Review
Neurosciences
Xiang-Zhen Kong, Merel C. Postema, Tulio Guadalupe, Carolien de Kovel, Premika S. W. Boedhoe, Martine Hoogman, Samuel R. Mathias, Daan van Rooij, Dick Schijven, David C. Glahn, Sarah E. Medland, Neda Jahanshad, Sophia Thomopoulos, Jessica A. Turner, Jan Buitelaar, Theo G. M. van Erp, Barbara Franke, Simon E. Fisher, Odile A. van den Heuvel, Lianne Schmaal, Paul M. Thompson, Clyde Francks
Summary: Left-right asymmetry of the human brain is associated with psychiatric disorders, but previous research findings have been inconsistent. The ENIGMA-Laterality Working Group conducted large-scale studies and mapped the average asymmetry in healthy brains. They also found associations between brain asymmetry and age, sex, handedness, and brain volume. Moreover, they identified subtle changes in cortical thickness asymmetry in autism spectrum disorder and altered subcortical asymmetry in pediatric obsessive-compulsive disorder.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Ana Beatriz Ravagnani Salto, Marcos L. Santoro, Marcelo Q. Hoexter, Andrea Parolin Jackowski, Pedro M. Pan, Maria Conceicao Rosario, Sintia Belangero, Pedro Gomes Alvarenga, Victoria Fogaca Doretto, Afonso Mazine Tiago Fumo, Marcelo C. Batistuzzo, Pedro Macul Ferreira de Barros, Kiara R. Timpano, Vanessa K. Ota, Luis Augusto Rohde, Euripedes Constantino Miguel, James F. Leckman, Andre Zugman
Summary: The study found a significant relationship between OCS and the symmetrized percent change (SPC) of the right thalamus volume in children, but there was no significant relationship between changes in thalamic volume SPC and OCD-PRS. These findings suggest the need for further research to confirm the results and further characterize the specific nature of OCS symptoms associated with thalamic volumes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Katherine Parkin, Shanquan Chen, Marjan Biria, James Plaistow, Helen Beckwith, Isaac Jarratt-Barnham, Nuria Segarra, Yulia Worbe, Naomi A. Fineberg, Rudolf N. Cardinal, Trevor W. Robbins, Emilio Fernandez-Egea
Summary: Obsessive-compulsive symptoms (OCS) commonly occur in patients treated with clozapine and can significantly affect subjective wellbeing. This study found that OCS severity had a negative impact on wellbeing scores, independent of depressive and psychotic symptoms. However, OCS did not impair general functioning. Obsessional thinking and hoarding behavior, rather than compulsions, were specifically associated with decreased wellbeing, possibly due to the nature of the compulsions.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Hollie A. L. Burton, Luise Pickenhan, Claire Carson, Paul Salkovskis, Fiona Alderdice
Summary: This review synthesized evidence on the experiences of maternity care and mental health care for women with Obsessive Compulsive Disorder (OCD) during pregnancy and postpartum. The findings revealed three descriptive themes: experiences of barriers to treatment and care, experiences of treatment/care decision making, and experiences of treatment and care. Three analytic themes were also identified, which demonstrated tensions in balancing the health and safety of the baby and the mother, as well as the perception of a normal perinatal experience. The review highlighted significant gaps in the literature, particularly regarding maternity and pharmacological care experiences. Balancing these tensions is crucial to ensure that women with OCD receive the necessary care.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
Jean-Paul Fouche, Nynke A. Groenewold, Tatum Sevenoaks, Sarah Heany, Christine Lochner, Pino Alonso, Marcelo C. Batistuzzo, Narcis Cardoner, Christopher R. K. Ching, Stella J. de Wit, Boris Gutman, Marcelo Q. Hoexter, Neda Jahanshad, Minah Kim, Jun Soo Kwon, David Mataix-Cols, Jose M. Menchon, Euripedes C. Miguel, Takashi Nakamae, Mary L. Phillips, Jesus Pujol, Yuki Sakai, Je-Yeon Yun, Carles Soriano-Mas, Paul M. Thompson, Kei Yamada, Dick J. Veltman, Odile A. van den Heuvel, Dan J. Stein
Summary: The subcortical shape in OCD patients is associated with comorbidity and medication status, especially with comorbid depression and anxiety.
