Article
Biochemistry & Molecular Biology
Ying Wang, Yunjing Zhang, Xinwan Su, Qiongzi Qiu, Yuan Yuan, Chunhua Weng, Sailan Zou, Yan Tian, Weidong Han, Pengyuan Liu, Xingyi Guo, Jianhua Mao, Xianghui Fu, Ping Wang, Weiqiang Lin
Summary: This study found that circDVL1 is reduced in the serums and tissues from ccRCC patients, and negatively correlates with malignant features of ccRCC. Overexpression of circDVL1 inhibits proliferation and migration, induces apoptosis in ccRCC cells. Mechanistically, circDVL1 functions as a sponge for miR-412-3p, preventing its repression of target gene PCDH7 in ccRCC cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Huiming Jiang, Haibin Chen, Pei Wan, Meng Liang, Nanhui Chen
Summary: TMEM45A is significantly overexpressed in ccRCC patients, correlated with poor overall survival, and may promote tumorigenesis and metastasis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Lili Zhang, Xiaofang Luo, Sen Qiao
Summary: This study investigates the biological function and molecular mechanisms of METTL14 in the pathogenesis of clear-cell renal-cell carcinoma (ccRCC). The results show that METTL14 expression is significantly down-regulated in ccRCC tissues. Functional analysis reveals that upregulation of METTL14 inhibits proliferation and migration of ccRCC cells in vitro, and suppresses the activation of the PI3K/AKT signaling pathway. Furthermore, METTL14 regulates the Pten gene and promotes Pten expression through m6A modification of Pten mRNA. This study suggests that METTL14 may serve as a potential prognostic biomarker and therapeutic target for ccRCC.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Bo Zhan, Xiao Dong, Yulin Yuan, Zheng Gong, Bohan Li
Summary: The study reveals that HIF-1α is downregulated in ccRCC, inhibiting cell proliferation, migration, and invasion, which has important biological implications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
W. Liang, S. H. Chen, G. L. Yang, J. Y. Feng, Q. Ling, B. Wu, H. B. Yan, J. W. Cheng
Summary: This study demonstrates that zinc-finger protein 677 (ZNF677) acts as a tumor suppressor gene in clear cell renal cell carcinoma (ccRCC), inhibiting tumor cell proliferation and invasion, inducing apoptosis. Low expression of ZNF677 is associated with shorter overall survival. High expression of ZNF677 can be considered as a favorable prognostic indicator for ccRCC.
Article
Oncology
Yeda Chen, Zhu Wang, Qiong Deng, Yuting Chen, Hui Liang
Summary: Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) is a key gluconeogenesis enzyme that may play a significant role in the emergence and progression of kidney renal clear cell carcinoma (KIRC) by influencing energy metabolism. The study investigated the significance of PCK2 in KIRC by examining its relationship with clinical features and prognoses of different clinical subgroups. Experimental methods confirmed the downregulation of PCK2 in KIRC cell lines and tissues and revealed its inhibitory effects on cell proliferation, migration, and invasion, as well as its ability to regulate energy metabolite expression. PCK2 could serve as a diagnostic and prognostic biomarker for KIRC and a therapeutic target for the disease.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Balawant Kumar, Rizwan Ahmad, Giovanna A. Giannico, Roy Zent, Geoffrey A. Talmon, Raymond C. Harris, Peter E. Clark, Vinata Lokeshwar, Punita Dhawan, Amar B. Singh
Summary: The expression of claudin-2 is significantly decreased in PTE cells and ex-vivo cultured mouse kidneys subjected to dedifferentiation. Inhibition of claudin-2 induces mesenchymal plasticity and invasive mobility in these models. Overexpression of claudin-2 in RCC-derived cancer cells inhibits tumorigenic abilities, supporting a novel tumor-suppressive role of claudin-2 in RCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yadong Liu, Huiyan Lv, Xingyi Li, Jiannan Liu, Song Chen, Yaodong Chen, Yinshan Jin, Ruihua An, Shiliang Yu, Zhigang Wang
Summary: This study investigated the anti-tumor effects of Cyclovirobuxine (CVB) on clear cell renal cell carcinoma (ccRCC) and elucidated its mechanism by inhibiting multiple signaling pathways, reducing cell proliferation, promoting apoptosis, and blocking epithelial-mesenchymal transition. CVB targeted insulin-like growth factor binding protein 3 (IGFBP3) to exert anti-ccRCC effects, providing a potential therapeutic regimen for ccRCC treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Hong Xie, Jun Song, Jason Godfrey, Romain Riscal, Nicolas Skuli, Itzhak Nissim, M. Celeste Simon
Summary: The accumulation of glycogen is a consistent feature of clear cell renal cell carcinoma (ccRCC). However, it has been found that glycogen is not essential for tumor cell proliferation and survival in ccRCC, both in vivo and in vitro. This suggests that glycogen build-up in ccRCC tumor cells may be a secondary and seemingly non-essential consequence of HIF-1 alpha signaling.
