Article
Materials Science, Biomaterials
Qianting Luo, Xingyang Li, Wenchao Zhong, Wei Cao, Mingjing Zhu, Antong Wu, Wanyi Chen, Zhitong Ye, Qiao Han, Duraipandy Natarajan, Janak L. Pathak, Qingbin Zhang
Summary: This study found that C2S-induced macrophagic inflammation is likely caused by mitochondrial dysfunction and autophagy. Furthermore, the macrophagic inflammation induced by C2S promotes osteogenic differentiation of BMSCs.
REGENERATIVE BIOMATERIALS
(2022)
Article
Pharmacology & Pharmacy
Daewon Han, Deokryong Kim, Haeil Kim, Jeonga Lee, Jungmook Lyu, Jong-Seok Kim, Jongdae Shin, Jeong Sig Kim, Do Kyung Kim, Hwan-Woo Park
Summary: In this study, it was found that Methylsulfonylmethane (MSM) can enhance the autophagy flux through the AMPK/mTOR/ULK1 pathway, improving hepatic steatosis and potentially serving as a treatment for obesity-related MAFLD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Lichao Yang, Xiaojing Cheng, Wei Shi, Hui Li, Qi Zhang, Shiping Huang, Xuejing Huang, Sha Wen, Ji Gan, Zhouxiang Liao, Junming Sun, Jinning Liang, Yiqiang Ouyang, Min He
Summary: This study established Vasn knockout mice and found that Vasn deficiency resulted in decreased body and liver weight, abnormal liver function, liver injury, and aberrant activation of hepatocyte autophagy. It was also observed that Vasn deletion upregulated hepatocyte autophagy through the mTOR-ULK1 signaling pathway. These findings provide new insight into the role of Vasn in liver functionality.
Review
Neurosciences
Sarah H. Berth, Dominick J. Rich, Thomas E. Lloyd
Summary: Autophagy is a crucial process for maintaining cellular homeostasis, and its disruption is commonly found in neurodegenerative diseases. Recent evidence suggests that autophagy also plays a role in regulating important axonal functions. This review discusses the kinase regulation of autophagy in neurons and provides an overview of how autophagic kinases regulate axonal processes, including axonal transport and degeneration and regeneration. It also examines the mechanisms of disruption leading to neurodegeneration, with a focus on the role of TBK1 in the pathogenesis of Amyotrophic Lateral Sclerosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Immunology
Juan Xiao, Xiaofang Shen, Ruiming Kou, Ke Wang, Lihong Zhai, Lu Ding, Huabo Chen, Chun Mao
Summary: This study aimed to investigate the protective role of kirenol in inflammation induced by lipopolysaccharide (LPS) in acute lung injury (ALI) cell and mouse models and unravel the underlying mechanisms, with a particular focus on autophagy. The results showed that kirenol could significantly inhibit inflammatory cytokines secretion and enhance autophagy, possibly through activating the AMPK-mTOR-ULK1 pathway. RNA sequencing results suggested the involvement of kirenol in acute inflammatory response and the AMPK signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Sisi Zhao, Shiqi Wang, Luxi Cao, Hai Zeng, Shujun Lin, Zhuowen Lin, Minan Chen, Mingmin Zhu, Zhao Pang, Yimin Zhang
Summary: This study aims to investigate the autophagy mediating mechanism underlying the neuroprotective effect of acupuncture in traumatic brain injury (TBI) rats. The results showed that acupuncture promoted neuronal autophagy on Day 3 after TBI, but inhibited it on Day 7 and Day 14, alleviating nerve damage. The mTOR/ULK1 pathway may be involved in the regulatory effect of acupuncture on autophagy in different stages of TBI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Zheng Chen, Jianguo Zhang, Chenyang Dong, Dongsheng Li, Yuehan Yin, Wenhai Yu, Yuezhi Chen
Summary: The study reveals that TNFAIP8 is significantly up-regulated in gastric cancer tissues and cells, enhancing cell viability, reducing apoptosis, and promoting cell migration. Moreover, TNFAIP8 overexpression promotes autophagy and inhibits the mTOR-Akt-ULK1 signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Environmental Sciences
Yun Zhang, Ming Yan, Shumeng Kuang, Yiqiang Lou, Shouqian Wu, Yurong Li, Zihan Wang, Hongjiao Mao
Summary: BPA inhibits osteocyte cell viability, promotes cell apoptosis, and induces cell death through autophagy. It also causes toxicity by generating oxidative stress in osteocytes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Critical Care Medicine
Mao-xia Liu, Jia Yang, Yan Qin, Zheng-da Li, Jun Jin, Yan-bing Zhang, Xin-jing Yang
Summary: The aim of this study was to investigate the effect of esmolol (ES) on LPS-induced cardiac injury and the possible mechanism. The results showed that ES could alleviate LPS-induced myocardial damage through activating the AMPK/mTOR/ULK1 signal pathway-regulated autophagy, which was demonstrated by hematoxylin-eosin staining and measurement of cardiac troponin.
