Article
Endocrinology & Metabolism
Shadab A. Rahman, Brianne A. Kent, Leilah K. Grant, Toni Clark, John P. Hanifin, Laura K. Barger, Charles A. Czeisler, George C. Brainard, Melissa A. St Hilaire, Steven W. Lockley
Summary: Spaceflight exposes crewmembers to circadian misalignment and sleep loss, which impair cognition and increase the risk of errors and accidents. This study compared the effects of an experimental dynamic lighting schedule (DLS) with a standard static lighting schedule (SLS) on circadian phase, self-reported sleep, and cognition during a simulated space mission. The results showed that DLS alleviated the drift in circadian phase and reduced the prevalence of self-reported sleep episodes occurring at an adverse circadian phase, indicating its potential in reducing the risk of sleep disruption in future missions.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Clinical Neurology
Mariam K. Arif, Phyllis C. Zee, Amy S. Paller, Stephanie J. Crowley, Till Roenneberg, Anna B. Fishbein
Summary: The study found that severe AD patients have later sleep onset and wake up times on weekends compared to others, resulting in a later sleep midpoint. Severe AD patients have lower levels of daytime light exposure and similar nighttime light exposure compared to others.
Review
Cell Biology
Deeksha Malhan, Britt Schoenrock, Muege Yalcin, Dieter Blottner, Angela Relogio
Summary: Alterations in the circadian system are common in aging on Earth and also observed in astronauts during and after space exploration. However, little is known about the common molecular alterations underlying terrestrial aging and space-related aging. This review focuses on the role of the circadian clock in visual, cardiovascular, central nervous, and musculoskeletal systems and summarizes the known molecular alterations associated with spaceflight.
Article
Multidisciplinary Sciences
Hongying Zhang, Yahong Wang, Ziyan Zhang, Lu Zhang, Chao Tang, Boqun Sun, Zhihao Jiang, Bo Ding, Peng Cai
Summary: The study investigated changes in activity and sleep of Drosophila melanogaster under simulated microgravity, revealing that different light conditions can impact fruit flies' behaviors, with normal photoperiod alleviating the effects. Gender and strains also showed varying responses to simulated microgravity, although the overall changes were minor.
Review
Clinical Neurology
Masashi Tabuchi, Kaylynn E. Coates, Oscar B. Bautista, Lauren H. Zukowski
Summary: Studies indicate that membrane potential dynamics regulated by photoreceptor and core clock molecules play a crucial role in neural coding, influencing synaptic plasticity, neural firing activity, and light-driven arousal. This mechanism has implications for understanding sleep architecture, memory processing, and neurological disorders.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Renske Lok, Marisol Duran, Jamie M. Zeitzer
Summary: This study examines the effectiveness of flash therapy, a sequence of light flashes applied during sleep, in shifting the circadian clock. The results show that flash therapy can cause significant delays in the circadian timing, up to 6 hours, with minimal impact on sleep. This finding may have practical implications for shift workers and jet travelers.
SCIENTIFIC REPORTS
(2023)
Review
Clinical Neurology
Sarah L. Chellappa
Summary: Individual differences in sensitivity to light have significant implications for the effects on sleep and circadian rhythms, yet these differences are often overlooked in real-life settings. Studies based on human laboratory and field research have identified links between individual traits such as age, sex, chronotype, genetic haplotypes, and the impact of evening/night light exposure on sleep and circadian rhythms. This highlights the importance of considering personalized lighting solutions to promote quality of life and health.
