Review
Immunology
Muhammad S. Soyfoo, Charles Nicaise
Summary: IL-33 plays a crucial role in Sjogren's syndrome by contributing to inflammation and interacting with other cytokines to exacerbate the disease progression.
AUTOIMMUNITY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Julie Sarrand, Muhammad Soyfoo
Summary: IL-33 is a newly discovered cytokine that acts as an alarmin to alert the innate immune system following cell death or necrosis. It has been found to be significantly upregulated in patients with SLE and lupus nephritis, suggesting its involvement in the pathology of SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Olav Sundnes, William Ottestad, Camilla Schjalm, Peter Lundback, Lars la Cour Poulsen, Tom Eirik Mollnes, Guttorm Haraldsen, Torsten Eken
Summary: This study observed a rapid and transient surge of IL-33 in a subset of critically injured patients, with more widespread tissue injuries and early coagulopathy. IL-33 displayed a half-life of 1.4 hours, while its decoy receptor sST2 showed a distinctly different pattern.
MOLECULAR MEDICINE
(2021)
Article
Critical Care Medicine
Daniel P. Cook, Christopher M. Thomas, Ashley Y. Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N. Gibson-Corley, Vasiliy V. Polosukhin, Allison E. Norlander, Dawn C. Newcomb, David A. Stoltz, R. Stokes Peebles
Summary: Type 2 inflammation is observed in cystic fibrosis patients. This study reveals that CFTR deficiency leads to increased expression and release of IL-33, and deletion of IL-33 reduces allergen-induced inflammation in the CF lung.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Federico Perez, Carolina Nayme Ruera, Emanuel Miculan, Paula Carasi, Fernando Gabriel Chirdo
Summary: The small intestine has a high rate of cell turnover, which further increases in response to infection or damage; Celiac disease is the most prevalent immune-based enteropathy, potentially involving pro-inflammatory pathways of programmed cell death and contributing to the disease through the release of alarmins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Corine Glineur, Ines Leleu, Sylviane Pied
Summary: Interleukin-33 (IL-33) plays a critical role in cerebral malaria and its signaling pathway may affect the permeability of brain and cerebrospinal barriers. IL-33 serum levels are higher in children with severe Plasmodium falciparum malaria and correlate with parasite load.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Melvin Zhang, Jennifer L. Duffen, Karl H. Nocka, Marion T. Kasaian
Summary: IL-13 regulates the activity of IL-33 by modulating the transmembrane and soluble forms of ST2, impacting the responsiveness to IL-33. IL-13-deficient mice showed exacerbated effects following IL-33 administration, highlighting the important regulatory role of IL-13 on IL-33.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chih-Feng Kuo, Wei-Yu Chen, Hai-Han Yu, Yu-Hsuan Tsai, Ya-Chu Chang, Chih-Peng Chang, Nina Tsao
Summary: The IL-33/ST2 axis was found to provide protective effect against Group A Streptococcus infection by enhancing innate immunity through promoting neutrophil migration and bactericidal activity. The absence of IL-33/ST2 axis led to increased mortality, more severe skin lesions, and higher bacterial loads in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Janani Panneerselvam, Venkateshwar Madka, Rajani Rai, Katherine T. Morris, Courtney W. Houchen, Parthasarathy Chandrakesan, Chinthalapally V. Rao
Summary: The Western-style diet high in fat is a major cause of obesity and increased risk of colon cancer, with inflammatory molecules playing a key role in the connection between obesity and colon tumorigenesis. IL-23 is significant in the impact of a Western-style diet on obesity, gut microbiome, and colon tumorigenesis, suggesting it as a potential target for prevention and treatment. Pro-inflammatory eicosanoids and gut bacterial toxins facilitate IL-23 production, which is crucial in the progression of obesity-associated colon tumors.
