Article
Immunology
Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Andrea Giovannelli, Patrizia Leone, Maurizio Federico
Summary: A new vaccination approach based on in vivo engineering of extracellular vesicles to induce CD8(+) T cytotoxic lymphocyte immunity, resulting in cross-presentation of antigens to prime antigen-specific CD8(+) T-cells and initiate immune responses against viruses.
Article
Biochemistry & Molecular Biology
Erin M. Bange, Nicholas A. Han, Paul Wileyto, Justin Y. Kim, Sigrid Gouma, James Robinson, Allison R. Greenplate, Madeline A. Hwee, Florence Porterfield, Olutosin Owoyemi, Karan Naik, Cathy Zheng, Michael Galantino, Ariel R. Weisman, Caroline A. G. Ittner, Emily M. Kugler, Amy E. Baxter, Olutwatosin Oniyide, Roseline S. Agyekum, Thomas G. Dunn, Tiffanie K. Jones, Heather M. Giannini, Madison E. Weirick, Christopher M. McAllister, N. Esther Babady, Anita Kumar, Adam J. Widman, Susan DeWolf, Sawsan R. Boutemine, Charlotte Roberts, Krista R. Budzik, Susan Tollett, Carla Wright, Tara Perloff, Lova Sun, Divij Mathew, Josephine R. Giles, Derek A. Oldridge, Jennifer E. Wu, Cecile Alanio, Sharon Adamski, Alfred L. Garfall, Laura A. Vella, Samuel J. Kerr, Justine Cohen, Randall A. Oyer, Ryan Massa, Ivan P. Maillard, Kara N. Maxwell, John P. Reilly, Peter G. Maslak, Robert H. Vonderheide, Jedd D. Wolchok, Scott E. Hensley, E. John Wherry, Nuala J. Meyer, Angela M. DeMichele, Santosha A. Vardhana, Ronac Mamtani, Alexander C. Huang
Summary: In patients with cancer and COVID-19, those with hematologic cancer show impaired immune responses compared to solid cancer patients. CD8 T cells play a crucial role in survival, even in the presence of limited humoral responses. The presence of SARS-CoV-2-specific T cell responses in hematologic cancer patients suggests a potential therapeutic target.
Article
Multidisciplinary Sciences
Matthias Reinscheid, Hendrik Luxenburger, Vivien Karl, Anne Graeser, Sebastian Giese, Kevin Ciminski, David B. Reeg, Valerie Oberhardt, Natascha Roehlen, Julia Lang-Meli, Kathrin Heim, Nina Gross, Christina Baum, Siegbert Rieg, Claudius Speer, Florian Emmerich, Susanne Breisinger, Daniel Steinmann, Bertram Bengsch, Tobias Boettler, Georg Kochs, Martin Schwemmle, Robert Thimme, Christoph Neumann-Haefelin, Maike Hofmann
Summary: The study demonstrates that COVID-19 mRNA booster vaccination induces a transient T effector cell response while preserving the CD8 memory T cell pool, allowing for reactivation of spike-specific CD8+ T cells during breakthrough infections or 4th vaccination.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Gathsaurie Neelika Malavige, Chandima Jeewandara, Graham S. Ogg
Summary: There are similarities between dengue and COVID-19 infections in terms of clinical presentations and immunopathogenesis, including shared symptoms and common risk factors for severe illness. Studying the similarities between these two infections is crucial for the development of more effective therapeutic interventions.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Multidisciplinary Sciences
Daniel M. Altmann, Rosemary J. Boyton
Summary: A diverse range of first-generation SARS-CoV-2 vaccines have been successful in controlling the COVID-19 pandemic, although inequitable distribution remains an issue. Future challenges include optimizing immunological boosting strategies and building an immune repertoire that can protect against upcoming viral variants.
