Review
Biochemistry & Molecular Biology
Chia-Chun Tseng, Ya-Wen Sung, Kuan-Yu Chen, Pin-Yi Wang, Chang-Yi Yen, Wan-Yu Sung, Cheng-Chin Wu, Tsan-Teng Ou, Wen-Chan Tsai, Wei-Ting Liao, Chung-Jen Chen, Su-Chen Lee, Shun-Jen Chang, Jeng-Hsien Yen
Summary: Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a severe manifestation of CTD that leads to significant morbidity and mortality. The disease can occur in diverse CTDs and is characterized by various histologic patterns. Abnormal immune system responses, especially in macrophages, play an important role in its pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Manuel Silverio-Antonio, Joana Martins-Martinho, Ana Teresa Melo, Francisca Guimaraes, Eduardo Dourado, Daniela Oliveira, Jorge Lopes, Andre Saraiva, Ana Gago, Margarida Correia, Ana L. Fernandes, Sara Dinis, Rafaela Teixeira, Susana P. Silva, Carlos Costa, Tiago Beirao, Carolina Furtado, Pedro Abreu, Carmo Afonso, Nikita Khmelinskii
Summary: This retrospective study aimed to identify predictors of interstitial lung disease (ILD) in patients with mixed connective tissue disease (MCTD). The study found that gastroesophageal involvement and lymphadenopathy at disease onset were associated with ILD. Additionally, it established that lymphadenopathy at disease onset and older age at diagnosis independently predicted ILD in MCTD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Linrui Xu, Faping Wang, Fengming Luo
Summary: The meta-analysis study indicated that rituximab (RTX) has higher improvement and stable rates for CTD-ILD, especially for ASS-ILD and non-ASS IIM-ILD. Although RTX has a satisfactory safety profile, further randomized trials are needed to evaluate its efficacy compared to other treatments for CTD-ILD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takuya Kotani, Masaki Ikemoto, Shogo Matsuda, Ryota Masutani, Tohru Takeuchi
Summary: In this study, it was found that the hybrid protein hMIKO-1 can suppress the abnormal activation of macrophages, reduce lung fibrosis in mice, and decrease the expression of related inflammation factors, indicating its potential as a therapeutic candidate for ILD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Hideaki Yamakawa, Tamiko Takemura, Shintaro Sato, Makiko Takatsuka, Hiroki Ohta, Tomotaka Nishizawa, Tomohiro Oba, Rie Kawabe, Keiichi Akasaka, Masanobu Horikoshi, Masako Amano, Kazuyoshi Kuwano, Hidekazu Matsushima
Summary: This study evaluated the utility of TBLC in determining therapeutic decision-making strategies for CTD-ILD patients. The results showed that TBLC can help determine an appropriate medication strategy, especially when UIP-like lesions are present. Additionally, the additional information provided by TBLC may be beneficial when considering early intervention and selecting anti-fibrotic agents.
BMC PULMONARY MEDICINE
(2023)
Article
Rheumatology
Goncalo Boleto, Silje Reiseter, Anna-Maria Hoffmann-Vold, Adrien Mirouse, Patrice Cacoub, Marco Matucci-Cerinic, Manuel Silverio-Antonio, Joao Eurico Fonseca, Ana Catarina Duarte, Jorge Pestana Lopes, Valeria Riccieri, Alain Lescoat, Erwan Le Tallec, Ivan Castellvi Barranco, Jose Luis Tandaipan, Paolo Airo, Masataka Kuwana, Hoda Kavosi, Jerome Avouac, Yannick Allanore
Summary: This study compared predictive factors for interstitial lung disease (ILD) in patients with mixed connective tissue disease (MTCD) and found different factors associated with ILD. The study also found that MCTD-ILD patients have increased mortality and that digital ulcers (DU) are associated with progressive lung disease.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Immunology
Nan-shu Xing, Guan-zhi Fan, Fei Yan, Yi-ping Liu, Rong Zhang
Summary: The efficacy and safety of RTX in CTD-ILD patients were systematically evaluated, showing RTX's superiority over conventional treatments, especially in improving forced vital capacity and MRSS in systemic sclerosis patients. RTX is able to improve or stabilize pulmonary function in CTD-ILD patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Willis S. Bowman, Gabrielle A. Echt, Justin M. Oldham
Summary: Interstitial lung disease (ILD) is a group of diverse lung disorders that can lead to irreversible pulmonary fibrosis. While idiopathic pulmonary fibrosis (IPF) is a common subtype, other ILD patients may develop a progressive fibrosing phenotype. Biomarker investigation has identified molecular markers that can predict disease endpoints, suggesting potential for biomarker implementation in ILD management.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Hakeem Olaosebikan, Olufunke Adeyeye, Richard Akintayo, Akpabio Akpabio, Ajibade Adenitan, Olufemi Adelowo, Olufemi Ojo, Fasan-Odunsi Abimbola
Summary: This study conducted a retrospective survey of CTD-ILD patients in Lagos, finding a relatively low prevalence of 9.7% with a predominance of female patients. Common clinical features included cough and crackles, and treatments involved medications and oxygen therapy, with some patients at risk for mortality.
