Article
Oncology
Iman Moussa, Rena S. Day, Ruosha Li, Ahmed Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M. Hassan
Summary: This study found an inverse association between monounsaturated fatty acid intake and hepatocellular carcinoma (HCC) risk, and a direct association between total polyunsaturated fatty acid intake and HCC risk. Omega-6 PUFA intake was directly associated with HCC risk, while long-chain omega-3 PUFA intake was inversely associated with HCC risk. No significant association was observed for saturated fat and HCC risk.
Article
Endocrinology & Metabolism
Emilie Montastier, Run Zhou Ye, Christophe Noll, Lucie Bouffard, Melanie Fortin, Frederique Frisch, Serge Phoenix, Brigitte Guerin, Eric E. Turcotte, Gary F. Lewis, Andre C. Carpentier
Summary: The study revealed a higher level of adipose tissue dietary fatty acid trapping in individuals with impaired glucose tolerance, limiting spillover to lean organs and partially offsetting the increase in palmitate appearance rate from intracellular lipolysis.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Michael Fridden, Andrdes Martinez Mora, Lars Lind, Ulf Riserus, Joel Kullberg, Fredrik Rosqvist
Summary: In this study conducted on participants of UK Biobank, it was found that intake of saturated and animal fat is positively associated with liver fat, visceral fat, and intermuscular fat, whereas biomarkers of polyunsaturated fat are inversely associated with these fat deposits. This suggests that the type of dietary fat is an important determinant of ectopic fat in the human body.
CLINICAL NUTRITION
(2023)
Article
Oncology
Fatemeh Shafie, Shirin Tajadod, Zahra Aslany, Pooneh Allahyari, Mahsa Vahdat, Soheila Shekari, Golsa Khalatbari Mohseni, Maryam Gholamalizadeh, Saeideh Mohammadi, Bojlul Bahar, Hanieh Shafaei, Saeid Doaei
Summary: This study aimed to investigate the association between breast cancer and dietary fat quality indices in Iranian women. The results showed that breast cancer patients had a higher total fat intake and a lower omega-3/omega-6 ratio. Total fat intake was significantly associated with breast cancer risk, suggesting that low-fat diets may have beneficial effects for breast cancer prevention.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ioanna Prapa, Amalia E. Yanni, Anastasios Nikolaou, Nikolaos Kostomitsopoulos, Nick Kalogeropoulos, Eugenia Bezirtzoglou, Vaios T. Karathanos, Yiannis Kourkoutas
Summary: This study found that dietary intervention with pistachio nuts in streptozotocin-induced diabetic rats resulted in changes in plasma and visceral adipose tissue fatty acid profiles, with an increase in monounsaturated fatty acids (MUFA) and oleic acid, and a decrease in polyunsaturated fatty acids (PUFA), total omega 6, and 18:2 omega 6. In addition, the pistachio diet also had a positive impact on gut microbiota.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Tong-sheng Huang, Teng Wu, Yan-di Wu, Xing-hui Li, Jing Tan, Cong-hui Shen, Shi-jie Xiong, Zi-qi Feng, Sai-fei Gao, Hui Li, Wei-bin Cai
Summary: Huang et al. investigated the effects of long-term statins administration in a mouse model for diabetes and found that it can worsen insulin resistance, renal inflammation and fibrosis. Statins play an important role in the treatment of diabetic nephropathy.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Jhih-Han Yeh, Yu-Tang Tung, Yu-Sheng Yeh, Yi-Wen Chien
Summary: Postmenopausal obesity is a serious issue and a high-fat diet may worsen lipid metabolism abnormalities. However, this study found that a specific ratio of experimental oil mixture can ameliorate these imbalances.
Article
Pharmacology & Pharmacy
Dominic Salamone, Giovanni Annuzzi, Bengt Vessby, Angela A. Rivellese, Lutgarda Bozzetto, Giuseppina Costabile, Kjeld Hermansen, Matti Uusitupa, Barbara J. Meyer, Gabriele Riccardi, KANWU Study Group
Summary: This study found that the composition of fatty acids in serum cholesterol esters can be used as an objective indicator of adherence to experimental diets, including changes in saturated and monounsaturated fatty acids, as well as fish oil supplementation.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Essi Hantikainen, Elin Roos, Rino Bellocco, Alessia D'Antonio, Alessandra Grotta, Hans-Olov Adami, Weimin Ye, Ylva Trolle Lagerros, Stephanie Bonn
Summary: This study investigated the association between fat intake and the incidence of Parkinson disease and found that a higher consumption of large amounts of saturated fat might be associated with an increased risk of Parkinson disease. A diet low in saturated fat may be beneficial for disease prevention.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Xiaolin Yao, Xin Xu, Shuo Wang, Dan Xia
Summary: This study found a significant positive association between saturated fatty acid intake and total mortality, while greater consumption of polyunsaturated fatty acids and monounsaturated fatty acids was strongly negatively associated with all-cause death and cardiovascular disease mortality.
FRONTIERS IN NUTRITION
(2021)
Article
Chemistry, Applied
Ziwei Pei, Lei Zhang, Congrong Fang, Jie Yang, Jingguang Li, Yunfeng Zhao, Yongning Wu
Summary: The study found that the intake of saturated fatty acids and trans fatty acids in the Chinese diet is decreasing, indicating a change in dietary habits among the Chinese population.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Medicine, Research & Experimental
Tia A. Griffith, Jake S. Russell, Saba Naghipour, Tessa J. Helman, Jason N. Peart, Nicolas J. C. Stapelberg, John P. Headrick, Eugene F. Du Toit
Summary: This study found that mice with type 2 diabetes (T2D) exhibited anxiety-like behavior, which was independent of body weight and blood glucose levels but may be related to resistance to leptin. Dietary n-3 polyunsaturated fatty acid (PUFA) did not show significant metabolic or behavioral benefits in T2D mice.
Article
Biochemistry & Molecular Biology
Maedeh Mozafarinia, Bahareh Sasanfar, Fatemeh Toorang, Amin Salehi-Abargouei, Kazem Zendehdel
Summary: The study indicates that a high-fat diet may increase the risk of breast cancer, especially in postmenopausal women. Individuals with high intake of animal fat and polyunsaturated fatty acids are more likely to develop BC, but there is no association in premenopausal women.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Nutrition & Dietetics
Wei Zeng, Qingzhe Jin, Xingguo Wang
Summary: There is a significant correlation between dietary fat consumption and cardiovascular disease in China over the past 30 years. Changes in fat intake have been closely related to the incidence of cardiovascular disease. Therefore, it is important for the government to raise awareness about dietary fat intake and educate the public to avoid high-fat diets.
Article
Nutrition & Dietetics
Mohsen Mazidi, Andre P. Kengne, Mario Siervo, Richard Kirwan
Summary: The study suggests that higher dietary intake of polyunsaturated fatty acids (PUFAs) is associated with improved renal function and lower risk of chronic kidney disease (CKD), while there is no significant association between monounsaturated fatty acids (MUFAs) intake and renal function or CKD risk. Genetically determined serum levels of PUFAs and MUFAs also do not show significant association with renal function and CKD risk.