Article
Immunology
Xing Zhang, HuaQiang Zhang, YingKui Gao, ZhongHua Hao, JingJing Liu, GuangWei Zhou, Fang Liu, Xiao Li, Chao Tong, XueBing Wang
Summary: This study found that Forsythoside A (FTA) can alleviate inflammation and oxidative stress in bovine mammary epithelial cells (MAC-T) induced by lipopolysaccharides (LPS), improve autophagy function, and inhibit cell apoptosis by activating the AMPK pathway. These results suggest that FTA inhibits LPS-induced autophagy, apoptosis, and inflammatory damage in MAC-T cells by activating the AMPK pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Li Zhu, Jiahe Wang, Zuping Wu, Sirui Chen, Yuying He, Yukun Jiang, Guowen Luo, Zhuoxuan Wu, Yuyu Li, Jing Xie, Shujuan Zou, Chenchen Zhou
Summary: This study investigated the role of AFF4 in the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and identified its mechanism of action. The study found that AFF4 expression was lower in inflamed periodontal tissues and lipopolysaccharides-treated hPDLSCs compared to controls, and it was up-regulated during osteogenic differentiation of hPDLSCs. Further experiments showed that AFF4 regulated the osteogenic differentiation of hPDLSCs by targeting autophagic activity.
CELL PROLIFERATION
(2023)
Article
Immunology
Youli Yu, Jialiang Pan, Mengting Liu, Haiqin Jiang, Jingshu Xiong, Lei Tao, Feng Xue, Fang Tang, Hongsheng Wang, Jianjun Dai
Summary: In this study, the role of GBP2b in regulating autophagy during M. bovis infection was investigated. The results showed that GBP2b is associated with autophagy, mTOR signaling, and AMPK signaling. Down-regulation of GBP2b impaired autophagy, promoting intracellular survival of M. bovis.
Article
Chemistry, Medicinal
Di Zhang, Yinghui Zhang, Zhilan Wang, Lei Lei
Summary: This study demonstrates the beneficial effects of thymoquinone (TQ) on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) and human hepatocellular carcinoma cells. TQ promotes hepatic autophagy through the AMPK/mTOR/ULK1 signaling pathway, reducing lipid accumulation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Md. Ataur Rahman, Yoonjeong Cho, Ghilsoo Nam, Hyewhon Rhim
Summary: Oxyresveratrol affects the function of astrocytes by promoting autophagy signaling and inhibiting APP production. Co-treatment with chloroquine significantly enhances autophagic flux, and the regulation of autophagy substrates and pathways by Oxyresveratrol depends on the PI3 kinase pathway.