CLINICAL RHEUMATOLOGY
(2021)
Article
Surgery
Amelie Riviere, Clement Picard, Cristina Berastegui, Victor Manuel Mora, Vincent Bunel, Laurent Godinas, Elena Salvaterra, Valeria Rossetti, Laurent Savale, Dominique Israel-Biet, Xavier Demant, Julien Bermudez, Federica Meloni, Peter Jaksch, Jesper Magnusson, Laurence Beaumont, Michael Perch, Jean-Francois Mornex, Christiane Knoop, John-David Aubert, Baptiste Hervier, Hilario Nunes, Marc Humbert, Jens Gottlieb, Yurdagul Uzunhan, Jerome Le Pavec
Summary: This study aimed to evaluate the survival rate and prognostic factors in lung transplant recipients with interstitial lung disease complicating idiopathic inflammatory myopathy (IIM-ILD). The study found that the post-transplant survival rate in IIM-ILD was similar to that in international all-cause transplantation registries and worse in patients with classical IIM. Muscle involvement was identified as the main factor associated with worse survival.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Immunology
Tihong Shao, Xiaodong Shi, Shanpeng Yang, Wei Zhang, Xiaohu Li, Jingwei Shu, Shehabaldin Alqalyoobi, Amir A. Zeki, Patrick S. Leung, Zongwen Shuai
Summary: CTD-related interstitial lung disease (CTD-ILD) is a major cause of morbidity and mortality, characterized by heterogeneity and complexity in clinical manifestations. The disease involves chronic inflammation of blood vessels and connective tissues, affecting multiple organ systems. Diagnosis and management of CTD-ILD require comprehensive assessment and precision medicine strategies due to its varied clinical course and etiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
David Roofeh, Kevin K. Brown, Ella A. Kazerooni, Donald Tashkin, Shervin Assassi, Fernando Martinez, Athol U. Wells, Ganesh Raghu, Christopher P. Denton, Lorinda Chung, Anna-Maria Hoffmann-Vold, Oliver Distler, Kerri A. Johannson, Yannick Allanore, Eric L. Matteson, Leticia Kawano-Dourado, John D. Pauling, James R. Seibold, Elizabeth R. Volkmann, Simon L. F. Walsh, Chester Oddis, Eric S. White, Shaney L. Barratt, Elana J. Bernstein, Robyn T. Domsic, Paul F. Dellaripa, Richard Conway, Ivan Rosas, Nitin Bhatt, Vivien Hsu, Francesca Ingegnoli, Bashar Kahaleh, Puneet Garcha, Nishant Gupta, Surabhi Khanna, Peter Korsten, Celia Lin, Stephen C. Mathai, Vibeke Strand, Tracy J. Doyle, Virginia Steen, Donald F. Zoz, Juan Ovalles-Bonilla, Ignasi Rodriguez-Pinto, Padmanabha D. Shenoy, Andrew Lewandoski, Elizabeth Belloli, Alain Lescoat, Vivek Nagaraja, Wen Ye, Suiyuan Huang, Toby Maher, Dinesh Khanna
Summary: This study aimed to establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). The results showed that using the proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression and progression over time.