Article
Medicine, General & Internal
C. Sabrina Tan, Ai-ris Y. Collier, Jingyou Yu, Jinyan Liu, Abishek Chandrashekar, Katherine McMahan, Catherine Jacob-Dolan, Xuan He, Vicky Roy, Blake M. Hauser, Jennifer E. Munt, Michael L. Mallory, Melissa Mattocks, John M. Powers, Rita M. Meganck, Marjorie Rowe, Rachel Hemond, Esther A. Bondzie, Kate H. Jaegle, Ralph S. Baric, Aaron G. Schmidt, Galit Alter, Mathieu Le Gars, Jerald Sadoff, Dan H. Barouch
Summary: By using heterologous Ad26.COV2.S vaccine as a booster for individuals previously vaccinated with BNT162b2, durable humoral and cellular immune responses can be achieved. This suggests potential benefits of heterologous prime-boost vaccine regimens for SARS-CoV-2.
Article
Virology
Daniela Fenoglio, Chiara Dentone, Alessia Parodi, Antonio Di Biagio, Federica Bozzano, Antonio Vena, Marina Fabbi, Francesca Ferrera, Tiziana Altosole, Bianca Bruzzone, Mauro Giacomini, Paolo Pelosi, Andrea De Maria, Matteo Bassetti, Raffaele De Palma, Gilberto Filaci
Summary: In severe COVID-19 patients, the expansion of circulating T cells may induce antibody response, inflammation, and regulation, potentially leading to a new form of biological target therapy.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Genetics & Heredity
Angelica J. M. de Leeuw, Maureen A. M. Oude Luttikhuis, Annemarijn C. Wellen, Christine Muller, Cornelis F. Calkhoven
Summary: The global COVID-19 pandemic has posed challenges to healthcare systems since late 2019, with obesity emerging as a major risk factor for severe disease. Systemic inflammation related to obesity and hyperactivation of the RAAS system may impact disease severity.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biology
Taehwan Oh, Green Kim, Seung Ho Baek, Youngmin Woo, Bon-Sang Koo, Eun-Ha Hwang, Kyuyoung Shim, You Jung An, Yujin Kim, Jinyoung Won, Youngjeon Lee, Kyung Seob Lim, Jae-Hak Park, Jung Joo Hong
Summary: We utilized a spatial transcriptome atlas to identify specific gene expression profiles of acute lung injury during SARS-CoV-2 infection. The alveolar regions showed activation of genes related to virus-induced cell death and the innate immune response, while inflamed vascular regions exhibited upregulation of interferon and complement pathway genes. Known biomarker genes were expressed in specific pulmonary microstructures, highlighting the importance of identifying key drivers of disease progression and clinically applicable biomarkers during SARS-CoV-2 infection.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medicine, General & Internal
Benjamin A. Krishna, Eleanor Y. Lim, Lenette Mactavous, Paul A. Lyons, Rainer Doffinger, John R. Bradley, Kenneth G. C. Smith, John Sinclair, Nicholas J. Matheson, Paul J. Lehner, Mark R. Wills, Nyaradzai Sithole
Summary: There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. Given the diagnostic challenges of Long COVID, this study investigated SARS-CoV-2-specific T cell responses in patients with confirmed SARS-CoV-2 infection and/or Long COVID. The findings suggest that IL-2 release from T cells may be a sensitive and specific marker for previous SARS-CoV-2 infection, even in patients without detectable SARS-CoV-2 antibodies.
Article
Immunology
Maria J. Citores, Aranzazu Caballero-Marcos, Valentin Cuervas-Mons, Roberto Alonso-Fernandez, Javier Graus-Morales, Ana Arias-Milla, Maricela Valerio, Patricia Munoz, Magdalena Salcedo
Summary: This study aimed to explore the long-term natural immunity against SARS-CoV-2 in liver transplant recipients compared to the non-transplanted population. The results showed similar T cell responses and antibody levels between liver transplant recipients and non-transplanted individuals, indicating comparable long-term immunity after COVID-19.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Multidisciplinary Sciences
Daniel M. Altmann, Catherine J. Reynolds, George Joy, Ashley D. Otter, Joseph M. Gibbons, Corinna Pade, Leo Swadling, Mala K. Maini, Tim Brooks, Amanda Semper, Aine Mcknight, Mahdad Noursadeghi, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Rosemary J. Boyton
Summary: This study analyzes the immune response in healthcare workers with mild or asymptomatic SARS-CoV-2 infection and compares it to those with Long Covid. The results show no significant differences in immune responses between the two groups up to 18 weeks post-infection and 1 year after vaccination, suggesting that immune response variations are unlikely to be a contributing factor to Long Covid development.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Simona Arientova, Katerina Matuskova, Oldrich Bartos, Michal Holub, Ondrej Beran
Summary: This study examined the dynamics and duration of immune responses after a three-dose regimen of the BNT162b2 mRNA vaccine. The results showed that the vaccine induced potent and enduring humoral and cellular immune responses, with enhanced protection after the third dose that remained stable up to a year later.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ross M. Kedl
Summary: This article describes the pre- and post-immunization experiences of an individual who participated in the Moderna phase III clinical trial and strongly suggests that the individual did not receive the placebo. Although the analysis is based on a single case, the results align well with existing published data and provide a comprehensive longitudinal evaluation of vaccine-elicited immunity within a single person. The findings, although anecdotal, offer valuable insights and guidance for future longitudinal studies with statistical significance.
