Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 32, Issue -, Pages 120-127Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2016.05.012
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Funding
- NIH [NIH AI0149558, AI114054]
- Max Planck Society
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Maintenance of genome integrity is essential. However, programmed DNA elimination removes specific DNA sequences from the genome during development. DNA elimination occurs in unicellular ciliates and diverse metazoa ranging from nematodes to vertebrates. Two distinct groups of nematodes use DNA elimination to silence germline-expressed genes in the soma (ascarids) or for sex determination (Strongyloides spp.). Data suggest that DNA elimination likely evolved independently in these nematodes. Recent studies indicate that differential CENP-A deposition within chromosomes defines which sequences are retained and lost during Ascaris DNA elimination. Additional studies are needed to determine the distribution, functions, and mechanisms of DNA elimination in nematodes.
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