Article
Clinical Neurology
Bhargava Gautham, Asheeb Abdulhak, Ravindranadh Chowdary Mundlamuri, Mariyappa Narayanan, Velmurugan Jayabal, Raghavendra Kenchaiah, Ajay Asranna, Bharath Rose Dawn, Saini Jitender, Chandana Nagaraj, Sandhya Mangalore, Kulanthaivelu Karthik, Nishanth Sadashiva, Anita Mahadevan, Jamuna Rajeswaran, Keshav Kumar, Arimappamagan Arivazhagan, Malla Bhaskara Rao, Sanjib Sinha
Summary: MEG can serve as a biomarker for predicting the surgical outcome in pediatric epilepsy. Cluster removal and regular cluster organization have predictive power in postsurgical prognostication in children, while the presence of scatters predicts poor outcome in children with focal cortical dysplasia.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Neurosciences
Michael W. Watkins, Ekta G. Shah, Michael E. Funke, Stephanie Garcia-Tarodo, Manish N. Shah, Nitin Tandon, Fernando Maestu, Christopher Laohathai, David Sandberg, Jeremy Lankford, Stephen Thompson, John Mosher, Gretchen Von Allmen
Summary: MEG is a valuable non-invasive clinical method used for localization of the epileptogenic zone and critical functional areas in patients with pharmaco-resistant epilepsy. Completing MEG as an inpatient can provide crucial localization data during an ongoing evaluation, contributing to surgical decision-making. In certain clinical circumstances, MEG data is essential for developing a treatment plan for surgical management of complicated or intractable epilepsy in children.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Miao Cao, Simon J. Vogrin, Andre D. H. Peterson, William Woods, Mark J. Cook, Chris Plummer
Summary: More informative quantitative techniques are urgently needed to assess strategies for epilepsy surgery objectively and non-invasively. Recent advances in network analysis and dynamical network modeling provide a novel and data-driven approach for a more objective assessment of the epileptogenic zone (EZ). However, further research is required to validate the effectiveness of these methods when applied to non-invasive neuroimaging data and neurophysiological data.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Graham W. Johnson, Leon Y. Cai, Saramati Narasimhan, Hernan F. J. Gonzalez, Kristin E. Wills, Victoria L. Morgan, Dario J. Englot
Summary: By developing a supervised machine learning technique using diffusion-weighted imaging, we successfully classified the seizure onset sites and surgical outcomes of patients with temporal lobe epilepsy. The results of the study demonstrated high accuracy in distinguishing patients from healthy controls and identifying seizure onset sites.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Neurosciences
Tim M. Tierney, Stephanie Mellor, George C. O'Neill, Ryan C. Timms, Gareth R. Barnes
Summary: This study investigates the interference rejection and spatial sampling properties of multi-axis Optically Pumped Magnetometer (OPM) data, finding that triaxial OPMs have excellent noise rejection properties and can adequately sample the neural space while minimizing cost, weight, and cross-talk.
Article
Clinical Neurology
Kirandeep Kaur, Ajay Garg, Madhavi Tripathi, Sarat P. Chandra, Gaurav Singh, Vibhin Viswanathan, Kamal Bharti, Vivek Singh, Bhargavi Ramanujam, Chandra Sekhar Bal, Mehar Chand Sharma, Ravindra Pandey, Deepti Vibha, Rajesh Kumar Singh, Pravat Kumar Mandal, Manjari Tripathi
Summary: This study compared the diagnostic value and accuracy of ictal SPECT and inter-ictal magnetoencephalography (MEG) in localizing the site for surgery in drug resistant epilepsy patients. SPECT was found to be non-informative for most patients, but reported better diagnostic output than MEG. MEG may be a useful alternative for patients in whom SPECT cannot be done or was non-localizing.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Multidisciplinary Sciences
Aikaterini Gialopsou, Christopher Abel, T. M. James, Thomas Coussens, Mark G. Bason, Reuben Puddy, Francesco Di Lorenzo, Katharina Rolfs, Jens Voigt, Tilmann Sander, Mara Cercignani, Peter Kruger
Summary: Recent progress in optically-pumped magnetometers (OPMs) has enhanced the capabilities of non-invasive brain function mapping through magnetoencephalography, allowing for improved spatial, source localization, and temporal resolution. The closer sensor proximity provided by OPMs has been shown to improve signal tracing and temporal resolution in brain responses to visual stimuli.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Stefan Rampp, Martin Kaltenhaeuser, Nadia Mueller-Voggel, Arnd Doerfler, Burkhard S. Kasper, Hajo M. Hamer, Sebastian Brandner, Michael Buchfelder
Summary: Epilepsy surgery is an effective treatment option for patients with drug-resistant focal epilepsies, and accurate localization of the epileptogenic zone is essential. This study investigates the relationship between node degree (ND) and the seizure onset zone (SOZ) in resting state magnetoencephalography (MEG) data. The findings suggest that ND in certain frequency bands is significantly related to the SOZ, indicating its potential as a new tool for presurgical evaluation of epilepsy surgery.