Article
Cell Biology
Lin-Jing Gong, Xin-Yuan Wang, Xu-dong Yao, Xu Wu, Wen-Yu Gu
Summary: In this study, a novel circular RNA, circESRP1, was identified with lower expression in ccRCC tissues. The circESRP1/miR-3942/CTCF positive-feedback loop was found to regulate ccRCC cell functions through c-Myc mediated EMT process, suggesting a potential novel target for ccRCC treatment.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Wei Li, Shi Xu, Naixiong Peng, Zejian Zhang, Hua He, Ruoyu Chen, Dong Chen, Jiqing Fan, Xisheng Wang
Summary: The expression of METTL7B is significantly upregulated in clear cell renal cell carcinoma (ccRCC), and it is associated with poor prognosis in patients. Downregulation of METTL7B inhibits cell proliferation, migration, induces cell cycle arrest, and promotes apoptosis, suggesting its potential as a therapeutic target in ccRCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jose Maria Zamora-Fuentes, Enrique Hernandez-Lemus, Jesus Espinal-Enriquez
Summary: In this study, a miR-gene co-expression network analysis was conducted to explore the progression of ccRC. The results revealed that miR-217 has different expression patterns in different stages and its target genes play significant roles in cancer progression, providing a new approach for identifying stage-dependent therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Akash K. Kaushik, Amy Tarangelo, Lindsey K. Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina T. Tcheuyap, Faeze Saatchi, Quyen N. Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D. Rao, Brandon Faubert, Panayotis Pachnis, Lauren G. Zacharias, Hieu Vu, Feng Cai, Thomas P. Mathews, Giannicola Genovese, Barbara S. Slusher, Payal Kapur, Xiankai Sun, Matthew Merritt, James Brugarolas, Ralph J. DeBerardinis
Summary: This study analyzed the metabolism of patient-derived xenografts from different subtypes of renal cell carcinoma. The findings showed that tumorgrafts from VHL-mutant clear cell RCC catabolize glutamine through multiple pathways, which may explain the challenges in achieving therapeutic responses by inhibiting glutaminase.
Article
Medicine, Research & Experimental
Zhuonan Liu, Tianshui Sun, Chiyuan Piao, Zhe Zhang, Chuize Kong
Summary: The study found that METTL13 is downregulated in ccRCC and is associated with poor prognosis; METTL13 can inhibit the growth and metastasis of ccRCC cells through multiple molecular mechanisms.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Lei Wang, Xiu-Xiu Liu, Yu-Meng Yang, Yan Wang, Yuan-Yuan Song, Shan Gao, Lu-Yuan Li, Zhi-Song Zhang
Summary: The study identified the important role of rhomboid family genes in the progression of kidney renal clear cell carcinoma, particularly highlighting the correlation between high expression levels of RHBDF2 gene and poor prognosis in the disease. Furthermore, it revealed that high RHBDF2 expression may promote cell migration in cancer tissues and inhibit immune cell activity by sustaining PD-L1 protein levels.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Yingkun Xu, Dan Shu, Meiying Shen, Qiulin Wu, Yang Peng, Li Liu, Zhenrong Tang, Shun Gao, Yuan Wang, Shengchun Liu
Summary: This study explores the potential mechanism of the PPAR signaling pathway in breast cancer and establishes a prognostic-related risk model. The risk model shows good prediction accuracy and can serve as an independent risk factor for BRCA patients.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Yingkun Xu, Yang Peng, Meiying Shen, Li Liu, Jinwei Lei, Shun Gao, Yuan Wang, Ailin Lan, Han Li, Shengchun Liu
Summary: This study aims to explore the potential mechanism of angiogenesis in breast cancer (BRCA) and construct a risk model for predicting prognosis. Through bioinformatics analysis, a risk model consisting of seven angiogenesis-related genes in BRCA was established, and its accuracy was validated. The findings provide valuable data and clues for future studies on angiogenesis in BRCA.
JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Li Liu, Chenxi Chen, Gang Tu, Yang Peng, Meiying Shen, Yingkun Xu, Shengchun Liu
Summary: Breast cancer is a highly heterogeneous disease and the second leading cause of death among women. The study identified three subtypes of pyroptosis that are strongly associated with breast cancer prognosis. Lung metastasis, a common complication of advanced breast cancer, significantly impacts patients' quality of life. The study also found that certain lncRNAs and a BRCA risk-score model could predict the occurrence of lung metastasis in breast cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Mathematical & Computational Biology
Xiunan Li, Jiayi Li, Leizuo Zhao, Zicheng Wang, Peizhi Zhang, Yingkun Xu, Guangzhen Wu
Summary: This study used bioinformatic analyses to identify potential prognostic markers and therapeutic targets for Adrenal cortical carcinoma (ACC) and identified 17 hub genes. CCNB1 and NDC80 genes were selected as potential biomarkers for ACC through multiple algorithms.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Genetics & Heredity
Zicheng Wang, Jiayi Li, Peizhi Zhang, Leizuo Zhao, Bingyin Huang, Yingkun Xu, Guangzhen Wu, Qinghua Xia
Summary: This study successfully established a predictive risk model for kidney renal clear cell carcinoma (KIRC) using various bioinformatics methods, and validated its effectiveness through correlation analysis and survival rate analysis.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Xiaoli Feng, Yang Jiang, Yue Cui, Yingkun Xu, Qi Zhang, Qinghua Xia, Yougen Chen
Summary: NEK2 is highly expressed in clear cell renal cell carcinoma (ccRCC), and its expression is associated with clinical outcomes. NEK2 plays an important role in regulating cell proliferation and metastasis in ccRCC.
Article
Genetics & Heredity
Jiayi Li, Haiguang Hou, Jinhao Sun, Zhaoxi Ding, Yingkun Xu, Guibao Li
Summary: The purpose of this study was to investigate the expression significance, predictive value, immunologic function, and biological role of transmembrane protein 158 (TMEM158) in the development of pan-cancer. Our findings revealed that TMEM158 was highly expressed in various cancer tissues and was associated with prognosis. Moreover, TMEM158 was significantly correlated with tumor mutational burden (TMB), microsatellite instability (MSI), and tumor immune cell infiltration in multiple cancers. TMEM158 may serve as a significant predictor of cancer prognosis and modulate immune responses to various types of cancer.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Multidisciplinary Sciences
Yuan Wang, Shun Gao, Yingkun Xu, Zhenrong Tang, Shengchun Liu
Summary: This study aimed to analyze the prognostic implications of mitochondrial function-related lncRNAs in breast cancer (BRCA) and their link to the immunological microenvironment. By analyzing clinical and transcriptome data of BRCA samples, mitochondrial function-related lncRNAs were identified and a prognostic signature was constructed. The study found that individuals in the higher-risk category had lower overall survival rates and decreased immune cell infiltration and function. This study provides new insights for the treatment and prognostic prediction of breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Jiechuan Qiu, Zicheng Wang, Yingkun Xu, Leizuo Zhao, Peizhi Zhang, Han Gao, Qingliang Wang, Qinghua Xia
Summary: This study identified 5 hub genes associated with clear cell renal cell carcinoma (ccRCC) and demonstrated that decreased expression of SLC34A1 is correlated with poor prognosis in ccRCC. SLC34A1 may serve as a molecular prognostic marker and therapeutic target for ccRCC patients.
Article
Oncology
Peizhi Zhang, Jiayi Li, Zicheng Wang, Leizuo Zhao, Jiechuan Qiu, Yingkun Xu, Guangzhen Wu, Qinghua Xia
Summary: This study aims to establish a new prognostic risk model of MAPK pathway related molecules in kidney renal clear cell carcinoma (KIRC) based on genome and transcriptome analysis. The results showed that this model has good predictive value for the prognosis of KIRC patients.
FRONTIERS IN ONCOLOGY
(2023)
Letter
Oncology
Qifei Wang, Wei Zhang, Xiaochen Qi, Jiayi Li, Yuanxin Liu, Quanlin Li, Yingkun Xu, Guangzhen Wu
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Ecology
Jiaao Sun, Feng Chen, Guangzhen Wu
Summary: The symbiotic bacteria in the human gut and their metabolites have a significant impact on the physiological and pathological processes of the host. The gut microbiota is increasingly recognized for its role in various human cancers, including cancer occurrence, progression, treatment, and prognosis. Understanding the functional role of the gut microbiota in cancer is crucial for personalized medicine development. This review highlights recent advances in research on the gut microbiota's association with human cancers and discusses the challenges and potential applications in antitumor therapy.
Article
Pathology
Leizuo Zhao, Zicheng Wang, Yingkun Xu, Peizhi Zhang, Jiechuan Qiu, Dengke Nie, Guangzhen Wu, Chen Chen, Yao Chang, Qinghua Xia
Summary: SPHK1 is abnormally overexpressed in clear cell renal cell carcinoma (ccRCC) and is associated with poor prognosis. Inhibition of SPHK1 can suppress proliferation, migration, and invasion of ccRCC cells, and reduce fatty acid metabolism, leading to slower tumor growth. Targeting SPHK1 may provide a potential therapeutic strategy for ccRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Meeting Abstract
Oncology
Yingkun Xu, Shengchun Liu