Article
Multidisciplinary Sciences
Xiaoyu Guo, Xue Ding, Juan Dong
Summary: In this study, the authors found that BSL proteins in Arabidopsis have different functions in the cell cortex and nucleus, regulating stomatal formation through the activation or deactivation of different signaling pathways.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Chuanlei Xiao, Huimin Guo, Jing Tang, Jiaying Li, Xuan Yao, Honghong Hu
Summary: The study systematically investigated the expression patterns of 19 putative Guard-cell-enriched GDSL Lipases (GGLs) in Arabidopsis, revealing diverse expression patterns in guard cells. Most GGLs were localized in the endoplasmic reticulum, and some in lipid droplets and nucleus. Further analysis showed the correlation of expression pattern and biological function, as well as the functional redundancy of GGLs in plant development and environmental adaptations. Phenotypic identification of ggl mutants indicated unique and redundant roles of GGLs in stomatal dynamics, density, morphology, and plant water relation, providing insights for controlling stomatal dynamics and development, plant growth, and adaptation to the environment.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Julian A. Harris, Bryan Faust, Arisbel B. Gondin, Marc Andre Damgen, Carl-Mikael Suomivuori, Nicholas A. Veldhuis, Yifan Cheng, Ron O. Dror, David M. Thal, Aashish Manglik
Summary: The neuropeptide substance P activates the neurokinin-1 receptor through interactions deep within the receptor, while interactions between the neuropeptide and the receptor extracellular loops regulate G protein signaling selectivity. This study sheds light on how different stimuli can lead to distinct G protein signaling at the same receptor.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Plant Sciences
Bin Li, Liyuan Hou, Chenggang Song, Zhengbiao Wang, Qiyang Xue, Yuanyang Li, Jianchun Qin, Ning Cao, Chengguo Jia, Yubin Zhang, Wuliang Shi
Summary: This article provides an update on the multiple roles of the calcium-sensing receptor (CAS) in regulating stomatal movement and calcium signaling in plants. It also discusses the possible phosphorylation mechanism of CAS and its involvement in abiotic and biotic stresses.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemical Research Methods
Kyoko Nakajima, Hideto Nakabayashi, Masahiro Kawahara
Summary: This study aims to control multiple cell fates simultaneously by combinatorially activating multiple cell fate-inducing CARs (cfiCARs). Through the co-expression of two antigen-specific CARs, the CARs transduce two different signals, which can arbitrarily control multiple cell fates. By utilizing natural receptors and engineered signaling domains, specific cell fates can be induced by activating downstream signaling molecules orthogonally. The study successfully demonstrates the simultaneous or sequential control of proliferation and apoptosis, showing the potential of cfiCARs in cell fate control and cell therapy efficacy improvement.
BIOTECHNOLOGY JOURNAL
(2022)
Article
Cell & Tissue Engineering
Madeline G. Andrews, Clara Siebert, Li Wang, Matthew L. White, Jayden Ross, Raul Morales, Megan Donnay, Gradi Bamfonga, Tanzila Mukhtar, Arpanaarjun Mckinney, Kaila Gemenes, Shaohui Wang, Qiuli Bi, Elizabeth E. Crouch, Neelroop Parikshak, Georgia Panagiotakos, Eric Huang, Aparna Bhaduri, Arnold R. Kriegstein
Summary: The differentiation of outer radial glia (oRG) cells and the production of inhibitory interneurons (INs) in the cerebral cortex are regulated by leukemia-inhibitory factor (LIF) signaling.
