Article
Food Science & Technology
Patricia Esteban, Sergio Redrado, Laura Comas, M. Pilar Domingo, M. Isabel Millan-Lou, Cristina Seral, Sonia Algarate, Concepcion Lopez, Antonio Rezusta, Julian Pardo, Maykel Arias, Eva M. Galvez
Summary: This study aimed to evaluate the antibiotic efficacy of Gliotoxin (GT) as monotherapy or in combination with other therapeutics against MRSA in vitro and in vivo.
Article
Immunology
Warren Rose, Michael Fantl, Matthew Geriak, Victor Nizet, George Sakoulas
Summary: Literature has shown the effectiveness of combination antimicrobial therapy in treating refractory MRSA bacteremia, but considerations need to be made on which regimens are more beneficial, potential harms, and which patients can benefit from more aggressive treatment. In addition, combination therapy for MRSA bacteremia does not need to be uniform throughout the treatment course, with options for early intensive treatment and later consolidation therapy.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Pharmacology & Pharmacy
Xiaonan Xu, Ni Lu, Pan Song, Mingzhen Zhou, Yuanxiao Li, Zirui Wang, Xin Gao
Summary: This study evaluated the efficacy and safety of different treatments for methicillin-resistant Staphylococcus aureus (MRSA). The results showed that vancomycin or daptomycin combined with antistaphylococcal beta-lactam had slightly better efficacy than vancomycin or daptomycin alone, but with slightly higher adverse events. Other treatments, such as antistaphylococcal beta-lactam and trimethoprim-sulfamethoxazole, did not show significant advantages compared to vancomycin or daptomycin treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Adson Avila de Souza, Adrianne Maia Lima, Daniele Dede Oliveira BezerraSousa, Francisca Cristiane Nogueira, Jose Carlos do Sacramento Neto, Lucas Pinheiro Dias, Nadine Monteiro Salgueiro Araujo, Celso Shiniti Nagano, Helio Vitoriano Nobre Junior, Cecilia Rocha da Silva, Livia Gurgel do Amaral Valente Sa, Joao Batista de Andrade Neto, Fatima Daiana Dias Barroso, Maria Elisabete Amaral de Moraes, Hermogenes David de Oliveira
Summary: This study isolated and characterized a thermostable trypsin inhibitor from chia seeds, which showed antibacterial activity against Staphylococcus aureus sensitive and resistant to methicillin. The trypsin inhibitor, named ShTI, displayed competitive inhibition and 1:1 stoichiometry ratio for the ShTI:trypsin complex. ShTI exhibited antibacterial activity alone and in combination with oxacillin, and its antibacterial action involved overproduction of reactive oxygen species and plasma membrane pore formation.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Microbiology
Rasoul Mirzaei, Hadi Esmaeili Gouvarchin Ghaleh, Reza Ranjbar
Summary: The study demonstrates that melittin alone exhibits strong inhibitory and eradication effects on biofilms formed by multidrug-resistant pathogens. Furthermore, melittin shows synergistic effects when combined with antibiotics, resulting in decreased toxicity. Therefore, the combination of melittin and antibiotics has the potential to be a candidate for further evaluation in vivo for infections caused by multidrug-resistant pathogens.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Jonathan Save, Yok-Ai Que, Jose Entenza, Gregory Resch
Summary: In this study, the efficacy of a combination therapy of bacteriophages and vancomycin was investigated in a rat model of MRSA infective endocarditis. The results showed that the phage cocktail alone was not able to control bacterial growth, but when combined with subtherapeutic doses of vancomycin, a significant decrease in bacterial load was observed. However, the administration of vancomycin significantly affected the local concentrations of phages in the vegetation and organs.