Review
Medicine, General & Internal
Rosanna W. Peeling, David L. Heymann, Yik-Ying Teo, Patricia J. Garcia
Summary: Diagnostics play a crucial role in the response to the COVID-19 pandemic. Molecular tests like PCR are recommended for confirming diagnosis in symptomatic individuals, while antigen rapid detection tests have the advantage of being easier to perform with faster results and lower cost. Antibody tests can inform public policy but should not be used as proof of immunity. All three types of tests continue to be important in transitioning from pandemic response to control.
Letter
Allergy
Cinzia Milito, Vassilios Lougaris, Giuliana Giardino, Alessandra Punziano, Alessandra Vultaggio, Maria Carrabba, Francesco Cinetto, Riccardo Scarpa, Rosa Maria Delle Piane, Lucia Baselli, Silvia Ricci, Beatrice Rivalta, Francesca Conti, Carolina Marasco, Antonio Marzollo, Davide Firinu, Federica Pulvirenti, Gianluca Lagnese, Emanuele Vivarelli, Caterina Cancrin, Baldassare Martire, Maria Giovanna Danieli, Andrea Pession, Angelo Vacca, Chiara Azzari, Giovanna Fabio, Andrea Matucci, Anna Rosa Soresina, Carlo Agostini, Giuseppe Spadaro, Raffaele Badolato, Maria Pia Cicalese, Alessandro Aiuti, Alessandro Pleban, Claudio Pignata, Isabella Quinti
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Oncology
F. Saettini, S. Radaelli, L. Ocello, G. M. Ferrari, P. Corti, F. Dell'Acqua, D. Ippolito, S. Foresti, C. Gervasini, R. Badolato, A. Biondi
Summary: Rubinstein-Taybi syndrome is an autosomal dominant disorder caused by variants in CREBBP or EP300, characterized by distinctive features, intellectual disability, and immunodeficiency. The clinical presentation is expanding to include complications such as autoinflammatory, autoimmune, and infectious conditions, and prompt treatment can reduce mortality rates.
PEDIATRIC HEMATOLOGY AND ONCOLOGY
(2022)
Article
Infectious Diseases
Elena Chiappini, Catiuscia Lisi, Vania Giacomet, Paola Erba, Stefania Bernardi, Paola Zangari, Antonio Di Biagio, Lucia Taramasso, Carlo Giaquinto, Osvalda Rampon, Clara Gabiano, Silvia Garazzino, Claudia Tagliabue, Susanna Esposito, Eugenia Bruzzese, Raffaele Badolato, Domenico Zanaboni, Monica Cellini, Maurizio Dedoni, Antonio Mazza, Andrea Pession, Anna Maria Giannini, Filippo Salvini, Icilio Dodi, Ines Carloni, Salvatore Cazzato, Pier Angelo Tovo, Maurizio de Martino, Luisa Galli
Summary: Early initiation of HAART is crucial to prevent immunological and clinical deterioration in perinatally HIV-1 infected children. However, due to the lack of adequate pediatric clinical studies, only a small number of antiretroviral drugs are licensed for use in children.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Elizabeth Chappell, Malte Kohns Vasconcelos, Ruth L. Goodall, Luisa Galli, Tessa Goetghebuer, Antoni Noguera-Julian, Laura C. Rodrigues, Henriette Scherpbier, Colette Smit, Alasdair Bamford, Siobhan Crichton, Marissa Luisa Navarro, Jose T. Ramos, Josiane Warszawski, Vana Spolou, Elena Chiappini, Elisabetta Venturini, Filipa Prata, Christian Kahlert, Magdalena Marczynska, Laura Marques, Lars Naver, Claire Thorne, Diana M. Gibb, Carlo Giaquinto, Ali Judd, Intira Jeannie Collins
Summary: In Europe, migrant children have virological and immunological outcomes at 1 year of ART that are comparable to domestic-born children, indicating potential equity in access to healthcare. However, there is some evidence of a difference in AIDS-free survival among migrant children, which needs further monitoring.