Article
Multidisciplinary Sciences
Stefan Bohn, Lorenz Hexemer, Zixin Huang, Laura Strohmaier, Sonja Lenhardt, Stefan Legewie, Alexander Loewer
Summary: SMAD-mediated signaling regulates cell fate decisions by responding to different ligands of the TGF(3 family, with the nature of the response determined by the proliferation status of the cells. Ligand identity modulates the strength of the response, which is correlated with SMAD nuclear-to-cytoplasmic translocation and gene expression changes. The proliferation state of the cell affects the sensitivity to TGF(3 superfamily members, while the pathway itself serves as a relay from the cell membrane to the nucleus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Plant Sciences
Jin Sun Kim, Byeong Wook Jeon, Jungmook Kim
Summary: Plants, as sessile organisms, have evolved complex stress-responsive signaling pathways to regulate the expression of transcription factors and biosynthesis of osmolytes for tolerance. Signaling peptides, acting like phytohormones, control various aspects of plant growth and development through cell-cell communication networks. Recent studies have shown the importance of several signaling peptides in plant responses to abiotic stress.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kui Zhang, Li Shen, Xue Wang, He Yang, Xiaolin Zhang, Guangzhao Pan, Chongyang Li, Haoyan Ji, Muhammad Nadeem Abbas, Cong Li, Hongjuan Cui
Summary: Scavenger receptor C (SR-C) in the silkworm plays a key role in protecting against bacterial pathogens by enhancing the expression of antimicrobial peptides through the Toll pathway in hemocytes, ultimately improving the survival rate of silkworm larvae.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Martin Stegmann, Patricia Zecua-Ramirez, Christina Ludwig, Ho-Seok Lee, Brenda Peterson, Zachary L. Nimchuk, Youssef Belkhadir, Ralph Hueckelhoven
Summary: Plant immune responses need to be tightly controlled for proper allocation of resources for growth and development. Recent research has discovered that some endogenous signaling peptides not only regulate plant development and growth but also play a regulatory role in plant immune responses. In this study, GLV2 peptides are identified as phytocytokines in Arabidopsis thaliana, enhancing sensitivity to bacterial elicitors and contributing to resistance against bacterial pathogens. The GLV2 signaling is perceived by RGI receptors and promotes PRR abundance independent of transcriptional regulation, controlling plant immunity through a previously undescribed phytocytokine activity mechanism.
Review
Hospitality, Leisure, Sport & Tourism
Lei Li, Jinye Liang, Cong Zhang, Tiemin Liu, Chao Zhang
Summary: Melanocortin 4 receptor (MC4R) is the most important single-gene cause of human metabolic disorders and has gained significant interest in the research of energy homeostasis and public health. Previous studies primarily focused on the central roles of MC4R, leaving the local expression and behavioral regulation unclear. This article reviews recent studies on the peripheral functions of MC4R and the direct physiological interaction between peripheral organs and central MC4R neurons, aiming to provide new directions for future research on MC4R signaling.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Cell Biology
Daniel Bastardo Blanco, Nicole M. Chapman, Jana L. Raynor, Chengxian Xu, Wei Su, K. C. Anil, Wei Li, Seon Ah Lim, Stefan Schattgen, Hao Shi, Isabel Risch, Yu Sun, Yogesh Dhungana, Yunjung Kim, Jun Wei, Sherri Rankin, Geoffrey Neale, Paul G. Thomas, Kai Yang, Hongbo Chi
Summary: PTEN loss leads to the accumulation of type-17 innate-like T cells through altered metabolic reprogramming and the involvement of mTOR, Foxo1, and IL-23-Stat3 signaling.
NATURE CELL BIOLOGY
(2022)
Review
Plant Sciences
Byeong Wook Jeon, Min-Jung Kim, Shashank K. Pandey, Eunkyoo Oh, Pil Joon Seo, Jungmook Kim
Summary: Root development is regulated by plant hormones, transcription factors, and recently identified small peptides and their receptors. Small peptides bind to receptors, inducing signaling for cell-to-cell communication and coordination of root development. The interconnection between peptide signaling and conventional phytohormone signaling, as well as the diversity of peptide-receptor interactions, have been discussed in recent studies.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Chemistry, Multidisciplinary
M. Florencia Sanchez, Marina S. Dietz, Ulrike Mueller, Julian Weghuber, Karl Gatterdam, Ralph Wieneke, Mike Heilemann, Peter Lanzerstorfer, Robert Tampe
Summary: Membrane receptor clustering is important for cell-cell communication, but its physiological role in cell signaling is still unclear. In this study, the researchers developed a dynamic platform to induce cluster formation of neuropeptide Y2 hormone receptors (Y2R) and found that receptor clustering enhanced the cell's response to ligands and played a key role in cell signaling.
Article
Biochemistry & Molecular Biology
Yuko Oda, Christian T. Wong, Dennis H. Oh, Mark B. Meyer, J. Wesley Pike, Daniel D. Bikle
Summary: The vitamin D receptor (VDR) and its ligand play a crucial role in regulating the fate of epidermal stem cells. Deletion of VDR in specific stem cells results in impaired migration and regeneration of the interfollicular epidermis, but not the sebaceous gland. Genomic analysis revealed a functional association between VDR and p63, a transcription factor essential for epidermal keratinocyte proliferation and differentiation. This study highlights the importance of VDR and its interaction with p63 in orchestrating epidermal stem cell fate.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Soon-Ki Han, Arvid Herrmann, Jiyuan Yang, Rie Iwasaki, Tomoaki Sakamoto, Benedicte Desvoyes, Seisuke Kimura, Crisanto Gutierrez, Eun-Deok Kim, Keiko U. Torii
Summary: This study reveals that precise cell-cycle control is crucial for the differentiation and formation of plant stomata. The identification of SMR4 as a molecular brake induced by MUTE provides insight into the regulation of cell cycle in stomatal-lineage cells. The interaction between SMR4 and specific cyclins highlights the importance of timely proliferative cell cycle for stomatal-lineage identity.
