Review
Nutrition & Dietetics
Marcin Delijewski, Aleksandra Barton, Beata Maksym, Natalia Pawlas
Summary: Iron is a crucial transition metal in physiological processes, but it can also be toxic due to its involvement in free radical formation. Impaired iron metabolism leads to iron deficiency, anemia, and iron overload, with different prevalences in transplant patients. Limited knowledge exists on iron metabolism in lung graft recipients and donors, complicated further by the potential impact of drugs. This overview highlights the importance of understanding iron turnover in transplant patients and assessing drug effects on iron metabolism for perioperative treatment in transplantology.
Article
Geriatrics & Gerontology
P. Lanz, M. Wieczorek, A. Sadlon, C. de Godoi Rezende Costa Molino, L. A. Abderhalden, D. J. Schaer, D. R. Spahn, G. Freystatter, E. J. Orav, A. Egli, H. A. Bischoff-Ferrari
Summary: This study aimed to assess whether baseline iron deficiency is associated with an increased risk of infections among community-dwelling older adults. The results indicated that iron deficiency was not associated with the overall infection rate, but may lead to an increased incidence of severe infections.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Letter
Medicine, General & Internal
Andrew J. Read, Akbar K. Waljee, Charity S. Chen, Robert Holleman, Kyle E. Kumbier, Sameer D. Saini
Summary: This cohort study examines the prevalence of appropriate testing for incident anemia in a large cohort from a national integrated health care system.
Article
Food Science & Technology
Jordi Mayneris-Perxachs, Wellington Amaral, Gabriele R. Lubach, Mark Lyte, Gregory J. Phillips, Joram M. Posma, Christopher L. Coe, Jonathan R. Swann
Summary: Infants worldwide are seriously affected by iron deficiency, but the lingering metabolic and microbial effects after natural recovery have been found in juvenile monkeys, while early treatment with iron dextran and B vitamins can prevent these long-term biochemical derangements.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jolanta Artym, Michal Zimecki, Marian L. Kruzel
Summary: Pregnancy requires higher levels of nutrients, including iron, for the growth and maintenance of the fetus. Iron deficiency during pregnancy can lead to serious health issues, making iron supplementation essential for pregnant women. Studies suggest that lactoferrin can be an effective prophylaxis and treatment for iron deficiency anemia during pregnancy, offering various beneficial effects on iron homeostasis and overall health.
Article
Nutrition & Dietetics
Andrea J. Sharma, Nicole D. Ford, Joanna E. Bulkley, Lindsay M. Jenkins, Kimberly K. Vesco, Anne M. Williams
Summary: This study assessed the feasibility of anemia, iron deficiency, and iron-deficiency anemia surveillance among first-trimester pregnancies using electronic health records. It found that approximately 2.7% of pregnancies had anemia, with about half of those cases having both low hemoglobin and low hematocrit. Iron deficiency was present in approximately 26.8% of pregnancies with anemia and 23.5% of pregnancies without anemia.
JOURNAL OF NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Heinz Zoller, Myles Wolf, Irina Blumenstein, Christian Primas, Stefan Lindgren, Lars L. Thomsen, Walter Reinisch, Tariq Iqbal
Summary: Despite comparable treatment efficacy for iron deficiency anaemia, FCM was associated with a higher incidence of hypophosphataemia compared to FDI. Further studies are needed to investigate the long-term clinical consequences of hypophosphataemia and the mechanisms underlying the differential effects of FCM and FDI on patient-reported fatigue.
Article
Nutrition & Dietetics
Andrea J. Sharma, Nicole D. Ford, Joanna E. Bulkley, Lindsay M. Jenkins, Kimberly K. Vesco, Anne M. Williams
Summary: The feasibility of monitoring anemia, iron deficiency, and iron-deficiency anemia among pregnant women using electronic health records has been assessed. This method can be used to monitor the prevalence and trends of anemia in pregnant women, but obtaining representative estimates of iron deficiency or iron-deficiency anemia may be challenging if iron assessment is not routine.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Suhua Xu, Hao Zheng, Zhaoxie Tang, Zhuohe Gu, Min Wang, Cuilan Tang, Yanqi Xie, Minli Kong, Jiajia Jing, Yanbin Su, Yanna Zhu
Summary: This study evaluated the effect of iron-rich foods (IRFs) on iron status and biomarkers of iron metabolism in late pregnancy. The results showed that IRFs can reduce the risk of iron deficiency and iron-deficiency anemia in late pregnancy. However, the current results are inadequate to confirm the ideal dosage.
JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Vito Leonardo Miniello, Maria Carmen Verga, Andrea Miniello, Cristina Di Mauro, Lucia Diaferio, Ruggiero Francavilla
Summary: The complementary feeding period between 6 and 24 months is crucial for infant nutrition and development, especially in addressing iron deficiency and anemia. Healthcare providers should follow guidelines to ensure adequate iron intake and address iron deficiency in infants during this critical period.
Article
Obstetrics & Gynecology
Michael Auerbach
Summary: Iron deficiency (ID) is a common disorder with low serum ferritin level. Transferrin saturation (TSAT) is the best indicator of iron status in early pregnancy or chronic inflammation. The guidelines do not recommend routine screening for ID, but urgent review is needed. Oral iron is associated with adverse effects, while intravenous iron is safer and more effective, especially for pregnant women with hemoglobin levels below 10.5 g/dL.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Food Science & Technology
Abhishek Kulkarni, Monika Khade, Sharadha Arun, Pranesh Badami, G. Raja Krishna Kumar, Tomal Dattaroy, Badrish Soni, Santanu Dasgupta
Summary: Iron deficiency anemia is a global concern that is often overlooked, with various commercial iron supplements potentially ineffective in addressing the issue. It is important to handle this situation with caution as it can have severe consequences if left untreated.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Chemistry, Medicinal
Natalia Scaramellini, Dania Fischer, Anand R. Agarvas, Irene Motta, Martina U. Muckenthaler, Christina Mertens
Summary: Mammalian cells rely on iron for various important functions and maintaining iron homeostasis is crucial. Imbalances in iron homeostasis can lead to iron deficiencies or iron overload diseases, which require clinical attention. Treating these conditions is important to prevent cellular damage and improve patient outcomes. Recent advancements in understanding iron homeostasis mechanisms have already impacted clinical practice and are expected to further enhance patient management in the future.
Article
Nutrition & Dietetics
Rishma Dhillon Pai, Yap Seng Chong, Lyra Ruth Clemente-Chua, Rima Irwinda, Trang Nguyen Khanh Huynh, Noroyono Wibowo, Maria Corazon Zaida Gamilla, Zaleha Abdullah Mahdy
Summary: The lack of standardized clinical practice is a global concern in the optimal management of iron deficiency and iron deficiency anemia in women, particularly in the Asia-Pacific region. This study aimed to determine best practices through a Delphi consensus process.
Article
Nutrition & Dietetics
Brian J. Sandri, Gabriele R. Lubach, Eric F. Lock, Pamela J. Kling, Michael K. Georgieff, Christopher L. Coe, Raghavendra B. Rao
Summary: This study revealed that rapid correction of infantile iron deficiency anemia using iron dextran injections resulted in significant metabolic changes, affecting pathways related to liver function, bile acid release, nucleoside release, and key neurological metabolites.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Jeremy Barben, Didier Menu, Clementine Rosay, Jeremie Vovelle, Anca-Maria Mihai, Valentine Nuss, Philippe d'Athis, Alain Putot, Patrick Manckoundia
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2020)
Article
Geriatrics & Gerontology
Melanie Dipanda, Jeremy Barben, Gilles Nuemi, Lucie Vadot, Valentine Nuss, Jeremie Vovelle, Alain Putot, Patrick Manckoundia
Article
Immunology
Pauline Walzer, Clementine Esteve, Jeremy Barben, Didier Menu, Christine Cuenot, Patrick Manckoundia, Alain Putot
Article
Environmental Sciences
Patrick Manckoundia, Clementine Rosay, Didier Menu, Valentine Nuss, Anca-Maria Mihai, Jeremie Vovelle, Gilles Nuemi, Philippe d'Athis, Alain Putot, Jeremy Barben
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Virology
Jeremy Barben, Alain Putot, Anca-Maria Mihai, Jeremie Vovelle, Patrick Manckoundia
Summary: This is a unique case report demonstrating the association between CLL transformation and hMPV infection. Due to the poor physical condition of the patient, CLL was not treated.
