Article
Nanoscience & Nanotechnology
Zhaoyan Zhao, Yuchen Xiao, Lingqing Xu, Ye Liu, Guanmin Jiang, Wei Wang, Bin Li, Tianchuan Zhu, Qingqin Tan, Lantian Tang, Haibo Zhou, Xi Huang, Hong Shan
Summary: COVID-19 is a worldwide pandemic characterized by massive morbidity and mortality, with uncontrolled inflammatory processes playing a significant role in fatalities. Glycyrrhizic acid nanoparticles show potential for inhibiting viral growth and reducing inflammation, with possible applications in treating COVID-19.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Multidisciplinary Sciences
Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sa Guimaraes, Monica Beatriz Mathor, Patricia dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira, Durvanei Augusto Maria, Silas Fernandes Eto, Neuza Maria Frazatti Gallina, Giselle Pidde, Carla Cristina Squaiella-Baptistao, Dilza Trevisan Silva, Isadora Maria Villas-Boas, Dayanne Carla Fernandes, Aline Vivian Vatti Auada, Alexandre Campos Banari, Antonio Francisco de Souza Filho, Camila Bianconi, Carla Lilian de Agostini Utescher, Denise Cristina Andre Oliveira, Douglas Oscar Ceolin Mariano, Flavia Ferreira Barbosa, Giuliana Rondon, Josana Kapronezai, Juliana Galvao da Silva, Mauricio Barbugiani Goldfeder, Priscila Comone, Regis Edgar Castilho Junior, Taiana Taina Silva Pereira, Fan Hui Wen, Denise Tambourgi, Ana Marisa Chudzinski-Tavassi
Summary: The new outbreak of COVID-19 has caused millions of deaths worldwide. Efforts are being made to find effective treatments, such as using immunoglobulin from immunized animals or plasma from convalescent patients. Clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with spike protein are underway. Researchers have developed an anti-SARS-CoV-2 equine F(ab ')(2) immunoglobulin that successfully neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster model of SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Bhaswati Chatterjee, Suman S. Thakur
Summary: The SARS-CoV-2 infection triggers phosphorylation in both host and virus, and affects multiple kinases and signaling pathways. This provides potential therapeutic targets for anti-COVID-19 drug discovery.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Lu Xia, Yujing Shi, Jie Su, Thomas Friedemann, Zhenggang Tao, Yunfei Lu, Yun Ling, Ying Lv, Ronghua Zhao, Zihan Geng, Xiaolan Cui, Hongzhou Lu, Sven Schroeder
Summary: The study demonstrated that Shufeng Jiedu capsules have antiviral and anti-inflammatory properties, significantly reducing virus load and inflammatory factors in COVID-19 patients while increasing immune cell levels. Clinical data showed that SFJDC therapy was most effective when initiated within the first 8 days after symptom onset.
Review
Biochemistry & Molecular Biology
Junyi Zhao, Xiafan Xu, Yifei Gao, Yijing Yu, Conglei Li
Summary: This review discusses the potential mechanisms underlying the increased thrombotic events and altered platelet count and activity in COVID-19. The researchers propose several potential antiviral strategies that platelets might undertake and discuss platelet-targeted therapeutic strategies in controlling COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Xixi Jing, Min Xu, Deye Song, Tingting Yue, Yali Wang, Pan Zhang, Yanjun Zhong, Min Zhang, Tommy Tsan-Yuk Lam, Nuno Rodrigues Faria, Erik De Clercq, Guangdi Li
Summary: Early elevated levels of cytokines like IL-6 are associated with high titers of IgG antibodies against COVID-19.
Article
Multidisciplinary Sciences
Chiara Ronchini, Sara Gandini, Sebastiano Pasqualato, Luca Mazzarella, Federica Facciotti, Marina Mapelli, Gianmaria Frige', Rita Passerini, Luca Pase, Silvio Capizzi, Fabrizio Mastrilli, Roberto Orecchia, Gioacchino Natoli, Pier Giuseppe Pelicci
Summary: In this study, we found that the probability of infection post-vaccination is significantly lower compared to natural infection, and the duration of infection is shorter. These findings are negatively correlated with circulating antibody levels.
