Review
Oncology
Alissa R. Kahn, Carla M. Schwalm, Julie Ann Wolfson, Jennifer M. Levine, Emily E. Johnston
Summary: This study aims to describe the impact of the COVID-19 pandemic on children with cancer, including morbidity and mortality, interruptions in cancer care and delays in diagnosis, and psychosocial effects. Although they have better outcomes compared to the general pediatric population, children with cancer still face increased risks, with socioeconomic and ethnic disparities present.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Oncology
Rebecca S. Parker, Justin Le, Andrew Doan, Paibel Aguayo-Hiraldo, Pia S. Pannaraj, Teresa Rushing, Jemily Malvar, Maurice R. O'Gorman, Jennifer Dien Bard, Chintan Parekh
Summary: Pediatric oncology patients are at higher risk for hospitalization with COVID-19, but the majority can undergo chemotherapy without delays in treatment. Viral load may be a potential predictor for the outcome of COVID-19 in pediatric cancer patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Editorial Material
Medicine, General & Internal
Eric J. Rubin, Lindsey R. Baden, Stephen Morrissey
Summary: This article discusses the vaccination of young children and pregnant women against Covid-19, covering the recent approval of Covid-19 vaccination for children under five and a new study on vaccination in pregnant women.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Pediatrics
Emanuele Nicastro, Lucio Verdoni, Laura Rachele Bettini, Giovanna Zuin, Adriana Balduzzi, Giovanni Montini, Andrea Biondi, Lorenzo D'Antiga
Summary: The clinical burden of COVID-19 is mainly due to over-inflammation and immune-mediated multiorgan injury, with immunosuppression playing a downsized role in determining outcomes. Children show resistance to severe manifestations of COVID-19, possibly due to effective recognition by the innate immune system and controlled pro-inflammatory signaling.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Karel Kostev, Lee Smith, Ai Koyanagi, Marcel Konrad, Louis Jacob
Summary: The prevalence of post-COVID-19 condition was low in COVID-19 children and adolescents in Germany. Older children and adolescents were more likely to be diagnosed with post-COVID-19 condition. Anxiety disorders, somatoform disorders, and allergic rhinitis were significantly associated with post-COVID-19 condition.
PEDIATRIC RESEARCH
(2022)
Editorial Material
Medicine, General & Internal
Eric J. Rubin, Lindsey R. Baden, Julie R. Inglefinger, Stephen Morrissey
Summary: This article is an interview discussing the effects of Covid-19 on children and adolescents, joined by a pediatrician. It provides advice to parents and aims to shed light on the impact of the virus on this demographic.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Daniel Natera-de Benito, Sergio Aguilera-Albesa, Laura Costa-Comellas, Mar Garcia-Romero, Maria Concepcion Miranda-Herrero, Julia Rubies Olives, Oscar Garcia-Campos, Elena Martinez del Val, Maria Josefa Martinez Garcia, Inmaculada Medina Martinez, Ramon Cancho-Candela, Miguel A. Fernandez-Garcia, Samuel Ignacio Pascual-Pascual, David Gomez-Andres, Andres Nascimento
Summary: This study described the clinical characteristics and outcomes of COVID-19 in 29 children with neuromuscular disorders, showing that no severe complications were observed and the majority of cases were asymptomatic or mild.
JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Carl A. Pierce, Sharlene Sy, Benjamin Galen, Doctor Y. Goldstein, Erika Orner, Marla Keller, Kevan C. Herold, Betsy Herold
Summary: Children infected with SARS-CoV-2 show a more robust early mucosal immune response compared to adults, which may contribute to favorable clinical outcomes. Higher levels of IFN signaling and other innate pathways were observed in children, along with increased levels of certain cytokines in nasal fluid, suggesting a more protective immune response in children against severe COVID-19.