Article
Immunology
Fan Deng, Jing-Juan Hu, Xiao Yang, Qi-Shun Sun, Ze-Bin Lin, Bing-Cheng Zhao, Zhi-Wen Yao, Si-Dan Luo, Ze-Ling Chen, Ying Liu, Zheng-Zheng Yan, Cai Li, Wei-Feng Liu, Ke-Xuan Liu
Summary: The study demonstrates that pravastatin can attenuate intestinal I/R injury by promoting the release of IL-13 from ILC2s, revealing a novel mechanism and therapeutic strategy for intestinal I/R injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Carolina N. Ruera, Emanuel Miculan, Federico Perez, Geronimo Ducca, Paula Carasi, Fernando G. Chirdo
Summary: Intestinal epithelial cells have rapid turnover and are maintained by different forms of cell death mechanisms. In inflammation, p31-43 can activate multiple cell death pathways, including apoptosis, pyroptosis, and necroptosis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mourad Azzout, Celine Dietrich, Francois Machavoine, Pauline Gastineau, Alix Bottier, Guillaume Lezmi, Maria Leite-de-Moraes
Summary: IL-33 combined with IL-12 can directly target MAIT cells to induce their activation and cytokine production. This novel mechanism of IL-33 activation provides insight into the mode of action by which human MAIT cells can promote inflammatory responses in a TCR-independent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Adithap Hansakon, Siranart Jeerawattanawart, Pornpimon Angkasekwinai
Summary: The cytokines IL-33 and IL-25, derived from epithelial cells, play important roles in driving type-2 inflammation during C. neoformans infection. However, the impact of these cytokines in regulating host T helper cell response during C. neoformans infection is still unclear. Our study showed that C. neoformans infection promoted an increase in T helper cells co-expressing IL-25 and IL-33 receptors in the lung during the late infection phase. Transcriptomic analysis revealed a cooperative effect of IL-25 and IL-33 in promoting IL-13 gene expression in effector T helper cells.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Diana Boraschi
Summary: Interleukin-1 (IL-1) is a cytokine that plays a significant role in inflammation and immune response, primarily produced by macrophages during defensive reactions. It belongs to a superfamily of structurally similar proteins and acts through binding to specific receptors on the plasma membrane of target cells. IL-1 family cytokines not only have innate immune and inflammatory effects but also appear to be involved in the development of adaptive immunity in vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qiyun Ma, Yan Qian, Jingxian Jiang, Jingjing Wu, Meijuan Song, Xinyu Li, Zhongqi Chen, Zhengxia Wang, Ranran Zhu, Zhixiao Sun, Mao Huang, Ningfei Ji, Mingshun Zhang
Summary: The IL-33/ST2 axis may play a protective role in neutrophil-dominant allergic airway inflammation, and deficiencies in IL-33 and ST2 can lead to excessive production of neutrophilic chemokines, exacerbating the severity of allergic inflammation in the lungs.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Rheumatology
Isabel Castro, Nicolas Albornoz, Sergio Aguilera, Maria-Jose Barrera, Sergio Gonzalez, Matilde Nunez, Patricia Carvajal, Daniela Jara, Carolina Lagos, Claudio Molina, Ulises Urzua, Marcela A. Hermoso, Maria-Julieta Gonzalez
Article
Biochemistry & Molecular Biology
Fernando Ezquer, Maria Elena Quintanilla, Francisco Moya-Flores, Paola Morales, Jose Manuel Munita, Belen Olivares, Glauben Landskron, Marcela A. Hermoso, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel
Summary: The study found that the mechanisms that normally limit heavy drinking are inhibited in alcohol-preferring animals, possibly due to gut microbiota. The vagus nerve plays a key role in regulating alcohol intake and rewarding effects. Bilateral vagotomy significantly reduces alcohol intake, while antibiotic treatment partially reduces the preference for sweet taste in alcohol-preferring rats.
Review
Biochemistry & Molecular Biology
Naschla Gasaly, Marcela A. Hermoso, Martin Gotteland
Summary: Butyrate plays a crucial role in maintaining the stability of the digestive ecosystem and reducing inflammation in both health and inflammatory bowel diseases. However, patients with IBD often show lower levels of butyrate-producing bacteria and butyrate content, leading to dysbiosis and impaired barrier function in the gut.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Michelle Hanus, Daniela Parada-Venegas, Glauben Landskron, Ana Maria Wielandt, Claudia Hurtado, Karin Alvarez, Marcela A. Hermoso, Francisco Lopez-Kostner, Marjorie De la Fuente
Summary: Colorectal cancer (CRC) is a common multifactorial disease influenced by genetic and environmental factors. The tumor microenvironment plays a crucial role in promoting or inhibiting tumor progression, making it a key target for cancer control.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jarupa Soongsathitanon, Pranisa Jamjuntra, Nuttavut Sumransub, Supaporn Yangngam, Marjorie De la Fuente, Glauben Landskron, Peti Thuwajit, Marcela A. Hermoso, Chanitra Thuwajit
Summary: Signals from the tumor microenvironment can influence cancer progression significantly, with immune cells and CAFs playing crucial roles in modulating tumor growth. The interaction between CAFs and tumor-infiltrating immune cells may serve as a potential therapeutic target for regulating the immunosuppressive microenvironment in breast cancer.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Review
Immunology
Naschla Gasaly, Paul de Vos, Marcela A. Hermoso
Summary: The diverse and dynamic microbial community of the human gastrointestinal tract plays a vital role in supporting the development and function of the gut immune barrier. Microbiota-derived metabolites are crucial mediators of host-microbial interactions and can regulate inflammation and immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Nayaret Chamorro, David A. Montero, Pablo Gallardo, Mauricio Farfan, Mauricio Contreras, Marjorie De la Fuente, Karen Dubois, Marcela A. Hermoso, Rodrigo Quera, Marjorie Pizarro-Guajardo, Daniel Paredes-Sabja, Daniel Ginard, Ramon Rossello-Mora, Roberto Vidal
Summary: The study found that patients with inflammatory bowel diseases (IBDs) have dysbiosis characterized by an increase in pro-inflammatory bacteria and a decrease in beneficial bacteria. The development of the disease is related to alterations in the gut microbiota, but the mechanisms are not fully understood. The research also identified a panel of bacterial biomarkers that can distinguish between a healthy gut microbiota and dysbiosis with high accuracy, which could be used for developing non-invasive diagnostic methods.