Article
Medicine, General & Internal
Yunqi Bao, Wei Zhang, Dandan Shi, Weili Bai, Dongdong He, Dan Wang
Summary: This study aimed to explore the relationship between serum tumor markers and CTD-ILD, and evaluate the clinical value of tumor markers in investigating ILD in CTD patients. Higher levels of CA153 and CYFRA21-1 were associated with an increased risk of developing CTD-ILD, indicating their potential use as biomarkers for detecting CTD-ILD in clinical practice.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshiharu Ohno, Kota Aoyagi, Daisuke Takenaka, Takeshi Yoshikawa, Aina Ikezaki, Yasuko Fujisawa, Kazuhiro Murayama, Hidekazu Hattori, Hiroshi Toyama
Summary: The study found that ML-based CT texture analysis software has the potential to improve interobserver agreement and accuracy for radiological finding assessments in patients with COPD, interstitial lung diseases or infectious diseases.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jongmin Lee, Kyuhwan Kim, Yong Suk Jo
Summary: This study compared the prevalence and clinical characteristics of progressive pulmonary fibrosis (PPF) in patients with connective tissue disease (CTD) related interstitial lung disease (ILD) according to different diagnostic criteria. The results showed that the prevalence of PPF varied depending on the diagnostic criteria used, but there was no difference in clinical characteristics.
RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Shirley Cohen-Mekelburg, Beth I. Wallace, Tony Van, Wyndy L. Wiitala, Shail M. Govani, Jennifer Burns, Rachel Lipson, Huifeng Yun, Jason Hou, James D. Lewis, Jason A. Dominitz, Akbar K. Waljee
Summary: This study in a national cohort of veterans examined the association between the use of anti-TNF or corticosteroids and all-cause mortality in patients with IBD. Results suggest that anti-TNF therapy may be linked to reduced mortality compared with prolonged corticosteroid use, particularly among patients with Crohn disease.
Article
Rheumatology
Beth Wallace, Meriah N. Moore, Andrew C. Heisler, Lutfiyya N. Muhammad, Jing Song, Daniel J. Clauw, Clifton O. Bingham, Marcy B. Bolster, Wendy Marder, Tuhina Neogi, Alyssa Wohlfahrt, Dorothy D. Dunlop, Yvonne C. Lee
Summary: High fibromyalgianess is associated with persistent glucocorticoid use independent of inflammatory activity. Participants with high/very high baseline fibromyalgianess were more likely to be taking prednisone at follow-up relative to those with low fibromyalgianess.
Article
Ophthalmology
Lindsey B. De Lott, Chun Chieh Lin, James F. Burke, Beth Wallace, Daniel Saukkonen, Akbar K. Waljee, Kevin A. Kerber
Summary: This retrospective cohort study analyzed insured ON patients in the United States and found that factors such as comorbidities, clinician type, visit number, and region were associated with glucocorticoid use. The study suggests the need for further exploration of the reasons for care variation in ON and patient/clinician preferences to optimize treatment.
OPHTHALMIC EPIDEMIOLOGY
(2023)
Article
Rheumatology
Meriah N. Moore, Beth Wallace, Jing Song, Lutfiyya N. Muhammad, Andrew C. Heisler, Daniel J. Clauw, Marcy B. Bolster, Wendy Marder, Tuhina Neogi, Alyssa Wohlfahrt, Dorothy D. Dunlop, Yvonne C. Lee
Summary: This study aimed to examine the correlation between the self-administered Fibromyalgia Survey Questionnaire (FSQ) and quantitative sensory testing (QST) in patients with rheumatoid arthritis (RA). The results showed a weak correlation between FSQ and QST, indicating that the two measures cannot be used interchangeably.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shirley Cohen-Mekelburg, Tony Van, Beth Wallace, Jeff Berinstein, Xianshi Yu, James Lewis, Jason Hou, Jason A. Dominitz, Akbar K. Waljee
Summary: Although traditional methods show an association between NSAID and IBD exacerbations, further analysis suggests that this may be secondary to residual bias. These findings may reassure patients and clinicians considering NSAID as a nonopioid pain management option.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Rheumatology
Yomei P. Shaw, Sara Hustek, Nina Nguyen, Makenzie Starlin, Kristin Wipfler, Beth I. Wallace, Kaleb Michaud
Summary: Although patients with rheumatic and musculoskeletal diseases are at higher risk of adverse outcomes from COVID-19, their willingness to be vaccinated is low. Concerns about vaccine side effects and worsening of symptoms contribute to vaccine hesitancy. This study aimed to understand the decision-making process of COVID-19 vaccination among patients with rheumatic and musculoskeletal diseases through qualitative analysis of their comments.
