Journal
FRONTIERS IN MICROBIOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.538602
Keywords
Candida; biofilms; biomaterials; antifungal; surface functionalization; nanoparticles; antifungal polymers
Categories
Funding
- Office of Naval Research [N000141712651]
- National Science Foundation Graduate Research Fellowship [1644760]
- U.S. Department of Defense (DOD) [N000141712651] Funding Source: U.S. Department of Defense (DOD)
Ask authors/readers for more resources
Candidaspecies can readily colonize a multitude of indwelling devices, leading to biofilm formation. These three-dimensional, surface-associatedCandidacommunities employ a multitude of sophisticated mechanisms to evade treatment, leading to persistent and recurrent infections with high mortality rates. Further complicating matters, the current arsenal of antifungal therapeutics that are effective against biofilms is extremely limited. Antifungal biomaterials are gaining interest as an effective strategy for combatingCandidabiofilm infections. In this review, we explore biomaterials developed to preventCandidabiofilm formation and those that treat existing biofilms. Surface functionalization of devices employing clinically utilized antifungals, other antifungal molecules, and antifungal polymers has been extremely effective at preventing fungi attachment, which is the first step of biofilm formation. Several mechanisms can lead to this attachment inhibition, including contact killing and release-based killing of surrounding planktonic cells. Eliminating mature biofilms is arguably much more difficult than prevention. Nanoparticles have shown the most promise in disrupting existing biofilms, with the potential to penetrate the dense fungal biofilm matrix and locally target fungal cells. We will describe recent advances in both surface functionalization and nanoparticle therapeutics for the treatment ofCandidabiofilms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available