Article
Clinical Neurology
Dodmalur Mallikarjuna Sindhu, Ravindranadh Chowdary Mundlamuri, Bhargava Goutham, Mariyappa Narayanan, Kenchaiah Raghavendra, Ajay Asranna, Lakshminarayanapuram Gopal Vishwanathan, Karthik Kulanthaivelu, Jitender Saini, Sandhya Mangalore, Rose Dawn Bharath, Nishanth Sadashiva, Anita Mahadevan, Rajeswaran Jamuna, Arimappamagan Arivazhagan, Malla Bhaskara Rao, Sanjib Sinha
Summary: This study assessed the role of MSI in predicting post-operative seizure outcome. The results showed that concordance between MSI and resection cavity was associated with good seizure outcomes at different follow-up periods. Complete resection of the MSI cluster was found to have a high chance of seizure freedom and can be used as a complementary noninvasive presurgical evaluation tool.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Review
Clinical Neurology
Mangor Pedersen, David F. Abbott, Graeme D. Jackson
Summary: Magnetoencephalography with optically pumped magnometers (OPM-MEG) is a wearable system that can record neuronal activity with high temporal and spatial resolution. Compared to conventional techniques, OPM-MEG has more advantages and shows potential in epilepsy surgery evaluation.
Article
Clinical Neurology
Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte, Gerard R. Hall, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Summary: By comparing the interictal magnetoencephalography (MEG) band power from patients with surgical failure to normative maps, we were able to identify patient-specific abnormalities and propose three mechanisms contributing to poor surgical outcome. We developed markers of these mechanisms and validated them against patient outcomes.
Article
Neurosciences
Elena Boto, Ryan M. Hill, Molly Rea, Niall Holmes, Zelekha A. Seedat, James Leggett, Vishal Shah, James Osborne, Richard Bowtell, Matthew J. Brookes
Summary: Optically-pumped magnetometers (OPMs) have the potential to improve data quality and wearability in magnetoencephalography (MEG), with results showing high similarity to state-of-the-art cryogenic MEG systems. This indicates the potential for OPMs to ultimately replace traditional sensors for MEG measurements.
Article
Neurosciences
Chloe E. Meehan, Christine M. Embury, Alex Wiesman, Mikki Schantell, Sara L. Wolfson, Jennifer O'Neill, Susan Swindells, Craig M. Johnson, Pamela E. May, Daniel L. Murman, Tony W. Wilson
Summary: This study examines the neural dynamics underlying visuospatial processing in individuals with HIV-associated neurocognitive disorder (HAND) and Alzheimer's disease (AD). The results show both common and unique neurophysiological alterations among patients with HAND and ADS disorders in regions serving visuospatial processing.
Article
Clinical Neurology
Adrish Anand, John F. Magnotti, David N. Smith, Ron Gadot, Ricardo A. Najera, Mohamed I. R. Hegazy, Jay R. Gavvala, Ben Shofty, Sameer A. Sheth
Summary: This study analyzed MEG data and found that MEG clusters with 14 or more dipoles are strongly associated with ictal activity in epilepsy patients. These findings are important for guiding preoperative planning of sEEG implantation.
JOURNAL OF NEUROSURGERY
(2022)
Article
Computer Science, Interdisciplinary Applications
Soumyanil Banerjee, Ming Dong, Min-Hee Lee, Nolan O'Hara, Csaba Juhasz, Eishi Asano, Jeong-Won Jeong
Summary: This study developed a novel deep relational reasoning network for children with focal epilepsy, which significantly improved the prediction of language impairment scores and seizure outcomes. The proposed dilated CNN + RN approach outperformed other algorithms and provided explainable artificial intelligence models for identifying crucial brain hubs related to language function and seizure refractoriness.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Clinical Neurology
Carolina Ferreira-Atuesta, Jane de Tisi, Andrew W. McEvoy, Anna Miserocchi, Jean Khoury, Ruta Yardi, Deborah T. Vegh, James Butler, Hamin J. Lee, Victoria Deli-Peri, Yi Yao, Feng-Peng Wang, Xiao-Bin Zhang, Lubna Shakhatreh, Pakeeran Siriratnam, Andrew Neal, Arjune Sen, Maggie Tristram, Elizabeth Varghese, Wendy Biney, William P. Gray, Ana Rita Peralta, Alexandre Rainha-Campos, Antonio J. C. Goncalves-Ferreira, Jose Pimentel, Juan Fernando Arias, Samuel Terman, Robert Terziev, Herm J. Lamberink, Kees P. J. Braun, Willem M. Otte, Fergus J. Rugg-Gunn, Walter Gonzalez, Carla Bentes, Khalid Hamandi, Terence J. O'Brien, Piero Perucca, Chen Yao, Richard J. Burman, Lara Jehi, John S. Duncan, Josemir W. Sander, Matthias Koepp, Marian Galovic
Summary: More than half of adults with epilepsy undergoing resective epilepsy surgery achieve long-term seizure freedom and might consider withdrawing antiseizure medications. Predictive models were developed and validated to identify factors contributing to seizure recurrence after starting postoperative antiseizure medication withdrawal.