Article
Gastroenterology & Hepatology
Shirley Cohen-Mekelburg, Tony Van, Jeffrey A. Berinstein, Xianshi Yu, Deena Kelly Costa, Beth I. Wallace, Sameer Saini, Andrew J. Admon, Peter D. R. Higgins, Ji Zhu, Akbar K. Waljee
Summary: This study examined the association between facility characteristics and the adoption of ustekinumab for inflammatory bowel disease. The results showed that ustekinumab adoption increased over time and was higher in urban facilities with more teamwork. Early adopters were more likely to be high-volume facilities. These findings suggest the importance of targeted dissemination strategies to improve medication uptake and enhance inflammatory bowel disease care.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, Research & Experimental
Beth I. Wallace, Hui-Ju Tsai, Paul Lin, Kristian Aasbjerg, Ann Chen Wu, Yi-Fen Tsai, Christian Torp-Pedersen, Akbar K. Waljee, Tsung-Chieh Yao
Summary: This study investigated and compared the prescription patterns of oral corticosteroids (OCS) in the general populations of the United States, Taiwan, and Denmark from 2009 to 2018. The findings showed a steady increase in OCS use, particularly short-term prescribing to healthy adults, in all three countries.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Rheumatology
Beth I. Wallace, Bryant R. England, Joshua F. Baker, Jorge Rojas, Brian C. Sauer, Punyasha Roul, Gary A. Kunkel, Tawnie J. Braaten, Alison Petro, Ted R. Mikuls, Grant W. Cannon
Summary: In a real-world cohort of chronic glucocorticoid users with rheumatoid arthritis, half successfully tapered and a third discontinued prednisone within 6 months of initiating a new biologic or targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD).
ACR OPEN RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Yomei Shaw, Beth Wallace, Hallie Chabrier, Charlotte Cochrane, Christina Kim, Katherine Taylor, Armaan Patel, Nima Keyvan, Vinayak Swaroop, Nina Nguyen, Sara Hustek, Meriah Moore, Andrew Admon, Kaleb Michaud
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Beth Wallace, Bryant England, Joshua Baker, Gary Kunkel, Tawnie Braaten, Jorge Rojas, Alison Petro, Punyasha Roul, Ted Mikuls, Brian Sauer, Grant Cannon
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Beth Wallace, Yuqing Gao, H. Myra Kim, Punyasha Roul, Ted Mikuls, Daniel Clauw, Bryant England, Joshua Baker, Brian Sauer, Grant Cannon, Shirley Cohen-Mekelberg, Wyndy Wiitala, Jeremy Sussman, Rodney Hayward, Akbar Waljee
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Shirley Cohen-Mekelburg, Tony Van, Beth I. Wallace, Jeffrey Berinstein, Xianshi Yu, James D. Lewis, Jason K. Hou, Jason A. Dominitz, Akbar K. Waljee
Meeting Abstract
Rheumatology
Beth Wallace, Meriah Moore, Andrew Heisler, Lutfiyya Muhammad, Jing Song, Daniel Clauw, Clifton Bingham, Marcy Bolster, Wendy Marder, Tuhina Neogi, Alyssa Wohlfahrt, Dorothy Dunlop, Yvonne Lee
ARTHRITIS & RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
Meriah Moore, Beth Wallace, Jing Song, Lutfiyya Muhammad, Andrew Heisler, Daniel Clauw, Marcy Bolster, Wendy Marder, Tuhina Neogi, Alyssa Wohlfahrt, Dorothy Dunlop, Yvonne Lee
ARTHRITIS & RHEUMATOLOGY
(2021)