Article
Medical Laboratory Technology
Aneta Radziwon-Balicka, Elias F. Wiwe, Tomas O. Jensen, Signe G. Nielsen, Miljena Copois, Niclas Sunde, Nina C. Peytz, Dhergam A. A. Al-Mousawi, Mie C. Hansen, Jesper F. Petersen, Anne S. Norskov, Maria E. Lendorf, Young B. L. Hansen, Thomas S. Hansen, Melanie A. Burkhardt, Kristian M. Hansen, Claus A. J. Jensen
Summary: This study evaluated a novel antithrombotic formulation blood tube for measuring various blood analytes. The results showed that the novel tube demonstrated comparable results to the gold standard tubes for hematological, biochemical, and D-dimer analyses. This suggests that the novel tube has the potential to be used in clinical laboratories for simultaneous analysis of multiple blood parameters.
CLINICA CHIMICA ACTA
(2022)
Article
Surgery
Zi Jun Wu, Mohamed M. Ibrahim, Amanda R. Sergesketter, Ryan M. Schweller, Brett T. Phillips, Bruce Klitzman
Summary: This study tested the effectiveness of topical minoxidil and iloprost as pharmacologic delay agents for improving flap viability. The results showed that preoperative application of these vasodilators can significantly improve the viability of flaps, comparable to surgical delay. Noninvasive pharmacologic delay may reduce postoperative complications without the need for an additional operation.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Cell Biology
Divya Dasagrandhi, Anusuyadevi Muthuswamy, Jayachandran Kesavan Swaminathan
Summary: Atherosclerosis, characterized by lipid deposition and inflammation in vascular intima, is the main pathology behind cardiovascular diseases. Understanding the pathophysiology of this disease is crucial for early diagnosis and effective treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Evan Paul Tracy, Virginia Stielberg, Gabrielle Rowe, Daniel Benson, Sara S. Nunes, James B. Hoying, Walter Lee Murfee, Amanda Jo LeBlanc
Summary: Pathologies of the vasculature, especially the microvasculature, are complex and often result in loss of vascular function. Cellular and cell-free therapies offer potential solutions to restore vascular function.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nurul Aiza Mohd Sabri, Siew-Keah Lee, Dharmani Devi Murugan, Wei Chih Ling
Summary: The study found that EGCG can improve vascular function and lower blood pressure in hypertensive subjects by reducing vascular oxidative stress and increasing the bioavailability of NO.
SCIENTIFIC REPORTS
(2022)
Review
Orthopedics
Umberto Tarantino, Chiara Greggi, Ida Cariati, Patrizio Caldora, Rodolfo Capanna, Antonio Capone, Roberto Civinini, Stefano Colagrande, Pietro De Biase, Francesco Falez, Giovanni Iolascon, Davide Maraghelli, Laura Masi, Marco Matucci Cerinic, Giuseppe Sessa, Maria L. Brandi
Summary: Bone marrow edema (BME) is a relevant finding, although nonspecific, usually indicating the presence of an underlying pathology. Magnetic resonance imaging (MRI) is the gold standard technique for detecting BME, as it allows for an accurate diagnosis, which is crucial due to the heterogeneity of BME-related diseases. Depending on the severity of painful symptoms and MRI evidence, different treatment strategies can be applied: physical modalities, pharmacological options, and surgical therapy.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Review
Biochemistry & Molecular Biology
Beata Franczyk, Jill Dybiec, Weronika Frak, Julia Krzeminska, Joanna Kucmierz, Ewelina Mlynarska, Magdalena Szlagor, Magdalena Wronka, Jacek Rysz
Summary: This review focuses on the main pathophysiological mechanisms of coronary artery spasm (CAS), including endothelial dysfunction, chronic inflammation, oxidative stress, smooth muscle hypercontractility, atherosclerosis and thrombosis, and mutations leading to deficient ALDH2 activity. These findings offer novel insights into the underlying mechanisms of CAS and may guide the development of diagnostic and therapeutic targets for cardiovascular diseases in the future.