Article
Immunology
Paulina Garcia-Gonzalez, Fabian Tempio, Camila Fuentes, Consuelo Merino, Leonardo Vargas, Valeska Simon, Mirliana Ramirez-Pereira, Veronica Rojas, Eduardo Tobar, Glauben Landskron, Juan Pablo Araya, Mariela Navarrete, Carla Bastias, Rocio Tordecilla, Macarena A. Varas, Pablo Maturana, Andres E. Marcoleta, Miguel L. Allende, Rodrigo Naves, Marcela A. Hermoso, Flavio Salazar-Onfray, Mercedes Lopez, Maria Rosa Bono, Fabiola Osorio
Summary: This study reveals distinct immunological dynamics in severe COVID-19 patients, with increased frequencies of certain immune cellular subsets and SARS-CoV-2-specific antibodies. Patients requiring invasive mechanical ventilation show a unique immune response compared to those on high flow oxygen nasal cannula. Recovered patients begin to regain normal immune cell proportions after 100 days and maintain high levels of SARS-CoV-2-specific IgG, indicating immunological memory.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Guillermo Schmeda-Hirschmann, Alberto Burgos-Edwards, Antonieta Rojas de Arias, Camila Lopez-Torres, Charlotte Palominos, Sebastian Fuentes-Retamal, Yarela Herrera, Karen Dubois-Camacho, Felix A. Urra
Summary: This study analyzed a traditional recipe used by the Mbya culture in Paraguay to treat cancer with the native toad Rhinella schneideri. The composition of the recipe was determined and its effects on human breast cancer cells were evaluated. The results showed that the recipe contains various metabolites, including alkaloids and bufadienolide derivatives. The recipe did not have cytotoxic effects on breast cancer cells, but it increased mitochondrial bioenergetics and inhibited cell migration.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Glauben Landskron, Karen Dubois-Camacho, Octavio Orellana-Serradell, Marjorie De la Fuente, Daniela Parada-Venegas, Mirit Bitran, David Diaz-Jimenez, Shuang Tang, John A. Cidlowski, Xiaoling Li, Hector Molina, Carlos M. Gonzalez, Daniela Simian, Jaime Lubascher, Victor Pola, Martin Montecino, Tjasso Blokzijl, Klaas Nico Faber, Maria-Julieta Gonzalez, Rodrigo Quera, Marcela A. Hermoso
Summary: This study investigates the relationship between LRH-1 expression and distribution with altered corticosteroid responses in ulcerative colitis (UC) patients. It is found that reduced glucocorticoid receptor (GR)-mediated intestinal steroidogenesis may be related to increased colonic mucosa GR isoform beta (GR beta) content and cytoplasmic LRH-1 levels. The study also suggests LRH-1 as a potential marker for glucocorticoid-impaired response in UC.
Article
Biochemistry & Molecular Biology
Waleska Saitz, David A. Montero, Mirka Pardo, Daniela Araya, Marjorie De la Fuente, Marcela A. Hermoso, Mauricio J. Farfan, Daniel Ginard, Ramon Rossello-Mora, Dave A. Rasko, Felipe Del Canto, Roberto M. Vidal
Summary: The study aimed to identify molecular markers for screening AIEC strains. By analyzing outer membrane proteins and genes in AIEC strains, the study found that chuA, eefC, and fitA genes are significantly correlated with AIEC strains and can serve as markers for AIEC strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jessica Astorga, Naschla Gasaly, Karen Dubois-Camacho, Marjorie de la Fuente, Glauben Landskron, Klaas Nico Faber, Felix A. Urra, Marcela A. Hermoso
Summary: Inflammatory Bowel Disease (IBD) is a disease characterized by a loss of intestinal barrier function due to an abnormal interaction between the immune response and the gut microbiota. Imbalance in cholesterol homeostasis and mitochondrial bioenergetics are key factors in activating the inflammasome-mediated response. The dysmorphic mitochondria in intestinal epithelial cells under inflammatory conditions promote metabolic shifts towards glycolysis and down-regulation of antioxidant signaling. Dietary phytochemicals have a therapeutic potential in restoring intestinal metabolism and function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Denise Montt-Blanchard, Raimundo Sanchez, Karen Dubois-Camacho, Jaime Leppe, Maria Teresa Onetto
Summary: This study compared the glycemic variability and exercise-related diabetic management strategies of adults with type 1 diabetes achieving higher and lower physical activity loads. The results showed that active individuals with diabetes were able to maintain glycemic control within recommended values regardless of activity loads, but had a higher prevalence of hypoglycemia during nighttime and used fewer post-activity management strategies.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Oncology
Supaporn Yangngam, Suyanee Thongchot, Ananya Pongpaibul, Kulthida Vaeteewoottacharn, Somchai Pinlaor, Peti Thuwajit, Seiji Okada, Marcela A. Hermoso, Chanitra Thuwajit