Article
Cardiac & Cardiovascular Systems
Weikang Bian, Zhicheng Wang, Xiaobo Li, Xiao-Xin Jiang, Hongsong Zhang, Zhizhong Liu, Dai-Min Zhang
Summary: In this study, weighted gene coexpression network analysis (WGCNA) was used to identify the key module and hub genes for heart failure (HF). Differential gene expression analysis, coexpression network construction, functional enrichment analysis, and protein-protein interaction network construction were conducted to identify potential hub genes. The results may provide potential biomarkers for the diagnosis of HF and enhance our understanding of the molecular mechanisms underlying HF.
Article
Biochemical Research Methods
Junyu Long, Shan Huang, Yi Bai, Jinzhu Mao, Anqiang Wang, Yu Lin, Xu Yang, Dongxu Wang, Jianzhen Lin, Jin Bian, Xiaobo Yang, Xinting Sang, Xi Wang, Haitao Zhao
Summary: By employing WGCNA method, this study analyzed gene expression profiles and clinical features of 36 CCA patients, identifying 1478 aberrantly expressed genes in CCA. Seven coexpression modules significantly correlated with clinical traits were identified, with green and blue modules showing significant association with tumor differentiation. Survival analysis revealed 17 hub genes as prognostic biomarkers for CCA patients.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Oncology
Fengwei Li, Qinjunjie Chen, Yang Yang, Meihui Li, Lei Zhang, Zhenlin Yan, Junjie Zhang, Kui Wang
Summary: In this study, 1019 DEGs were filtered to construct four coexpression modules. The red module, which showed the highest correlations with iCCA patients' recurrence status, family history, and day to death, was identified as the key module. Genes in the key module were enriched in genes and pathways related to tumorigenesis and tumor progression. Validation studies revealed estrogen receptor 1 (ESR1) as the real hub gene associated with iCCA recurrence, playing a critical role in suppressing iCCA progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Huan Deng, Qingqing Hang, Dijian Shen, Yibi Zhang, Ming Chen
Summary: Our study identified 486 differentially coexpressed genes associated with LUAD, with ten hub genes closely correlated with overall survival. Through functional enrichment analysis and protein-protein interaction network establishment, we found that CHRDL1 and SPARCL1 may serve as potential therapeutic and prognostic indicators for LUAD.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Qixin Guo, Qiang Qu, Luyang Wang, Shengen Liao, Xu Zhu, Anning Du, Qingqing Zhu, Iokfai Cheang, Rongrong Gao, Xinli Li
Summary: This study aimed to explore the molecular mechanisms of DCM and identify potential gene biomarkers. Four hub genes were identified as potential biomarkers for DCM. The findings have significant implications for the diagnosis and treatment of DCM.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Review
Biochemistry & Molecular Biology
Elena Ferrari, Valeria Naponelli, Saverio Bettuzzi
Summary: Members of the LMTK subfamily, consisting of LMTK1-3, are membrane-anchored kinases known to impact key cellular events like proliferation and apoptosis. They have been linked to cancer, particularly in prostate cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yanyan Wang, Kang Cui, Mingzhi Zhu, Yuanting Gu
Summary: This study analyzed the RNA-Sequencing and clinical data of breast cancer patients from TCGA database using the weighted gene coexpression network analysis (WGCNA) method. They identified coexpression modules related to breast cancer and discovered potential prognostic biomarkers.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Medicine, Research & Experimental
Zhenyuan Han, Huiping Ren, Jingjing Sun, Lihui Jin, Qin Wang, Chuanbin Guo, Zhen Tian
Summary: This study utilized WGCNA to construct a gene coexpression network for IMPA and identified FZD2 as a central gene associated with the clinical malignancy of IMPA. The expression dynamic of FZD2 correlates negatively with the histological grade of IMPA and serves as a promising histological indicator for the precise prediction of IMPA stages.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Angeliki Ditsiou, Teresa Gagliano, Mark Samuels, Viviana Vella, Christos Tolias, Georgios Giamas
Summary: In the last decade, LMTK3 has been recognized as a key player in breast cancer and other types of cancers, with evidence showing its involvement in multiple signaling pathways. The identification of a potential LMTK3 inhibitor opens up new possibilities for developing novel cancer treatments based on the roles of LMTK3.
Article
Medicine, Research & Experimental
Chuxiang Lei, Dan Yang, Wenlin Chen, Haoxuan Kan, Fang Xu, Hui Zhang, Wei Wang, Lei Ji, Yuehong Zheng
Summary: Chemotaxis and the complement system were identified as crucial pathways in TAA, and macrophages with interactive immune cells may regulate this pathological process. In TAA, immune responses including leukocyte adhesion, mononuclear cell proliferation, and T cell activation are important. The hub genes CX3CR1, C3, and C3AR1 were identified as potential drivers of TAA, with good diagnostic accuracy. Additionally, infiltrating immune cells in TAA and normal tissues, particularly macrophages and natural killer cells, showed differences in proportion.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Physiology
Biyun Teng, Chaozheng Xie, Yu Zhao, Qiu Zeng, Fangbiao Zhan, Yangyang Feng, Zhe Wang
Summary: This study aims to explore the potential molecular mechanisms and effective targeted therapies for preventing and delaying abdominal aortic aneurysm (AAA) rupture. Through analysis of gene expression data and drug databases, the study identified hypoxic molecules associated with AAA rupture and predicted related traditional Chinese medicine candidates.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Feng Lin, Haiqi Zhang, Jinglei Bao, Long Li
Summary: This study identified 11 hub miRNAs and found that DEmRNAs were significantly enriched in the N-glycan biosynthesis pathway, which contributes to the early diagnosis and treatment of AD.
WORLD NEUROSURGERY
(2021)
Article
Pediatrics
Wangkai Liu, Yihua Su, Sitao Li, Haitian Chen, Yumei Liu, Xiaoyu Li, Wei Shen, Xinqi Zhong, Fan Wu, Qiong Meng, Xiaoyun Jiang
Summary: This study identified a significantly downregulated coexpression module related to the bronchopulmonary dysplasia (BPD) phenotype, enriched in genes associated with human T-cell leukemia virus infection and the mitogen-activated protein kinase pathway. The decreased expression of hub genes FOS, BTG2, JUN, and EGR1 in infants with BPD could serve as biomarkers for early diagnosis of BPD.
PEDIATRIC PULMONOLOGY
(2021)
Article
Genetics & Heredity
Lin Chen, Yong Wang, Juan Huang, Binbin Hu, Wei Huang
Summary: This study identified four hub genes (SLC18A2, L1CAM, S100A12, and CXCR4) and seven immune cell types (neutrophils, T follicular helper cells, myeloid-derived suppressor cells, type 1 helper cells, immature B cells, immature dendritic cells, and CD56 bright natural killer cells) associated with the pathogenesis of PD. The combined model of the four genes showed a high accuracy in differentiating PD patients from healthy controls.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Chenkai Huang, Juanjuan Zhou, Yuan Nie, Guihai Guo, Anjiang Wang, Xuan Zhu
Summary: This study identified differentially co-expressed genes associated with hepatocellular carcinoma (HCC) and found that the overexpression of FYN gene is positively correlated with the prognosis of HCC patients. Furthermore, experimental results showed that overexpression of FYN gene can inhibit tumor growth and promote tumor cell apoptosis.