Review
Medicine, General & Internal
Elizabeth R. Volkmann, Kristofer Andreasson, Vanessa Smith
Summary: Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Research advancements have improved our understanding of its disease pathogenesis and clinical phenotypes and expanded our treatment options. Early and accurate diagnosis, as well as ongoing risk stratification, play a crucial role in predicting organ involvement and disease progression. Treatment should be tailored to individual patients, considering their goals of care, and balancing side effects with efficacy.
Review
Respiratory System
Tyler Pitre, Johnny Su, Sonya Cui, Ryan Scanlan, Christopher Chiang, Renata Husnudinov, Muhammad Faran Khalid, Nadia Khan, Gareth Leung, David Mikhail, Pakeezah Saadat, Shaneela Shahid, Jasmine Mah, Lisa Mielniczuk, Dena Zeraatkar, Sanjay Mehta
Summary: This study compared the effects of different medications for pulmonary arterial hypertension (PAH) through a network meta-analysis. The findings suggest that combination therapy with endothelin receptor antagonist (ERA) and phosphodiesterase-5 inhibitors (PDE5i), as well as monotherapy with riociguat, can reduce clinical worsening in PAH patients. Additionally, PDE5i, intravenous/subcutaneous prostanoids, and riociguat may decrease mortality compared to placebo. Combination therapy with ERA+PDE5i and riociguat may also increase 6-min walk distance in PAH patients.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Immunology
Melanie Borrmann, Florian Brandes, Benedikt Kirchner, Matthias Klein, Jean-Noel Billaud, Marlene Reithmair, Markus Rehm, Gustav Schelling, Michael W. Pfaffl, Agnes S. Meidert
Summary: COVID-19 infection leads to degradation of the endothelial protective glycocalyx layer, resulting in the release of major glycocalyx components. These circulating proteins and their degradation products can feedback on immune and endothelial cells, activating molecular signaling cascades associated with microvascular injury in COVID-19. The study found that plasma concentrations of glycocalyx components were highest in COVID-19 ARDS patients, and the degradation of endothelial glycocalyx components may lead to immune activation and more severe systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Qiang Wu, Feijun Luo, Xiao-Ling Wang, Qinlu Lin, Gao-Qiang Liu
Summary: ACEIPs are peptides that reduce Ang II levels by inhibiting ACE activity, potentially providing therapeutic effects for vascular dysfunction diseases. Methods for large-scale preparation of ACEIPs include enzymatic hydrolysis and microbial fermentation, with sources from animals, plants, and marine organisms. The vasodilatory, anti-inflammatory, and vascular remodeling effects of ACEIPs are promising, yet further research is needed to understand the molecular mechanisms of signal transduction regulation in vivo.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2022)
Review
Clinical Neurology
Kirsten B. Dorschel, John E. Wanebo
Summary: The etiology and pathophysiological mechanisms of moyamoya angiopathy (MMA) are largely unknown. Aberrant angiogenesis and inflammation may play a role in the pathogenesis of MMA. This literature review discusses the molecular mechanisms associated with cerebrovascular dysfunction, aberrant angiogenesis, and inflammation in MMA, as well as treatment strategies and future research perspectives.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Keivan Golshiri, Ehsan Ataei Ataabadi, Eloisa Rubio-Beltran, Sophie Dutheil, Wei Yao, Gretchen L. Snyder, Robert E. Davis, Ingrid van der Pluijm, Renata Brandt, Ingrid M. Van den Berg-Garrelds, Antoinette MaassenVandenBrink, Rene de Vries, A. H. Jan Danser, Anton J. M. Roks
Summary: The study emphasizes the crucial role of phosphodiesterase 1 in vascular function and suggests that its inhibition could potentially be a powerful tool for enhancing nitric oxide-cGMP signaling and treating age-related arteriopathy. Treatment with the selective phosphodiesterase 1 inhibitor ITI-214 showed promising effects in improving vascular aging features in Ercc1(Delta/-) mice, indicating its therapeutic potential in preventing cardiovascular complications associated with aging and progeria.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Review
Medicine, Research & Experimental
Wei Pan, Wei Jie, Hui Huang
Summary: Vascular calcification is a pathological vascular disorder associated with various diseases, posing a threat to human health. Although there is no acknowledged effective therapeutic strategy to reverse or cure vascular calcification, some studies focusing on its underlying molecular mechanisms provide promising prospects for its treatment.