BRAIN AND BEHAVIOR
(2022)
Article
Psychology, Multidisciplinary
Liliana Dell'Osso, Benedetta Nardi, Chiara Bonelli, Davide Gravina, Francesca Benedetti, Luca Del Prete, Gabriele Massimetti, Giulia Amatori, Barbara Carpita, Ivan Mirko Cremone
Summary: Recent research emphasizes the importance of a dimensional perspective on mental disorders, particularly the conceptualization of an obsessive-compulsive spectrum. The current study aims to evaluate the psychometric characteristics of the Obsessive-Compulsive Spectrum-Short Version (OBS-SV) questionnaire. The results demonstrate strong reliability and validity of the OBS-SV, showing significant correlations with other measures of obsessive-compulsive symptoms.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Psychiatry
Tamar C. Katz, Thanh Hoa Bui, Jennifer Worhach, Gabrielle Bogut, Kinga K. Tomczak
Summary: Tourettic OCD (TOCD) is a unique condition with overlapping symptoms of OCD and CTD. It is characterized by complex tic-like behaviors with compulsive and anxious features. TOCD is an intermediate neuropsychiatric disorder distinct from TS or OCD alone. The treatment of TOCD is complex and often resistant to treatment, requiring a combination of pharmacology and behavioral therapy.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Iliyan Ivanov, Premika S. W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Srinivas Balachander, Justin T. Baker, Nerisa Banaj, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Juliana B. Diniz, Benjamin A. Ely, Jamie D. Feusner, Sonia Ferreira, Kate D. Fitzgerald, Martine Fontaine, Patricia Gruner, Gregory L. Hanna, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Keisuke Ikari, Anthony James, Fern Jaspers-Fayer, Hongyan Jiang, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Jun Soo Kwon, Luisa Lazaro, Yanni Liu, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, David Mataix-Cols, Jose M. Menchon, Luciano Minuzzi, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Sanghoon Oh, Chris Perriello, John C. Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Y. C. Janardhan Reddy, Daniela Rodriguez Manrique, Yuki Sakai, Eiji Shimizu, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, David F. Tolin, Daan van Rooij, Dick J. Veltman, Ysbrand D. van der Werf, Guido A. van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je-Yeon Yun, Mojtaba Zarei, Fengrui Zhang, Qing Zhao, Neda Jahanshad, Sophia Thomopoulos, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Joseph O'Neill
Summary: This study measured the volumes of subcortical brain structures in OCD patients of different ages and on different medications. The results suggest that medication may have macroscopic effects on brain structures, and these effects may vary depending on the age of the patient and the type of medication.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Mariela Rance, Zhiying Zhao, Brian Zaboski, Stephen A. Kichuk, Emma Romaker, William N. Koller, Christopher Walsh, Cheyenne Harris-Starling, Suzanne Wasylink, Thomas Adams Jr, Patricia Gruner, Christopher Pittenger, Michelle Hampson
Summary: This study aimed to use fMRI neurofeedback as a treatment for OCD. The results showed that neurofeedback targeting the aPFC can reduce symptoms in OCD, but did not significantly affect control over the aPFC. Future studies should optimize the training protocol and clarify the mechanism of action.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Nur Dikmeer, Lutfullah Besiroglu, Maria A. Di Biase, Andrew Zalesky, Meltem I. Kasal, Aslihan Bilge, Ercan Durmaz, Serap Polat, Fazil Gelal, Nabi Zorlu
Summary: In comparison to healthy controls, OCD patients showed reduced FA and increased RD in certain key areas of the brain. OCD group also exhibited weaker connectivity in the right hemisphere compared to controls. Siblings of OCD patients had intermediate levels of white matter microstructure and connectivity, suggesting a familial predisposition for OCD.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Psychiatry
Vera Nezgovorova, Casara Jean Ferretti, Stefano Pallanti, Eric Hollander
Summary: Exacerbation or new onset of OCD symptoms during COVID-19 is an understudied area. Increased proinflammatory immune response in COVID-19 patients may be associated with the onset of obsessive-compulsive symptoms, and targeted anti-cytokine treatments can help mitigate these symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Johanna Otte, Nathalie Schicktanz, Dorothee Bentz
Summary: The aim of this study was to investigate the change in obsessive-compulsive symptoms (OCSs) from before to during the COVID-19 pandemic within the Swiss general population, and to examine the possible relationship of OCSs to stress and anxiety. The results showed that OCSs significantly increased during the pandemic, particularly in the washing dimension. Self-reported stress and anxiety were weakly associated with the severity of OCSs. The study suggests that all individuals with OCSs should be considered as risk groups for symptom deterioration during a pandemic and when assessing its possible long-term effects.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Katalin Csigo
Summary: Obsessive-compulsive disorder (OCD) is a difficult-to-treat disorder with diverse symptoms. This study focuses on object relations theory to understand OCD symptoms, particularly the concept of the obsessive position. The study distinguishes between the obsessive ego-state and the realistic ego-state, proposing OCD as a disorder of personality and ego organization. The application of a modified psychoanalytic methodology is advocated, with a glimpse into a psychoanalytic therapy session with an OCD patient.