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yi-Hao Chan, Siew-Wai Fong, Chek-Meng Poh, Guillaume Carissimo, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Yun Shan Goh, Jackwee Lim, Weili Xu, Rhonda Sin-Ling Chee, Anthony Torres-Ruesta, Cheryl Yi-Pin Lee, Matthew Zirui Tay, Zi Wei Chang, Wen-Hsin Lee, Bei Wang, Seow-Yen Tan, Shirin Kalimuddin, Barnaby Edward Young, Yee-Sin Leo, Cheng- Wang, Bernett Lee, Olaf Rotzschke, David Chien Lye, Laurent Renia, Lisa F. P. Ng
Summary: This study comprehensively characterized the immune responses of asymptomatic COVID-19 patients, finding that they exhibit stronger protective mechanisms, lower levels of pro-inflammatory responses, and more effective immune responses compared to symptomatic patients. Additionally, asymptomatic patients had higher levels of growth factors associated with cellular repair in their bodies.
EMBO MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Makoto Hiki, Yoko Tabe, Tomohiko Ai, Yuya Matsue, Norihiro Harada, Kiichi Sugimoto, Yasushi Matsushita, Masakazu Matsushita, Mitsuru Wakita, Shigeki Misawa, Mayumi Idei, Takashi Miida, Naoto Tamura, Kazuhisa Takahashi, Toshio Naito
Summary: Serologic anti-SARS-CoV-2 antibody analysis can complement PCR for diagnosing COVID-19, especially within 14 days after symptom onset. Patients with severe symptoms showed higher IgG and IgM antibody positivity within 1 week of symptom onset, while mild to moderate cases had higher positivity rates between 1-2 weeks after symptom onset.
Article
Immunology
Mark B. Salzman, Cheng-Wei Huang, Christopher M. O'Brien, Rhina D. Castillo
Summary: This report discusses 3 cases of patients in California who experienced multisystem inflammatory syndrome (MIS) after receiving vaccination and being infected with SARS-CoV-2. It also mentions 3 cases of adults who were not vaccinated developing MIS during a period when around 7% of the adult population had received at least one vaccine.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Hidetsugu Fujigaki, Masato Inaba, Michiko Osawa, Saya Moriyama, Yoshimasa Takahashi, Tadaki Suzuki, Kenya Yamase, Yukihiro Yoshida, Yo Yagura, Takayoshi Oyamada, Masao Takemura, Yohei Doi, Kuniaki Saito
Summary: This study investigated the kinetics and neutralizing activity of various Ag-specific Ab isotypes against SARS-CoV-2 in serum of COVID-19 patients, with IgG against RBD showing the best correlation with virus-neutralizing activity. The results provide valuable information for the selection of serological tests for seroprevalence and vaccine evaluation studies.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Virology
Angela Huynh, Donald M. Arnold, James W. Smith, Jane C. Moore, Ali Zhang, Zain Chagla, Bart J. Harvey, Hannah D. Stacey, Jann C. Ang, Rumi Clare, Nikola Ivetic, Vasudhevan T. Chetty, Dawn M. E. Bowdish, Matthew S. Miller, John G. Kelton, Ishac Nazy
Summary: COVID-19 is a global pandemic caused by SARS-CoV-2. The study found that anti-SARS-CoV-2 antibodies were detected in recovered individuals up to 180 days post-symptom onset, indicating a humoral immune response to the virus. Serological surveys are important for assessing population-level immunity based on RT-PCR-determined infection numbers.
