Article
Immunology
Bolin Wang, Jianle Chen, Chuwei Zhang, Qingrong Zhang, Zhihan Zhu, Ling Qiu, Jun Yan, Zihan Li, Xinghua Zhu, Yi Zhang, Yun Jiang
Summary: This study demonstrates the potential of a novel delivery system, the platelet membrane-coated nanoparticle complex, in effectively delivering bFGF and VEGFA genes to deep burn wounds and promoting wound healing.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Juan-Juan Wang, Kun-Fang Wu, Ding-Ding Wang
Summary: Diabetic retinopathy (DR) is a severe complication of diabetes mellitus, and the long non-coding RNA linc00174 has been found to play a significant role in its pathogenesis. Through experiments on HRMECs and human vitreous humor samples, researchers identified that linc00174 exacerbates diabetic retinal microangiopathy by regulating the miR-150-5p/VEGFA pathway, suggesting a potential novel therapeutic target for DR treatment.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Que Bai, Caiyun Zheng, Na Sun, Wenting Chen, Qian Gao, Jinxi Liu, Fangfang Hu, Tong Zhou, Yanni Zhang, Tingli Lu
Summary: This study presents an oxygen-releasing hydrogel that promotes cell survival, migration, and tube formation under hypoxic conditions, and facilitates tissue repair by reducing inflammation, increasing angiogenesis, and collagen deposition.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Zhijie Chen, Lianlian Wang, Changjun Guo, Minglong Qiu, Liang Cheng, Kaizhe Chen, Jin Qi, Lianfu Deng, Chuan He, Xinming Li, Yufei Yan
Summary: The QK-SF hydrogel has dual functional roles in promoting angiogenesis and immunoregulation for tissue repair and wound healing. It can be prepared via an easy manufacturing process, exhibits good gel stability and low cytotoxicity to cultured HUVECs, triggers macrophage polarization from M1 to M2, and shows high capacity for inducing endothelial growth, migration, and angiogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Minting Liu, Ying Chen, Qiang Zhu, Junjun Tao, Changming Tang, Huajun Ruan, Yunlong Wu, Xian Jun Loh
Summary: This study discovered that supercritical CO2 extracted pearl peptide hydrogels have the potential to promote wound healing. These hydrogels can increase skin fibroblast viability, enhance antioxidant stress resistance, promote tissue remodeling and angiogenesis, and significantly accelerate wound healing.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Shuo Dong, Ji Wang, Zongke Guo, Yanhao Zhang, Wenhui Zha, Yang Wang, Chao Liu, Hanlei Xing, Xinsong Li
Summary: A study found that injecting nanoparticles called VEGFA mRNA-LNP into skin wounds can promote wound healing and increase the rate of blood vessel formation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Polymer Science
Abdul Qadir, Samreen Jahan, Mohd Aqil, Musarrat Husain Warsi, Nabil A. Alhakamy, Mohamed A. Alfaleh, Nausheen Khan, Athar Ali
Summary: Medicinal plants have been used since ancient times and are gradually proving their effectiveness in modern drug delivery systems, while nanotechnology is emerging as a promising strategy in disease control and shows potential advantages for treating skin burn wounds.
Article
Dermatology
Saranchimeg Enkhtuvshin, Erdenezaya Odkhuu, Khongorzul Batchuluun, Battogtokh Chimeddorj, Enkhtur Yadamsuren, Naranbat Lkhagvasuren
Summary: This study aimed to identify risk factors for post-burn scarring in children aged 0-18 years. A total of 182 participants were followed for 6 months after being diagnosed with upper and lower extremity burns. The degree and location of the burn were found to significantly affect scar development.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Immunology
Rida Siddique, Malik Hassan Mehmood, Liaqat Hussain, Abdul Malik, Ayesha Sethi, Maryam Farrukh, Shaneel Kousar
Summary: Burn management is a complex process involving multiple phases of wound healing. The use of medicinal plants and phytochemicals as alternative agents for burn wound management shows promise due to their biocompatibility, cost-effectiveness, and cultural acceptance. This review highlights the therapeutic potential of 35 medicinal herbs and 10 phytochemicals in burn wound healing, including their mechanisms of action such as modulation of inflammatory cytokines and oxidative stress. The review also emphasizes the need for efficacious alternative agents to combat the high cost of synthetic drugs and antibiotic resistance.
INFLAMMOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Fateme Fayyazbakhsh, Michael J. Khayat, Ming C. Leu
Summary: This study utilized clinically relevant hydrogels to fabricate 3D-printed dressings for the treatment of deep partial-thickness burn wounds. The findings revealed that a 3D-printed dressing with 75% gelatin and 25% alginate exhibited the best balance between mechanical properties, hydration activity, and in vitro biological response.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Pharmacology & Pharmacy
Cheng Yang, Yuhui Chen, Hai Huang, Shicai Fan, Chengliang Yang, Liping Wang, Wenqiang Li, Wenxin Niu, Jianwen Liao
Summary: The ROS-sensitive hydrogel prepared in this study showed strong free radical scavenging ability, accelerated wound healing, and promoted tissue regeneration in experiments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biophysics
Qingrong Zhang, Chuwei Zhang, Liang Feng, Lei Wang, Jun Qi, Yipeng Dong, You Lang Zhou, Kesu Hu, Yi Zhang
Summary: Deep burns are difficult to heal quickly, but a study found that using a combination therapy of PLGA nanoparticles carrying bFGF and VEGFA genes can effectively promote wound healing and increase the percentage of wound closure.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Medicine, General & Internal
Samuel Knoedler, Leonard Knoedler, Martin Kauke-Navarro, Yuval Rinkevich, Gabriel Hundeshagen, Leila Harhaus, Ulrich Kneser, Bohdan Pomahac, Dennis P. Orgill, Adriana C. Panayi
Summary: Tregs play a critical role in skin wound healing, helping to balance immune homeostasis and promote healthy wound repair. Understanding the function and mechanisms of Tregs is important for understanding wound pathologies and developing new treatment strategies.
MILITARY MEDICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Hassaninejad Farahani, Fatemeh Moraffah, Nasrin Samadi, Mohammad Sharifzadeh, Hamidreza Motasadizadeh, Alireza Vatanara
Summary: Lactiplantibacillus plantarum cells were encapsulated in a mixture of cationic and anionic polymers and freeze-dried, resulting in a stable composition. The effects of polymer concentrations and prebiotics on probiotic viability and swelling behavior were examined using a D-optimal design. The optimized formulation showed a viability percentage of over 82% and should be stored refrigerated. In vivo testing demonstrated improved wound healing indicators and the ability to modify wound inflammatory responses, making it comparable to silver sulfadiazine ointment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biophysics
Karan Razdan, Shashi Kanta, Ekta Chaudhary, Seema Kumari, Deepak Kumar Rahi, Ashok Kumar Yadav, Vivek Ranjan Sinha
Summary: The study developed and characterized levofloxacin-loaded clove oil nanoscale emulgel and evaluated its therapeutic efficacy in Pseudomonas aeruginosa biofilm-infected burn wounds in mice. The results showed that the emulgel dispersed biofilms, closed wounds, promoted re-epithelialization and collagen deposition, and cleared the infection within 7 days, indicating its effectiveness in treating biofilm-infected burn wounds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)