Article
Oncology
Norman Brito-Dellan, Nikolaos Tsoukalas, Carme Font
Summary: Cancer and COVID-19 have similarities in terms of thrombosis, D-dimer levels, and the failure of anticoagulation therapy. Cancer patients are more vulnerable to COVID-19 and have a higher mortality rate. Managing cancer-associated thrombosis in COVID-19 patients requires special considerations. Cancer patients should be given priority for COVID-19 vaccination, although they may have a weaker immune response. Additional doses and booster shots of the COVID-19 vaccine are recommended for patients undergoing active cancer treatment.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Pediatrics
Chiara Giraudo, Giulia Fichera, Lucia Pilati, Anna Laura Cortinovis, Celeste Cavallin, Sofia Bertin, Monica Zuliani, Diego Cecchin
Summary: Since the early phases of the COVID-19 pandemic, it has been recognized that children experience mild respiratory symptoms, but it took longer to understand the potential severe musculoskeletal symptoms they may develop, including arthritis and myositis. Diagnostic imaging, although rarely used, has shown muscle edema and synovitis in children with COVID-19. Further use of diagnostic imaging to evaluate musculoskeletal involvement in children with COVID-19 is strongly encouraged.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Conor McCafferty, Tengyi Cai, Delphine Borgel, Dominique Lasne, Sylvain Renolleau, Meryl Vedrenne-Cloquet, Damien Bonnet, Jemma Wu, Thiri Zaw, Atul Bhatnagar, Xiaomin Song, Suelyn van den Helm, Natasha Letunica, Chantal Attard, Vasiliki Karlaftis, Slavica Praporski, Vera Ignjatovic, Paul Monagle
Summary: This study utilized proteomics to analyze plasma proteins in healthy children, children with MIS-C, and children with COVID-19 ARDS, and identified the affected pathways. The results revealed differentially expressed proteins among these groups and identified key pathways associated with MIS-C and COVID-19 ARDS.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Francesca Maria Consonni, Barbara Durante, Marcello Manfredi, Augusto Bleve, Chiara Pandolfo, Valentina Garlatti, Virginia Vita Vanella, Emilio Marengo, Elettra Barberis, Barbara Bottazzi, Sara Bombace, Ilaria My, Gianluigi Condorelli, Valter Torri, Antonio Sica
Summary: Despite being more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the mechanisms underlying the predisposition of cancer patients to severe forms of coronavirus disease 2019 (COVID-19) remain unknown. Utilizing a combination of flow cytometry and multiomics, this study identifies immunometabolic pathways that intersect with cancer and SARS-CoV-2 infection. The findings suggest that cancer not only dampens the inflammatory state in COVID-19 patients but also weakens their metabolic state through interference with NAD(+)-dependent immune homeostasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Hiam Chemaitelly, Sawsan AlMukdad, Houssein H. Ayoub, Heba N. Altarawneh, Peter Coyle, Patrick Tang, Hadi M. Yassine, Hebah A. Al-Khatib, Maria K. Smatti, Mohammad R. Hasan, Zaina Al-Kanaani, Einas Al-Kuwari, Andrew Jeremijenko, Anvar H. Kaleeckal, Ali N. Latif, Riyazuddin M. Shaik, Hanan F. Abdul-Rahim, Gheyath K. Nasrallah, Mohamed G. Al-Kuwari, Hamad E. Al-Romaihi, Adeel A. Butt, Mohamed H. Al-Thani, Abdullatif Al-Khal, Roberto Bertollini, Laith J. Abu-Raddad
Summary: A study in Qatar found that the BNT162b2 vaccine provided modest and rapidly waning protection against Covid-19 in children aged 5 to 11, while it gave stronger and more durable protection in adolescents aged 12 to 17, possibly due to the higher antigen dose.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Gerard C. Millen, Roland Arnold, Jean-Baptiste Cazier, Helen Curley, Richard G. Feltbower, Ashley Gamble, Adam W. Glaser, Richard G. Grundy, Lennard Y. W. Lee, Martin G. McCabe, Robert S. Phillips, Charles A. Stiller, Csilla Varnai, Pamela R. Kearns
Summary: This study aimed to provide evidence on the incidence and outcomes of SARS-CoV-2 in children with cancer attending hospitals in the UK. The study found that children with cancer appear to have similar risk of severe SARS-CoV-2 infection compared to the general pediatric population, with an estimated incidence of 3% in this group. This supports the continued delivery of standard treatment for children with cancer during the pandemic.
BRITISH JOURNAL OF CANCER
(2021)
Article
Microbiology
Michael T. Hawkes, Michael F. Good
Summary: According to a mathematical epidemiological model, childhood vaccination against COVID-19 can have modest public health benefits, including reducing child morbidity and mortality and decreasing adult cases, hospitalizations, and mortality. However, the ethical considerations and global social justice, especially in terms of prioritizing children in high-income settings over vulnerable adults in low-income settings, should also be taken into account.
Article
Nursing
Merav Ben Natan, Heba Igbarin, Arwa Watted
Summary: This study aimed to compare factors affecting mothers' satisfaction with care in the Emergency Department (ED) for children with autistic spectrum disorder (ASD) and children without ASD. The results showed that mothers of children with ASD expressed lower satisfaction, especially in terms of waiting times, attentiveness and responsiveness of nurses, coordination and cooperation among ED staff, and the overall organization of work in the ED. Communication difficulties in children predicted mothers' satisfaction with care.
JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
(2024)
Article
Nursing
Xiaodan Zhang, Jiao Xie, Weijing Wu, Lifang Cao, Zheyi Jiang, Zhu Li, Yamin Li
Summary: This study examined the relationship between stress, mental resilience, and coping style, and the mediation effect of mental resilience between stress and coping style among parents of children with cochlear implants. The results showed that mental resilience mediated the relationship between stress and active coping style. This study provides a theoretical basis for developing an active coping care program for these parents.
JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
(2024)