CURRENT PSYCHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Pasquale Paribello, Bernardo Carpiniello, Roberto Murgia, Antonio Andrea Porcheddu, Sabrina El-Kacemi, Marco Pinna, Martina Contu, Giulia Costa, Rossella Barbarossa, Egea Sanna, Sara Carucci, Alessandro Zuddas, Paola Fadda, Simona Dedoni, Carlotta Siddi, Patrizia Congiu, Michela Figorilli, Michela Fanzecco, Monica Puligheddu, Antonella Gagliano, Federica Pinna, Maria Scherma, Mirko Manchia
Summary: Obsessive-compulsive disorder (OCD) is a common and highly disabling mental disorder. Different subgroups of OCD may have different impacts on cognition, functioning, sleep quality, and treatment response. There is a lack of evidence on the variation of brain-derived neurotrophic factor (BDNF) levels in OCD subgroups. Assessing inflammatory states, electroencephalogram, and polysomnography to characterize these subtypes has been hardly explored. The present project aims to increase accuracy in characterizing different OCD subtypes through clinical, cognitive, and sleep markers, along with other possible markers that may be biologically plausible.
APPLIED SCIENCES-BASEL
(2023)
Article
Clinical Neurology
Yimeng Pan, Chuanyong Xu, Tingxin He, Zhen Wei, Carol A. Seger, Qi Chen, Ziwen Peng
Summary: Background:The relationship between cognitive function and psychopathological symptoms has been an important research field. Methods:This study used network analysis to construct networks of cognitive variables and OCD-related symptoms in patients with OCD and healthy controls. Results:The study highlighted the important role of variables such as obsession and IQ from a network perspective. Conclusions: These results deepen our understanding of the multivariate relationship between cognitive dysfunction and OCD symptoms and may promote the prediction and diagnosis of OCD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Petra J. W. Pouwels, Chris Vriend, Feng Liu, Niels T. de Joode, Maria C. G. Otaduy, Bruno Pastorello, Frances C. Robertson, Ganesan Venkatasubramanian, Jonathan Ipser, Seonjoo Lee, Marcelo C. Batistuzzo, Marcelo Q. Hoexter, Christine Lochner, Euripedes C. Miguel, Janardhanan C. Narayanaswamy, Rashmi Rao, Y. C. Janardhan Reddy, Roseli G. Shavitt, Karthik Sheshachala, Dan J. Stein, Anton J. L. M. van Balkom, Melanie Wall, Helen Blair Simpson, Odile A. van den Heuvel
Summary: This study aimed to translate neuroimaging findings in neuropsychiatric research to worldwide populations by using a harmonized MRI data acquisition and quality assessment method. The results showed that there was less variation within sites than between sites in terms of image quality measures (IQMs) and outcome measures. IQMs had less of an impact on outcome measures after preprocessing. Continuous monitoring of IQMs per site is valuable to detect potential artifacts and outliers.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Eamonn Kennedy, Emily L. Dennis, Hannah M. Lindsey, Terri deRoon-Cassini, Stefan Du Plessis, Negar Fani, Milissa L. Kaufman, Nastassja Koen, Christine L. Larson, Sarah Laskowitz, Lauren A. M. Lebois, Rajendra A. Morey, Mary R. Newsome, Cori Palermo, Nicholas J. Pastorek, Abigail Powers, Randall Scheibel, Soraya Seedat, Antonia Seligowski, Dan J. Stein, Jennifer Stevens, Delin Sun, Paul Thompson, Maya Troyanskaya, Sanne J. H. van Rooij, Amanda A. Watts, Carissa W. Tomas, Wright Williams, Frank G. Hillary, Mary Jo Pugh, Elisabeth A. Wilde, David F. Tate
Summary: This study uses a multisite mega analysis to derive quantitative recommendations for equating scores across measures of PTSD severity. The results suggest that harmonization and covariate adjustments can significantly improve inference of scores across different instruments.
