Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 39, Issue -, Pages 30-38Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2015.12.006
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Funding
- Bristol Myers Squibb
- Roche
- Ventana
- Pfizer
- Celgene
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Melanoma is at the forefront of development of systemic therapeutics with both molecular targeted therapies and immune checkpoint inhibitors as cornerstones of treatment. Although responses to molecularly targeted therapy is largely from blockade of oncogenic pathways, evidence is emerging of the immunomodulatory effects from BRAF inhibition. Additionally programmed-death-1 (PD-1) inhibitors have revolutionized the treatment of melanoma and are set to pave future improvements in other solid tumors. Combinations of PD-1 inhibitors with novel immune checkpoints or with molecularly targeted therapies are under investigation and may improve on the considerable progress made.
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