Article
Cardiac & Cardiovascular Systems
Vera Paar, Bernhard Wernly, Zhichao Zhou, Lukas J. Motloch, Uta C. Hoppe, Alexander Egle, Michael Lichtenauer
Summary: The study found that autologous serum and fibrin significantly increased the secretion of cytokines and chemokines, affecting the inflammatory response. Anti-coagulation may be a promising tool for the treatment of COVID-19, helping to reduce cytokine storm and thrombotic complications.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Letter
Rheumatology
Martin Sebastian Winkler, Peter Korsten, Claudia Binder, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell Biology
J. L. Cordeiro, J. D. Neves, F. Nicola, A. F. Vizuete, E. F. Sanches, C. A. Goncalves, C. A. Netto
Summary: In this study, arundic acid (AA) was administered in a collagenase-induced intracerebral hemorrhage (ICH) rodent model, and it was found that AA could prevent motor dysfunction, reduce S100B levels, and decrease astrogliosis and microglial activation, which in turn led to a decrease in the production of proinflammatory cytokines and reactive oxygen species (ROS).
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Bichismita Sahu, Santosh Kumar Behera, Rudradip Das, Tanay Dalvi, Arnab Chowdhury, Bhaskar Dewangan, Kiran Kalia, Amit Shard
Summary: This study designed scaffolds derived from peptide nucleic acid (PNA) and conducted in-silico screening to identify a compound with similar binding affinity to RdRp. Compound 12 showed comparable pharmacokinetics to remdesivir but with significantly lower toxicity, making it a potential candidate for the treatment of COVID-19.
CURRENT COMPUTER-AIDED DRUG DESIGN
(2022)
Article
Oncology
Yi Liao, Senmao Li, Hao Chen, Chunyu Chen, Jintuan Huang, Feng Lin, Jianping Wang, Zuli Yang
Summary: A risk prediction system combining FIT and risk factors was developed to improve the sensitivity of colonoscopy screening. The system effectively stratified participants into high risk and low risk groups, with better predictive ability for colorectal neoplasia compared to using FIT alone.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente Martin, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia
Summary: This study aimed to examine the association between height and risk of gastric cancer. Through a large pooled analysis of case-control studies, the study found no significant association between adult height and gastric cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Maria A. Karalexi, Marina Servitzoglou, Vassilios Papadakis, Denis Kachanov, Maja Cesen Mazic, Margaret Baka, Maria Moschovi, Maria Kourti, Sofia Polychronopoulou, Eftichia Stiakaki, Emmanuel Hatzipantelis, Helen Dana, Kalliopi Stefanaki, Astero Malama, Marios S. Themistocleous, Katerina Strantzia, Tatyana Shamanskaya, Panagiota Bouka, Paraskevi Panagopoulou, Maria Kantzanou, Evangelia Ntzani, Nick Dessypris, Eleni Th. Petridou
Summary: The prognosis of children with neuroblastoma varies depending on the stage and biology of the tumor, and early-stage neuroblastoma has a better prognosis. Treatment with anti-GD2 antibody can improve the prognosis of high-risk patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Ophthalmology
Massimiliano Serafino, Andrea Lembo, Matteo Scaramuzzi, Andrea Dellavalle, Paolo Nucci
Summary: Pulled-in-two syndrome is a serious complication of strabismus surgery, where an extraocular muscle is ruptured. Transposition of the inferior oblique muscle can be a potential technique for treatment if the muscle cannot be retrieved.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jin Kyun Oh, Yan Nuzbrokh, Winston Lee, Jose Ronaldo Lima de Carvalho, Nan Kai Wong, Janet Sparrow, Rando Alliikmets, Stephen H. Tsang
Summary: This case report describes two brothers with progressive vision loss and night blindness, showing typical symptoms of pigmented paravenous retinochoroidal atrophy. Genetic analysis revealed a mutation in the CRX gene in both individuals.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Psychology, Clinical