Article
Clinical Neurology
Sarah J. J. Gascoigne, Leonard Waldmann, Gabrielle M. M. Schroeder, Mariella Panagiotopoulou, Jess Blickwedel, Fahmida Chowdhury, Alison Cronie, Beate Diehl, John S. S. Duncan, Jennifer Falconer, Ryan Faulder, Yu Guan, Veronica Leach, Shona Livingstone, Christoforos Papasavvas, Rhys H. H. Thomas, Kevin Wilson, Peter N. N. Taylor, Yujiang Wang
Summary: Understanding fluctuations in seizure severity is important for treatment outcomes and assessing novel treatments. Current methods rely on qualitative interpretations, but quantitative measures would complement existing approaches. We developed a library of quantitative EEG markers to assess the spread and intensity of abnormal electrical activity during and after seizures.
Article
Clinical Neurology
Fenglai Xiao, Lorenzo Caciagli, Britta Wandschneider, Marine Fleury, Lawrence Binding, Davide Giampiccolo, Andrea Hill, Marian Galovic, Jaqueline Foong, Dong Zhou, Josemir W. Sander, John S. Duncan, Matthias J. Koepp
Summary: Using statistical parametric mapping-derived measures, this study investigated the changes in brain activation and connectivity in focal epilepsy patients before and after perampanel treatment. The results showed increased activation in the left OFC and decreased activation in the left thalamus and left caudate, as well as decreased connectivity between the left OFC and precuneus/left medial frontal lobe. These findings highlight the brain regions associated with the therapeutic effects and affective side effects of perampanel.
Article
Clinical Neurology
Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte, Gerard R. Hall, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Summary: By comparing the interictal magnetoencephalography (MEG) band power from patients with surgical failure to normative maps, we were able to identify patient-specific abnormalities and propose three mechanisms contributing to poor surgical outcome. We developed markers of these mechanisms and validated them against patient outcomes.
Article
Clinical Neurology
Davide Giampiccolo, Lawrence P. Binding, Lorenzo Caciagli, Roman Rodionov, Chris Foulon, Jane de Tisi, Alejandro Granados, Roisin Finn, Debayan Dasgupta, Fenglai Xiao, Beate Diehl, Emma Torzillo, Jan Van Dijk, Peter N. Taylor, Matthias Koepp, Andrew W. McEvoy, Sallie Baxendale, Fahmida Chowdhury, John S. Duncan, Anna Miserocchi
Summary: Around 50% of patients experience seizure freedom after frontal lobe surgery for drug-resistant epilepsy, but only about 30% maintain long-term seizure freedom. Early seizure recurrence may result from incomplete removal of the epileptogenic lesion, while delayed recurrence can still happen after complete excision. This suggests the presence of a common epileptogenic network that facilitates seizures in both nearby and distant dormant epileptic foci. Our study indicates that dysfunction within the thalamic and striatal networks may contribute to epileptogenesis, and disconnection of cortico-thalamostriatal pathways may underpin long-term seizure freedom.
Letter
Clinical Neurology
Davide Giampiccolo, John S. Duncan
Article
Clinical Neurology
Alfredo Lucas, Eli J. J. Cornblath, Nishant Sinha, Peter Hadar, Lorenzo Caciagli, Simon S. S. Keller, Leonardo Bonilha, Russell T. T. Shinohara, Joel M. M. Stein, Sandhitsu Das, Ezequiel Gleichgerrcht, Kathryn A. A. Davis
Summary: This study used network neuroscience to investigate the interictal whole-brain network of bilateral temporal lobe epilepsy (BiTLE). The study found that compared to unilateral temporal lobe epilepsy (UTLE), BiTLE patients had a higher level of network segregation, and these differences can assist in non-invasively identifying this patient population prior to invasive procedures.