Article
Psychiatry
Borwin Bandelow, Christer Allgulander, David S. Baldwin, Daniel Lucas da Conceicao Costa, Damiaan Denys, Nesrin Dilbaz, Katharina Domschke, Elias Eriksson, Naomi A. Fineberg, Josef Hattenschwiler, Eric Hollander, Hisanobu Kaiya, Tatiana Karavaeva, Siegfried Kasper, Martin Katzman, Yong-Ku Kim, Takeshi Inoue, Leslie Lim, Vasilios Masdrakis, Jose M. Menchon, Euripedes C. Miguel, Hans-Jurgen Moller, Antonio E. Nardi, Stefano Pallanti, Giampaolo Perna, Dan Rujescu, Vladan Starcevic, Dan J. Stein, Shih-Jen Tsai, Michael Van Ameringen, Anna Vasileva, Zhen Wang, Joseph Zohar
Summary: This study presents the third version of the guideline for the pharmacological treatment of anxiety, obsessive-compulsive, and posttraumatic stress disorders. It provides recommendations based on efficacy and acceptability of available treatments, evaluated through rigorous methods. The study highlights the importance of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) as first-line medications, and cognitive behavioral therapy (CBT) as the first-line psychotherapy for anxiety disorders.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Materials Science, Multidisciplinary
Parastoo Agharezaei, Tanay Sahu, Jonathan Shock, Paul G. O'Brien, Kulbir Kaur Ghuman
Summary: In recent years, computational methods have been rapidly advancing, allowing for material simulations to explore the potential of undiscovered materials in catalyst design. This review article focuses on evolutionary-based optimization techniques, specifically Genetic Algorithms, and discusses the descriptors and appraisal for key chemical reactions. These insights will aid researchers in utilizing evolutionary-based optimization techniques for catalyst design and discovery.
COMPUTATIONAL MATERIALS SCIENCE
(2023)
Article
Psychology, Developmental
Chris Hollis, Charlotte L. Hall, Kareem Khan, Rebecca Jones, Louise Marston, Marie Le Novere, Rachael Hunter, Per Andren, Sophie D. Bennett, Beverley J. Brown, Liam R. Chamberlain, E. Bethan Davies, Amber Evans, Natalia Kouzoupi, Caitlin McKenzie, Charlotte Sanderson, Isobel Heyman, Joseph Kilgariff, Cristine Glazebrook, David Mataix-Cols, Eva Serlachius, Elizabeth Murray, Tara Murphy
Summary: This study evaluated the long-term clinical and cost effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for treating tics. The results showed that online ERP therapy reduced tic severity and had long-lasting effects at 12 and 18 months after treatment initiation. The economic evaluation indicated that online ERP therapy is a cost-effective intervention.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Constantinos Constantinides, Laura K. M. Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M. Diaz-Caneja, Gary Donohoe, Stefan Du Plessis, Jesse Edmond, Stefan Ehrlich, Robin Emsley, Lisa T. Eyler, Paola Fuentes-Claramonte, Foivos Georgiadis, Melissa Green, Amalia Guerrero-Pedraza, Minji Ha, Tim Hahn, Frans A. Henskens, Laurena Holleran, Stephanie Homan, Philipp Homan, Neda Jahanshad, Joost Janssen, Ellen Ji, Stefan Kaiser, Vasily Kaleda, Minah Kim, Woo-Sung Kim, Matthias Kirschner, Peter Kochunov, Yoo Bin Kwak, Jun Soo Kwon, Irina Lebedeva, Jingyu Liu, Patricia Mitchie, Stijn Michielse, David Mothersill, Bryan Mowry, Victor Ortiz-Garcia de la Foz, Christos Pantelis, Giulio Pergola, Fabrizio Piras, Edith Pomarol-Clotet, Adrian Preda, Yann Quide, Paul E. Rasser, Kelly Rootes-Murdy, Raymond Salvador, Marina Sangiuliano, Salvador Sarro, Ulrich Schall, Andre Schmidt, Rodney J. Scott, Pierluigi Selvaggi, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Therese van Amelsvoort, Javier Vazquez-Bourgon, Daniela Vecchio, Aristotle Voineskos, Cynthia S. Weickert, Thomas Weickert, Paul M. Thompson, Lianne Schmaal, Theo G. M. van Erp, Jessica Turner, James H. Cole, Danai Dima, Esther Walton
Summary: Schizophrenia patients show evidence of advanced brain ageing, which is not associated with clinical characteristics.