Article
Infectious Diseases
Carla Colombo, Marco Cipolli, Valeria Dacco, Paola Medino, Federico Alghisi, Maura Ambroni, Raffaele Badolato, Fiorella Battistini, Elisabetta Bignamini, Rosaria Casciaro, Fabiana Ciciriello, Mirella Collura, Isabella Comello, Michela Francalanci, Francesca Ficili, Anna Folino, Salvatore Leonardi, Giuseppina Leonetti, Maria Cristina Lucanto, Francesca Lucca, Massimo Maschio, Valeria Mencarini, Barbara Messore, Giovanna Pisi, Giovanna Pizzamiglio, Piercarlo Poli, Valeria Raia, Luca Riberi, Mirco Ros, Novella Rotolo, Angela Sepe, Giovanni Taccetti, Pamela Vitullo, Gianfranco Alicandro
Summary: This study aimed to describe the clinical course of COVID-19 in cystic fibrosis patients and identify risk factors for severe COVID-19. The study found that certain clinical features were associated with an increased risk of COVID-19 hospitalization.
Article
Immunology
Manuela Baronio, Francesco Saettini, Luisa Gazzurelli, Stefano Rossi, Antonio Marzollo, Silvia Ricci, Daniele Zama, Boaz Palterer, Canessa Clementina, Lodi Lorenzo, Marco Chiarini, Alessandra Sottini, Luisa Imberti, Chiara Gorio, Linda Rossini, Raffaele Badolato, Alessandro Plebani, Daniele Moratto, Vassilios Lougaris
Summary: Our study found that patients with JS may experience significant numerical and maturational alterations in the T-, B-, and NK-cell compartments. These findings suggest that JS patients should be regularly monitored from an immunological point of view.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Federico Alberici, Stefania Affatato, Daniele Moratto, Federica Mescia, Elisa Delbarba, Alice Guerini, Martina Tedesco, Peter D. Burbelo, Roberta Zani, Ilaria Castagna, Agnese Gallico, Mattia Tonoli, Margherita Venturini, Aldo M. Roccaro, Mauro Giacomelli, Jeffrey Cohen, Viviana Giustini, Kerry Dobbs, Helen C. Su, Chiara Fiorini, Virginia Quaresima, Fabio Battista Viola, Valerio Vizzardi, Mario Gaggiotti, Nicola Bossini, Paola Gaggia, Raffaele Badolato, Luigi D. Notarangelo, Marco Chiarini, Francesco Scolari
Summary: Dialysis and kidney transplant patients with COVID-19 exhibit immunophenotype abnormalities, with kidney transplant recipients showing more profound alterations of the innate immune system and lower anti-spike antibody response.