Article
Environmental Sciences
Patrick Manckoundia, Gilles Nuemi, Arthur Hacquin, Didier Menu, Clementine Rosay, Jeremie Vovelle, Valentine Nuss, Camille Baudin-Senegas, Jeremy Barben, Alain Putot
Summary: The effectiveness of direct oral anticoagulants (DOAC) is comparable to vitamin K antagonists (VKA) in treating atrial fibrillation and venous thromboembolism (VTE). However, DOACs are less commonly prescribed compared to VKAs. Older individuals taking DOACs are typically female, have less severe comorbidities, and take fewer medications, while those taking VKAs are older, have more severe comorbidities, and take more medications.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Caroline Laborde, Julien Bador, Arthur Hacquin, Jeremy Barben, Sophie Putot, Patrick Manckoundia, Alain Putot
Summary: In older patients above 75 years old, about one third of those with bacteremic UTI related to GNB did not exhibit typical UTI symptoms. Early diagnosis of UTI was associated with better survival outcomes according to the study findings.
Article
Environmental Sciences
Anca-Maria Mihai, Jeremy Barben, Melanie Dipanda, Jeremie Vovelle, Valentine Nuss, Camille Baudin-Senegas, Alain Putot, Patrick Manckoundia
Summary: Healthcare workers in geriatric environments were tested for COVID-19, with symptomatic cases more likely to be positive. Working in acute geriatric units and nursing homes was associated with increased risk of infection. Further studies are needed to assess the risks and consequences of COVID-19 in healthcare workers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Jeremie Vovelle, Celine Row, Fabrice Larosa, Julien Guy, Anca-Maria Mihai, Marc Maynadie, Jeremy Barben, Patrick Manckoundia
Summary: Lymphoid neoplasms are a diverse group of lymphoid tumors that can be challenging to diagnose, especially in older patients. Blood lymphocyte immunophenotyping plays a crucial role in rapid noninvasive diagnosis. Criteria for BLI prescription in geriatric patients include lymphadenopathy, splenomegaly, lymphocytosis, and thrombocytopenia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jeremy Barben, Oumar Billa, Julie Collot, Thomas Collot, Patrick Manckoundia, Leila Bengrine-Lefevre, Tienhan Sandrine Dabakuyo-Yonli, Valerie Quipourt
Summary: This study aimed to assess the health-related quality of life (HRQoL) in primary caregivers of older cancer patients after 5 years of initial treatment. It also compared the HRQoL between former primary caregivers whose caregiving relationship had ceased and current caregivers, and determined the perceived burden of the primary caregivers.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Geriatrics & Gerontology
Marie Perret, Aurelie Bertaut, Julie Niogret, Sophie Marilier, Pierre Jouanny, Patrick Manckoundia, Leila Bengrine-Lefevre, Valerie Quipourt, Jeremy Barben
Summary: This study aimed to identify factors associated with the efficacy and tolerance of immune checkpoint blockers (ICB) in older patients. The results showed that concomitant use of antiplatelet medications may affect efficacy, and concomitant use of proton pump inhibitors may affect tolerance.
Article
Oncology
Jeremy Barben, Valerie Quipourt, Jeremie Vovelle, Alain Putot, Patrick Manckoundia
Summary: An 82-year-old woman with advanced lung cancer treated with gefitinib was admitted to the emergency unit for dyspnea. Despite initial suspicion of COVID-19 pneumonia based on chest CT findings, the final diagnosis was Pneumocystis jirovecii pneumonia confirmed by PCR. Physicians need to be cautious to avoid misdiagnosing COVID-19 in cancer patients on small-molecule therapy like gefitinib and corticosteroids.
Article
Geriatrics & Gerontology
Valentine Nuss, Jeremy Barben, Caroline Laborde, Jeremie Vovelle, Martha Deidda, Anca-Maria Mihai, Alain Putot, Patrick Manckoundia
Article
Medicine, General & Internal
Alain Putot, Emmanuel Bouhey, Jennifer Tetu, Jeremy Barben, Eleonore Timsit, Sophie Putot, Patrick Ray, Patrick Manckoundia
JOURNAL OF CLINICAL MEDICINE
(2020)