Article
Chemistry, Medicinal
Jiepeng Tong, Yiheng Jiang, Hao Xu, Xuehang Jin, Li Zhang, Shuaibing Ying, Wei Yu, Yunqing Qiu
Summary: The emergence of vancomycin-resistant Enterococci (VRE) is limiting treatment options for infections. This study investigated the resistance mechanism and evaluated the effects of different antibiotics alone or in combination against VRE isolates. The results suggest that FM combined with DAP could be a potential therapeutic option for VRE infections.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Immunology
Katherine H. Wu, George Sakoulas, Matthew Geriak
Summary: A telephone survey comparing patient satisfaction with vancomycin vs daptomycin outpatient parenteral antimicrobial therapy (OPAT) found that patients receiving daptomycin reported higher satisfaction, possibly due to its less cumbersome treatment regimen. Simplified treatment regimens may lead to increased patient satisfaction.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Christopher Ross, Basir Syed, Joanna Pak, Vishal Jhanji, Jason Yamaki, Ajay Sharma
Summary: The study investigated the stability of vancomycin ophthalmic drops prepared in different solutions stored at room temperature or under refrigeration for 28 days. Results showed that vancomycin ophthalmic drops prepared using PBS, BSS, and normal saline were stable up to the tested time point of 28 days, irrespective of their storage temperature.
Article
Biochemistry & Molecular Biology
Mauricio Osorio, Marcela Carvajal, Alejandra Vergara, Estefania Butassi, Susana Zacchino, Carolina Mascayano, Margarita Montoya, Sophia Mejias, Marcelo Cortez-San Martin, Yesseny Vasquez-Martinez
Summary: Prenylated flavonoids are important natural compounds with significant biological activity, particularly in antimicrobial functions. Compounds 11, 12, and 13 showed strong inhibitory activity against human pathogenic fungi and clinical isolated Staphylococcus aureus MRSA, indicating the key structural requirements for antibacterial activity. Additionally, the combination of prenylated flavonoids with commercial antibiotics significantly enhanced the antibacterial activity against drug-resistant bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Maria Cardells Peris, Alba Martinez, Marina Pascual Ortiz, Chirag C. Sheth, Veronica Veses
Summary: The study found that icariin alone did not have any antimicrobial effect on S. aureus or MRSA clinical isolates. However, when used in combination with amoxycillin-clavulanate or ampicillin, icariin enhanced their antimicrobial effect. This study demonstrates the potential utility of icariin in reducing the spread of antibiotic resistance, but further research is needed to determine the optimal concentration and clinically relevant combinations.
Article
Engineering, Biomedical
Renee L. Tonkin, Anna Klockner, Adrian Najer, Carolina J. Simoes da Silva, Cecile Echalier, Marc S. Dionne, Andrew M. Edwards, Molly M. Stevens
Summary: This study develops a hierarchical microparticle system for bacteria-activated single- and dual-antibiotic drug delivery, effectively killing antibiotic-resistant bacteria.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Infectious Diseases
Maria Sole Valentino, Paola Borgia, Virginia Deut, Ines Lorenzi, Paola Barabino, Elisabetta Ugolotti, Marcello Mariani, Francesca Bagnasco, Elio Castagnola
Summary: Monitoring antibiotic use in pediatric population is challenging, especially in determining the relationship between specific pathogens, infections, and antibiotic use. A retrospective analysis of the consumption of anti-MRSA drugs from 2017 to 2021 revealed an increase in the use of daptomycin and ceftaroline, accompanied by a decrease in vancomycin use. Additionally, an increase in MRSA bloodstream infections with a vancomycin MIC of 1, representing 100% of cases in 2021, was observed, along with difficulties in achieving effective vancomycin plasma concentrations in children.
Article
Immunology
Elisabeth A. Hoyer, Marritta Joseph, Sheldon L. Kaplan, Jesus G. Vallejo, Jonathon Chase McNeil
Summary: This study aimed to examine clinical factors and guide empiric treatment for pediatric acute hematogenous osteomyelitis (AHO). The findings suggest that critically ill children with CRP >7 mg/dL, subperiosteal abscess, and history of soft tissue infection are more likely to have MRSA infection, and empiric vancomycin use could be considered. Further validation is needed.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Infectious Diseases
Sophie H. Buitinck, Matty Koopmans, Rogier M. Determann, Rogier R. Jansen, Peter H. J. van der Voort
Summary: This retrospective analysis found that topical treatment with vancomycin in a 2% sticky oral paste combined with nasogastric tube administration was effective in eliminating MRSA carriage in critically ill patients, and prevented secondary MRSA infections.
