zhang, Biling Gu, Hongji Wang, Zhenzhen Xu, Xiaojun Zhu, Yuechun Shi, Yue Hao
Summary: As Moore's law has reached its limits, traditional computing architectures are struggling to meet the increasing demand for computing power. Photonic neural computing offers a promising solution to overcome this limitation. However, achieving nonlinear computing is challenging. In this study, a coherent photonic spiking neural network is proposed and experimentally demonstrated, which utilizes Mach-Zehnder modulators as synapses and an integrated quantum-well Fabry-Perot laser with a saturable absorber as photonic spiking neurons. The architecture successfully achieves both linear and nonlinear computations, paving the way for constructing large-scale coherent photonic spiking neural networks.
PHOTONICS RESEARCH
(2023)
Article
Mathematics, Applied
Md Mahmudul Hasan, Xianyi Zeng
Summary: We present a central compact hybrid-variable method (CHVM) for first-order hyperbolic problems with moderate or less discontinuities. The CHVM incorporates the compact difference strategy and a hybrid-variable discretization technique to achieve higher accuracy. The method is tested on one-dimensional linear advection equations, Burgers' equation, and the Euler equations to evaluate its performance.
JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS
(2023)
Review
Engineering, Environmental
Bismark Sarkodie, Quan Feng, Changhai Xu, Zhenzhen Xu
Summary: Desizing and biodegradability are crucial processes in the textile industry. Desizing helps to improve the efficiency and quality of subsequent stages, while biodegradability ensures environmental sustainability. However, there is a lack of reviews on the desizability, biodegradability, and mechanisms of sizing agents. This review discusses commonly used desizing methods and factors affecting desizing mechanism and biodegradability. Understanding these factors and mechanisms can contribute to the development of sizing agents with efficient desizing and biodegradability.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Xuan Zhou, Fei Fei, Wei Song, Hehua Ma, Zhenzhen Xu, Jing Yue, Bei Cao, Runbin Sun, Yu Zhao, Yuanxun Yang, Junyi Jiang, Yan Geng, Zuyi Weng, Juan Li
Summary: In this study, we investigated the effects of ouabain on proliferation and metabolism in psoriatic keratinocytes. Ouabain significantly decreased cell viability, induced apoptosis, and caused cell cycle arrest. Metabolomics analysis revealed that ouabain impaired glutathione metabolism. Mechanistically, ouabain downregulated the amino acid transporter SLC7A11, leading to reduced cysteine uptake and inhibited glutathione synthesis. The impaired glutathione synthesis and oxidative stress caused by ouabain may contribute to its cytotoxicity towards psoriatic keratinocytes. These findings provide experimental evidence for further exploring ouabain as a potential anti-psoriatic agent.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Computer Science, Information Systems
Kaixuan Liu, Chun Zhu, Xuyuan Tao, Pascal Bruniaux, Xianyi Zeng, Jianping Wang
Summary: Fit evaluation is important in garment products development and sales, as it can reduce the development cost and return rate. In this research, an intelligent fit evaluation technology was proposed using decision tree C4.5 algorithm. The proposed model accurately predicts clothing fit and requires less learning samples, with high prediction accuracy and without real try-on.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Engineering, Marine
Yuemin Zheng, Jin Tao, Jouni Hartikainen, Feng Duan, Hao Sun, Mingwei Sun, Qinglin Sun, Xianyi Zeng, Zengqiang Chen, Guangming Xie
Summary: In this paper, a trajectory tracking control method for underactuated unmanned ships is proposed by using a three-degree-of-freedom ship model, trajectory tracking line-of-sight guidance law, and Deep Deterministic Policy Gradient algorithm. The method effectively addresses the coupling problem and uncertainty issues to ensure safe and stable navigation during offshore operations.
Article
Public, Environmental & Occupational Health
Chun-Qing Li, Hao Kong, Zhen-Zhen Xu, Jia-Hui Ma, Xue-Ying Li
Summary: This study compared the predictive abilities of two frailty indices (mFI and RAI-rev) in predicting life-threatening morbidity and mortality in older patients undergoing high-risk abdominal surgery. The results showed that both frailty indices displayed poor discrimination for postoperative life-threatening morbidity and mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Business
Zhebin Xue, Qing Li, Xianyi Zeng
Summary: With the rapid development of the Internet and new media, social media data analysis has become increasingly important for understanding user behavior in the fashion industry. This paper examines the current status of social media user behavior analysis applied to fashion and apparel, and explores its potential for advanced product development and decision-making in the era of big data.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Article
Biochemistry & Molecular Biology
Wenjie Ding, Yuanbin Zhu, Jinlei Han, Hui Zhang, Zhenzhen Xu, Haris Khurshid, Fang Liu, Robert Hasterok, Xinlian Shen, Kai Wang
Summary: Through chromatin immunoprecipitation, researchers identified that the centromeric sequences of Gossypium anomalum only contained retrotransposon-like repeats and lacked long arrays of satellites. These repeats were found in African-Asian and Australian lineage species, suggesting a common ancestor. Interestingly, copy number variations were observed among lineages, indicating that sequence content is not crucial for the adaptive evolution of centromeric repeats, at least for retrotransposon-like repeats.
CHROMOSOME RESEARCH
(2023)
Article
Polymer Science
Chaohui Zhang, Wei Li, Zhenzhen Xu
Summary: This study investigated the effects of P(ATC-co-AA) on the adhesion, film properties, and desizability of cornstarch. The results showed that P(ATC-co-AA) branches improved adhesion to cotton fibers and reduced starch film brittleness. The adhesion and desizability of S-g-P(ATC-co-AA) depended on the mole percentage of ATC units, with higher percentages benefiting adhesion but hindering desizability. S-g-P(ATC-co-AA) with a mole percentage of 57.7% exhibited good sizing properties and easy desizing.
Article
Chemistry, Multidisciplinary
Jianfu Li, Yanlei Geng, Zhenzhen Xu, Pinhua Zhang, Gaston Garbarino, Maosheng Miao, Qingyang Hu, Xiaoli Wang
Summary: External mechanical stress alters the nature of chemical bonds and triggers novel reactions. By compressing silver iodide, mechanical stress weakens the Ag-I ionic bonds and activates the global diffusion of super-ions. This unconventional mechanism of an unexpected decomposition reaction reveals the sophisticated chemistry of simple inorganic compounds under extreme conditions.