DEVELOPMENTAL CELL
(2022)
Review
Biochemistry & Molecular Biology
Daniel T. Zuch, Siamsa M. Doyle, Mateusz Majda, Richard S. Smith, Stephanie Robert, Keiko U. Torii
Summary: The epidermis, as the outermost layer of plants, plays a critical role in plant-environment interactions. Differentiation of specialized epidermal cell types occurs during leaf development, but how these cells coordinate as a unit is not well understood. This review highlights the regulatory mechanisms governing the fate, differentiation, and positioning of these specialized cell types, emphasizing their shared developmental origins, fate flexibility, and hormonal controls, while also discussing computational modeling approaches to integrate mechanical properties of individual epidermal cell types and tissue properties.
Article
Chemistry, Analytical
Shixiao Li, Yijian Xu, Zhiyu Zhan, Pengyuan Du, Linwei Liu, Zikai Li, Huawei Wang, Pengfei Bai
Summary: This paper proposes a dynamic adaptive display model based on TFT-EWD, which combines DC and AC driving modes to achieve high-quality display of static images and dynamic videos, solving common issues of flickering and image persistence.
Article
Biochemistry & Molecular Biology
Shuka Ikematsu, Tatsushi Umase, Mako Shiozaki, Sodai Nakayama, Fuko Noguchi, Tomoaki Sakamoto, Hongwei Hou, Gholamreza Gohari, Seisuke Kimura, Keiko U. Torii
Summary: Land plants have evolved the ability to adapt to moist environments through phenotypic plasticity. The inhibition of stomatal development in amphibious plants submerged in water is regulated by independent pathways. Ethylene and light play essential roles in this process.
Editorial Material
Plant Sciences
Makoto Hayashi, Ari Pekka Mahonen, Hitoshi Sakakibara, Keiko U. Torii, Masaaki Umeda
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Daniel T. Zuch, Arvid Herrmann, Eun-Deok Kim, Keiko U. Torii
Summary: Cell division and differentiation in plants need to be coordinated for functional tissue formation. The transcription factor MUTE plays a crucial role in regulating the cell cycle and orchestrating the symmetric division and differentiation of stomatal precursor cells in Arabidopsis. MUTE accumulates in the early G2 phase, while its direct target FAMA accumulates in late G2 through mitosis.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Satomi Negoro, Tomo Hirabayashi, Rie Iwasaki, Keiko U. Torii, Naoyuki Uchida
Summary: Temperature plays a crucial role in the successful sexual reproduction of plants. The secreted peptide EPFL6 promotes the elongation of stamens and coordinates the growth of reproductive tissues in Arabidopsis thaliana. Modulating the activity of the receptor ER can rescue reproduction failure caused by insufficient stamen elongation.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Computer Science, Artificial Intelligence
Xiaoyu Yu, Fuchao Li, Pengfei Bai, Yan Liu, Yinglu Chen
Summary: Data augmentation helps diversify the information in the dataset, and copy-paste augmentation generates new class information to mitigate class imbalance. The authors propose a self-adaptive data augmentation algorithm called CPA, which addresses the issues of over-fitting and under-fitting. CPA generates class weights based on model evaluation results and class imbalance information, replenishes different amounts of class information accordingly, and incorporates the generated images into the training dataset. Experimental results show that CPA can alleviate class imbalance.