MOLECULAR PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Federica Piras, Nerisa Banaj, Valentina Ciullo, Fabrizio Piras, Giuseppe Ducci, Francesco Demaria, Stefano Vicari, Gianfranco Spalletta
Summary: In a study of children and adolescents with OCD, certain dysfunctional beliefs and cognitive traits were found to predict symptom severity. Self-oriented and socially prescribed perfectionism and intolerance to uncertainty were associated with higher obsession severity, while excessive concerns with the expectations of others were linked to greater severity of obsessions and compulsions about harm due to aggression/injury/violence/natural disasters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Charlene Omrawo, Konstantinos Ioannidis, Jon E. Grant, Nina Lutz, Samuel R. Chamberlain, Dan J. Stein, Jeggan Tiego, Martin Kidd, Christine Lochner
Summary: Problematic usage of the internet (PUI) is a growing concern in the digitalized world. Existing screening tools for PUI lack evaluation of their psychometric properties and do not adequately measure both the severity of PUI and the nature of diverse problematic online activities. The Internet Severity and Activities Addiction Questionnaire (ISAAQ), consisting of two parts, was developed to address these limitations. This study validated the psychometric properties of ISAAQ Part A using data from three countries, demonstrating its reliability and providing insights into problematic online activities.
COMPREHENSIVE PSYCHIATRY
(2023)
Article
Clinical Neurology
Michael A. Strumberger, Isabelle Haeberling, Sophie Emery, Mona Albermann, Noemi Baumgartner, Naima Bucher, Suzanne Erb, Silke Bachmann, Lars Woeckel, Ulrich Mueller-Knapp, Brigitte Contin-Waldvogel, Bruno Rhiner, Susanne Walitza, Gregor Berger, Christian Cajochen, Klaus Schmeck
Summary: This study found a significant association between hypersomnia and middle insomnia symptoms and elevated CRP levels in pediatric depression, which was not linked to alterations in body mass index.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Willem B. Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea L. Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Sara Bertolin Triquell, Silvia Brem, Federico Calesella, Beatriz Couto, Damiaan A. J. P. Denys, Marco A. N. Echevarria, Goi Khia Eng, Sonia Ferreira, Jamie D. Feusner, Rachael G. Grazioplene, Patricia Gruner, Joyce Y. Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, Jose M. Menchon, Pedro S. Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y. C. Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H. Simpson, Carles Soriano-Mas, Nuno M. Sousa, Gianfranco Spalletta, Emily R. Stern, S. Evelyn Stewart, Philip Szeszko, Jinsong Tang, Sophia Thomopoulos, Anders L. Thorsen, Yoshida Tokiko, Hirofumi Tomiyama, Benedetta Vai, Ilya M. Veer, Ganesan Venkatasubramanian, Nora C. Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A. van Leeuwen, Hein J. F. van Marle, Laurens A. van de Mortel, Anouk van der Straten, Ysbrand D. van der Werf, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Guido A. van Wingen
Summary: Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. A mega-analysis of data from 1024 OCD patients and 1028 healthy controls revealed widespread abnormalities in functional connectivity in OCD, including global hypo-connectivity and few hyper-connections mainly with the thalamus. Classification performances based on resting-state connectivity were poor, indicating that it is not an accurate biomarker for identifying individual patients.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
David Mataix-Cols, Kayoko Isomura, Gustaf Brander, Isabell Brikell, Paul Lichtenstein, Zheng Chang, Henrik Larsson, Ralf Kuja-Halkola, Kevin J. Black, Anna Sidorchuk, Lorena Fernandez de la Cruz
Summary: A Swedish study found that 20% of children with tic disorders continued to have chronic tic disorders into adulthood, with childhood psychiatric comorbidities and family history of psychiatric disorders being the strongest risk factors for tic disorder persistence.