JOURNAL OF NEPHROLOGY
(2022)
Article
Immunology
Alessia Morreale, Laura Dotta, Donatella Vairo, Tullia Bazzana, Vassilios Lougaris, Annarosa Soresina, Alessandro Plebani, Silvia Clara Giliani, Fulvio Porta, Alberto Matteelli, Luca Oscar Redaelli De Zinis, Raffaele Badolato
Summary: The article presents an algorithm that can be used for diagnosing pediatric nontuberculous mycobacterial disease and identifying patients who may have underlying immune system defects.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Genetics & Heredity
Francesco Saettini, Grazia Fazio, Maria Teresa Bonati, Daniele Moratto, Valentina Massa, Elisabetta Di Fede, Silvia Castiglioni, Daniela Marchetti, Marco Chiarini, Alessandra Sottini, Maria Iascone, Giovanni Cazzaniga, Luisa Imberti, Andrea Biondi, Cristina Gervasini, Raffaele Badolato
Summary: This study characterizes two patients with Rubinstein-Taybi syndrome (RSTS) carrying the same EP300 variant, and identifies distinct clinical manifestations and immunological features. The findings provide important insights into the pathogenesis and diagnosis of this syndrome.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Immunology
Ornella Patrizi, Manuela Baronio, Luisa Gazzurelli, Stefano Rossi, Sara Rezzola, Emanuela Marcenaro, Alessandro Plebani, Raffaele Badolato, Silvia Parolini, Vassilios Lougaris, Giovanna Tabellini
Summary: DOCK8 deficiency affects the function and expression of NK cells, leading to decreased response to viral infections and impaired migration to lymph nodes.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Giuliana Giardino, Cinzia Milito, Vassilios Lougaris, Alessandra Punziano, Maria Carrabba, Francesco Cinetto, Riccardo Scarpa, Rosa Maria Dellepiane, Silvia Ricci, Beatrice Rivalta, Francesca Conti, Antonio Marzollo, Davide Firinu, Emilia Cirillo, Gianluca Lagnese, Caterina Cancrini, Baldassare Martire, Maria Giovanna Danieli, Andrea Pession, Angelo Vacca, Chiara Azzari, Giovanna Fabio, Annarosa Soresina, Carlo Agostini, Giuseppe Spadaro, Raffaele Badolato, Maria Pia Cicalese, Alessandro Aiuti, Alessandro Plebani, Isabella Quinti, Claudio Pignata
Summary: COVID-19 manifestations and outcomes in patients with inborn errors of immunity are still debated. In this retrospective study, the Italian Primary Immunodeficiencies Network (IPINet) described the experience of 114 patients. The most common immunodeficiencies were 22q11.2 deletion syndrome in children and common variable immunodeficiency in adults. Hospitalization rate was higher in older patients and those with chronic lung disease.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Emilia Cirillo, Agata Polizzi, Annarosa Soresina, Rosaria Prencipe, Giuliana Giardino, Caterina Cancrini, Andrea Finocchi, Beatrice Rivalta, Rosa M. Dellepiane, Lucia A. Baselli, Davide Montin, Antonino Trizzino, Rita Consolini, Chiara Azzari, Silvia Ricci, Lorenzo Lodi, Isabella Quinti, Cinzia Milito, Lucia Leonardi, Marzia Duse, Maria Carrabba, Giovanna Fabio, Patrizia Bertolini, Paola Coccia, Irene D'Alba, Andrea Pession, Francesca Conti, Marco Zecca, Claudio Lunardi, Manuela Lo Bianco, Santiago Presti, Laura Sciuto, Roberto Micheli, Dario Bruzzese, Vassilios Lougaris, Raffaele Badolato, Alessandro Plebani, Luciana Chessa, Claudio Pignata
Summary: This study investigated the disease characteristics and genotype-phenotype correlation in an Italian cohort of AT patients and found that lymphopenia and specific genotypes are associated with poorer clinical outcomes.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Manuela Cortesi, Annarosa Soresina, Laura Dotta, Chiara Gorio, Marco Cattalini, Vassilios Lougaris, Fulvio Porta, Raffaele Badolato
Summary: Autoimmune cytopenias in IEI typically have a more severe and chronic course, and genetic characterization is crucial for early diagnosis and targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Chiara Mameli, Marina Picca, Roberto Buzzetti, Maria Elisabetta Pace, Raffaele Badolato, Claudio Cravidi, Gian Vincenzo Zuccotti, Paola Marchisio
Summary: This study aimed to estimate the incidence of acute respiratory tract infections (ARTIs) in children aged 0-5 years in an outpatient setting. The results showed that infants aged 1-12 months had the highest incidence rate. The COVID-19 pandemic significantly reduced the incidence of ARTIs.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Meeting Abstract
Allergy
S. Rossi, M. Baronio, G. Tessarin, L. Gazzurelli, R. Badolato, G. Tabellini, S. Parolini, A. Plebani, V Lougaris