Article
Genetics & Heredity
Fengxia Liu, Mujun Li
Summary: This study investigates the role of BNIP3-induced autophagy in primordial follicle loss following ovarian tissue transplantation (OTT). The results show that BNIP3 and autophagy play crucial roles in the depletion of primordial follicles, suggesting BNIP3 as a potential therapeutic target for this condition after OTT.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Chemistry, Multidisciplinary
Yiyuan Kang, Jia Liu, Suhan Yin, Yanping Jiang, Xiaoli Feng, Junrong Wu, Yanli Zhang, Aijie Chen, Yaqing Zhang, Longquan Shao
Article
Cell Biology
Liangjiao Chen, Pengyan Qiao, Hongchen Liu, Longquan Shao
Summary: The study found that ACP NPs are safe for macrophages, but at high concentrations, they promote autophagy and induce ROS production. ACP NPs change the morphology of macrophages and induce polarization into M1 type, thus promoting the expression of inflammatory cytokines. ACP NPs/macrophage-modulated environments weaken the osteogenic ability of BMSCs.
Review
Chemistry, Multidisciplinary
Yanli Zhang, Yulin Zhang, Junrong Wu, Jia Liu, Yiyuan Kang, Chen Hu, Xiaoli Feng, Wenjing Liu, Haiyun Luo, Aijie Chen, Lili Chen, Longquan Shao
Summary: The potential of carbon nanomaterials in the biomedical field is significant, however, their interaction with vascular endothelium can affect biomedical efficiency. This study focused on the impact of CBNs on physiological endothelial barriers, discussed factors influencing CBN-endothelium interaction, and highlighted the importance of balancing therapeutic efficacy and biocompatibility.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell & Tissue Engineering
Haiyun Luo, Wenjing Liu, Yanli Zhang, Yeqing Yang, Xiao Jiang, Shiqing Wu, Longquan Shao
Summary: This study explored the biological effect of m(6)A methylation in DPSCs, revealing m(6)A methylated hallmarks and a regulatory role of METTL3 in cell cycle control. METTL3 depletion associated with cell cycle, mitosis, and alteration of METTL3 resulted in cell cycle arrest, with Polo-like kinase 1 (PLK1) identified as the target of METTL3-mediated m(6)A methylation in DPSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Yajie Yang, Yaokun Zhang, Yiyuan Kang, Chen Hu, Yanli Zhang, Huimin Liang, Jie You, Longquan Shao
Summary: The study found that the biological safety of tantalum particles was within clinically acceptable levels, with no significant impact on cell apoptosis and inflammatory cytokine release. Additionally, the phosphorylation levels of NF-kappa B and ERK were lower in cells exposed to tantalum compared to the control groups.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Engineering, Environmental
Xuan Lai, Menglei Wang, Yixia Zhu, Xiaoli Feng, Huimin Liang, Junrong Wu, Li Nie, Li Li, Longquan Shao
Summary: This study found that zinc oxide nanoparticles can enter psoriasis-like skin lesions and promote inflammation and keratinocyte apoptosis through nuclear translocation of p-NFicB p65 and cysteine deficiency. The research serves as a reminder to the public that ZnO NPs have harmful effects on the recovery of inflammatory skin diseases.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Ting Sun, Yiyuan Kang, Jia Liu, Yanli Zhang, Lingling Ou, Xiangning Liu, Renfa Lai, Longquan Shao
Summary: This review provides an overview of the toxicokinetics of nanomaterials (NMs) and their potential risks to the liver, including inducing liver diseases and enhancing toxic effects. The article highlights the various liver diseases that NMs may cause, while summarizing the potential risks of NMs in susceptible liver individuals.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yiyuan Kang, Jia Liu, Yanping Jiang, Suhan Yin, Zhendong Huang, Yanli Zhang, Junrong Wu, Lili Chen, Longquan Shao
Summary: The interactions between inorganic-based nanomaterials (NMs) and biological membranes are crucial for developing NM-based therapeutics and addressing nanotoxicology issues. Biological membranes act as platforms mediating NM-immune system contacts, and the challenges and potential applications in these areas are discussed in the overview. Understanding these concepts will enhance the design of therapeutic NM for drug delivery systems by leveraging NMs-membrane interactions and functions.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Nanoscience & Nanotechnology