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Dick Schijven, Merel C. Postema, Masaki Fukunaga, Junya Matsumoto, Kenichiro Miura, Sonja M. C. de Zwarte, Neeltje E. M. van Haren, Wiepke Cahn, Hilleke E. Hulshoff Pol, Rene S. Kahn, Rosa Ayesa-Arriola, Victor Ortiz-Garcia de la Foz, Diana Tordesillas-Gutierrez, Javier Vazquez-Bourgon, Benedicto Crespo-Facorro, Dag Alnaes, Andreas Dahl, Lars T. Westlye, Ingrid Agartz, Ole A. Andreassen, Erik G. Jonsson, Peter Kochunov, Jason M. Bruggemann, Stanley V. Catts, Patricia T. Michie, Bryan J. Mowry, Yann Quide, Paul E. Rasser, Ulrich Schall, Rodney J. Scott, Vaughan J. Carr, Melissa J. Green, Frans A. Henskens, Carmel M. Loughland, Christos Pantelis, Cynthia Shannon Weickert, Thomas W. Weickert, Lieuwe De Haan, Katharina Brosch, Julia-Katharina Pfarr, Kai G. Ringwald, Frederike Stein, Andreas Jansen, Tilo T. J. Kircher, Igor Nenadic, Bernd Kramer, Oliver Gruber, Theodore D. Satterthwaite, Juan Bustillo, Daniel H. Mathalon, Adrian Preda, Vince D. Calhoun, Judith M. Ford, Steven G. Potkin, Jingxu Chen, Yunlong Tan, Zhiren Wang, Hong Xiang, Fengmei Fan, Fabio Bernardoni, Stefan Ehrlich, Paola Fuentes-Claramonte, Maria Angeles Garcia-Leon, Amalia Guerrero-Pedraza, Raymond Salvador, Salvador Sarro, Edith Pomarol-Clotet, Valentina Ciullo, Fabrizio Piras, Daniela Vecchio, Nerisa Banaj, Gianfranco Spalletta, Stijn Michielse, Therese van Amelsvoort, Erin W. Dickie, Aristotle N. Voineskos, Kang Sim, Simone Ciufolini, Paola Dazzan, Robin M. Murray, Woo-Sung Kim, Young-Chul Chung, Christina Andreou, Andre Schmidt, Stefan Borgwardt, Andrew M. McIntosh, Heather C. Whalley, Stephen M. Lawrie, Stefan Du Plessis, Hilmar K. Luckhoff, Freda Scheffler, Robin Emsley, Dominik Grotegerd, Rebekka Lencer, Udo Dannlowski, Jesse T. Edmond, Kelly Rootes-Murdy, Julia M. Stephen, Andrew R. Mayer, Linda A. Antonucci, Leonardo Fazio, Giulio Pergola, Alessandro Bertolino, Covadonga M. Diaz-Caneja, Joost Janssen, Noemi G. Lois, Celso Arango, Alexander S. Tomyshev, Irina Lebedeva, Simon Cervenkav, Carl M. Sellgrenv, Foivos Georgiadis, Matthias Kirschner, Stefan Kaiser, Tomas Hajek, Antonin Skoch, Filip Spaniel, Minah Kim, Yoo Bin Kwak, Sanghoon Oh, Jun Soo Kwon, Anthony James, Geor Bakker, Christian Knochel, Michael Stablein, Viola Oertel, Anne Uhlmann, Fleur M. Howells, Dan J. Stein, Henk S. Temmingh, Ana M. Diaz-Zuluaga, Julian A. Pineda-Zapata, Carlos Lopez-Jaramillo, Stephanie Homan, Ellen Ji, Werner Surbeck, Philipp Homan, Simon E. Fishera, Barbara Franke, David C. Glahn, Ruben C. Gur, Ryota Hashimoto, Neda Jahanshad, Eileen Luders, Sarah E. Medland, Paul M. Thompson, Jessica A. Turner, Theo G. M. van Erp, Clyde Francks
Summary: Left-right asymmetry is an important feature of the healthy brain that may be altered in schizophrenia. This study used a large sample size and consistent methods to investigate structural brain asymmetries in schizophrenia, finding significant differences. These differences may reflect changes at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Psychiatry