IET COMPUTER VISION
(2023)
Article
Biochemical Research Methods
Mukul K. Midha, Charu Kapil, Michal Maes, David H. Baxter, Seamus R. Morrone, Timothy J. Prokop, Robert L. Moritz
Summary: The efficient generation of peptide molecular ions by the electrospray source is the major contribution to ion detectability in liquid chromatography-driven mass spectrometry-based proteomics. The newly designed vacuum insulated probe heated electrospray ionization (VIP-HESI) source coupled with a Bruker timsTOF PRO mass spectrometer in microspray mode demonstrates superior performance. VIP-HESI significantly improves chromatography signals compared to electrospray ionization (ESI) and nanospray ionization, providing increased protein detection with higher quantitative precision and enhancing reproducibility of sample injection amounts.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Chemistry, Analytical
Yijian Xu, Shixiao Li, Ziyang Wang, Heng Zhang, Zikai Li, Bo Xiao, Wei Guo, Linwei Liu, Pengfei Bai
Summary: Gray scale consistency in electrowetting displays (EWDs) is crucial, but traditional driving waveforms fail to achieve pixel aperture ratio consistency and lead to gray inconsistency. This paper proposes a multi-direct current (DC) overdriving waveform to ensure gray scale consistency and enhance EWD performance. The waveform consists of a start-up driving phase and a stable driving phase, with a square wave of 79% duty cycle and 43 Hz frequency in the stable phase, supplemented by an overdriving pulse. Applied to a TFT-EWD, this waveform results in an average difference of only 2.79% between increasing and decreasing driving voltages, and achieves 3.7 times aperture ratio at low voltages compared to DC driving.
Article
Materials Science, Multidisciplinary
Zhou Zuolang, Min Xiaohua, Bai Pengfei, Wang Enze, Zhang Weilin
Summary: The oxidation behavior and precipitation behavior of Ti-15Mo-xO(x=0.1, 0.2, 0.3, 0.4, 0.5, wt%) alloys were investigated. At 873 K, the oxidation products were composed of TiO2, Ti3O and Ti6O, and the oxygen contents had no significant effect on the oxidation behavior, which was controlled by titanium diffusion. At 1073 K, the oxidation products were TiO2, and the oxygen contents significantly affected the oxidation behavior. The a phase precipitation increased with the increase of oxygen content and aging time at 837 K.
RARE METAL MATERIALS AND ENGINEERING
(2023)
Article
Plant Sciences
Liangliang Chen, Alicia M. M. Cochran, Jessica M. M. Waite, Ken Shirasu, Shannon M. M. Bemis, Keiko U. U. Torii
Summary: Plants perceive signals through cell-surface receptors to coordinate their development and environmental response. PUB30 and PUB31, two closely related ubiquitin E3 ligases, regulate ERECTA signaling by promoting its degradation, thereby ensuring optimal signaling outputs for inflorescence/pedicel growth and stomatal development.
Article
Geriatrics & Gerontology
Adam R. Burns, Jack Wiedrick, Alicia Feryn, Michal Maes, Mukul K. Midha, David H. Baxter, Seamus R. Morrone, Timothy J. Prokop, Charu Kapil, Michael R. Hoopmann, Ulrike Kusebauch, Eric W. Deutsch, Noa Rappaport, Kengo Watanabe, Robert L. Moritz, Richard A. Miller, Jodi A. Lapidus, Eric S. Orwoll
Summary: By studying the proteome changes induced by interventions known to increase mouse lifespan, we identified a set of proteins and biological mechanisms related to enhancing longevity. Although each intervention resulted in different protein changes, we found a group of proteins that responded to multiple interventions and were associated with peroxisomal oxidation and fatty acid metabolism.
Proceedings Paper
Engineering, Electrical & Electronic
Jing Xiao, Xiaoxuan Guo, Haonan Shi, Pengfei Bai, Wenlan Gong, Chunsen Tang
Summary: This paper proposes a non-blind-zone Foreign Object Detection (FOD) scheme in Wireless Power Transfer (WPT) system, based on the impedance characteristics of the detection coil with double-layer structure. Through the design of a double-layer coil, the distribution of the magnetic field is made uniform, improving detection accuracy and eliminating blind zones for certain sizes of metal foreign objects. Experimental analysis verifies the sensitivity and stability of the metal FOD system, showing that it can detect metal foreign objects as small as a paper clip without blind zones, regardless of the presence of a strong magnetic field.
2022 IEEE 9TH INTERNATIONAL CONFERENCE ON POWER ELECTRONICS SYSTEMS AND APPLICATIONS, PESA
(2022)
Article
Biochemistry & Molecular Biology
Nandarapu Kumarswamyreddy, Ayami Nakagawa, Hitoshi Endo, Akie Shimotohno, Keiko U. Torii, Jeffrey W. Bode, Shunsuke Oishi
Summary: Chemical protein synthesis of plant-derived cysteine-rich secretory proteins and their late-stage derivatization has been achieved using distinct chemoselective amide bond forming reactions. The synthesized EPFs exhibit bioactivity on stomatal development and suitable fluorescent variants have been identified for subcellular localization of EPFs using comprehensive synthesis of EPF derivatives.
RSC CHEMICAL BIOLOGY
(2022)