Yunhui Liao, Ruolan Wang, Shaozhen Wang, Yifan Xie, Huanhao Chen, Runjia Huang, Longquan Shao, Qiuhua Zhu, Yanshan Liu
Summary: The new AIE-active Schiff base TBTDC NPs exhibit good biocompatibility, impressive two-photon bioimaging capability, high O-1(2) generation quantum yield, specific targeting, and photostability in PDT. They also show remarkable cytotoxicity for tumor cells and potential for suppressing tumor growth in nude mice.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Haiyun Luo, Wenjing Liu, Yachuan Zhou, Yanli Zhang, Junrong Wu, Ruolan Wang, Longquan Shao
Summary: This study reveals the important role of m(6)A in dental pulp stem cell differentiation and the key role of METTL3 in this process. The results demonstrate that dynamic m(6)A signaling plays a crucial role in the temporal control of dental pulp stem cell differentiation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Biomedical
Aijie Chen, Ruolan Wang, Yiyuan Kang, Jia Liu, Junrong Wu, Yanli Zhang, Yulin Zhang, Longquan Shao
Summary: This study found that zinc oxide nanoparticles can enter the brain through the tongue-brain pathway and cause a decrease in taste sensitivity and taste aversion learning ability by reducing synaptic transmission and inducing neuroinflammation. The neuroinflammation originates from neurons and is mediated by the activation of the JAK-STAT signaling pathway, which inhibits the Neurexin1-PSD95-Neurologigin1 pathway. Blocking the activation of the JAK-STAT pathway prevents neuroinflammation and the reduction in Neurexin1-PSD95-Neurologigin1. These findings reveal the impact of zinc oxide nanoparticles on neuronal function and provide a novel mechanism.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yingjing Pan, Tianci Lin, Longquan Shao, Yulin Zhang, Qiao Han, Liyuan Sheng, Rui Guo, Ting Sun, Yanli Zhang
Summary: In this study, a puerarin-attached lignin nanoparticle-incorporated hydrogel was found to promote angiogenesis, possibly through puerarin-mediated autophagy activation and increase in PPAR beta/delta. This research is of great significance for the treatment of ischemic diseases.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Environmental
Yanli Zhang, Yulin Zhang, Ye Lei, Junrong Wu, Yiyuan Kang, Shuo Zheng, Longquan Shao
Summary: During pregnancy, the human body is vulnerable to external stimuli, including zinc oxide nanoparticles (ZnO-NPs). This study investigates the effects of prenatal ZnO-NP exposure on fetal brain tissue development. The findings suggest that ZnO-NPs can cross the blood-brain barrier and enter fetal brain tissue, causing mitochondrial damage, autophagosome overaccumulation, microglial inflammation, and neuronal damage. These findings highlight the importance of understanding the effects of prenatal ZnO-NP exposure on fetal brain development and raising awareness of the use of ZnO-NPs among pregnant women.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Materials Science, Biomaterials
Ziyi Liu, Ruijie Wang, Wenjing Liu, Yushan Liu, Xiaoli Feng, Fujian Zhao, Pei Chen, Longquan Shao, Mingdeng Rong
Summary: Silicon nitride is an emerging bioceramic material that promotes osteogenesis due to its unique surface chemistry and excellent mechanical properties. The mechanisms of osteogenesis promotion and the optimization of molding process are important for its clinical applications.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Chenguang Zhang, Wenliang Wang, Xiaodong Hao, Yong Peng, Yulin Zheng, Jia Liu, Yiyuan Kang, Fujian Zhao, Zhengtang Luo, Junjie Guo, Bingshe Xu, Longquan Shao, Guoqiang Li
Summary: This study utilized GaN/AlGaN materials with controlled polarity to induce endogenous electrical stimulation for bone regeneration, finding that Ga-polarity GaN/AlGaN nanofilms showed superior bone repair in vivo and promoted osteogenic differentiation of bone mesenchymal stem cells in vitro. Additionally, the study revealed that bone morphogenetic protein-6 (BMP6) may be an electrically sensitive osteogenic protein.
ADVANCED FUNCTIONAL MATERIALS
(2021)