Journal
MOLECULAR THERAPY-NUCLEIC ACIDS
Volume 21, Issue -, Pages 229-241Publisher
CELL PRESS
DOI: 10.1016/j.omtn.2020.05.032
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Funding
- National Natural Science Foundation of China [81972214, 81972256, 81772932, 81872496, 81302065]
- Nantong Science and Technology Project [JC2018125]
- Scientific Research Fund Project of Anhui Medical University [2018xkj058]
- Jiangsu 333 Program [BRA2017205]
- Nantong Medical Key Talents Training Plan (Key 43)
- Construction of Clinical Medical Center for Tumor Biological Samples in Nantong [HS2016004]
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Numerous studies have suggested that dysregulated long noncoding RNAs (lncRNAs) contributed to the development and progression of many cancers. lncRNA OIP5 antisense RNA 1 (OIP5-AS1) has been reported to be increased in several cancers. However, the roles of OIP5-AS1 in liver hepatocellular carcinoma (LIHC) remain to be investigated. In this study, we demonstrated that OIP5-AS1 was upregulated in LIHC tissue specimens and its overexpression was associated with the poor survival of patients with LIHC. Furthermore, loss-of function experiments indicated that OIP5-AS1 promoted cell proliferation and inhibited cell apoptosis both in vitro and in vivo. Moreover, binding sites between OIP5-AS1 and hsa-miR-26a-3p as well as between hsa-miR-26a-3p and EPHA2 were confirmed by luciferase assays. Finally, a rescue assay was performed to prove the effect of the OIP5-AS1/hsa-miR-26a-3p/EPHA2 axis on LIHC cell biological behaviors. Based on all of the above findings, our results suggested that OIP5-AS1 promoted LIHC cell proliferation and invasion via regulating the hsa-miR-26a-3p/EPHA2 axis.
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