Beata Bothe, Monika Koos, Lena Nagy, Shane W. Kraus, Zsolt Demetrovics, Marc N. Potenza, Aurelie Michaud, Rafael Ballester-Arnal, Dominik Batthyany, Sophie Bergeron, Joel Billieux, Peer Briken, Julius Burkauskas, Georgina Cardenas-Lopez, Joana Carvalho, Jesus Castro-Calvo, Lijun Chen, Giacomo Ciocca, Ornella Corazza, Rita Csako, David P. Fernandez, Elaine F. Fernandez, Lois Fournier, Hironobu Fujiwara, Johannes Fuss, Roman Gabrhelik, Ateret Gewirtz-Meydan, Biljana Gjoneska, Mateusz Gola, Joshua B. Grubbs, T. Hashim Hashim, Md. Saiful Islam, Mustafa Ismail, Martha C. Jimenez-Martinez, Tanja Jurin, Ondrej Kalina, Verena Klein, Andras Kolto, Chih-Ting Lee, Sang-Kyu Lee, Karol Lewczuk, Chung-Ying Lin, Christine Lochner, Silvia Lopez-Alvarado, Katerina Lukavska, Percy Mayta-Tristan, Ionut Milea, Dan J. Miller, Olga Orosova, Gabor Orosz, Fernando P. Ponce, Gonzalo R. Quintana, Gabriel C. Quintero Garzola, Jano Ramos-Diaz, Kevin Rigaud, Ann Rousseau, Marco De Tubino Scanavino, Marion K. Schulmeyer, Pratap Sharan, Mami Shibata, Sheikh Shoib, Vera L. Sigre Leiros, Luke Sniewski, Ognen Spasovski, Vesta Steibliene, Dan J. Stein, Julian Strizek, Aleksandar Stulhofer, Berk C. Unsal
Summary: This study comprehensively examined compulsive sexual behavior disorder (CSBD) in 42 countries, different genders, and sexual orientations, and validated the CSBD-19 and CSBD-7 scales as screening tools. Results showed that 4.8% of participants were at high risk of CSBD, with differences found based on country and gender. The study contributes to a better understanding of CSBD in underrepresented populations and provides freely accessible screening tools in 26 languages.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2023)
Review
Neurosciences
Harsh Pathak, Vanteemar S. Sreeraj, Ganesan Venkatasubramanian
Summary: Transcranial alternating current stimulation (tACS) may alleviate associated symptoms in schizophrenia by modulating neuronal oscillations through sinusoidal alternating current. Preliminary research has shown promising results in the utility of tACS for schizophrenia, particularly in the areas of cognitive deficits and positive symptoms. However, more rigorous randomized controlled trials are needed to substantiate these early findings.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Psychiatry
Sheri-Michelle Koopowitz, Karen Thea Mare, Marilyn Lake, Christopher du Plooy, Nadia Hoffman, Kirsten A. Donald, Susan Malcolm-Smith, Lynne Murray, Heather J. Zar, Peter Cooper, Dan J. Stein
Summary: This study investigated the effects of dialogic book-sharing on language development, neurocognitive function, and socio-emotional domains in 3.5-year-old children from low-income South African communities. The results showed no significant differences between the intervention and control groups after 4 months post-intervention.
COMPREHENSIVE PSYCHIATRY
(2024)