Article
Cardiac & Cardiovascular Systems
Anette Varbo, Borge G. Nordestgaard
Summary: The study found that high directly measured remnant cholesterol is associated with increased risk of ischaemic heart disease and myocardial infarction. Directly measured remnant cholesterol is superior to calculated remnant cholesterol in identifying individuals at increased risk.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Anette Varbo, Borge G. Nordestgaard
Summary: This study found that high directly measured remnant cholesterol is associated with increased risk of cardiovascular disease, and direct measurement of remnant cholesterol is superior in identifying individuals at increased risk compared to calculated remnant cholesterol.
EUROPEAN HEART JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Nicholas G. Norwitz, Adrian Soto-Mota, Bob Kaplan, David S. Ludwig, Matthew Budoff, Anatol Kontush, David Feldman
Summary: When lean individuals adopt carbohydrate-restricted diets, they may experience changes in their lipid profile, with increased LDL-C and HDL-C levels and decreased TG levels. Some lean individuals, called Lean Mass Hyper-Responders (LMHR), exhibit a pronounced hyperlipidemic response to the diet. The Lipid Energy Model (LEM) suggests that carbohydrate restriction in lean individuals drives increased secretion and uptake of TG contained in VLDL, leading to significant elevations in LDL-C and HDL-C levels and low TG levels.
Review
Pharmacology & Pharmacy
Jelena Vekic, Aleksandra Zeljkovic, Aleksandra Stefanovic, Natasa Bogavac-Stanojevic, Ioannis Ilias, Jose Silva-Nunes, Anca Pantea Stoian, Andrej Janez, Manfredi Rizzo
Summary: There is compelling evidence linking increased levels of low-density lipoprotein cholesterol (LDL-C) to the development of atherosclerotic cardiovascular disease (CVD). However, recent data shows that the majority of patients in Europe are unable to achieve their recommended LDL-C targets. To address this issue, a new approach to lipid-lowering, involving more intensive and earlier intervention, has been proposed for high-risk patients. Additionally, novel lipid biomarkers, such as small dense LDL particles (sdLDL), should be considered as potential therapeutic targets.
Review
Chemistry, Medicinal
Sahar Dadkhah Tehrani, Mehrnaz Shojaei, Mohammad Bagherniya, Matteo Pirro, Amirhossein Sahebkar
Summary: This systematic review aimed to evaluate the efficacy of phytochemicals on lipid parameters in patients with hypertriglyceridemia (HTG). Forty-eight RCTs including 53 arms and comprising 3,478 HTG patients met the eligibility criteria. Phytochemicals significantly reduced the serum levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B, while increasing high-density lipoprotein cholesterol levels in HTG patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Aashiq Hussain, Jihong Lian, Russell Watts, Tomas Gutierrez, Randal Nelson, Ing Swie Goping, Richard Lehner
Summary: The study suggests that inhibiting microsomal triglyceride transfer protein (MTP) can reduce hyperlipidemia and tumor growth in obese mice. The tumor shrinkage effect is related to changes in circulating lipids, but not tumor cell viability. No compensatory mechanisms were detected in response to decreased hyperlipidemia. This research provides a potential approach for adjuvant therapy to reduce tumor growth in obese patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Environmental Sciences
Ziwei Chen, Jing He, Lihua Chen, Xiaohui Wu, Xiaohong Yu
Summary: This study investigated the association between nickel exposure and serum lipid profiles. The findings revealed a linear association between nickel exposure and serum total cholesterol and LDL-C, while a nonlinear association was observed with HDL-C. However, no significant relationship was found between nickel exposure and triglyceride levels.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Obstetrics & Gynecology
Zhen Wang, Lanlan Fang, Ze Wu, Yuxi Li, Qiongqiong Jia, Jung-Chien Cheng, Ying-Pu Sun
Summary: The meta-analysis findings suggest that patients with premature ovarian insufficiency (POI) have significantly higher levels of serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride, but no significant difference in high-density lipoprotein cholesterol (HDL-C) levels compared to controls. These results indicate that elevations in unfavorable lipids may contribute to the increased risk of cardiovascular diseases observed in patients with POI.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Biochemistry & Molecular Biology
Amirhossein Sahebkar, Zahra Heidari, Zahra Kiani, Masoumeh Atefi, Azadeh Zareie, Mehrnaz Shojaei, Gholamreza Askari, Prashant Kesharwani, Mohammad Bagherniya
Summary: This meta-analysis evaluated the effects of the DASH diet on lipid profiles based on clinical controlled trials. The results showed that following the DASH diet significantly reduced serum triglycerides and low-density lipoprotein cholesterol levels, but had no significant effect on serum total cholesterol and high-density lipoprotein cholesterol levels. Therefore, the DASH diet can be considered as a strategy for the prevention and complementary management of dyslipidemia.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Ji Hye Huh, Eun Roh, Seong Jin Lee, Sung-Hee Ihm, Kyung-Do Han, Jun Goo Kang
Summary: This retrospective, longitudinal study demonstrated that high levels of remnant cholesterol are associated with an increased risk of incident type 2 diabetes (T2D), particularly in individuals without traditional T2D risk factors and metabolic abnormalities. These findings suggest that remnant cholesterol profiles provide additional information in predicting future progression of T2D, independent of conventional lipid parameters.
