Article
Immunology
Mark B. Salzman, Cheng-Wei Huang, Christopher M. O'Brien, Rhina D. Castillo
Summary: This report discusses 3 cases of patients in California who experienced multisystem inflammatory syndrome (MIS) after receiving vaccination and being infected with SARS-CoV-2. It also mentions 3 cases of adults who were not vaccinated developing MIS during a period when around 7% of the adult population had received at least one vaccine.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Eman A. Toraih, Mohammad H. Hussein, Rami M. Elshazli, Adam Kline, Ruhul Munshi, Nasrin Sultana, Sharven Taghavi, Mary Killackey, Juan Duchesne, Manal S. Fawzy, Emad Kandil
Summary: In pediatric COVID-19 patients with multisystem inflammatory syndrome, typical symptoms like fever and mucocutaneous changes were common, but atypical gastrointestinal and neurocognitive symptoms were also prevalent. Monitoring cardiac and renal function, as well as early interventions, are crucial in preventing further morbidity in these patients.
WORLD JOURNAL OF PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Parastoo Hosseini, Mohammad Sadegh Fallahi, Gisou Erabi, Majid Pakdin, Seyed Mahdi Zarezadeh, Arezoo Faridzadeh, Sarina Entezari, Arina Ansari, Mohadeseh Poudineh, Niloofar Deravi
Summary: COVID-19 caused by SARS-CoV-2 has raised significant concerns globally. Some patients infected with SARS-CoV-2 may experience post-COVID-19 complications such as multisystem inflammatory syndrome and autoimmune diseases. This review discusses the molecular and pathophysiological mechanisms as well as therapeutic opportunities for these complications.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Infectious Diseases
Chizaram Onyeaghala, Datonye Alasia, Orezioghene Eyaru, Nsirimobu Paul, Omosivie Maduka, Nosakhare Osemwegie, Nkem Ugwueze, Collins Ordu, Ebitei Igbosi, Mary Irabor, Emeka Eyidia
Summary: Most reports of Multisystem Inflammatory Syndrome (MIS-C) have come from Europe and North America, with a paucity of reports in Africa, despite children of African ancestry accounting for over 40% of cases in other regions. Enhanced surveillance and awareness for MIS-C in children with COVID-19 in Africa are crucial due to the higher prevalence in children of African ancestry. A case report of a 12-year-old Nigerian girl with MIS-C highlights the need for vigilance, expanded surveillance efforts, and early recognition and diagnosis in Nigeria and Africa.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Cristina Maria Mihai, Tatiana Chisnoiu, Claudia Simona Cambrea, Corina Elena Frecus, Larisia Mihai, Adriana Luminita Balasa, Alina Zorina Stroe, Anca Elena Gogu, Any Docu Axelerad
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a disease that can occur in children after SARS-CoV-2 infection, characterized by neurological symptoms. This study examined 30 cases of children with MIS-C in terms of symptoms, laboratory tests, and disease progression, and treatment was administered according to the MIS-C protocol. The patients showed improvement in their condition, and symptoms remitted within days to weeks.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew J. Bock, Micheal A. Kuhn, Richard E. Chinnock
Summary: Pediatric heart transplant recipients have a high rate of COVID-19 infection at 21%, with 55% being asymptomatic. Despite the high infection rate, they have good tolerance to COVID-19, with only 5% requiring hospitalization and no mortality cases.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Review
Immunology
Gavriela Feketea, Vasiliki Vlacha, Ioana Corina Bocsan, Emilia Vassilopoulou, Luminita Aurelia Stanciu, Mihnea Zdrenghea
Summary: This article discusses the role of vitamin D in viral infections, as well as its association with MIS-C and Kawasaki disease. It emphasizes the importance of vitamin D levels in predicting the severity of MIS-C.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Brittany P. Boribong, Thomas J. LaSalle, Yannic C. Bartsch, Felix Ellett, Maggie E. Loiselle, Jameson P. Davis, Anna L. K. Gonye, David B. Sykes, Soroush Hajizadeh, Johannes Kreuzer, Shiv Pillai, Wilhelm Haas, Andrea G. Edlow, Alessio Fasano, Galit Alter, Daniel Irimia, Moshe Sade-Feldman, Lael M. Yonker
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory disease characterized by SARS-CoV-2 antigenemia, cytokine storm, and immune dysregulation. Neutrophils in MIS-C display a distinct signature of granulocytic myeloid-derived suppressor cells (G-MDSC) and altered metabolism. Extensive neutrophil extracellular trap (NET) formation is observed in MIS-C.
