Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 37, Issue -, Pages 46-50Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2015.12.005
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Funding
- [R01 GM058465]
- [F31 GM101944]
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Long noncoding RNAs (lncRNAs) were discovered in eukaryotes more than 30 years ago [1]. Recent advances in genomics have led to the discovery that lncRNAs are transcribed pervasively across the genome [2(.),3,4,5(.)]. There are an increasing number of reports that identify lncRNAs whose expression is modulated during cell differentiation or in disease states. However, biological functions for the vast majority of them are yet to be determined. Here, we propose two ways to identify lncRNAs that have biological functions: to identify lncRNAs with dedicated preinitiation complexes (PICs), and to focus on those whose transcription is highly regulated.
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