Article
Oncology
Xuehui Wang, Changle Ji, Jiashu Hu, Xiaochong Deng, Wenfang Zheng, Yunhe Yu, Kaiyao Hua, Xiqian Zhou, Lin Fang
Summary: Hsa_circ_0005273 is overexpressed in breast cancer tissues and cell lines, promoting BC progression by regulating the miR-200a-3p/YAP1 axis and inactivating the Hippo signaling pathway.
Depletion of hsa_circ_0005273 inhibits tumor cell proliferation, migration, and cell cycle progression, suggesting it as a potential therapeutic target for breast cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Shunshuan Han, Xiyu Zhao, Yao Zhang, Felix Kwame Amevor, Bo Tan, Mengen Ma, Houyang Kang, Jianping Wang, Qing Zhu, Huadong Yin, Can Cui
Summary: This study reveals that miR-34a-5p regulates the autophagy and apoptosis of chicken granulosa cells by targeting LEF1 to mediate the Hippo-YAP signaling pathway.
Correction
Oncology
Xuehui Wang, Changle Ji, Jiashu Hu, Xiaochong Deng, Wenfang Zheng, Yunhe Yu, Kaiyao Hua, Xiqian Zhou, Lin Fang
Summary: The amended version of this paper has been published and is accessible through the original article.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Dianyun Ren, Yan Sun, Dan Zhang, Dan Li, Zhiqiang Liu, Xin Jin, Heshui Wu
Summary: The research demonstrates that SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway through the hnRNPK-YAP1 axis. Inhibition of SGLT2 alone or in combination with YAP1 inhibition may represent a promising therapeutic approach for pancreatic cancer.
Article
Chemistry, Medicinal
Massimo Moro, Orazio Fortunato, Giulia Bertolini, Mavis Mensah, Cristina Borzi, Giovanni Centonze, Francesca Andriani, Daniela Di Paolo, Patrizia Perri, Mirco Ponzoni, Ugo Pastorino, Gabriella Sozzi, Mattia Boeri
Summary: Despite improvements in therapies and screening strategies, lung cancer prognosis remains poor, especially for patients with metastatic tumors. Cancer stem cells (CSCs) are a major cause of the low survival rate, and microRNA miR-486-5p has been identified as a potential therapeutic target for lung cancer.
Article
Biochemistry & Molecular Biology
Mengting Wu, Qiongzi Qiu, Qing Zhou, Jia Li, Juze Yang, Chengcai Zheng, Aoran Luo, Xufan Li, Honghe Zhang, Xiaodong Cheng, Weiguo Lu, Pengyuan Liu, Bingjian Lu, Yan Lu
Summary: This study identifies circFBXO7, a novel circRNA, as a tumor suppressor in ovarian cancer. The circFBXO7/miR-96-5p/MTSS1 axis is found to be an important regulator in the Wnt/beta-catenin signaling pathway.
Article
Oncology
Dan Yu, Haiping Liu, Jianli Qin, Mengjie Huangfu, Xiao Guan, Xumei Li, Luwei Zhou, Tong Dou, Yisa Liu, Lin Wang, Minglei Fu, Juan Wang, Xu Chen
Summary: miR-30a-5p is downregulated in CRC and associated with inactivation of the Hippo signaling pathway; Curcumol can increase miR-30a-5p expression, activate the Hippo signaling pathway, and inhibit CRC cell invasion and migration.
Article
Biochemistry & Molecular Biology
Bing-jun Chen, Jian Jiang, Tan Li, Hong-jie Jiang, Xin-hua Liang, Ya-ling Tang
Summary: The invasion and metastasis of salivary adenoid cystic carcinoma (SACC) is closely related to collective invasion. The downregulation of FAT1 and upregulation of YAP1 are associated with collective invasion and distant metastasis in SACC. The miR-183-5p/FAT1/YAP1 signaling pathway plays a critical role in SACC collective invasion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Xi Liu, Jun Quan, Zhaolong Shen, Zequn Zhang, Zhijian Chen, Liang Li, Xiaorong Li, Gui Hu, Xiaofeng Deng
Summary: This study found that MT2A was downregulated in CRC and was associated with the tumor M stage. MT2A overexpression inhibited CRC cell proliferation and migration, as well as growth and metastasis in animal models. MT2A overexpression promoted the phosphorylation of MST1, LAST2, and YAP1, thereby inhibiting the Hippo signaling pathway. Thus, MT2A and MST1 may be potential therapeutic targets for CRC patients.
CANCER CELL INTERNATIONAL
(2022)
Article
Medical Laboratory Technology
Ruixin Li, Zhihao Hu, Zhuoyin Wang, Tianyu Zhu, Guojun Wang, Bulang Gao, Jingtao Wang, Xiumei Deng
Summary: MiR-125a-5p can promote gastric cancer growth and invasion by upregulating the expression of EphA2, TAZ, and TEAD2, while also reversing the EMT process.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Endocrinology & Metabolism
D. B. Wu, C. Liu, W. J. Guo, B. S. Li, L. Hong
Summary: In ovarian cancer, BUB1B, negatively regulated by miR-486-5p, promotes the progression of OC and holds promise as a therapeutic target.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Cell Biology
Hualin Chen, Wenjie Yang, Yingjie Li, Zhigang Ji
Summary: PLAGL2 is overexpressed in bladder cancer tissues and is associated with decreased survival. Mechanistically, overexpressed PLAGL2 activates the RACGAP1/RhoA GTPase/YAP1 signaling pathway, promoting proliferation and metastasis of bladder cancer cells. Targeting the core nodes of this signaling pathway may have therapeutic potential for bladder cancer.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Rahul D. Kamdar, Brittney S. Harrington, Emma Attar, Soumya Korrapati, Jyoti Shetty, Yongmei Zhao, Bao Tran, Nathan Wong, Carrie D. House, Christina M. Annunziata
Summary: Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer-related death in women worldwide, and chemoresistant, stem-like tumor-initiating cells (TICs) contribute to disease relapse. The NF-κB pathway and its transcription factors (RelA and RelB) have been found to promote TIC survival and chemoresistance. This study demonstrates that NF-κB signaling differentially regulates miRNA expression through RelA and RelB in EOC cells, and the miRNAs, hsa-miR-452-5p and hsa-miR-335-5p, play a role in TIC persistence. These findings provide new insights into preventing EOC recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gangli Yan, Zhiwei Tao, Xiaobing Xing, Ziying Zhou, Xinghua Wang, Xing Li, Fengguang Li
Summary: This study investigates the role of miR-192-5p in hypoxic-ischemic brain damage (HIBD) and its relationship with the Yes-associated protein 1 (YAP1)-mediated Hippo signaling pathway. The findings suggest that inhibiting miR-192-5p or overexpressing YAP1 can alleviate neurobehavioral impairment and neuronal damage in HIBD.
NEUROCHEMICAL RESEARCH
(2022)
Article
Oncology
Zhengjun Guo, Kai Zhou, Qiang Wang, Yusheng Huang, Jia Ji, Yuan Peng, Xiaoyue Zhang, Taihao Zheng, Zhen Zhang, Daochen Chong, Zhenzhou Yang
Summary: The study showed that RUNX2 is highly expressed in the early stage of gastric cancer and correlated with poor clinical outcomes, Hp infection, new neoplastic events, therapeutic outcomes, ethnicity, race, and tumor stage. The oncogenic properties of RUNX2 are mediated through the regulation of YAP1, highlighting their essential roles in gastric carcinogenesis.