Article
Multidisciplinary Sciences
Jeffrey Hubbard, Mio Kobayashi Frisk, Elisabeth Ruppert, Jessica W. Tsai, Fanny Fuchs, Ludivine Robin-Choteau, Jana Husse, Laurent Calvel, Gregor Eichele, Paul Franken, Patrice Bourgin
Summary: This study revealed that sustained direct light effects (SDLE) play a crucial role in sleep-wake cycle (SWc) regulation, with over 80% of SDLE being mediated through melanopsin and half of them being relayed through the suprachiasmatic nuclei (SCN). This suggests an important ancillary function for the SCN in addition to its role in the circadian system. The findings emphasize the need to consider SDLE, in addition to circadian drive, when dealing with the health consequences of exposure to atypical light in society.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Psychology, Applied
Cristiano L. Guarana, Christopher M. Barnes, Wei Jee Ong
Summary: The article investigates the effects of blue-light filtration on work-related outcomes, suggesting that wearing blue-light filtering glasses can improve sleep quality and quantity, leading to increased work engagement and performance. The study found that this intervention can effectively enhance organizational outcomes, especially for individuals who tend to sleep later in the day.
JOURNAL OF APPLIED PSYCHOLOGY
(2021)
Review
Clinical Neurology
Emily J. Ricketts, Daniel S. Joyce, Ariel J. Rissman, Helen J. Burgess, Christopher S. Colwell, Leon C. Lack, Michael Gradisar
Summary: Light exposure plays a significant role in regulating circadian rhythms, and disruptions to this regulation can lead to various impairments. This is particularly relevant for adolescents, whose sleep-wake patterns are affected by reduced daytime light exposure and prolonged use of electronic devices in the evening. Implementing measures to adjust light intensity, spectra, duration, and delivery modality can support the sleep-wake health of adolescents in different contexts.
SLEEP MEDICINE REVIEWS
(2022)
Article
Endocrinology & Metabolism
Gideon P. Dunster, Isabelle Hua, Alex Grahe, Jason G. Fleischer, Satchidananda Panda, Kenneth P. P. Wright Jr, Celine Vetter, Jennifer H. Doherty, Horacio O. de la Iglesia
Summary: Despite the availability of electric light, sleep timing is delayed during the winter. However, daily exposure to daylight can prevent this delayed phase of the circadian clock.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Melissa A. St Hilaire, Maria L. Amundadottir, Shadab A. Rahman, Shantha M. W. Rajaratnam, Melanie Ruger, George C. Brainard, Charles A. Czeisler, Marilyne Andersen, Joshua J. Gooley, Steven W. Lockley
Summary: This study investigates the contributions of different wavelengths of monochromatic light to human melatonin suppression and circadian resetting responses. The results show that, initially, short-wavelength (S) cones and long- and medium-wavelength (L+M) cones have a significant contribution, while the contribution of melanopsin-containing intrinsically-photosensitive retinal ganglion cells (ipRGCs) becomes dominant over time. The first few minutes of light exposure play a crucial role in the phase resetting response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Clinical Neurology
Manuel Spitschan
Summary: Light exposure has a significant impact on human physiology and behavior through circadian and neuroendocrine photoreception. Recent research has looked into using temporally patterned stimuli to manipulate these responses. This mini-review aims to introduce basic concepts in time-varying stimuli and provide recommendations for documenting time-varying light exposures.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Shu K. E. Tam, Laurence A. Brown, Tatiana S. Wilson, Selma Tir, Angus S. Fisk, Carina A. Pothecary, Vincent Van der Vinne, Russell G. Foster, Vladyslav V. Vyazovskiy, David M. Bannerman, Mary E. Harrington, Stuart N. Peirson
Summary: Light plays a key role in synchronizing circadian rhythms and sleep patterns. Exposure to dim artificial lighting in the evening can cause coordinated realignment of circadian rhythms, sleep patterns, and short-term memory processes in mice, even affecting molecular clock rhythms and neuronal activity patterns.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Clinical Neurology
Daniel Chih Yung Cheng, James L. Ganner, Christopher J. Gordon, Craig L. Phillips, Ronald R. Grunstein, Maria Comas
Summary: Combined melatonin and bright light therapies have significant effects on improving sleep and circadian outcomes, with better efficacy in elderly populations compared to patients with delayed sleep-wake phase disorder. Adverse effects of melatonin in elderly populations should be carefully considered, and future studies should further investigate the separate and combined effects of these therapies in different target populations.
SLEEP MEDICINE REVIEWS
(2021)