L. A. Rescorla, M. Y. Ivanova, T. M. Achenbach, Vera Almeida, Meltem Anafarta-Sendag, Ieva Bite, J. Carlos Caldas, John William Capps, Yi-Chuen Chen, Paola Colombo, Margareth da Silva Oliveira, Anca Dobrean, Nese Erol, Alessandra Frigerio, Yasuko Funabiki, Reda Gedutiene, Halldor S. Guomundsson, Min Quan Heo, Young Ah Kim, Tih-Shih Lee, Manuela Leite, Jianghong Liu, Jasminka Markovic, Monika Misiec, Marcus Mueller, Kyung Ja Oh, Veronica Portillo-Reyes, Wolfgang Retz, Sandra B. Sebre, Shupeng Shi, Sigurveig H. Siguroardottir, Roma Simulioniene, Elvisa Sokoli, Dragana Milijasevic, Ewa Zasepa
Summary: This study compares self-reports and collateral reports of older adults' mental health across 19 societies, finding that the OASR and OABCL are efficient assessments that can be used internationally to screen for various problems and strengths.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Nikhil Maroli, Balu Bhasuran, Jeyakumar Natarajan, Ponmalai Kolandaivel
Summary: This study utilized text mining and named entity recognition methods to identify the co-occurrence of important COVID 19 genes/proteins in the interaction network. Molecular docking and molecular dynamics simulation revealed the inhibition mechanism of key proteins and confirmed the affinity of procyanidin towards critical receptors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Public, Environmental & Occupational Health
Anya P. G. F. Vieira-Meyer, Maira B. Coutinho, Helena P. G. Santos, Maria Saintrain, George T. de M. Candeiro
Summary: This study investigated the knowledge and practice of Brazilian public primary and secondary health care dentists during the COVID-19 pandemic. The majority of these dentists believed in the transmission of COVID-19 through dental procedures, but had a fair level of knowledge about COVID-19 symptoms. There was skepticism about the effectiveness of personal protective equipment and biosafety procedures in preventing COVID-19 transmission. Factors such as country region, social distancing, dental specialty, and the use of protective measures influenced the likelihood of dentists performing dental treatment during the pandemic. The study concludes that additional preventive measures and internationally accepted guidelines are needed to address the challenges brought by COVID-19.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Review
Clinical Neurology
Christoph Eckhard Heyde, Ulrich Josef Albert Spiegl, Anna Voelker, Nicolas von der Hoeh, Jeanette Henkelmann
Summary: The prevalence of nonspecific pyogenic spondylodiskitis has increased, causing high morbidity and mortality. The diagnosis is often delayed due to nonspecific clinical manifestations at the early stage. CT can assess the bony condition, while MRI is still the gold standard for diagnosis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Review
Endocrinology & Metabolism
Kirti Baraskar, Pratibha Thakur, Renu Shrivastava, Vinoy K. Shrivastava
Summary: The SARS CoV-2 virus uses the ACE-2 receptor to enter host cells and infect pulmonary, renal, and cardiac tissues. The Delta and Omicron variants have mutations in the spike protein RBD region, which result in increased interaction with the ACE-2 receptor. The Omicron variant has a higher binding affinity to the receptor compared to the Delta variant.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Endocrinology & Metabolism
Kirti Baraskar, Pratibha Thakur, Renu Shrivastava, Vinoy Kumar Shrivastava
Summary: This study aimed to investigate the effects of the antidote gallic acid (GA) on expression-related changes in GLUT-4 and IRS-1 in the visceral adipose tissue and on the subsequent development of insulin resistance in a high-fat diet (HFD)-induced obesity animal model. The results showed that GA administration significantly improved serum triglycerides, cholesterol, and LDL cholesterol levels in HFD mice. In the visceral adipose tissue of the HFD + GA experimental group, GA improved the serum antioxidative profile and upregulated mRNA expression of GLUT-4 and IRS-1.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2023)
Article
Rehabilitation
Danielle Brasil-Barros-da-Silva, Emerson Fachin-Martins
Summary: This study aimed to explore the association between the usage of forearm crutches and pain complaints and health conditions. The study found different patterns of pain complaints between permanent and temporary users, with temporary female users more likely to be injured due to external causes. Additionally, both types of users reported varying levels of pain, with only permanent users reporting mild pain.
ASSISTIVE TECHNOLOGY
(2022)