Article
Behavioral Sciences
Andrea McKavanagh, Adam Ridzuan-Allen, Barbara A. K. Kreilkamp, Yachin Chen, Jose V. Manjon, Pierrick Coupe, Martyn Bracewell, Kumar Das, Peter N. Taylor, Anthony G. Marson, Simon S. Keller
Summary: This study investigated the differences in volume, estimated myelin content, and functional connectivity of midbrain structures in patients with idiopathic generalized epilepsy (IGE). The results revealed increased volume in the right red nucleus and differences in structural volumes of the right subthalamic nucleus between non-refractory and refractory IGE patients. Functional connectivity alterations were also observed, including decreased connectivity between the left substantia nigra and thalamus, and increased connectivity between the right subthalamic nucleus and superior frontal gyrus in IGE patients.
EPILEPSY & BEHAVIOR
(2023)
Editorial Material
Clinical Neurology
John S. Duncan, Peter N. Taylor
Article
Clinical Neurology
Lawrence Peter Binding, Debayan Dasgupta, Peter Neal Taylor, Pamela Jane Thompson, Aidan G. O'Keeffe, Jane de Tisi, Andrew William McEvoy, Anna Miserocchi, Gavin P. Winston, John S. Duncan, Sjoerd B. Vos
Summary: This study found a relationship between white matter fiber bundle damage and language change after temporal lobe epilepsy surgery. In surgeries on the language-dominant hemisphere, damage to the arcuate fasciculus and inferior fronto-occipital fasciculus was associated with decline in language performance at 3 months. In surgeries on the language-nondominant hemisphere, increased resection of the middle longitudinal fasciculus was related to decline in language performance at 3 months.
Article
Clinical Neurology
Claudia Zeicu, Antoine Legouhy, Catherine A. Scott, Joana F. A. Oliveira, Gavin P. Winston, John S. Duncan, Sjoerd B. Vos, Maria Thom, Samden Lhatoo, Hui Zhang, Ronald M. Harper, Beate Diehl
Summary: This study investigated the volume and microstructure of the amygdala in patients with epilepsy and found that those with focal-to-bilateral tonic-clonic seizures (FBTCS) had increased amygdala volumes and decreased neurite density compared to healthy controls. Furthermore, patients with post-convulsive central apnea (PCCA) had the highest increase in amygdala volume. These structural alterations may be associated with cardiorespiratory patterns mediated by the amygdala after FBTCS.
Article
Clinical Neurology
Nishant Sinha, John S. Duncan, Beate Diehl, Fahmida A. Chowdhury, Jane de Tisi, Anna Miserocchi, Andrew William Mcevoy, Kathryn A. Davis, Sjoerd B. Vos, Gavin P. Winston, Yujiang Wang, Peter Neal Taylor
Summary: This study aimed to investigate the impact of the relationship between brain structure and function on the success of epilepsy surgery. The results showed that patients with stronger structure-function coupling in brain areas implanted with EEG electrodes had better control of seizure activity.
Article
Clinical Neurology
Gabrielle M. Schroeder, Philippa J. Karoly, Matias Maturana, Mariella Panagiotopoulou, Peter N. Taylor, Mark J. Cook, Yujiang Wang
Summary: In this observational study, researchers analyzed the variability of seizures in patients with chronic intracranial EEG recordings and found that the variability is modulated by different factors on multiple timescales. These findings have important implications for the treatment of epilepsy.
BRAIN COMMUNICATIONS
(2023)
Article
Neuroimaging
James J. Gugger, Nishant Sinha, Yiming Huang, Alexa E. Walter, Cillian Lynch, Priyanka Kalyani, Nathan Smyk, Danielle Sandsmark, Ramon Diaz-Arrastia, Kathryn A. Davis
Summary: Traumatic brain injury (TBI) leads to diffuse axonal injury and maladaptive changes in network function, resulting in incomplete recovery and persistent disability. Normative modeling can capture network deviations in TBI patients and predict post-TBI symptoms and functional status. Structural network deviation scores could be useful for targeted therapies in clinical trials.
NEUROIMAGE-CLINICAL
(2023)
Correction
Clinical Neurology
John M. Bernabei, Nishant Sinha, T. Campbell Arnold, Erin Conrad, Ian Ong, Akash R. Pattnaik, Joel M. Stein, Russell T. Shinohara, Timothy H. Lucas, Dani S. Bassett, Kathryn A. Davis, Brian Litt