CELL REPORTS MEDICINE
(2022)
Review
Immunology
Amr Ehab El-Qushayri, Abdullah Reda, Jaffer Shah
Summary: This paper aimed to study the characteristics, laboratory data, and outcomes of monkeypox virus (MPV) and COVID-19 co-infection. Three male patients with multiple comorbid conditions and a history of sexual activity with men prior to infection were diagnosed with PCR and admitted to the hospital. All cases were effectively managed and recovered well during hospitalization. Future investigations with larger sample sizes are needed to establish a definitive cause-effect association between SARS-CoV-2 and MPV co-infection and patient outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Mariawy Riollano-Cruz, Esra Akkoyun, Eudys Briceno-Brito, Shanna Kowalsky, James Reed, Roberto Posada, Emilia Mia Sordillo, Michael Tosi, Rebecca Trachtman, Alberto Paniz-Mondolfi
Summary: Following the outbreak of the COVID-19 pandemic in 2020, children have been reported to develop a systemic inflammatory syndrome related to the virus. The pediatric patients mainly come from Hispanic/Latino and Black/African American backgrounds in New York City.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Pediatrics
Saboor Saeed, Jianqing Cao, Jinjiao Xu, Yi Zhang, Xuyang Zheng, Liya Jiang, Chunming Jiang, Xinjuan Zhang
Summary: MIS-C is a rare but serious complication of SARS-CoV-2 infection in children, with unknown pathophysiology. A case report of an 11-year-old girl who developed MIS-C after receiving the second dose of Covid-19 vaccination is presented, but her symptoms improved after treatment with intravenous immunoglobulin, methylprednisolone, and oral aspirin.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Paulina Krawiec, Violetta Opoka-Winiarska, Elzbieta Pac-Kozuchowska
Summary: This study presented four children with overlapping IBD flare and PIMS-TS/MIS-C, where IBD recognition often preceded the onset of PIMS-TS/MIS-C. These patients presented with gastrointestinal symptoms at PIMS-TS/MIS-C onset and required IVIG, ASA, and in some cases, steroids for treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Tzu-Chen Lo, Yu-Yen Chen
Summary: This study aimed to better understand the epidemiological and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) following COVID-19. Research found that MIS-C associated with COVID-19 shares features similar to Kawasaki disease and may be related to post-infective immune dysregulation. Further studies are needed to elucidate the underlying pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Abby Basalely, Shari Gurusinghe, James Schneider, Sareen S. Shah, Linda B. Siegel, Gabrielle Pollack, Pamela Singer, Laura J. Castellanos-Reyes, Steven Fishbane, Kenar D. Jhaveri, Elizabeth Mitchell, Kumail Merchant, Christine Capone, Ashley M. Gefen, Julie Steinberg, Christine B. Sethna
Summary: This study found a high incidence of acute kidney injury in patients with COVID-19 and MIS-C, with associations to lower serum albumin levels and higher white blood cell counts, suggesting a link to inflammation and dehydration.
