Importance and Evidence of Extent of Resection in Glioblastoma

Maximal safe resection is an essential part of the multidisciplinary care of patients with glioblastoma. A growing body of data shows that gross total resection is an independent prognostic factor associated with improved clinical outcome. The relationship between extent of glioblastoma (GB) resection and clinical benefit depends critically on the balance between cytoreduction and avoiding neurologic morbidity. The definition of the extent of tumor resection, how this is best measured pre- and postoperatively, and its relation to volume of residual tumor is still discussed. We review the literature supporting extent of resection in GB, highlighting the importance of a standardized definition and measurement of extent of resection to allow greater collaboration in research projects and trials. Recent developments in neurosurgical techniques and technologies focused on maximizing extent of resection and safety are discussed.

Automated summary

Maximal safe resection is crucial for glioblastoma patients, with gross total resection being an independent prognostic factor for better clinical outcomes. However, the relationship between extent of resection and clinical benefit depends on balancing cytoreduction and avoiding neurologic morbidity. Standardization and measurement of extent of resection are important for collaboration in research and trials. Recent advancements in neurosurgical techniques focus on maximizing extent of resection while ensuring safety.