Article
Cardiac & Cardiovascular Systems
Robert S. Rosenson, Aleesha Shaik, Wenliang Song
Summary: Elevated concentrations of triglyceride-rich lipoprotein remnants (TRLs) are linked to atherosclerotic cardiovascular events, with new therapies targeting TRL metabolism pathways showing promise in reducing atherosclerosis. Clinical trials of these therapies, such as inhibitors of angiopoietin-like 3 protein and apolipoprotein C-III, will provide further guidance on cardiovascular risk management in patients with elevated remnant cholesterol.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Prakriti Gaba, Michelle L. O'Donoghue, Jeong-Gun Park, Stephen D. Wiviott, Dan Atar, Julia F. Kuder, KyungAh Im, Sabina A. Murphy, Gaetano M. De Ferrari, Zbigniew A. Gaciong, Kalman Toth, Ioanna Gouni-Berthold, Jose Lopez-Miranda, Francois Schiele, Francois Mach, Jose H. Flores-Arredondo, J. Antonio G. Lopez, Mary Elliott-Davey, Bei Wang, Maria Laura Monsalvo, Siddique Abbasi, Robert P. Giugliano, Marc S. Sabatine
Summary: This study found that long-term achievement of lower LDL-C levels (below 20 mg/dL) in patients with atherosclerotic cardiovascular disease was associated with a lower risk of cardiovascular events without significant safety concerns.
Review
Biochemistry & Molecular Biology
Xin Su, Xiang Chen, Bin Wang
Summary: Hypothyroidism is closely related to hyperlipidemia, characterized by abnormal blood lipid levels. In addition to thyroid hormones, thyroid-stimulating hormones also play a role in cholesterol metabolism, which may exacerbate the progression of hyperlipidemia.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Environmental Sciences
Eleni Papadopoulou, Alina Nicolescu, Line S. Haug, Trine Hus, Calin Deleanu, Hubert Dirven, Birgitte Lindeman
Summary: This study explores the association between serum PFAS concentrations and lipoprotein subclasses. After adjusting for confounders, the adjusted models found positive associations between several PFASs and cholesterol concentrations in large to medium sized HDL and medium sized LDL particles. Significant associations were observed between certain PFASs and cholesterol in large to medium LDL particle sizes among women. The study also found that most PFASs tended to be associated with a reduction in VLDL particle number and VLDL triglyceride.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cardiac & Cardiovascular Systems
Renato Quispe, Seth Shay Martin, Erin Donelly Michos, Isha Lamba, Roger Scott Blumenthal, Anum Saeed, Joao Lima, Rishi Puri, Sarah Nomura, Michael Tsai, John Wilkins, Christie Mitchell Ballantyne, Stephen Nicholls, Steven Richard Jones, Mohamed Badreldin Elshazly
Summary: High remnant cholesterol (RC) levels are associated with ASCVD in individuals without known ASCVD, independent of traditional risk factors, LDL-C, and apoB levels. The discordant group with high RC/low LDL-C, but not the low RC/high LDL-C group, showed increased ASCVD risk compared to the concordant group.
EUROPEAN HEART JOURNAL
(2021)