KIDNEY INTERNATIONAL
(2021)
Review
Pediatrics
Grant S. Schulert, Sydney A. Blum, Randy Q. Cron
Summary: Various genetic approaches have identified associations between severe COVID-19 and MIS-C in children and adults, pointing to genes related to antiviral functions, viral cell entry, immune regulation, chemotaxis of white blood cells, and lymphocyte cytolytic function.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Immunology
Khitam Muhsen, Ziona Haklai, Yael Applbaum, Ethel-Sherry Gordon, Ada Shteiman, Aharona Glatman-Freedman, Eyal Leshem
Letter
Critical Care Medicine
Eyal Leshem, Yoram Klein, Yael Haviv, Haim Berkenstadt, Itai M. Pessach
INTENSIVE CARE MEDICINE
(2020)
Review
Dermatology
Muskaan Sachdeva, Raffaele Gianotti, Monica Shah, Lucia Bradanini, Diego Tosi, Stefano Veraldi, Michael Ziv, Eyal Leshem, Roni P. Dodiuk-Gad
JOURNAL OF DERMATOLOGICAL SCIENCE
(2020)
Letter
Dermatology
Muskaan Sachdeva, Monica Shah, Michael Ziv, Eyal Leshem, Roni P. Dodiuk-Gad
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2020)
Letter
Public, Environmental & Occupational Health
Dana Lev, Asaf Biber, Tamar Lachish, Eyal Leshem, Eli Schwartz
JOURNAL OF TRAVEL MEDICINE
(2020)
Editorial Material
Public, Environmental & Occupational Health
Dana Lev, Gilad Yahalom, Shira Rabinowicz, Eyal Leshem, Eli Schwartz
JOURNAL OF TRAVEL MEDICINE
(2020)
Article
Pediatrics
Shira Rabinowicz, Atar Lev, Yu Nee Lee, Diti Machnes-Maayan, Uriel Katz, Amir Vardi, David Mishali, Raz Somech
Summary: Patients with Down syndrome have an increased diversity in T cell receptor gamma repertoire but decreased clonal expansion compared to non-syndromic patients. The V and J gene usages are similar between the two groups, indicating that differences in TRG repertoire may contribute to DS patients' predisposition to infections and autoimmune diseases. Using next-generation sequencing techniques can reveal repertoire abnormalities not seen with previous methods.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Shira Rabinowicz, Orly Levkovitz, Leah Leibovitch, Irit Schushan-Eisen, Iris Morag, Chava Rosen, Ayala Maayan-Metzger, Tzipora Strauss
EUROPEAN JOURNAL OF PEDIATRICS
(2020)
Article
Public, Environmental & Occupational Health
Shira Rabinowicz, Eyal Leshem, Eli Schwartz
Summary: This study retrospectively reviewed cases of acute schistosomiasis in 18 children and 24 adults from trips to Africa and Southeast Asia. Children typically presented with respiratory symptoms, eosinophilia, and fever, but reported fatigue less commonly compared to adults. Despite a high infection rate, the severity of acute illness and rates of hospitalization were similar between children and adults.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Clinical Neurology
Livnat Brill, Esther Ganelin-Cohen, Ron Dabby, Shira Rabinowicz, Efrat Zohar-Dayan, Netaniel Rein, Eyal Aloni, Yuval Karmon, Adi Vaknin-Dembinsky
Summary: MOGAD are distinct autoimmune diseases that occur at all stages of life with a significantly higher prevalence in children; the main clinical presenting phenotype in the entire cohort is ON and young children most often presented with ON or ADEM.
FRONTIERS IN NEUROLOGY
(2021)
Letter
Medicine, General & Internal
Sharon Amit, Gili Regev-Yochay, Arnon Afek, Yitshak Kreiss, Eyal Leshem
Article
Clinical Neurology
M. Segev, B. Djurabayev, E. Hadi, Y. Yinon, S. Rabinowicz, C. Hoffmann, S. Shrot
Summary: The study found that in monochorionic twins complicated with single intrauterine fetal death who underwent routine third trimester MR imaging, there were smaller brain biometric measurements but normal diffusivity in surviving twins, suggesting normal parenchymal microstructure.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Michal Tzadok, Nasrin Hamed, Gali Heimer, Efrat Zohar-Dayan, Shira Rabinowicz, Bruria Ben Zeev
Summary: This retrospective study suggests that cannabidiol-enriched artisanal cannabis oil may be an effective and safe long-term treatment for refractory epilepsy.
PEDIATRIC NEUROLOGY
(2022)