Development of Complement Factor H–Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae

Requirement of Complement C6 for Intact Innate Immune Responses in Mice

(2020) Fatemeh Fattahi et al.   JOURNAL OF IMMUNOLOGY

Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome–related factor H mutation

(2019) Yoshiyasu Ueda et al.   KIDNEY INTERNATIONAL

Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016

(2019) Jane Rowley et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

(2019) Sunita Gulati et al.   PLOS BIOLOGY

Gonorrhoea

(2019) Magnus Unemo et al.   Nature Reviews Disease Primers

Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae

(2018) Jutamas Shaughnessy et al.   JOURNAL OF IMMUNOLOGY

Disseminated Gonococcal Infections in Patients Receiving Eculizumab: A Case Series

(2018) Page E Crew et al.   CLINICAL INFECTIOUS DISEASES

The role of gonococcal Neisserial surface protein A (NspA) in serum resistance and comparison of its factor H binding properties with that of its meningococcal counterpart

(2018) Lisa A. Lewis et al.   INFECTION AND IMMUNITY

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines

(2017) Emilie Alirol et al.   PLOS MEDICINE

Azithromycin-resistant Neisseria gonorrhoeae isolates in Guangzhou, China (2009–2013): coevolution with decreased susceptibilities to ceftriaxone and genetic characteristics

(2016) Jing-Yao Liang et al.   BMC INFECTIOUS DISEASES

The novel 2016 WHONeisseria gonorrhoeaereference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization

(2016) Magnus Unemo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Novel Factor H–Fc Chimeric Immunotherapeutic Molecule againstNeisseria gonorrhoeae

(2016) Jutamas Shaughnessy et al.   JOURNAL OF IMMUNOLOGY

Phase-Variable Heptose I Glycan Extensions Modulate Efficacy of 2C7 Vaccine Antibody Directed againstNeisseria gonorrhoeaeLipooligosaccharide

(2016) Srinjoy Chakraborti et al.   JOURNAL OF IMMUNOLOGY

Techno-economic analysis of a transient plant-based platform for monoclonal antibody production

(2016) Somen Nandi et al.   mAbs

Emerging azithromycin-resistance among the Neisseria gonorrhoeae strains isolated in Hungary

(2016) Alexandra Brunner et al.   Annals of Clinical Microbiology and Antimicrobials

The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development

(2016) Aimee Tan et al.   Frontiers in Immunology

Occurrence of high-level azithromycin-resistantNeisseria gonorrhoeaeisolates in China

(2015) Juan Xue et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effect of linker flexibility and length on the functionality of a cytotoxic engineered antibody fragment

(2015) Maximilian Klement et al.   JOURNAL OF BIOTECHNOLOGY

Anti-infective immunoadhesins from plants

(2015) Keith Wycoff et al.   PLANT BIOTECHNOLOGY JOURNAL

α-2,3-Sialyltransferase Expression Level Impacts the Kinetics of Lipooligosaccharide Sialylation, Complement Resistance, and the Ability of Neisseria gonorrhoeae to Colonize the Murine Genital Tract

(2015) Lisa A. Lewis et al.   mBio

Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors

(2015) David Ermert et al.   PLoS Pathogens

Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

(2014) M. Unemo et al.   CLINICAL MICROBIOLOGY REVIEWS

Linker Length Matters, Fynomer-Fc Fusion with an Optimized Linker Displaying Picomolar IL-17A Inhibition Potency

(2014) Michela Silacci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and characterization of structured protein linkers with differing flexibilities

(2014) J. S. Klein et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Manufacturing Economics of Plant-Made Biologics: Case Studies in Therapeutic and Industrial Enzymes

(2014) Daniel Tusé et al.   Biomed Research International

Fusion protein linkers: Property, design and functionality

(2012) Xiaoying Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Predictive models for transient protein expression in tobacco (Nicotiana tabacum L.) can optimize process time, yield, and downstream costs

(2012) J.F. Buyel et al.   BIOTECHNOLOGY AND BIOENGINEERING

Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain

(2012) J. Camara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Crosstalk between Human IgG Isotypes and Murine Effector Cells

(2012) M. B. Overdijk et al.   JOURNAL OF IMMUNOLOGY

Utility of the P19 suppressor of gene-silencing protein for production of therapeutic antibodies inNicotianaexpression hosts

(2012) Freydoun Garabagi et al.   PLANT BIOTECHNOLOGY JOURNAL

Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone

(2011) Makoto Ohnishi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Characterization of the Interaction between SialylatedNeisseria gonorrhoeaeand Factor H

(2011) Jutamas Shaughnessy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of C3a Receptors, C5a Receptors, and Complement Protein C6 Deficiency in Collagen Antibody-Induced Arthritis in Mice

(2011) N. K. Banda et al.   JOURNAL OF IMMUNOLOGY

Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections

(2011) Ann E. Jerse et al.   Frontiers in Microbiology

Recombinant Anthrax Toxin Receptor-Fc Fusion Proteins Produced in Plants Protect Rabbits against Inhalational Anthrax

(2010) Keith L. Wycoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Infections of People with Complement Deficiencies and Patients Who Have Undergone Splenectomy

(2010) S. Ram et al.   CLINICAL MICROBIOLOGY REVIEWS

Phasevarions Mediate Random Switching of Gene Expression in Pathogenic Neisseria

(2009) Yogitha N. Srikhanta et al.   PLoS Pathogens

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL